# /usr/local/bin/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/sh00612.fasta.nr -Q ../query/FLJ00276.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 FLJ00276, 426 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7826239 sequences Expectation_n fit: rho(ln(x))= 5.6039+/-0.000193; mu= 9.2542+/- 0.011 mean_var=85.3420+/-16.793, 0's: 39 Z-trim: 41 B-trim: 2582 in 1/66 Lambda= 0.138833 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 37, opt: 25, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|34526503|dbj|BAC85129.1| FLJ00276 protein [Homo ( 426) 3010 612.5 5.8e-173 gi|119624337|gb|EAX03932.1| FYVE, RhoGEF and PH do ( 377) 684 146.6 9.2e-33 gi|123993873|gb|ABM84538.1| FYVE, RhoGEF and PH do ( 655) 684 146.8 1.4e-32 gi|23271131|gb|AAH23645.1| FYVE, RhoGEF and PH dom ( 655) 684 146.8 1.4e-32 gi|61213572|sp|Q7Z6J4.1|FGD2_HUMAN RecName: Full=F ( 655) 684 146.8 1.4e-32 gi|158261861|dbj|BAF83108.1| unnamed protein produ ( 655) 680 146.0 2.5e-32 gi|114607222|ref|XP_527374.2| PREDICTED: FYVE, Rho ( 655) 678 145.6 3.3e-32 gi|109070980|ref|XP_001116976.1| PREDICTED: simila ( 655) 668 143.6 1.3e-31 gi|114607224|ref|XP_001173495.1| PREDICTED: FYVE, ( 654) 661 142.2 3.4e-31 gi|73972747|ref|XP_538892.2| PREDICTED: similar to ( 657) 655 141.0 7.9e-31 gi|194040425|ref|XP_001929608.1| PREDICTED: simila ( 656) 653 140.6 1e-30 gi|194223464|ref|XP_001495203.2| PREDICTED: simila ( 656) 634 136.8 1.5e-29 gi|111120294|gb|ABH06332.1| FYVE, RhoGEF and PH do ( 656) 620 134.0 1e-28 gi|164518928|ref|NP_001101087.2| FYVE, RhoGEF and ( 655) 603 130.6 1.1e-27 gi|18256145|gb|AAH21845.1| Fgd2 protein [Mus muscu ( 461) 601 130.1 1.1e-27 gi|31415681|gb|AAP45200.1| Fgd2-like protein splic ( 579) 601 130.1 1.3e-27 gi|74217786|dbj|BAE33605.1| unnamed protein produc ( 655) 601 130.2 1.4e-27 gi|61213586|sp|Q8BY35.1|FGD2_MOUSE RecName: Full=F ( 655) 601 130.2 1.4e-27 gi|85375916|gb|ABC70180.1| FGD2 [Mus musculus] ( 655) 601 130.2 1.4e-27 gi|3599940|gb|AAC35430.1| faciogenital dysplasia p ( 727) 601 130.2 1.5e-27 gi|194375267|dbj|BAG62746.1| unnamed protein produ ( 283) 572 124.1 4.2e-26 gi|56204925|emb|CAI20471.1| FYVE, RhoGEF and PH do ( 697) 562 122.4 3.4e-25 gi|126309939|ref|XP_001379109.1| PREDICTED: simila ( 689) 548 119.6 2.3e-24 gi|149487029|ref|XP_001518582.1| PREDICTED: simila ( 283) 421 93.8 5.3e-17 gi|148690671|gb|EDL22618.1| FYVE, RhoGEF and PH do ( 500) 348 79.4 2.1e-12 gi|149043514|gb|EDL96965.1| FYVE, RhoGEF and PH do ( 381) 345 78.7 2.6e-12 gi|149019709|gb|EDL77857.1| FYVE, RhoGEF and PH do ( 579) 337 77.3 1.1e-11 gi|148665005|gb|EDK97421.1| FYVE, RhoGEF and PH do ( 580) 336 77.1 1.2e-11 gi|15705417|gb|AAL05632.1|AF402612_1 actin-binding ( 603) 336 77.1 1.3e-11 gi|149019706|gb|EDL77854.1| FYVE, RhoGEF and PH do ( 743) 337 77.3 1.3e-11 gi|61213042|sp|O88387.1|FGD4_RAT RecName: Full=FYV ( 766) 337 77.3 1.3e-11 gi|119608936|gb|EAW88530.1| FYVE, RhoGEF and PH do ( 471) 334 76.6 1.4e-11 gi|109096110|ref|XP_001084857.1| PREDICTED: simila ( 471) 334 76.6 1.4e-11 gi|71297337|gb|AAH45552.1| FGD4 protein [Homo sapi ( 471) 334 76.6 1.4e-11 gi|149019707|gb|EDL77855.1| FYVE, RhoGEF and PH do ( 864) 337 77.4 1.5e-11 gi|148665006|gb|EDK97422.1| FYVE, RhoGEF and PH do ( 743) 336 77.1 1.5e-11 gi|74203974|dbj|BAE28995.1| unnamed protein produc ( 754) 336 77.1 1.5e-11 gi|61213610|sp|Q91ZT5.1|FGD4_MOUSE RecName: Full=F ( 766) 336 77.1 1.5e-11 gi|194211823|ref|XP_001499753.2| PREDICTED: FYVE, ( 766) 336 77.1 1.5e-11 gi|148665004|gb|EDK97420.1| FYVE, RhoGEF and PH do ( 864) 336 77.2 1.7e-11 gi|114645385|ref|XP_001135948.1| PREDICTED: hypoth ( 673) 334 76.7 1.8e-11 gi|114645387|ref|XP_001135623.1| PREDICTED: hypoth ( 719) 334 76.7 1.9e-11 gi|114645377|ref|XP_001135790.1| PREDICTED: hypoth ( 750) 334 76.7 2e-11 gi|109096106|ref|XP_001085322.1| PREDICTED: simila ( 766) 334 76.7 2e-11 gi|16552927|dbj|BAB71413.1| unnamed protein produc ( 766) 334 76.7 2e-11 gi|114645381|ref|XP_001136045.1| PREDICTED: hypoth ( 766) 334 76.7 2e-11 gi|116241363|sp|Q96M96.2|FGD4_HUMAN RecName: Full= ( 766) 334 76.7 2e-11 gi|90082537|dbj|BAE90450.1| unnamed protein produc ( 789) 334 76.7 2.1e-11 gi|221041604|dbj|BAH12479.1| unnamed protein produ ( 851) 334 76.8 2.2e-11 gi|114645379|ref|XP_520721.2| PREDICTED: hypotheti ( 853) 334 76.8 2.2e-11 >>gi|34526503|dbj|BAC85129.1| FLJ00276 protein [Homo sap (426 aa) initn: 3010 init1: 3010 opt: 3010 Z-score: 3261.5 bits: 612.5 E(): 5.8e-173 Smith-Waterman score: 3010; 100.000% identity (100.000% similar) in 426 aa overlap (1-426:1-426) 10 20 30 40 50 60 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|345 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFPH 10 20 30 40 50 60 70 80 90 100 110 120 FLJ002 SFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|345 SFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQS 70 80 90 100 110 120 130 140 150 160 170 180 FLJ002 EELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|345 EELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLHL 130 140 150 160 170 180 190 200 210 220 230 240 FLJ002 HHPGLHLSYLGLRLIHLGLHLPHLGLHLCHLHLSLRGLHLCHPGLYLSYLGFHLIHLGFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|345 HHPGLHLSYLGLRLIHLGLHLPHLGLHLCHLHLSLRGLHLCHPGLYLSYLGFHLIHLGFH 190 200 210 220 230 240 250 260 270 280 290 300 FLJ002 LIHLGLHLPHLGLYLSHLGLHLPHLGFHQCHPGLYLSHLGLYLPYLGLYPPSSGAAVPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|345 LIHLGLHLPHLGLYLSHLGLHLPHLGFHQCHPGLYLSHLGLYLPYLGLYPPSSGAAVPIL 250 260 270 280 290 300 310 320 330 340 350 360 FLJ002 AKSAGFNQCSPVVLGTSSEPGVCITTSSGPHSTPQEAAVSHFLDGKMRPIEVKLLAEGTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|345 AKSAGFNQCSPVVLGTSSEPGVCITTSSGPHSTPQEAAVSHFLDGKMRPIEVKLLAEGTP 310 320 330 340 350 360 370 380 390 400 410 420 FLJ002 EADPMNLPAFLSSFSTTLRPRARKWSPVLVEGHLAPHPLRPCPTTSPGPCPLCTHPPRHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|345 EADPMNLPAFLSSFSTTLRPRARKWSPVLVEGHLAPHPLRPCPTTSPGPCPLCTHPPRHP 370 380 390 400 410 420 FLJ002 LFTRFG :::::: gi|345 LFTRFG >>gi|119624337|gb|EAX03932.1| FYVE, RhoGEF and PH domain (377 aa) initn: 708 init1: 684 opt: 684 Z-score: 744.4 bits: 146.6 E(): 9.2e-33 Smith-Waterman score: 684; 100.000% identity (100.000% similar) in 105 aa overlap (30-134:77-181) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::::::::: gi|119 PVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFP 50 60 70 80 90 100 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ 110 120 130 140 150 160 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::::::::::::::: gi|119 SEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDN 170 180 190 200 210 220 >>gi|123993873|gb|ABM84538.1| FYVE, RhoGEF and PH domain (655 aa) initn: 708 init1: 684 opt: 684 Z-score: 741.1 bits: 146.8 E(): 1.4e-32 Smith-Waterman score: 684; 100.000% identity (100.000% similar) in 105 aa overlap (30-134:355-459) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::::::::: gi|123 PVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFP 330 340 350 360 370 380 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|123 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ 390 400 410 420 430 440 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::::::::::::::: gi|123 SEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDN 450 460 470 480 490 500 >>gi|23271131|gb|AAH23645.1| FYVE, RhoGEF and PH domain (655 aa) initn: 708 init1: 684 opt: 684 Z-score: 741.1 bits: 146.8 E(): 1.4e-32 Smith-Waterman score: 684; 100.000% identity (100.000% similar) in 105 aa overlap (30-134:355-459) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::::::::: gi|232 PVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFP 330 340 350 360 370 380 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|232 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ 390 400 410 420 430 440 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::::::::::::::: gi|232 SEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDN 450 460 470 480 490 500 >>gi|61213572|sp|Q7Z6J4.1|FGD2_HUMAN RecName: Full=FYVE, (655 aa) initn: 708 init1: 684 opt: 684 Z-score: 741.1 bits: 146.8 E(): 1.4e-32 Smith-Waterman score: 684; 100.000% identity (100.000% similar) in 105 aa overlap (30-134:355-459) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::::::::: gi|612 PVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFP 330 340 350 360 370 380 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|612 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ 390 400 410 420 430 440 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::::::::::::::: gi|612 SEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDN 450 460 470 480 490 500 >>gi|158261861|dbj|BAF83108.1| unnamed protein product [ (655 aa) initn: 704 init1: 680 opt: 680 Z-score: 736.7 bits: 146.0 E(): 2.5e-32 Smith-Waterman score: 680; 99.048% identity (100.000% similar) in 105 aa overlap (30-134:355-459) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::::::::: gi|158 PVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFP 330 340 350 360 370 380 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ 390 400 410 420 430 440 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::.:::::::::::: gi|158 SEDLGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDN 450 460 470 480 490 500 >>gi|114607222|ref|XP_527374.2| PREDICTED: FYVE, RhoGEF (655 aa) initn: 702 init1: 678 opt: 678 Z-score: 734.6 bits: 145.6 E(): 3.3e-32 Smith-Waterman score: 678; 99.048% identity (99.048% similar) in 105 aa overlap (30-134:355-459) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::::::::: gi|114 PVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFP 330 340 350 360 370 380 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: gi|114 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDTQEQELQ 390 400 410 420 430 440 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::::::::::::::: gi|114 SEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAKLKYHDN 450 460 470 480 490 500 >>gi|109070980|ref|XP_001116976.1| PREDICTED: similar to (655 aa) initn: 668 init1: 668 opt: 668 Z-score: 723.7 bits: 143.6 E(): 1.3e-31 Smith-Waterman score: 668; 97.143% identity (98.095% similar) in 105 aa overlap (30-134:355-459) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::::::::: gi|109 PVFKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFP 330 340 350 360 370 380 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ ::::::::::::::::::::: ::::::::::.:::::::::::::::::::: :::::: gi|109 HSFLVSGKQRTLELQARSQEEKISWMQAFQAAVDQIEKRNETFKAAAQGPEGDTQEQELQ 390 400 410 420 430 440 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::::::::::::::: gi|109 SEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYNDN 450 460 470 480 490 500 >>gi|114607224|ref|XP_001173495.1| PREDICTED: FYVE, RhoG (654 aa) initn: 564 init1: 564 opt: 661 Z-score: 716.2 bits: 142.2 E(): 3.4e-31 Smith-Waterman score: 661; 98.095% identity (98.095% similar) in 105 aa overlap (30-134:355-458) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::::::::: gi|114 PVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFP 330 340 350 360 370 380 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: : gi|114 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDTQEQE-Q 390 400 410 420 430 440 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::::::::::::::: gi|114 SEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAKLKYHDN 450 460 470 480 490 500 >>gi|73972747|ref|XP_538892.2| PREDICTED: similar to FYV (657 aa) initn: 655 init1: 655 opt: 655 Z-score: 709.7 bits: 141.0 E(): 7.9e-31 Smith-Waterman score: 655; 96.190% identity (97.143% similar) in 105 aa overlap (30-134:357-461) 10 20 30 40 50 FLJ002 TPLTPCSVRARSSRSPSAATTPWSATFSWVIQVGAQFQVRTRIDVAGMKVRELMDAEFP :::::::::::::::::::::::: ::::: gi|739 PVLKISFRRSDPMERYLFLFNNMLLYCIPKVIQVGAQFQVRTRIDVAGMKVRELTDAEFP 330 340 350 360 370 380 60 70 80 90 100 110 FLJ002 HSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQ :::::::::::::::::::::::::::: :::::::::::::::::.:::::: :::::: gi|739 HSFLVSGKQRTLELQARSQEEMISWMQACQAAIDQIEKRNETFKAAVQGPEGDTQEQELQ 390 400 410 420 430 440 120 130 140 150 160 170 FLJ002 SEELGLRAPQWVRDKHGDHVHALPGALQRSDAPSPPLPGLRLCEYSCQHSCLHLRHPGLH ::::::::::::::: gi|739 SEELGLRAPQWVRDKMVTMCMRCREPFNALRRRRHHCRACGFVVCAKCSDYRAELKYDDN 450 460 470 480 490 500 426 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (2 proc) start: Sat Feb 28 05:38:34 2009 done: Sat Feb 28 05:45:04 2009 Total Scan time: 882.140 Total Display time: 0.060 Function used was FASTA [version 34.26.5 April 26, 2007]