# 0 KIAA0921, 1658 aa # 1 KIAA0743 (1205 aa) # 2 KIAA0578 (1542 aa) # 3 KIAA1763 (1322 aa) # 4 KIAA1714 (1175 aa) # 5 KIAA0868 (1339 aa) // exp sw-scr id% from to 1 1.3e-131 5576 61.4 2 1205 2 4.9e-87 6324 59.8 62 1542 3 3.8e-11 877 26.0 197 1134 4 1.9e-09 888 26.5 231 1169 5 2.3e-05 807 24.4 195 1236 // 0 ( 1) SLSGGRGPGGAGAAVGMASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARW 1 ( -) ............................................................ 2 ( 62) .............................LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 61) AGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLV-DGRLRLRFTLSCAEPATLQL 1 ( -) ............................................................ 2 ( 93) -NACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLA 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 120) DTPVADDRWHMVLLTRDARRTALAVDG-EARAAEVRSKRREMQVASDLFVGGIPPDVRLS 1 ( -) ............................................................ 2 ( 152) DTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAA 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 179) AL--TLSTVKYEPPFRGLLANLKLGERP--PALLGSQGL-----RGATADPLCAPARNP- 1 ( -) ............................................................ 2 ( 212) ALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEG 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 229) --CANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLN----SEGKEEFVA 1 ( 2) ....................CAFSGI----CTLHFHSC---SEINSS----LAAREENVA 2 ( 272) GVCLNGGVCSVVDDQAV-CDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA 3 ( 197) ..........................................................VV 4 ( 231) ..........................................................VV 5 ( 195) ..........................................................VI // 0 ( 283) TFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH-T-GKSADYVNLSLKSGAVWL 1 ( 31) TFRGSEYLCYDLSQNPIQSSSDEITLSFKTWQRNGLILH-T-GKSADYVNLALKDGAVSL 2 ( 331) TFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH-T-GKSADYVNLALKNGAVSL 3 ( 199) DLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLH-REGPNGDHITLQLRRARLFL 4 ( 233) YFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLH-REGQHGNHITLELIKGKLVF 5 ( 197) NFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGE-GQQGDYITLELKKAKLVL // 0 ( 341) VINLGS---GAFEALVEPVN---GKF-NDNAWHDVRVTRNLRQHAGIGHAMVTISVDGIL 1 ( 89) VINLGS---GAFEAIVEPVN---GKF-NDNAWHDVKVTRNLRQ--------VTISVDGIL 2 ( 389) VINLGS---GAFEALVEPVN---GKF-NDNAWHDVKVTRNLRQ--------VTISVDGIL 3 ( 258) LINSGE---AKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQ--------VNFTVDE-H 4 ( 292) FLNSGN---AKLPSTIAPVTLTLGSLLDDQHWHSVLIE--------LLDTQVNFTVDK-H 5 ( 256) SLNLGSNQLGPIYGHTSVMT---GSLLDDHHWHSVVIERQGRS--------INLTLDRSM // 0 ( 394) TTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVS---NNFMGCLKDVVYKNNDFKLEL 1 ( 134) TTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVS---NNFMGCLKEVVYKNNDIRLEL 2 ( 434) TTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVS---NNFMGCLKEVVYKNNDVRLEL 3 ( 306) RHHFHARGEFNLMNLDYEISFGGIPA----PGKSVSFPHRNFHGCLENLYYNGVD----I 4 ( 340) THHFQAKGDSSYLDLNFEISFGGIPT----PGRSRAFRRKSFHGCLENLYYNGVD----V 5 ( 305) QHF-RTNGEFDYLDLDYEITFGGIPFSGK-PSSSSR---KNFKGCMESINYNGVNIT-DL // 0 ( 451) SRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTE 1 ( 191) SRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTE 2 ( 491) SRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTE 3 ( 358) IDLAKQQKPQIIAMGNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWN 4 ( 392) TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQFRTWN 5 ( 359) AR-RKKLEPSN--VGNLSFSCVEPYTV-PVFFNAT-SYLEVPGRLNQDLFSVSFQFRTWN // 0 ( 511) PNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYL-LLDMGSGGIKLRASSRKVN 1 ( 251) PNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYL-LLDMGSGTIKVKATQKKAN 2 ( 551) PNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYL-LLDMGSGTIKIKALLKKVN 3 ( 417) KAGLLLFSELQLISGG------------ILLFLSDGKLKSNLYQPGKLPSDITAGV-ELN 4 ( 451) RAGHLLFGELRR---GSGS---------FVLFLKDGKLKLSLFQPGQSPRNVTAGA-GLN 5 ( 414) PNGLLVFSHFADNLGNVEIDLTESKVGVH-INITQTKMSQ-I-DISSGS--------GLN // 0 ( 570) DGEWCHVDFQRDGRKGSISVNSR---ST--PFLATGDSEILDLESELYLGGLPE---GGR 1 ( 310) DGEWYHVDIQRDGRSGTISVNSR---RT--PFTASGESEILDLEGDMYLGGLPE---N-R 2 ( 610) DGEWYHVDFQRDGRSGTISVNTL---RT--PYTAPGESEILDLDDELYLGGLPE---N-K 3 ( 464) DGQWHSVSLSAKKNHLSVAVDGQMASAA--PLL--GPEQIYS-GGTYYFGGCPDKSFGSK 4 ( 498) DGQWHSVSFSAKWSHMNVVVDDD---TAVQPLVAV----LIDSGDTYYFGGCLDNSSGSG 5 ( 463) DGQWHEVRFLAKENFAILTIDGD---EA--SAVRTNSPLQVKTGEKYFFGGF-------- // 0 ( 622) VDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQ-GAVGV---APFCSRETL- 1 ( 361) AGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQ-NAAGV---KSSCSRMSA- 2 ( 661) AGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQ-STAGV---KPSCSKETA- 3 ( 519) CKSPL----------GGFQGCMRLISISGKVVDL--ISVQQ-GSLGN---FSDLQIDSCG 4 ( 551) CKSPL----------GGFQGCLRLITIGDKAVD--PILVQQ-GALGSFRDLQIDSCGIT- 5 ( 510) --LNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFAN---VSIDMCAII- // 0 ( 677) --KQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCER-------EA-------TVLSY 1 ( 416) --KQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCER-------EA-------SILSY 2 ( 716) --KPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCER-------EA-------TVLSY 3 ( 563) ISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSIY----EQ-------SCEAY 4 ( 597) --DRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYY 5 ( 564) --DRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIY----EP-------SCEAY // 0 ( 721) --------------DGS-------MYM-KI-----MLPNAMHTEAEDVSLRF-------- 1 ( 460) --------------DGS-------MYM-KI-----IMPMVMHTEAEDVSFRF-------- 2 ( 760) --------------DGS-------MFM-KI-----QLPVVMHTEAEDVSLRF-------- 3 ( 612) KHRGNT--------SGF-------YYI-DSDGSGPLEPFLLYCNMTETAWTI-------- 4 ( 655) IDA-----------DGS-------GPLGPF-----LVYCNMTADAAWTVVQH-------- 5 ( 611) KHLGQTSNYYWIDPDGSGPLGPLKVYC-NM-----TEDKVWTIVSHDLQMQTPVVGYNPE // 0 ( 746) ---MSQRAYGLM-MATTS--R-ESADTLRLELDG-G--QMKLTVNL---------GKG-P 1 ( 485) ---MSQRAYGLL-VATTS--R-DSADTLRLELDG-G--RVKLMVNLDCIRINCNSSKG-P 2 ( 785) ---RSQRAYGIL-MATTS--R-DSADTLRLELDA-G--RVKLTVNLDCIRINCNSSKG-P 3 ( 648) ---IQHNGSDLTRVRNTN--P-ENPYAGFFEYVA-SMEQLQATINR---------AEH-C 4 ( 684) ---GGPDAVTLR-GAPSG--HPRSAVSFAYAAGA-G--QLRSAVNL---------AER-C 5 ( 665) KYSVTQLVYSAS-MDQISAIT-DSAEYCEQYVSYFC--KMSRLLNT---------PDGSP // 0 ( 786) ETLFAGH----KLNDNE------WHTVRVVRR-----GKSLQLSV-DNV-TVEGQMAGAH 1 ( 534) ETLYAGQ----KLNDNE------WHTVRVVRR-----GKSLKLTV-DDD-VAEGTMVGDH 2 ( 834) ETLFAGY----NLNDNE------WHTVRVVRR-----GKSLKLTV-DDQQAMTGQMAGDH 3 ( 691) EQEFTYYCKKSRLVNKQDGTPLSWWVGRTNETQTYWGGSSPDLQK-CTC-GLEGNCIDSQ 4 ( 725) EQRLALRCGTARRPDSRDGTPLSWWVGRTNET-----HTYWGVSLPDAQ-KCTCGLEGNC 5 ( 712) YTWWVGK----A---NE------KH-YYWGGS-----GPGIQKCA---C-GIERNCTDPK // 0 ( 829) M-------RLEFH-NIETGIMTERRFISVVPSNFIGHL--S-GLVFN--GQPYMDQCKDG 1 ( 577) T-------RLEFH-NIETGIMTEKRYISVVPSSFIGHL--Q-SLMFN--GLLYIDLCKNG 2 ( 878) T-------RLEFH-NIETGIITERRYLSSVPSNFIGHL--Q-SLTFN--GMAYIDLCKNG 3 ( 749) YYCNCDADRNEWT-N-DTGLLAYKEHLPV--TKIVITD--T-GRLHS--EAAY----KLG 4 ( 779) I-------DSQYYCNCDAG-RNEWTSDTIVLSQ-KEHLPVT-QIVMTDAGRPHSEAAYTL 5 ( 749) Y----------YC-NCDADYKQWRKDAGFL--SYKDHL--PVSQVVV--GDTDR-QGSEA // 0 ( 876) DITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS 1 ( 624) DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 2 ( 925) DIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 3 ( 796) PLL-CRGDRSFW------NSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENL 4 ( 829) GPLLCRGDQSFW------NSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENL 5 ( 791) KLSVGPLRCQ-GDRNYW-NAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENM // 0 ( 936) GNGNDFIVIEL-VKG-Y-IHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTL 1 ( 684) GDGNDFIAVEL-VKG-Y-IHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSL 2 ( 985) GDGNDFIVVEL-VKG-Y-LHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTV 3 ( 849) GIA-DFIRIEL-RSPTV-VTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEA-SL 4 ( 883) GI-TDFIRIELHAPT-E-VTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGA-SL 5 ( 849) GK-EDFIKLEL-KSA-TEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQA-SL // 0 ( 993) KIDS---RTVTQ----HSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD-GFQGCLAS 1 ( 741) KVDT---KVVTQ----VINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRD-GFQGCLAS 2 ( 1042) KIDT---KITTQ----ITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKE-GFQGCLAS 3 ( 905) QVDQLTPKTQPA----PADGHVLLQLNSQLFVGG------------TATRQRGFLGCIRS 4 ( 939) QVDQLPQKMQPA----PADGHVRLQLNSQLFIGG------------TATRQRGFLGCIRS 5 ( 905) QVD----RLPQQIRKAPTEGHTRLELYSQLFVGG------------AGGQQ-GFLGCIRS // 0 ( 1045) VDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYG 1 ( 793) VDLNGRLPDLINDALHRSGQIKRGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYS 2 ( 1094) VDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFS 3 ( 949) LQLNGMTLDLEERA-QVTPEVQPGCRGHCSSYGKL-CRNGGKCRERPIGFFCDCTFSAYT 4 ( 983) LQLNGVALDLEERATVTPG-VEPGCAGHCST-YGHLCRNGGRCREKRRGVTCDCAFSAYD 5 ( 948) LRMNGVTLDLEERAKVTSGFIS-GCSGHCTSYGT-NCENGGKCLERYHGYSCDCSNTAYD // 0 ( 1105) GPVCN-DPGTTYIFGKGGALIT-----YTW--P--------------P---N-------- 1 ( 853) GNQCN-DPGATYIFGKSGGLIL-----YTW--P--------------A---N-------- 2 ( 1154) GPLCN-DPGTTYIFSKGGGQIT-----YKW--P--------------P---N-------- 3 ( 1007) GPFCS-NEISAY-FGSGSSVI------YNF--Q--------------E---NYLL----- 4 ( 1041) GPFCS-NEISAY-FATGSSMTYHFQEHYTL--S--------------E---NSSSLVSSL 5 ( 1006) GTFCNKDVGA---FFEEGMWLR-----YNFQAPATNARDSSSRVDNAPDQQN-------- // 0 ( 1132) --DRPST----------RMDRLAVGFS--THQRSAVLVRVDSASGLGDYLQLHI-DQ-GT 1 ( 880) --DRPST----------RSDRLAVGFS--TTVKDGILVRIDSAPGLGDFLQLHI-EQ-GK 2 ( 1181) --DRPST----------RADRLAIGFS--TVQKEAVLVRVDSSSGLGDYLELHI-HQ-GK 3 ( 1035) --SKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFV--SSFYKEYLSVII-AKNGS 4 ( 1080) HRDVTLT----------R-EMITLSFR--TTRTPSLLLYVSSF--YEEYLSVILANN-GS 5 ( 1050) --SHPDL----------AQEEIRFSFS--TTKAPCILLYISSFT--TDFLAVLV-KPTGS // 0 ( 1176) VGVIFNV----G--T----DDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWP-VNE 1 ( 924) IGVVFNI----G--T----VDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWP-VNE 2 ( 1225) IGVKFNV----G--T----DDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWP-VIE 3 ( 1090) LQIRYKL----N--KYQEPDVVNFDFKN--MADGQLHHIMINREEGVVFIEID....... 4 ( 1124) LQIRYKLDRHQN--P----DAFTFDFKN--MADGQLHQVKINRE--EAVVMVEVIP.... 5 ( 1093) LQIRYNL----GGTR----EPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSY // 0 ( 1225) RYPAG------------------------------RQLTIFNSQAAIKIG-----GR-DQ 1 ( 973) HYPTG------------------------------RQLTIFNTQAQIAIG-----GK-DK 2 ( 1274) RYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIG-----GK-EQ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( 1145) HLPSS------------------------------SD-TLFNSPKSLFLGKVIETGKIDQ // 0 ( 1249) -----GRP-FQGQVSGLYYNGLKVLALA---AESDPNVRTEGHLRLVGEGPSVL-LSAET 1 ( 997) -----GRL-FQGQLSGLYYDGLKVLNMA---AENNPNIKINGSVRLVGEVPSIL-GTTQT 2 ( 1328) -----GQP-FQGQLSGLYYNGLKVLNMA---AENDANIAIVGNVRLVGEVPSSM--TTES 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( 1174) EIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMS // 0 ( 1299) TATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEE 1 ( 1047) T--SMPPEMSTTVMETTTTMATTTTRKNRST----ASIQPTSDDLVSSAECSSDDEDFVE 2 ( 1377) TATAMQSEMSTSIMETTTTLATSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDP 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( 1234) SAT......................................................... // 0 ( 1359) CEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPP 1 ( 1101) CEPST------------------------------------------------------- 2 ( 1436) CEPSS------------------------------------------------------- 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1419) SGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKP 1 ( -) ------------------------------------------------------------ 2 ( -) ------------------------------------------------------------ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1479) APRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRR 1 ( -) ------------------------------------------------------------ 2 ( -) ------------------------------------------------------------ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1539) PPPLRPGVTSAPGFPHLPTANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCIL 1 ( 1106) -------------------ANPTEPGIRRV-PGASEVIRESSSTTGMVVGIVAAAALCIL 2 ( 1441) -------------------ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCIL 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1598) ILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYY 1 ( 1146) ILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYY 2 ( 1482) ILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYY 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1658) V 1 ( 1205) V 2 ( 1542) V 3 ( -) . 4 ( -) . 5 ( -) . //