# 0 KIAA2034, 1571 aa # 1 KIAA0866 (1984 aa) # 2 KIAA1512 (2010 aa) # 3 KIAA1000 (1956 aa) # 4 KIAA0216 (2067 aa) # 5 KIAA1319 (1208 aa) // exp sw-scr id% from to 1 8.6e-124 6054 59.8 451 1971 2 1.6e-57 3108 36.8 514 2006 3 8.8e-50 2665 33.1 464 1947 4 1.1e-19 1158 26.8 784 1988 5 5.6e-15 815 25.8 280 1193 // 0 ( 1) RLNRALD-RSPRQGASFLGILDIAGFEIFQLN------SFEQLCINYTNEKLQQLFNHTM 1 ( 451) RVNKALD-KTHRQGASFLGILDIAGFEIFEVN------SFEQLCINYTNEKLQQLFNHTM 2 ( 514) RINQTLDTKLPRQ--FFIGVLDIAGFEIFEFN------SFEQLCINFTNEKLQQFFNQHM 3 ( 464) RINRALDAKLSRQ--FFIGILDITGFEILEYN------SLEQLCINFTNEKLQQFFNWYM 4 ( 784) .VNRALK-SSQHSLCSMM-IVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERT 5 ( -) ............................................................ // 0 ( 54) FVLEQEEYQREGIPWTFLDF---------GLDL---QPCIDLIERPANPPGLLALLDEEC 1 ( 504) FILEQEEYQREGIEWNFIDF---------GLDL---QPCIELIERPNNPPGVLALLDEEC 2 ( 566) FVLEQEEYKREGIDWVFIDF---------GLDL---QPCIDLIEKPL---GILSILEEEC 3 ( 516) FVLEQEEYKKESIEWVSIGF---------GLDL---QACIDLIEKPM---GILSILEEEC 4 ( 841) FVQELERYKEENIELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEA 5 ( -) ............................................................ // 0 ( 102) WFPKATDKSFVEKVAQEQG---GH-P-KFQRPR---HLRDQ--ADFSVLHYAGK--VDYK 1 ( 552) WFPKATDKSFVEKLCTEQG---SH-P-KFQKPK---QLKDK--TEFSIIHYAGK--VDYN 2 ( 611) MFPKASDASFRAKLYDNHA---GKSP-NFQQPRPDKKRKYQ--AHFEVVHYAGV--VPYS 3 ( 561) MFPKATDLTFKTKLFDNHF---GK-SVHLQKPK---PDKKKFEAHFELVHYAGV--VPYN 4 ( 901) LVPGASEDTLLERLFSYYGPQEGD-K-KGQSPLL--HSSKP--HHFLLGHSHGTNWVEYN 5 ( -) ............................................................ // 0 ( 150) ANEWL-MKNMDPLNDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGSAERC 1 ( 600) ASAWL-TKNMDPLNDNVTSLLNASSDKFVADLWKD------------------------- 2 ( 663) IVGWL-EKNKDPLNETVVPIFQKSQNRLLATLYEN---------YAGSCSTEPPKS---- 3 ( 612) ISGWL-EKNKDLLNETVVAVFQKSSNRLLASLFEN---------YMSTDSAIPFGEKKRK 4 ( 955) VTGWLNYTKQNPATQNAPRLLQDSQKKIISNL------------FLGR-----AGSATVL 5 ( -) ............................................................ // 0 ( 209) SSAISPPGVEG--IVGLEQVSSLGDG--PPGGRPRRGMFRTVGQLYKESLSRLMATLSNT 1 ( 634) --------VDR--IVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNT 2 ( 709) -------GVK-------EK-------------RKKAASFQTVSQLHKENLNKLMTNLRAT 3 ( 662) KGA----------------------------------SFQTVASLHKENLNKLMTNLKST 4 ( 998) SGSIA--GLEGGSQLALRRATSMRKT--FTTGMAAVKKKSLCIQM-KLQVDALIDTIKKS 5 ( -) ............................................................ // 0 ( 265) NPSFVRCIVPNHEKRAGKLEPR-------------------------LVLD------QLR 1 ( 684) TPNFVRCIIPNHEKRSGKLDAF-------------------------LVLE------QLR 2 ( 742) QPHFVRCIVPNENKTPGVMDAF-------------------------LVLH------QLR 3 ( 688) APHFVRCINPNVNKIPGILDPY-------------------------LVLQ------QLR 4 ( 1053) KLHFVHCFLPVAEGWAG--EPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLR 5 ( -) ............................................................ // 0 ( 294) CNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKG-----FMDGKQACEKMIQALE 1 ( 713) CNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKG-----FMDGKQACILMIKALE 2 ( 771) CNGVLEGIRICRQGFPNRLLYTDFRQRYRILNPSAIPDDT----FMDSRKATEKLLGSLD 3 ( 717) CNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSK----FVSSRKAAEELLGSLE 4 ( 1111) GSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLD 5 ( -) ............................................................ // 0 ( 349) LDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSA 1 ( 768) LDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTA 2 ( 827) LDHTQYQFGHTKVFFKAGLLGVLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDA 3 ( 773) IDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILEERDA 4 ( 1171) LEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLA 5 ( -) ............................................................ // 0 ( 409) LRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREV 1 ( 828) MKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENEL 2 ( 887) LFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKR 3 ( 833) LILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQR 4 ( 1231) IRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKER 5 ( -) ............................................................ // 0 ( 469) GELQGRVAQLEEERARLAEQLRAEAELCAEAE-----ETRGRLAARKQELELVVSELEAR 1 ( 888) KELEQKHSQLTEEKNLLQEQLQAETELYAEAE-----EMRVRLAAKKQELEEILHEMEAR 2 ( 947) QELEETHVSITQEKNDLALQLQAEQDNLADAE-----ERCHLLIKSKVQLEGKVKELSER 3 ( 893) EELKAKQVSLTQEKNDLILQLQAEQETLANVE-----EQCEWLIKSKIQLEARVKELSER 4 ( 1291) NELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ-TQYDAL 5 ( -) ............................................................ // 0 ( 524) VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE-GARQKLQLEKVTTEA-----KMKKFE 1 ( 943) LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE-AARQKLQLEKVTAEA-----KIKKLE 2 ( 1002) LEDEEEVNADLAARRRKLEDECTELKKDIDDLE-LTLAKAEKEKQATEN-----KVKNLT 3 ( 948) VEEEEEINSELTARGRKLEDECFELKKEIDDLE-TMLVKSEKEKRTTEH-----KVKNLT 4 ( 1350) KKQME--VMEMEVMEARLIR-AAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEF 5 ( -) ............................................................ // 0 ( 578) EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR 1 ( 997) DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 2 ( 1056) EEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLE 3 ( 1002) EEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALE 4 ( 1407) EDKLEVEQQN------KRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLE 5 ( -) ............................................................ // 0 ( 638) KEEKGRQELEKLKRRLDGESSELQEQM--VEQQQR--AEELRAQLGRKEEELQA-ALA-- 1 ( 1057) KEEKSRQELEKLKRKLEGDASDFHEQI--ADLQAQ--IAELKMQLAKKEEELQA-ALA-- 2 ( 1116) QEKKLRMDTERAKRKLEGDLKLTQESV--ADAAQD--KQQLEEKLKKKDSELSQ-LSL-- 3 ( 1062) QERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELR----KKELELSQ-MNS-- 4 ( 1461) GQQVRNHELEKKQRRFDSELS----QA--HEEAQR--EKLQREKLQREKDMLLAEAFSLK 5 ( 280) ......QSFEE-PRRSAQDPTMLQFKS--TPDLLR--DQQEAAPPG-SVDHMKA-TIY-- // 0 ( 691) -RAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1 ( 1110) -RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 2 ( 1169) -RVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLE 3 ( 1115) -KVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLE 4 ( 1513) QQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELD 5 ( 325) -GILREGSSESET--SVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLD // 0 ( 750) DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQAR 1 ( 1169) DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 2 ( 1228) EAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQ 3 ( 1174) EVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQ 4 ( 1573) EQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY 5 ( 382) EEVKK-------RQKLEPSQVGLERQLEEKTE-ECSRLQELLERRKGEAQQSNKELQNMK // 0 ( 810) RGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA-- 1 ( 1229) RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-- 2 ( 1288) RVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ-- 3 ( 1234) QVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQL-- 4 ( 1633) EDKQKVLREKRELEGKLATL-----SDQVNRRDFESEKR-LRKDLKRTKALLADAQLMLD 5 ( 434) RLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL-LETRELLEEVLEGKQ--- // 0 ( 868) RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH-DAQEL---LQEETRA 1 ( 1287) RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DTQEL---LQEETRQ 2 ( 1346) LADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLE-ELRRQ---LEEESKA 3 ( 1292) ANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIE-DLRGQ---LEKETKS 4 ( 1687) HLKNSAPSKREIAQLKN---QLEESEFTCAAAVKARKAMEVEIE-DLHLQ---IDDIAKA 5 ( 490) RVE--EQLRLRERELTALKGALKEEVASR---DQEVEHVRQQYQRDTEQLRRSMQDATQD // 0 ( 924) KLALGSRVRAMEAEAAGLREQLEEEAAAR-------ERAGRELQTAQAQLSEWRRRQEE- 1 ( 1343) KLNVSTKLRQLEEERNSLQDQLDEEMEAK-------QNLERHISTLNIQLSDSKKKLQD- 2 ( 1402) KSALAHAVQALRHDCDLLREQHEEEAEAQ-------AELQRLLSKANAEVAQWRSKYEA- 3 ( 1348) QSALAHALQKAQRDCDLLREQYEEEQEVK-------AELHRTLSKVNAEMVQWRMKYEN- 4 ( 1740) KTALEEQLSRLQREKNEIQNRLEEDQEDM-------NELMKKHKAAVAQAS----RDLA- 5 ( 545) HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM // 0 ( 976) --EA-GA-LEAG----EEARRRAA--REAEALTQRLAEKTETVDRLERGRRRLQQELDDA 1 ( 1395) --FA-ST-VEAL----EEGKKRFQ--KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 2 ( 1454) --DAIQR-TEEL----EEAKKKLA--LRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 3 ( 1400) --NVIQR-TEDL----EDAKKELA--IRLQEAAEAMGVANARNASLERARHQLQLELGDA 4 ( 1788) --QI-ND-LQAQ----LE---------EANKEKQELQEKLQA---LQSQVEFLEQSMVDK 5 ( 605) EEEL-GEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQ--SQEVAGR // 0 ( 1026) TMDLEQQ---RQLV---------STLE--KKQ-RKFDQLLAEEKAAVLRAVEERE-RAEA 1 ( 1445) VVDLDNQ---RQLV---------SNLE--KKQ-RKFDQLLAEEKNISSKYADERD-RAEA 2 ( 1505) TLELERA---TSAA---------AALD--KKQ-RHLERALEERR----RQEEEMQ-R-EL 3 ( 1451) LSDLGKV---RSAA---------ARLD--QKQ-LQSGKALADWKQK-----HEES-QALL 4 ( 1828) SLVSRQEAKIRELE---------TRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAA 5 ( 662) HRDRELE---KQLAVLRVEADRGRELE--EQN-LQLQKTLQQLRQDCEEASKAKM-VAEA // 0 ( 1070) EGREREARALS-----LTRALEEEQEAREELERQN-RALRA--ELEALLSSKDDVGKSVH 1 ( 1489) EAREKETKALS-----LARALEEALEAKEELERTN-KMLKA--EMEDLVSSKDDVGKNVH 2 ( 1544) EAAQRESRGLGTELFRLRHGHEEALEALETLKREN-KNLQE--EISDLTDQVSLSGKSIQ 3 ( 1490) DASQKEVQALSTELLKLKNTYEESIVGQETLRREN-KNLQE--EISNLTNQVREGTKNLT 4 ( 1879) ENREKE-QNKR-----LQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQS-- 5 ( 715) EATVLGQRRAA-----VETTLRETQEENDEFRRRI-LGLEQ--QLKETRGLVDG-GEAVE // 0 ( 1122) ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD-LQGRDEAG 1 ( 1541) ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD-LQARDEQN 2 ( 1601) ELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRK-LAEKDEEC 3 ( 1547) EMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERK-LSEKDEEI 4 ( 1931) -LQADLKLAFKRIGDLQAAI---EDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVD 5 ( 766) A-----RLRDKL-QRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA-QRGLARLG // 0 ( 1181) EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1 ( 1600) EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 2 ( 1660) ANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 3 ( 1606) ENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSL 4 ( 1987) SE.......................................................... 5 ( 819) QEQQT-LNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQL // 0 ( 1241) RKMQAQMKE-LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1 ( 1660) RKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 2 ( 1720) RLMQAQLKE-EQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLA 3 ( 1666) GQLQIQIKD-LQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLS 4 ( -) ............................................................ 5 ( 878) QAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA // 0 ( 1300) QQDRDEMADEVAN----GNLSKAAILEEKRQLEG---RLGQLEEELEEEQSNSELLNDRY 1 ( 1719) DLEKEELAEELAS----SLSGRNALQDEKRRLEA---RIAQLEEELEEEQGNMEAMSDRV 2 ( 1779) EQELLEATERLNL----LHSQNTGLLNQKKKLEA---DLAQLSGEVEEAAQERREAEEKA 3 ( 1725) EEELLEATERINL----FYTQNTSLLSQKKKLEA---DVARMQKEAEEVVQECQNAEEKA 4 ( -) ............................................................ 5 ( 938) RLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRV // 0 ( 1353) RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAAL 1 ( 1772) RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 2 ( 1832) KKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKL 3 ( 1778) KKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKL 4 ( -) ............................................................ 5 ( 998) NRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEG--FQKPSASLSQL // 0 ( 1413) ESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1 ( 1832) EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 2 ( 1892) EAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKV 3 ( 1838) ESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKV 4 ( -) ............................................................ 5 ( 1056) ESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQL---SLRV // 0 ( 1473) KQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTL-RNRLRR--GPLTFT 1 ( 1892) KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL-KSKLRR--GNETSF 2 ( 1952) KSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKL-RARTRDALGP---. 3 ( 1898) QNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKL-KIKAR-----.... 4 ( -) ............................................................ 5 ( 1113) KALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRK--A----- // 0 ( 1530) TRTVRQVFR--LEEGVASDEEAEEA-QPGSGPSPEPEGSPPAHPQ 1 ( 1949) VPSRRSGGRRVIENADGSEEETD-..................... 2 ( -) ............................................. 3 ( -) ............................................. 4 ( -) ............................................. 5 ( 1166) SRSAAESAL--KNEGLSSDEEFDSVYDPSS............... //