# 0 KIAA0449, 1628 aa # 1 KIAA1708 (1657 aa) # 2 KIAA0359 (760 aa) # 3 KIAA1405 (993 aa) # 4 KIAA0531 (999 aa) # 5 KIAA0639 (1835 aa) // exp sw-scr id% from to 1 8.7e-106 6324 60.1 6 1634 2 2.2e-08 879 29.4 23 729 3 5.2e-08 771 33.4 41 586 4 1.5e-07 933 27.3 43 895 5 1.8e-07 848 29.6 11 783 // 0 ( 1) LQRAMAGQGDCCVKVAVRIRPQLSKE--------------KIEGCH--ICTSVTPGEPQV 1 ( 6) ............VRVAVRIRPQLAKE--------------KIEGCH--ICTSVTPGEPQV 2 ( 23) ............VRVVVRCRPMNGKE--------------KAASYDKVVDVDVKLGQVSV 3 ( -) ............................................................ 4 ( 43) ....MADPAECSIKVMCRFRPLNEAE--------------ILRGDK--FIPKFK-GDETV 5 ( 11) ........GDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNP--VNTNLSKGDAR- // 0 ( 45) LLGKD------KAFTYDFVF-DLDTWQEQIYS------TCVSK-LIEGCFEGYNATVLAY 1 ( 38) FLGKD------KAFTFDYVF-DIDSQQEQIYI------QCIEK-LIEGCFEGYNATVFAY 2 ( 57) KNPKGTAHEMPKTFTFDAVY-DWNAKQFELYD------ETFRP-LVDSVLQGFNGTIFAY 3 ( 41) ..............................................QGVTEGYNGTIFAY 4 ( 82) VIGQG------KPYVFDRVL-PPNTTQEQVYN------ACAKQ-IVKDVLEGYNGTIFAY 5 ( 60) --GQP------KVFAYDHCFWSMDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAY // 0 ( 91) GQTGAGKTYTM-GTGFDMATSEEEQGIIPRAIAH-LFGGIAER--KRRAQEQGVAGPEFK 1 ( 84) GQTGAGKTYTM-GTGFDVNIVEEELGIISRAVKH-LFKSIEEK--KHIAIKNGLPAPDFK 2 ( 109) GQTGTGKTYTM--EG--IRGDPEKRGVIPNSFDH-IFTHIS------RSQNQ-----QYL 3 ( 55) GQTGSGKSFTM--QGLPDPPSQ--RGIIPRAFEH-VFESV-----------QCAENTKFL 4 ( 128) GQTSSGKTHTMEGKLHD----PQLMGIIPR-IAHDIFDHI-------YSMDENL---EFH 5 ( 112) GQTGSGKSYTM------MGTADQP-GLIPR-----LCSGLFERTQKEENEEQS-----FK // 0 ( 147) VSAQFLELYNEEILDLFDSTRDPDTRHRRSNIKIHEDANGGIYTTGVTSRLIHSQEELIQ 1 ( 140) VNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQ 2 ( 153) VRASYLEIYQEEIRDLL--SKDQTKR-----LELKERPDTGVYVKDLSSFVTKSVKEIEH 3 ( 99) VRASYLEIYNEDVRDLLGA----DTKQK---LELKEHPEKGVYVKGLSMHTVHSVAQCEH 4 ( 173) IKVSYFEIYLDKIRDLLDVSK--------TNLAVHEDKNRVPYVKGCTERFVSSPEEVMD 5 ( 155) VEVSYMEIYNEKVRDLLD----P--KGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIES // 0 ( 207) CLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRMCTQPDLVNEAVTGLPDGTPPSSEY 1 ( 200) CLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIISESAQMNEF 2 ( 206) VMNVGNQNRSVGATNMNEHSSRSHAIFVITI----ECSE--------VGL-DG-----EN 3 ( 152) IMETGWKNRSVGYTLMNKDSSRSHSIFTISI-------EMSAVDE-----------RGKD 4 ( 225) VIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETE--------------------- 5 ( 209) LMSEGNKSRTVAATNMNEESSRSHAVFKITLTH----TLYD-VKSGTSGEKVG------- // 0 ( 267) ETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQS---KKVVH 1 ( 260) ETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKS---KRATH 2 ( 248) HIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDG-----KSTH 3 ( 194) HLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALVDGR---CK--H 4 ( 264) KKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGT---K--TH 5 ( 257) -----KLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQSAGKNKNKF // 0 ( 324) VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVN-- 1 ( 317) VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVN-- 2 ( 303) IPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVN-- 3 ( 249) VPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRIN-- 4 ( 319) VPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLE 5 ( 312) VPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVN-- // 0 ( 382) ---------QDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGAEGYSDLFR-ENAML 1 ( 375) ---------QDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFH-ENAML 2 ( 361) ---------EDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGS--G-GGGEE 3 ( 307) ---------EDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLL 4 ( 379) LTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGE-AVPEDEQISAKD----QKNLE 5 ( 370) ---------EDPNARIIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQ-EMTVT // 0 ( 432) QKENGALRLRVKAMQEAI-DAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIE 1 ( 425) QTENNNLRVRIKAMQETV-DALRSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIE 2 ( 409) EEEEG---------EEGE-EEGDDKDDYWREQQEKLEIEKR--------AIVEDHSLVAE 3 ( 358) PQP--VIQHDMEAEKQLIREEYEERLARLKADYKAEQESRA-RLEEDITAMRNSYDVRLS 4 ( 434) PCDNTPI---IDNIAPVV-AGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQ----LAE 5 ( 420) WEEK--LRKTEEIAQE--------RQKQLESLGISLQSSGIKVGDDKCFLVNLNADPALN // 0 ( 491) ELRTKLL-ESEAMNESLRRSLSRASARSPYSLGASPAAPAFGGSP-ASSMEDAS---EVI 1 ( 484) DLRAKLL-ESEAVNENLRKNLTRATARAPYFSGSSTFSPTI-----LSSDKETI---EII 2 ( 451) EKMRLLK-EKEKKMEDLRRE-KDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQ---KIL 3 ( 415) TLEENLRKETEAVLQVGVLYKAEVMSRAEFASSAE-YPPAFQYET-VVKPKVFS---TTD 4 ( 486) KLKQQML-DQDELLASTRRDYEKIQEELTRLQIENEAAK-----------DEVK---EVL 5 ( 470) ELLVYYL-KEHTL-------IGSANSQDIQLCG-------MGILP-EHCIIDITSEGQVM // 0 ( 546) RRAKQDLERL------KKKE--VRQR-RKSPEK---EAFKKRAKLQQEN---S---E-ET 1 ( 535) DLAKKDLEKL------KRKE--KRKK-KSVAGK---EDNTDTDQEKKEEKGVS---EREN 2 ( 506) EQKRQEIAEQ------KRREREIQQQ-MESRDE---ETLE----LKETY---S---S-LQ 3 ( 470) TLPSDDV---------SKTQ--VSSRFAELPKV---EPSKSEISLGSSE---SSSLE-ET 4 ( 531) ----QALEELAVNYDQKSQE--VEDK-TRANEQLTDELAQKTTTLTTTQ---R---E-LS 5 ( 514) LTPQKNTRTF------VNG-----SS-VSSPIQ---LHHGDRILWGNNH---F---F-RL // 0 ( 587) DENEAEEEEEERD--ESGCE---EEEGR-EDE--DEDSGSEES---LVDSDSDPE-E--K 1 ( 580) NELEVEESQEVSD--HEDEE---EEEEE-EED--DIDGG--ES---SDESDSESD-E--K 2 ( 545) QEVDIKTKKLKKL--FSKLQ---AVKAEIHDL--QEEHIKERQ---ELEQTQNEL-T--R 3 ( 512) SVSEAFPGPEEPSNVEVSMP---TEESR-SRYFLDECLGQEAAGHLLGEQNYLPQ-EEPQ 4 ( 577) QLQELSNHQKKRA--TEILNLLLKDLGE-IGG--IIGTNDVKT---LADVNGVIE-E--E 5 ( 552) NLPKKKKKAERED--E---D---QDPSM-KNE--N---SSEQL---DVDGDSSSEVS--S // 0 ( 633) EVNFQA--DLADLTCEI--------EIKQKLI-----D---ELENSQRR--L---QTLKH 1 ( 624) -ANYQA--DLANITCEI--------AIKQKLI-----D---ELENSQKR--L---QTLKK 2 ( 592) ELKLKH--LIIENFIPL--------EEKSKIMNRAFFD---EEEDHWKLHPI---TRLEN 3 ( 567) EVPLQGLLGLQDPFAEV--------EAK................................ 4 ( 626) FTMARL--YISKMKSEVKSLVNRSKQLESAQM-----DSNRKMNASERE--LAACQLLIS 5 ( 593) EVNFNY--EYA----QM--------EVTMKAL-----G---SNDPMQSI--L---NSLEQ // 0 ( 670) QYEEK---LILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIKAD---YEKRLRE--- 1 ( 660) QYEEK---LMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSE---YEKKLQA--- 2 ( 636) QQMMK---RPVSAVGYKRPLSQHARMSMMIRPEARYRAENIVLLELD---MPSRT----- 3 ( -) ............................................................ 4 ( 677) QHEAK---IKSLTDYMQNMEQKR-RQLEE--SQDSLSEELA-KLRAQEKMHEVSFQD--- 5 ( 626) QHEEEKRSALERQRLMYEHELEQLRRRLSPEKQNCRSMDRFSFHSPS---AQQRLRQWAE // 0 ( 721) -----MNRD-LQKLQAAQKEHARL---LKNQSRY-ERE-----L-KKLQAEVAEMKKAKV 1 ( 711) -----MNKE-LQRLQAAQKEHARL---LKNQSQY-EKQ-----L-KKLQQDVMEMKKTKV 2 ( 685) ------TRD-YEGPAIAPKVQAALDAALQDEDEI-QVD-----A-SSFESTANKKSKAR. 3 ( -) ............................................................ 4 ( 727) -----KEKEHLTRLQDAE-EMKKA---LEQQMES-HREAHQKQL-SRLRDEIEEKQK--- 5 ( 683) EREATLNNS-LMRLRE-QIVKANL---LVREANYIAEE-----LDKRTEYKVTLQIPASS // 0 ( 765) ALMKQMREEQQRRRLVETKRN---REIAQLKKEQRRQEFQIRALE--SQKRQQ------- 1 ( 755) RLMKQMKEEQEKARLTESRRN---REIAQLKKDQRKRDHQLRLLE--AQKRNQ------- 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( 773) -IIDEIRDLNQKLQLEQEKLS---SDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLKG 5 ( 733) LDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLDNRL-LDMRDLY--QEWKEC------- // 0 ( 813) -EMVLRRKTQEVSALRRL-AKPMSERVAGRAGLKPPMLDSGAEVSASTTSSEAESGARSV 1 ( 803) -EVVLRRKTEEVTALRRQ-VRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTG 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( 829) LEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDND--DGGGSAAQKQKISFLENNLEQL 5 ( 783) -E.......................................................... // 0 ( 871) SSIVRQWNRKINHFLGDHPAPTVNGTRPARKKFQKKGAS-QSF-SKAARLKWQSLERRII 1 ( 861) A---QQKMRIPVARVQALPTPATNGN---RKKYQRKGLTGRVFISKTARMKWQLLERRVT 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( 887) TKVHKQLVR................................................... 5 ( -) ............................................................ // 0 ( 929) DIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEV 1 ( 915) DIIMQKMTISNMEADMNRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMES 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 989) LAANIDYINDGITDCQATIVQLEETKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDK 1 ( 975) LTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINK 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1049) GLQVAQKEAQIRLLEGRLRQTDMAGSSQNHLLLDALREKAEAHPELQALIYNVQQ----- 1 ( 1035) GLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSV 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1104) --ENGYASTDEEI---SEFSEGSFSQSFTMKGSTSHDDFKFKSEPKLSAQMKAVSAECLG 1 ( 1095) PLENVEDSTDEDAPLNSPGSEGSTLSSDLMK-LCGEVKPKNKARRRTTTQMELLYADSSE 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1159) PPLDISTKNIT--KSLASLVEIKEDGVGFSVRDPYYRDR-VSRTVSLPTRGSTFPRQS-- 1 ( 1154) LASDTSTGDASLPGPLTPVAEGQEIGMNTETSGTSAREKELSPPPGLPSKIGSISRQSSL 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1214) ---RATETSPLTRRKSYDRGQPIRS-----TDVG-----FTPPSSPPTRPRNDRNVFSRL 1 ( 1214) SEKKIPEPSPVTRRKAYEKAEKSKAKEQKHSDSGTSEASLSPPSSPPSRPRNELNVFNRL 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1261) TSNQSQGSAL-DK-----------------GIISPVGGAKGARTAPLQCVSMAEGHTKPI 1 ( 1274) TVSQGNTSVQQDKSDESDSSLSEVHRSSRRGIINPFPASKGIRAFPLQCIHIAEGHTKAV 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1303) LCLDATDELLFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSTSYI 1 ( 1334) LCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYI 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1363) KVWDIRDSAKCIRTLTSSGQVISGDACAATSTRAITSAQGEHQINQIALSPSGTMLYAAS 1 ( 1394) KVWDIRDSAKCIRTLTSSGQVTLGDACSASTSRTVAIPSGENQINQIALNPTGTFLYAAS 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1423) GNAVRIWELSRFQPVGKLTGHIGPVMCLTVTQTASQHDLVVTGSKDHYVKMFELGECVTG 1 ( 1454) GNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQDLIITGSKDHYIKMFDVTEGALG 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1483) TIGPTHNFEPPHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCAL 1 ( 1514) TVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCAL 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1543) AFIPGRPMLLSACRAGVIKVWNVDNFTPIGEIKGHDSPINAICTNAKHIFTASSDCRVKL 1 ( 1574) GVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRTVRI 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 1603) WNYVPGLTPCLPRRVLAIKGRATTLP 1 ( 1634) W......................... 2 ( -) .......................... 3 ( -) .......................... 4 ( -) .......................... 5 ( -) .......................... //