# 0 KIAA0463, 1963 aa # 1 KIAA1550 (1462 aa) # 2 KIAA1206 (1912 aa) # 3 KIAA0315 (1841 aa) # 4 KIAA0620 (1985 aa) # 5 KIAA0407 (2143 aa) // exp sw-scr id% from to 1 0 7147 70.8 1 1462 2 2.4e-86 3461 34.3 30 1901 3 2.4e-58 3321 33.5 16 1837 4 1.3e-52 3246 32.9 20 1974 5 1.6e-45 3340 32.3 24 2136 // 0 ( 1) GFGRLPDSELRAGRGASRRPQQPAAAEVDRA-GTEGQTDVAELESCEGQPGKVEQMSTHR 1 ( -) ............................................................ 2 ( -) ............................................................ 3 ( -) ............................................................ 4 ( 20) ...........AGRKRLADPGPPPASRRLRAPGSRPR--LAPCTRRAAQPAHARMAP--- 5 ( -) ............................................................ // 0 ( 60) SRLLTAAPLSMEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMP-QFSTFHSENRDWT 1 ( -) ............................................................ 2 ( 30) ..............................LCLLLLLLSPPPLPLT-GAHRFSAPNT--T 3 ( 16) ....................................LLGAGASLRPRKLDFFRSEKE--- 4 ( 64) -RAAGGAPLSARAAAASPPPFQTPPRCPVPLLLLLLLGAARAGALE-IQRRFPSPT---P 5 ( 24) ..................................WVLTLQP---LP---PTAFTPNGTY- // 0 ( 119) FNHLTVHQGTGAVYVGAINRVYKLTG-NLTIQVAHKTGPEEDNKSCYPPLIVQP-CSEVL 1 ( -) ............................................................ 2 ( 57) LNHLALAPGRGTLYVGAVNRLFQLSP-ELQLEAVAVTGPVIDSPDCVPFRDPAE-CPQA- 3 ( 37) LNHLAVDEASGVVYLGAVNALYQLDA-KLQLEQQVATGPALDNKKCTPPIEASQ-CHEA- 4 ( 119) TNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPR 5 ( 43) LQHLARDPTSGTLYLGATNFLFQLSP-GLQLEATVSTGPVLDSRDCLPPVMPDE-CPQAQ // 0 ( 177) TLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDD--LF-ILV-------EPSHKKE- 1 ( -) ............................................................ 2 ( 114) QLTDNANQLLLVSSRAQELVACGQVRQGVCETRRLGD--VAEVLY-------QAEDPGD- 3 ( 94) EMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLR-LFY-------EDGSGEK- 4 ( 179) RLTDNYNKILQLDPGQGLVVVCGSIYQGFCQLRRRGN--IS-AVAVRFPPAAPPAEPVT- 5 ( 101) P-TNNPNQLLLV--SPGALVVCGSVHQGVCEQRRLGQ--LEQLLL-------RPERPGDT // 0 ( 226) HYLSSVN-----KTGTM-YGVIVR-SEGEDG-K--LFIGTAVD--GK-QDY-FP---TLS 1 ( -) ............................................................ 2 ( 164) GQFVAAN-----TPGVATVGLVVP-LPGRD--L--LLVARGLA--GK-LSAGVP---PLA 3 ( 145) SFVAS-N-----DEGVA-TVGLVS-STGPGG-DRVLFVGKG-N--GP-HDN-GI---IVS 4 ( 235) VFPSMLNVAANHPNAST-VGLVLPPAAGAGGSR--LLVGATYT--GYGSSF-FPRNRSLE 5 ( 149) QYVAAND-----PAVST-VGLVAQ-GLAGEP-L--LFVGRGYTSRGV-GGG-IP---PIT // 0 ( 269) SRKL-P-RDPESSAMLDYELHSDFVS--SLIKIPSDT--LALVSHFDIFYIYGFASGGFV 1 ( -) ............................................................ 2 ( 208) IRQL-AGSQPFSSEGLGRLVVGDF-------------------SDYNNSYVGAFADARSA 3 ( 188) TRLL-D-RTDSREAFEAYTDHATYKA--GYLS--TNT--QQFVAAFE--------DGPYV 4 ( 289) DHRF-E-NTPEI-AIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVSA-FL 5 ( 194) TRALWP-PDPQ--AAFSYE---------ETAKLAVGR--LSEYSHH---FVSAFARGASA // 0 ( 323) YFLTVQP--ETPEGVAINS---AGDLFYTSR--IVRLC------KDDPKF-HSYVSLPFG 1 ( -) ............................................................ 2 ( 248) YFVFRR------RGARAQA---E----YRSY--VARVC------LGDTNL-YSYVEVPLA 3 ( 232) FFVFNQQ--D--KHPARNR----------TL--LARMC------REDPNY-YSYLEMDLQ 4 ( 345) HPSDPPPGAQSYAYLALNSEARAGDKESQARSLLARICLPHGAGGDAKKLTESYIQLGLQ 5 ( 237) YFLFLRR--DL-------Q---AQSRAFRAY--VSRVC------LRDQHY-YSYVELPLA // 0 ( 369) CTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQ-YHHPPDD------ 1 ( -) ............................................................ 2 ( 286) CQGQG----LIQAAFLA-PG--------------TLLGVFAAGPRG-TQ----------- 3 ( 269) CRDPDIH----AAAF----GTCLAASVAAPGSGRVLYAVFSRDSRS-SGGP--G------ 4 ( 405) C--AGGAGR----------GDLYSRLVSVFPARERLFAVFERPQGS-PAARAAP------ 5 ( 276) CE--GGRYGLIQAAAVATSRE--------VAHGEVLFAAFSSAAPPTVGRPPSAAAGASG // 0 ( 422) -SALCAFPIRAINLQIKGRLQSCYQG-----EGNLELNWLLGK---DVQ-----CT-KA- 1 ( -) ............................................................ 2 ( 315) -AALCAFPMVELGASMEQARRLCYTAGGRGPSGAEEATVEYGV---TSR-----CV-TL- 3 ( 312) -AGLCLFPLDKVHAKMEANRNACYTGTR---EARDIFYKPFHG---DIQ-----CGGHA- 4 ( 446) -AALCAFRFADVRAAIRAARTACFV------EPAPDVVAVLDS---VVQGTGPACE-RKL 5 ( 326) ASALCAFPLDEVDRLANRTRDACYTR-----EGRAEDGTEVAYIEYDVN-----SD-CA- // 0 ( 466) -----PVPID--DNF-CGL-D-INQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVV 1 ( 1) ..............................................TSVIAYVYKNHSLA 2 ( 364) -----PLDSP--ESYPCGD-EHTPSPIAGRQPLEVQPLLKLGQP-VSAVAALQADGHMIA 3 ( 359) -----PGSSK--SFP-CGS-EHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVA 4 ( 495) NIQLQPEQLD------CGAAH-LQHPLSILQPLKATPVFRAPG--LTSVAVASVNNYTAV 5 ( 374) -----QLPVDTLDAYPCGS-DHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIA // 0 ( 516) FVGTKSGKLKKIRADGPPHGGVQYEMVSVLKD-GSPILRDMAFS-IDQRYLYVMSERQVT 1 ( 15) FVGTKSGKLKKIRVDGPRGNALQYETVQVV-D-PGPVLRDMAFS-KDHEQLYIMSERQLT 2 ( 415) FLGDTQGQLYKVFLHGS-QGQV-YHSQQVGPP-GSAISPDLLLD-SSGSHLYVLTAHQVD 3 ( 410) FLGTSDGRILKVYL--TPDG-TSSEYDSILVEINKRVKRDLVLS-GDLGSLYAMTQDKVF 4 ( 546) FLGTVNGRLLKINLN-ESMQVVSRRVVTVAY--GEPVHHVMQFDPADSVYLYLMTSHQMA 5 ( 428) FLGDSQGQLHRVYL-GPGSDGHPYSTQSI-QQ-GSAVSRDLTFD-GTFEHLYVMTQSTLL // 0 ( 574) RVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKC-----QQAWEPNRFAASISQ- 1 ( 72) RVPVESCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERC-----ERSKEPRRFASEMKQ- 2 ( 471) RIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQC-----GRAGQLNQWLWSYEE- 3 ( 466) RLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAEC-----PRAEEASHWLWSRSKS 4 ( 603) RVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQHFWTSA--SEGPSR- 5 ( 484) KVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSEC-----SRGQGPEQWLWSFQPE // 0 ( 628) --CVSL-A-VHPSSISV-SEHSRL----LSLVVSDAPDLSAG--IACAFGN----LTEVE 1 ( 126) --CVRL-T-VHPNNISV-SQYNVL----LVLETYNVPELSAG--VNCTFED----LSEMD 2 ( 525) --D-SH-C-LHIQSLLP-GHHPRQEQGQVTLSVPRLPILDADEYFHCAFGD----YDSL- 3 ( 521) --CVAVTS-AQPQNMSR-RAQGEV-----QLTVSPLPALSEEDELLCLFGE----SPPHP 4 ( 660) --CPAM-T-VLPSEIDVRQEYPGM----ILQISGSLPSLSGME-MACDYGNNIRTVARVP 5 ( 539) LGCLQV-AAMSPANIS--REETRE----VFLSVPDLPPLWPGESYSCHFGE-----HQSP // 0 ( 673) GQVSGSQVICISPGPKD-VP-VIPLDQDWFGLELQLRSKETGKIFVS-T-EFKFYNC-S- 1 ( 171) GLVVGNQIQCYSPAAKE-VPRIITENGDHHVVQLQLKSKETGMTFAS-T-SFVFYNC-S- 2 ( 574) AHVEGPHVACVTP-PQDQVP-LNPPGTDHVTVPLALMFEDV--TVAA-T-NFSFYDC-S- 3 ( 568) ARVEGEAVICNSP--SS-IP-VTPPGQDHVAVTIQLLLRR-GNIFLT-SYQYPFYDCRQ- 4 ( 711) GPAFGHQIAYCNLLPRDQFP-PFPPNQDHVTVEMSVRV--NGRNIVK-A-NFTIYDC-SR 5 ( 587) ALLTGSGVMCPSPDPSE-AP-VLPRGADYVSVSVELR---FGAVVIAKT-SLSFYDC-V- // 0 ( 727) -----A------HQL------CLSCVNSAFRCHWCKYRNLCT---H-D------P----T 1 ( 226) -----V------HNS------CLSCVESPYRCHWCKYRHVCT---H-D------P----K 2 ( 626) -----A------VQALEAAAPCRACVGSIWRCHWCPQSSHCVYGEH-C------PEGERT 3 ( 621) -----A------MSLEENLP-CISCVSNRWTCQWDLRYHECR---EAS------P----N 4 ( 765) TAQVYP------HTA------CTSCLSAQWPCFWCSQQHSCV---S-N------Q----S 5 ( 639) -----AVTELRPSAQ------CQACVSSRWGCNWCVWQHLCT---H-KASCDAGP----M // 0 ( 756) TCSFQE------------------------------------------------------ 1 ( 255) TCSFQE------------------------------------------------------ 2 ( 668) IYSAQE------------------------------------------------------ 3 ( 656) P---ED------------------------------------------------------ 4 ( 799) RCEASP------------------------------------------------------ 5 ( 680) VASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPS // 0 ( 762) -----------G--RINI------------SED--CPQ---------------------- 1 ( 261) -----------G--RVKL------------PED--CPQ---------------------- 2 ( 674) -----------V--DIQV------------RGPGACPQ---------------------- 3 ( 659) -----------GIVRAHM------------EDS--CPQ---------------------- 4 ( 805) -----------N--PTS-------------PQD--CPR---------------------- 5 ( 740) LLSPWGPWAGSG--SISSPGSTGSPLHEEPSPP--SPQNGPGTAVPAPTDFRPSATPEDL // 0 ( 773) ----LVPTE-EILIP------------------------------VGEVKP----ITLKA 1 ( 272) ----LLRVD-KILVP------------------------------VEVIKP----ITLKA 2 ( 687) ----VEGLAGPHLVP------------------------------VGWESH----LALRV 3 ( 672) ----FLGPS-PLVIP------------------------------MNHETD----VNFQG 4 ( 815) ----TLLSP-LAPVP------------------------------TGGSQN----ILVPL 5 ( 796) LASPLSPSE-VAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREG // 0 ( 794) RNLPQ------------------------------------PQSGQRGYE---------- 1 ( 293) KNLPQ------------------------------------PQSGQRGYE---------- 2 ( 709) RNLQH------------------------------------FRGLPASFH---------- 3 ( 693) KNLDT------------------------------------VKGSS-------------- 4 ( 836) ANTAF------------------------------------FQGA--ALE---------- 5 ( 855) GELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGLWELEEA // 0 ( 808) --------CVLNIQGA----IHRV--PALRF----------------------------- 1 ( 307) --------CILNIQGS----EQRV--PALRF----------------------------- 2 ( 723) --------CWLELPGE----LRGL--PATLEETAG------------------------- 3 ( 703) ----------LHVGSD----LLKFMEPVTMQ----------------------------- 4 ( 848) --------CSFGLEEI----FE-----AVWV----------------------------- 5 ( 915) TLGASSCPCVESVQGSTLMPVHVE--REIRLLGRNLHLFQDGPGDNECVMELEGLEVVVE // 0 ( 825) ----------NSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCA 1 ( 324) ----------NSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVHLYKCG 2 ( 744) ----------DSGLIHCQAHQF-YPSMSQRELPVPIYVTQGEAQRLDNTHALYVILYDCA 3 ( 720) ----------ESGTFAFRTPKLSHDANE--TLPLHLYVKSYGK-NIDS--KLHVTLYNCS 4 ( 862) ----------NESVVRC-DQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCA 5 ( 973) ARVECEPPPDTQCHVTCQQHQLSYEALQ-PELRVGLFLRRAGRLRVDSAEGLHVVLYDCS // 0 ( 875) AQRESCGLCL-KADRKFECGWCS-GER-RCTLHQHCTSPSSPWLDWSSHNVKCSNPQITE 1 ( 374) AMRESCGLCL-KADPDFACGWCQ-GPG-QCTLRQHCPAQESQWLELSGAKSKCTNPRITE 2 ( 793) MGHPDCSHCQ-AANRSLGCLWCADGQP-ACRYGPLCPPGAVELL--------CPAPSIDA 3 ( 765) FGRSDCSLCR-AANPDYRCAWCG-GQS-RCVYEALCNTTS-----------ECPPPVITR 4 ( 911) MGSPDCSQCLGREDLGHLCMWSD-G----CRLR----GPLQPMAG------TCPAPEIRA 5 ( 1032) VGHGDCSRCQ-TAMPQYGCVWCE-GERPRCVTREACGEAEAV-------ATQCPAPLIHS // 0 ( 932) ILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVC---EMG 1 ( 431) IIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVC---EMG 2 ( 843) VEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVC---VTS 3 ( 811) IQPETGPLGGGIRITILGSNLGVQAGDI-QRISVAGRNCSFQPERYSVSTRIVC---VIE 4 ( 956) IEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVC---VTG 5 ( 1083) VEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASG // 0 ( 989) HALVGTTSG---PVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITG 1 ( 488) EAKPSQHAG---FVEICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITG 2 ( 900) PAPNGTT-G---PVRVAIKSQPPGI---SSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRG 3 ( 867) AAETPFTGGVEVDVFGKLGRSPPNV------QFTFQQPKPLSVEPQQGPQAGGTTLTIHG 4 ( 1013) PA-PGPLSG---VVT--VNASKE---GKSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHG 5 ( 1143) EEVAGATAV---EVP---GRGR----GVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNG // 0 ( 1046) HYLGAGS--S--VAVYLGN-QTCEFYGRSMSE-IVC-VSPPSSNGLGPVPVSVSVDR-AH 1 ( 545) TNLNAGS--N--VVVMFGK-QPCLFHRRSPSY-IVC--NTTSSDEVLEMKVSVQVDR-AK 2 ( 953) QHLQTGG--N--TSAFVGG-QPCPILEPVCPEAIVC-RTRPQA---APGEAAVLVVF-GH 3 ( 921) THLDTGS--QEDVRVTLNG-VPCKVT-KFGAQ-LQC-VTGPQATR-GQMLLEVSYGG-SP 4 ( 1064) NDLHVGS--E--LQVLVNDTDPCTELMRTDTS-IAC-TMPEGALP-APVPVCVRFERRGC 5 ( 1193) SKLLTGRLED--IRVVVGD-QPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATE-RR // 0 ( 1098) V-DSNL---QFEYIDDPRVQRIEPEWSIASGHTPLTITG--------FNLDVIQEPRIRV 1 ( 596) I-HQDL---VFQYVEDPTIVRIEPEWSIVSGNTPIAVWG--------THLDLIQNPQIRA 2 ( 1003) A-QRTLLASPFRYTANPQLVAAEPSASFRGGGRLIRVRG--------TGLDVVQRPLLSV 3 ( 973) VPNPGI---FFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSW 4 ( 1117) V-HGNL---TFWYMQNPVITAISPRRSPVSGGRTITVAG--------ERFHMVQNVSMAV 5 ( 1249) L-QRG----QFKYTLDPNITSAGPTKSFLSGGREICVRG--------QNLDVVQTPRIRV // 0 ( 1146) KFN----------GK-ESVNV-------------------CKVV-------NTTTL---T 1 ( 644) KHG----------GK-EHINI-------------------CEVL-------NATEM---T 2 ( 1054) WLE----------AD-AEVQA-------------------SRAQ-------PQDPQPRRS 3 ( 1030) QPP----------REAESLQP-------------------MTVVGTDYVFHNDTKV---V 4 ( 1165) HHI----------GR-EPT-L-------------------CKVL-------NSTLI---T 5 ( 1296) TVVSRMLQPSQGLGR-RRRVVPETACSLGPSCSSQQFEEPCHVN-------SSQLI---T // 0 ( 1166) CLAP--------------------------SLTTDYRPGLDTV----ERP-DEFGFV--- 1 ( 664) CQAP--------------------------ALALGPDHQSDLT----ERP-EEFGFI--- 2 ( 1077) CGAPAADPQACIQLGGGLLQCSTVCSVNSSSLLLCRSPAVPDR----AHP-QRVFFT--- 3 ( 1058) FLSP--------------------------AV-----P---------EEP-EAYNLTVLI 4 ( 1184) CPSP--------------------------GALSNASAPVDFFINGRAYA-DEVAVA--- 5 ( 1345) CRTP--------------------------AL-----PGLP------EDPWVRVEFI--- // 0 ( 1192) -FNN-VQSLLIYND--TKFI--YYPNPTFELLS---P---TGVLDQKPGSPIILKGKNLC 1 ( 690) -LDN-VQSLLILNK--TNFT--YYPNPVFEAFG---P---SGILELKPGTPIILKGKNLI 2 ( 1129) -LDN-VQVDFASASGGQGFL--YQPNPRLAPLSREGP---ARPYRLKPGHVLDVEGEGL- 3 ( 1077) EMDG-HRALLRTEA--GAFE--YVPDPTFE--N---F---TGGVKKQVNKLIHARGTNLN 4 ( 1214) -EEL-LDPEEAQRG--SRFRLDYLPNPQFSTAK---R---EKWIKHHPGEPLTLVIHKE- 5 ( 1365) -LDNLVFDFATLNP--TPFS--YEADPTLQPLN---PEDPTMPFRHKPGSVFSVEGENLD // 0 ( 1240) PPASGG-AKLNYTVLIGETPCAV-T-VSETQLLCEPP-------N----LTGQHK----- 1 ( 738) PPVAGGNVKLNYTVLVGEKPCTV-T-VSDVQLLCESP-------N----LIGRHK----- 2 ( 1181) --NLGI-SKEEVRVHIGRGECLVKT-LTRTHLYCEPPAHAPQPAN----GSGLPQ----- 3 ( 1124) KAMT----LQEAEAFVGAERCTMKT-LTETDLYCEPP-------E----VQPPPKRRQKR 4 ( 1263) QDSLGL-QSHEYRVKIGQVSCDI-QIVSDRIIHCSVN-------ESLGAAVGQLP----- 5 ( 1417) LAMS----KEEVVAMIGDGPCVVKT-LTRHHLYCEPPVEQ----P----LPRHHA----- // 0 ( 1281) --------V----------MVHVGGMVFSPGSV---SVISDSLLT-LP--AIVSIAAGGS 1 ( 780) --------V----------MARVGGMEYSPGMV---YIAPDSPLS-LP--AIVSIAVAGG 2 ( 1228) --------F----------VVQMGNVQLALGPV---QYEAEPPLSAFPVEAQAGVGMGAA 3 ( 1168) DTTHNLPEF----------IVKFGSREWVLGRVEYDTRVSDVPLS-LI--LPLVIVP--- 4 ( 1309) --------I----------TIQVGN--FNQ-TI---ATLQLGGSE-TA--IIVSIVIC-S 5 ( 1459) --------LREAPDSLPEFTVQMGNLRFSLGHV---QYDGESPGA-FPVAAQVGLGVGTS // 0 ( 1317) LLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDL 1 ( 816) LLIIFIVAVLIAYKRKSRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDL 2 ( 1267) VLIAAVLLLTLMYRHKSKQALRDYQKVLVQLESLETGVGDQCRKEFTDLMTEMTDLSSDL 3 ( 1212) -MVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDV 4 ( 1341) VLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKEL 5 ( 1507) LLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDL // 0 ( 1377) DRS-GIPYLDYRTYAMRVLF-P------------------------GIEDHPVLRELEVQ 1 ( 876) DGA-GIPFLDYRTYTMRVLF-P------------------------GIEDHPVLRDLEVP 2 ( 1327) EGS-GIPFLDYRTYAERAFF-P------------------------GHGGCPLQPKPEGP 3 ( 1271) HEA-GIPVLDYKTYTDRVFFLPSKD---------------------GDKDVMITGKLDIP 4 ( 1401) NRSQGIPFLEYKHFVTRTFF-PKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIP 5 ( 1567) LGS-GIPFLDYKVYAERIFF-P------------------------GHRESPLHRDLGVP // 0 ( 1411) G-NGQ-QHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLE 1 ( 910) G-YRQ-ERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLIMTVLQSKLE 2 ( 1361) GEDGHCATVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHGKLE 3 ( 1309) E-PRR-PVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLE 4 ( 1460) E-SCR-PNMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLE 5 ( 1601) E-SRR-PTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLE // 0 ( 1469) YATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLF 1 ( 968) YATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLF 2 ( 1421) YLTDIMRTLLGDLAAHYV-HRN-PKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLY 3 ( 1367) YYTDIMHTLFLELLEQYVVAKN-PKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLY 4 ( 1518) YYTSIMKELLVDLIDAS-AAKN-PKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFF 5 ( 1659) YFTDILRTLLSDLVAQYVA-KN-PKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLY // 0 ( 1529) MLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNC---VNPDN---ENSP 1 ( 1028) SLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLVLSC---VSPDN---ANSP 2 ( 1479) MLFRAIQYQVDKGPVDAVTGKAKRTLNDSRLLREDVEFQPLTLMVL--VGPGAGGAAGSS 3 ( 1426) KLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSV---IVQD----EGVD 4 ( 1576) LLLCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAKPRNLN----VSFQG---CGMD 5 ( 1717) MLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGA---GEAQ // 0 ( 1583) E---IPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDI 1 ( 1082) E---VPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSGARMILQDEDI 2 ( 1537) EMQRVPARVLDTDTITQVKEKVLDQVYKGTPFSQRPSVHALDLEWRSGLAGHLTLSDEDL 3 ( 1479) A---IPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQI-LSDLDL 4 ( 1629) S---LSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYILRDLDD 5 ( 1774) G---VPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDV // 0 ( 1640) TTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRY--DSSFRYT 1 ( 1139) TTKIENDWKRLNTLAHYQVPDGSVVALVSKQVTAYNAVNNSTVSRTSASKY--ENMIRYT 2 ( 1597) TSVTQNHWKRLNTLQHYKVPDGATVGLVPQ------LHRGSTISQSLAQR---------- 3 ( 1535) TSQREGRWKRVNTLMHYNVRDGATLIL----------------SKVGVSQQPEDSQQDLP 4 ( 1686) TSVVEDGRKKLNTLAHYK------------------IPEGASLAMSLIDKK--DNTL--- 5 ( 1831) TSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKH-------------VLRE--NQDY--- // 0 ( 1698) GSPDSLRSRAPMITPDLESGVKVWHLVKNHDH-GD----------QKEGDRGS------- 1 ( 1197) GSPDSLRSRTPMITPDLESGVKMWHLVKNHEH-GD----------QKEGDRGS------- 2 ( 1641) -CP--LGENIPTLEDGEEGGVCLWHLVKATEE-PEGAKVRCSSLREREPAR-A------- 3 ( 1579) GERHAL----------LEEENRVWHLVRPTDE-VD----------EGKSKRGSVKEKERT 4 ( 1723) GRVKDL---------DTE---KYFHLVLPTDELAE----------PKKSHRQSHRK---- 5 ( 1873) -VPGE---RTPMLEDVDEGGIRPWHLVKPSDE-PE----------PPRPRRGSLRGGERE // 0 ( 1740) --KMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHS 1 ( 1239) --KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHG 2 ( 1689) --KAIPEIYLTRLLSMKGTLQKFVDDTFQAILS-VNR--PIPIAVKYLFDLLDELAEKHG 3 ( 1618) --KAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP---GHAVPPAVKYFFDFLDEQAEKHN 4 ( 1757) --KVLPEIYLTRLLSTKGTLQKFLDDLFKAILSI--REDKPPLAVKYFFDFLEEQAEKRG 5 ( 1918) RAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST---SRPVPLAVKYFFDLLDEQAQQHG // 0 ( 1798) IHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHR 1 ( 1297) IHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHR 2 ( 1744) IEDPGTLHIWKTNSLLLRFWVNALKNPQLIFDVRVSDNVDAILAVIAQTFIDSCTTSEHK 3 ( 1673) IQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHK 4 ( 1813) ISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDACLSVIAQAFIDACSISDLQ 5 ( 1975) ISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHK // 0 ( 1858) LGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLS 1 ( 1357) LGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMS 2 ( 1804) VGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAELSGNYTSAPHCLE 3 ( 1733) LSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLV 4 ( 1873) LGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNV 5 ( 2035) LGRDSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARV // 0 ( 1918) ALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES 1 ( 1417) ALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLMSLDS 2 ( 1864) ALQELYNHIHRYYDQIISALEEDPVGQKLQLACRLQQV........ 3 ( 1793) ALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENK. 4 ( 1933) AMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALM.... 5 ( 2095) ALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAV.... //