# 0 KIAA0620, 1985 aa # 1 KIAA0315 (1841 aa) # 2 KIAA0407 (2143 aa) # 3 KIAA0463 (1963 aa) # 4 KIAA1550 (1462 aa) # 5 KIAA1206 (1912 aa) // exp sw-scr id% from to 1 1.1e-65 3340 35.0 8 1838 2 2.9e-36 3179 32.7 4 2140 3 4.5e-32 3246 33.0 12 1959 4 1.9e-31 2893 36.2 1 1458 5 2.5e-31 3471 35.5 27 1909 // 0 ( 1) PGCAARLSRARAPGPGAAGAGRKRLADPGPPPASRRLRAPGSRPR--LAPCTRRAAQPAH 1 ( -) ............................................................ 2 ( -) ............................................................ 3 ( 12) ...................AGRGASRRPQQPAAAEVDRA-GTEGQTDVAELESCEGQPGK 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 59) ARMAP----RAAGGAPLSARAAAASPPPFQTPPRCPVPLLLLLLLGAARAG-ALEIQRR- 1 ( 8) ......................................LWALTLLGLLGAG-ASLRPRKL 2 ( 4) ...............................PCQVTMPALGPALLQALWAGWVLTLQPL- 3 ( 52) VEQMSTHRSRLLTAAPLSMEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAA-GMPQFST- 4 ( -) ............................................................ 5 ( 27) ...................................PFGLCLLLLLLSPPPL-PLTGAHR- // 0 ( 113) --FPSP-T---PT-NNF----ALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDS 1 ( 29) DFFRSE-K---EL-NHL----AVDEASGVVYLGAVNALYQLD-AKLQLEQQVATGPALDN 2 ( 32) --PPTAFT---PN-GTYLQHLARDPTSGTLYLGATNFLFQLS-PGLQLEATVSTGPVLDS 3 ( 110) --FHSE-NRDWTF-NHL----TVHQGTGAVYVGAINRVYKLTG-NLTIQVAHKTGPEEDN 4 ( -) ............................................................ 5 ( 50) --FSAP-N---TTLNHL----ALAPGRGTLYVGAVNRLFQLS-PELQLEAVAVTGPVIDS // 0 ( 162) PLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVVCGSIYQGFCQLRRRGNISAVAV 1 ( 79) KKC-TPPIEASQC-HEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNIS---L 2 ( 85) RDCLPPVMPDE-CPQAQP-TNNPNQLLLVSPGA--LVVCGSVHQGVCEQRRLGQLEQLLL 3 ( 161) KSCYPPLIVQP-CSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILV- 4 ( -) ............................................................ 5 ( 99) PDC-VPFRDPAECPQAQ-LTDNANQLLLVSSRAQELVACGQVRQGVCETRRLGDVAEVLY // 0 ( 222) RFPPAAPPAEPVTVFPSMLNVAANHPNASTVGLVLP-PAAGAGGSRLL-VGATYTGYGSS 1 ( 134) RLFYEDGSGEKSFV-------ASNDEGVATVGLV---SSTGPGGDRVL-----FVGKGNG 2 ( 141) R------PERP----GDTQYVAANDPAVSTVGLV----AQGLAGEPLLFVGRGYTSRGVG 3 ( 219) ------EPSHKKEHYLSSVN------KTGTMYGVIV-RSEGEDG-KLF-IGTAVDGK-QD 4 ( -) ............................................................ 5 ( 157) Q---AEDPGDG--QF-----VAANTPGVATVGLVVPLP-----GRDLL-LVA-------- // 0 ( 280) FFPRNRSLEDHRFENTPEI-AIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLG 1 ( 179) --P-------H--DNGIIV-STRLLD-RTDSREAF----EAYTDHAT-YKAGYLSTNTQQ 2 ( 187) -------------GGIPPI-TTRAL-WPPDPQAAFSY------EETAKLAVGRLSEYSHH 3 ( 263) YFP---TLSSRKLPRDPESSAMLDYELHSDFVS--SLIKIPSD--TLALVSHFDIFYIYG 4 ( -) ............................................................ 5 ( 193) -----RGLAGKLSAGVPPL-AIRQL------AGSQPF----SSEGLGRLVVGDFSDYNNS // 0 ( 339) FVSA-FLHPSDPPPGAQSYAYLALNSEARAGDKE-SQA-RSLLARICLPHGAGGDAKKLT 1 ( 221) FVAA-F---EDGP-----YVFFVFNQQ----DKHPARN-RTLLARMCRE-----DPNYY- 2 ( 226) FVSA-FAR------GASAY-FLFLRRDLQA---Q-SRAFRAYVSRVCL-------RDQHY 3 ( 316) FASGGFVYFLTVQP--ETPEGVAINS---AGDLF-YTS-R--IVRLC------KDDPKF- 4 ( -) ............................................................ 5 ( 237) YVGA-F---AD----ARS-AYFVF--RRRGARAQ-AEY-RSYVARVCL-----GDTN--L // 0 ( 396) ESYIQLGLQC--AG----GAGR----------GDLYSRLVSV---FPARER-LFAVFE-- 1 ( 261) -SYLEMDLQC--RDPDIHAAAF----------GTCLAASVAA----PGSGRVLYAVFS-- 2 ( 267) YSYVELPLAC--EG----GR-Y----------GLIQAAAVATSREVAHGEV-LFAAFSSA 3 ( 360) HSYVSLPFGCTRAG----VEYRLLQAAYLAKPGDSLAQAFNI---TSQDDV-LFAIFS-- 4 ( -) ............................................................ 5 ( 277) YSYVEVPLAC--QG-------Q----------GLIQA----A---FLAPGT-LLGVF--- // 0 ( 434) ------RPQGSPAARAAPAALCAFRFADVRAAIRAARTACFV--EP--APDVV-AVLDSV 1 ( 302) ------RD--SRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTRE--ARDIFYKPFHGD 2 ( 309) APPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYT--REGRAEDGT-EVA-YI 3 ( 410) ------KGQKQYHHPPDDSALCAFPIRAINLQIKGRLQSCYQG-EG--NLELN-WLLGKD 4 ( -) ............................................................ 5 ( 307) --------AAGP--RGTQAALCAFPMVELGASMEQARRLCYT--AG--GRGPS-GAEEAT // 0 ( 483) VQ-GTGPACERKLNIQLQ-PEQLD---CGAAHLQHPLSILQPLKATPVFR-APG--L--T 1 ( 352) IQ-CGGHA-------PGS-SKSFP---CGSEHLPYPLGSRDGLRGTAVLQ-RGG--LNLT 2 ( 365) EY-DVNSDCA-----QLP-VDTLDAYPCGSDHTPSPMASRVPLEATPILE-WPGIQL--T 3 ( 460) VQ------CTKA-------PVPIDDNFCGL-DINQPLGGSTPVEGLTLYT-TSRDRM--T 4 ( 1) ...........................................................T 5 ( 352) VEYGVTSRC---VTLPLDSPESYP---CGDEHTPSPIAGRQPLEVQPLLKLGQP--V--S // 0 ( 533) SVAVASVNNYTAVFLGTVNGRLLKINLN-ESMQVVSRRVVTVAY-GEPVHHVMQFDPADS 1 ( 397) AVTVAAENNHTVAFLGTSDGRILKVYLT-PDGTSSEYDSILVEI-NKRVKRDLVLS-GDL 2 ( 415) AVAVTMEDGHTIAFLGDSQGQLHRVYLG-PGSDGHPYSTQSIQQ-GSAVSRDLTFD-GTF 3 ( 503) SVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFS-IDQ 4 ( 2) SVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVD-PGPVLRDMAFSK-DH 5 ( 402) AVAALQADGHMIAFLGDTQGQLYKVFLH-GSQGQVYHSQQVGPP-GSAISPDLLLDSSGS // 0 ( 591) VYLYLMTSHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSS--QQH 1 ( 454) GSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAE--EAS 2 ( 472) EHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQW 3 ( 562) RYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKC-------QQ 4 ( 60) EQLYIMSERQLTRVPVESCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSK--EPR 5 ( 460) -HLYVLTAHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGRAG--QLN // 0 ( 649) FWTSA--SE-GPSRC-PAMT-VLPSEIDVRQEYPGMILQISGSLPSLSGM-EM-ACDYGN 1 ( 512) HWL-W--SR-SKS-C-VAVTSAQPQNMSRRAQ--GEVQLTVSPLPALSEEDEL-LCLFGE 2 ( 532) LWSFQ--PELGCLQV-AAMS---PANIS-REETREVFLSVPDLPPLWPGE-SY-SCHFGE 3 ( 615) AWEPNRFAA-SISQC-VSLA-VHPSSISV-SEHSRLLSLVVSDAPDLSAG--I-ACAFGN 4 ( 118) RF--A--SE-M-KQC-VRLT-VHPNNISVSQYNVLLVLE-TYNVPELSAG--V-NCTFED 5 ( 517) QWLWS--YE-EDSHCLHIQS-LLPGH-HPRQEQGQVTLSVP-RLPILDAD-EYFHCAFGD // 0 ( 702) NIRTVARVPGPAFGHQIAYCNLLPRDQFPPF-PPNQDHVTVEMSVRVN--GRNI--VKAN 1 ( 563) SPPHPARVEGEA-----VICNS-P-SSIPVT-PPGQDHVAVTIQLLLR--RGNIFLTSYQ 2 ( 583) H-----QSPALLTGSGV-MCPSPDPSEAPVL-PRGADYVSVSVELRFG--AVVI--AKTS 3 ( 668) ----LTEVEGQVSGSQVICISPGPKD-VPVI-PLDQDWFGLELQLRSKETGKIF--VSTE 4 ( 166) ----LSEMDGLVVGNQIQ-CYSPAAKEVPRIITENGDHHVVQLQLKSKETGMTF--ASTS 5 ( 570) -YDSLAHVEGP----HVA-CVTPPQDQVPLN-PPGTDHVTVPLALMFE--DVTV--AATN // 0 ( 757) FTIYDCSRTAQVYPHTACTSCLSAQWPCFWCSQQHSCVSNQ----------SRCEASP-- 1 ( 613) YPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHEC---------------R-EASP-- 2 ( 632) LSFYDCVAVTELRPSAQCQACVSSRWGCNWCVWQHLC-THK----------ASCDAGPMV 3 ( 720) FKFYNCS------AHQLCLSCVNSAFRCHWCKYRNLCTHDP----------TTCSFQE-- 4 ( 219) FVFYNCSV------HNSCLSCVESPYRCHWCKYRHVCTHDP----------KTCSFQE-- 5 ( 619) FSFYDCSAVQALEAAAPCRACVGSIWRCHWCPQSSHCVYGEHCPEGERTIYSAQEVDI-- // 0 ( -) ------------------------------------------------------------ 1 ( -) ------------------------------------------------------------ 2 ( 681) ASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSL 3 ( -) ------------------------------------------------------------ 4 ( -) ------------------------------------------------------------ 5 ( -) ------------------------------------------------------------ // 0 ( 805) ---------------------------NPTS-------PQDCPRT--------------- 1 ( 655) ---------------------------NPEDGIVRAHMEDSCPQF--------------- 2 ( 741) LSPWGPWAGSGSISSPGSTGSPLHEEPSPPS-------PQNGPGTAVPAPTDFRPSATPE 3 ( 762) ---------------------------GRINI------SEDCPQL--------------- 4 ( 261) ---------------------------GRVKL------PEDCPQL--------------- 5 ( 677) ---------------------------QVRG-------PGACPQVEG------------- // 0 ( 816) --LL-SPLAP-----VP------------------------------------------- 1 ( 673) --LGPSPLV------IP------------------------------------------- 2 ( 794) DLLA-SPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALDWLTR 3 ( 774) --VP-TEEIL-----IP------------------------------------------- 4 ( 273) --LR-VDKIL-----VP------------------------------------------- 5 ( 690) --LA-GPHL------VP------------------------------------------- // 0 ( 825) -----------TGG------SQNILVPLANTAFFQG--------A--ALECSF------- 1 ( 682) -----------MNH------ETDVNFQGKNLDTVKG--------S--SLHVGS------- 2 ( 853) EGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPS--SLDYQYDTP---- 3 ( 783) -----------VGE------VKPITLKARNLPQPQS--------GQRGYECVL------- 4 ( 282) -----------VEV------IKPITLKAKNLPQPQS--------GQRGYECILNIQ---- 5 ( 698) -----------VGW------ESHLALRVRNLQHFRGLP------A--SFHCWLELPGELR // 0 ( 851) GLEEIFE---AVW----------------------------------------------- 1 ( 708) DLLKFME---PVT----------------------------------------------- 2 ( 907) GLWELEE---ATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVME 3 ( 811) NIQGAIHRVPALR----------------------------------------------- 4 ( 313) GSEQRVP---ALR----------------------------------------------- 5 ( 733) GLPATLE---ETA----------------------------------------------- // 0 ( 861) ------VNESVVRC-D---QVVLHTT-RKSQV--FPLSLQLKGRPARFL--------DSP 1 ( 718) ------MQESGTFA-F---RTPKLSH-DANET--LPLHLYVKSY-GKNI--------DS- 2 ( 964) LEGLEVVVEARVEC-EPPPDTQCHVTCQQHQL--SYEALQPELRVGLFLRRAGRLRVDSA 3 ( 824) ------FNSSSVQCQN---SSYQYDG-MDISN--LAVDFAVVWNGNFII--------DNP 4 ( 323) ------FNSSSVQC-----QNTSYSY-EGMEINNLPVELTVVWNGHFNI--------DNP 5 ( 743) ------GDSGLIHC-Q---AHQFYPS-MSQRE--LPVPIYVTQGEAQRL--------DNT // 0 ( 900) EPMTVMVYNCAMGSPDCSQC-LG-REDLGHLCMW-SDG---CRLR-------G--PLQP- 1 ( 755) -KLHVTLYNCSFGRSDCSLC-RA-ANP-DYRCAW-CGGQSRC-VY-------E--ALCN- 2 ( 1021) EGLHVVLYDCSVGHGDCSRCQTA-MPQYG--CVW-CEG---ERPRCVTREACG--EAEA- 3 ( 864) QDLKVHLYKCAAQRESCGLC-L--KADRKFECGW-CSGERRCTLHQHCT---S--PSSP- 4 ( 363) AQNKVHLYKCGAMRESCGLC-L--KADPDFACGW-CQGPGQCTLR-------QHCPAQES 5 ( 782) HALYVILYDCAMGHPDCSHC-QAANRSLG--CLWCADGQPACRY--------G--PLCP- // 0 ( 944) ----MAG------T---CPAPEIRAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIG 1 ( 799) ----TTS------E---CPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQR-ISVA 2 ( 1071) ----VAT------Q---CPAPLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVA 3 ( 914) ----WLDWSSHNVK---CSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVA 4 ( 412) QWLELSG------AKSKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVA 5 ( 828) ----PGA------VELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVA // 0 ( 991) GVACEPLPDRYTVSEEIVCVTGPA-PGPLSGVVTVNA-S---K-----E--GK--SRD-- 1 ( 845) GRNCSFQPERYSVSTRIVCVIEAA-ETPFTGGVEVDVFG---K-----L--GR--SPPNV 2 ( 1118) GVPCAVDAQEYEVSSSLVCITGAS-GEEVAGATAVEV-P---G-----R--GRGVSEH-- 3 ( 967) GVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCI-G---ECKPEFM--TK--SHQ-- 4 ( 466) GVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICV-AVCRP-----E--FM--ARSS- 5 ( 878) SRPCNPEPSLYRTSARIVCVTSPA-PNGTTGPVRVAI-K---S-----QPPGI--SSQ-- // 0 ( 1035) RFSYVLPLVHS-LEPTMGPKAGGTRITIHGNDLHVGS--ELQVLVN-DTDPCTELMRT-D 1 ( 892) QFTFQQPKPLS-VEPQQGPQAGGTTLTIHGTHLDTGS--QEDVRVTLNGVPC-KVTKF-G 2 ( 1164) DFAYQDPKVHS-IFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVG-D-QPCHLLPEQ-Q 3 ( 1017) QYTFVNPSVLS-LNPIRGPESGGTMVTITGHYLGAGS--SVAVYLG-N-QTCEFYGRS-M 4 ( 515) QLYYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGS--NVVVMFG-K-QPCLFHRRS-P 5 ( 924) HFTYQDPVLLS-LSPRWGPQAGGTQLTIRGQHLQTGG--NTSAFVG-G-QPCPILEPVCP // 0 ( 1090) T-SIAC-TMPEGALP-APVPVCVRF---ERRGCVHGNLTFWYMQNPVITAISPRRSPVSG 1 ( 947) A-QLQC-VTGPQATR-GQMLLEVSY---GGSPVPNPGIFFTYRENPVLRAFEPLRSFASG 2 ( 1220) SEQLRC-ETSPRPTP-ATLPVAVWFGATERR-LQRGQ--FKYTLDPNITSAGPTKSFLSG 3 ( 1071) S-EIVC-VSPPSSNGLGPVPVSVSV---DR-AHVDSNLQFEYIDDPRVQRIEPEWSIASG 4 ( 570) S-YIVC-NTTSSDEV-LEMKVSVQV---DR-AKIHQDLVFQYVEDPTIVRIEPEWSIVSG 5 ( 979) E-AIVCRTRPQAA-P-GEAAVLVVF---GHAQRTLLASPFRYTANPQLVAAEPSASFRGG // 0 ( 1144) GRTITVAGERFHMVQNVSMAV----H-------HIGR-----------------EP-T-L 1 ( 1001) GRSINVTGQGFSLIQRFAMVVIAEPL-------QSWQ-----------------PP-R-E 2 ( 1275) GREICVRGQNLDVVQTPRIRV----T-------VVSRML---------------QP-S-Q 3 ( 1125) HTPLTITGFNLDVIQEPRIRV----K-------FNGK-----------------ES-VNV 4 ( 623) NTPIAVWGTHLDLIQNPQIRA----K-------HGGK-----------------EHIN-I 5 ( 1033) GRLIRVRGTGLDVVQRPLLSV----WLEADAEVQASRAQPQDPQPRRSCGAPAADP-Q-A // 0 ( 1174) ----------------------------CKVLNSTLITCPSPGALSNAS-----APVDFF 1 ( 1035) ----------------------------AESLQP--MTVVGTDYVFHND-----TKVVFL 2 ( 1307) GLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITCRTP-ALPGL-------PEDPW 3 ( 1156) ----------------------------CKVVNTTTLTCLAPSLTTDYR-----PGLDTV 4 ( 654) ----------------------------CEVLNATEMTCQAP-AL--AL-----GP-DHQ 5 ( 1087) ----------------------------CIQLGGGLLQCSTVCSVNSSSLLLCRSPA--- // 0 ( 1201) ---INGRAYADEV--AVAEELLDPEEAQRG-SRFRLDYLPNPQFS--TAKRE---KWIKH 1 ( 1060) SPAVPEEPEAYNL--TVLIEMDGHRALLRT-EAGAFEYVPDPTFENFTGGVK---KQVNK 2 ( 1359) ---VRVEFILDNL--VFDFATLNPTPFSYE-ADPTLQPL-NPEDP--TMP-------FRH 3 ( 1183) -------ERPDEF--GFVFNNVQSLLIYND-TKF--IYYPNPTFE--LLSPT---GVLDQ 4 ( 677) ---SDLTERPEEF--GF---ILDNVQSLLILNKTNFTYYPNPVFE--AFGPS---GILEL 5 ( 1116) ---VPDRAHPQRVFFTLDNVQVDFASASGG-QGFL--YQPNPRLA--PLSREGPARPYRL // 0 ( 1250) HPGEPLTLVIHKE-QDSL--G--LQSHEYRVKIGQVSCDIQIVSDRIIHCS--V------ 1 ( 1114) --------LIHAR-GTNL--NKAMTLQEAEAFVGAERCTMKTLTETDLYCE--P------ 2 ( 1403) KPGSVFS--VEGE-NLDL--A--MSKEEVVAMIGDGPCVVKTLTRHHLYCE--PPVEQPL 3 ( 1226) KPGSPIILKGKNLCPPAS--G--GAKLNYTVLIGETPCAVT-VSETQLLCE--------- 4 ( 724) KPGTPIILKGKNL-IPPVAGG--NVKLNYTVLVGEKPCTVT-VSDVQLLC---------- 5 ( 1168) KPGHVLD--VEGE-GLNL--G--ISKEEVRVHIGRGECLVKTLTRTHLYCEPPA------ // 0 ( 1297) --NESLGA--------AVGQLP-ITIQVGN--FNQ-TIATLQ------LG-GSE-----T 1 ( 1155) --PEVQPPPKRRQKRDTTHNLPEFIVKFGS--REW-VLGRVE------YD-TRV-----S 2 ( 1454) PRHHALRE--------APDSLPEFTVQMGN--LRF-SLGHVQ------YD-GESPGAFPV 3 ( 1272) --PPNL-----------TGQHK-VMVHVGGMVFSPGSVSVIS------DS-LLT-----L 4 ( 770) ---ES-PN--------LIGRHK-VMARVGG--MEY-SPGMVY------IAPDSP-----L 5 ( 1215) --HAPQPA--------NGSGLPQFVVQMGN--VQL-ALGPVQYEAEPPLS-AFP-----V // 0 ( 1331) AI--IVSIVIC-SVLL-LLSVVAL-FV-FC--TKSRRAERYWQKTLLQMEEMESQIREEI 1 ( 1198) DV--PLSLILP-LVIVPMVVVIAV-SV-YCYWRKSQQAEREYEKIKSQLEGLEESVRDRC 2 ( 1496) AA--QVGLGVG-TSLL-ALGVIIIVLM-YR--RKSKQALRDYKKVQIQLENLESSVRDRC 3 ( 1306) PA--IVSIAAGGSLLL-IIVIIVL-IA-YK--RKSRENDLTLKRLQMQMDNLESRVALEC 4 ( 803) SLPAIVSIAVA-GGLL-IIFIVAV-LIAYK--RKSRESDLTLKRLQMQMDNLESRVALEC 5 ( 1256) EA--QAGVGMG-AAVL-IAAVLLLTLM-YR--HKSKQALRDYQKVLVQLESLETGVGDQC // 0 ( 1383) RKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQG 1 ( 1253) KKEFTDLMIEMEDQTNDVHEA-GIPVLDYKTYTDRVFF------------LPSK----DG 2 ( 1549) KKEFTDLMTEMTDLTSDLLGS-GIPFLDYKVYAERIFFP--------------------G 3 ( 1359) KEAFAELQTDINELTSDLDRS-GIPYLDYRTYAMRVLFP--------------------- 4 ( 858) KEAFAELQTDIHELTSDLD-GAGIPFLDYRTYTMRVLFP--------------------- 5 ( 1309) RKEFTDLMTEMTDLSSDLEGS-GIPFLDYRTYAERAFFP------------------GHG // 0 ( 1443) SSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRC 1 ( 1296) DKDVMIT----GKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKV 2 ( 1588) HRES----PLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRA 3 ( 1397) ---GIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRG 4 ( 896) ---GIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRG 5 ( 1350) GCPLQPKPEGPGE---DGHC-ATVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRC // 0 ( 1503) SLASLLTIALHGKLEYYTSIMKELLVDLIDAS-A-AKN-PKLMLRRTESVVEKMLTNWMS 1 ( 1352) YFASLLTVALHGKLEYYTDIMHTLFLELLEQY-VVAKN-PKLMLRRSETVVERMLSNWMS 2 ( 1644) YVASLLTVALHGKLEYFTDILRTLLSDLVAQY-V-AKN-PKLMLRRTETVVEKLLTNWMS 3 ( 1454) NVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLE-NKNHPKLLLRRTESVAEKMLTNWFA 4 ( 953) NVASLIMTVLQSKLEYATDVLKQLLADLIDKNLE-SKNHPKLLLRRTESVAEKMLTNWFT 5 ( 1406) HVASLLSLALHGKLEYLTDIMRTLLGDLAAHY-V-HRN-PKLMLRRTETMVEKLLTNWLS // 0 ( 1560) ICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAKPRNLN 1 ( 1410) ICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVS 2 ( 1701) ICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLN 3 ( 1513) FLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILN 4 ( 1012) FLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLVLS 5 ( 1463) ICLYAFLREVAGEPLYMLFRAIQYQVDKGPVDAVTGKAKRTLNDSRLLREDVEFQPLTLM // 0 ( 1620) -VSF-Q---GCG-------MDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVD 1 ( 1470) -VIV-Q---DEG-------VDAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVV 2 ( 1761) -ALL-AVGPGAGE------AQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLD 3 ( 1573) CVNP-D---NEN-------SPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMD 4 ( 1072) CVSP-D---NAN-------SPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMD 5 ( 1523) -VLVGP---GAGGAAGSSEMQRVPARVLDTDTITQVKEKVLDQVYKGTPFSQRPSVHALD // 0 ( 1668) LEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYK------------------IPEGAS 1 ( 1518) LEWRPGST-AQILSDLDLTSQREGRWKRVNTLMHYN------------------VRDGAT 2 ( 1813) VEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYK------------------VPDGAT 3 ( 1622) LEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASAS 4 ( 1121) LEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQ------------------VPDGSV 5 ( 1579) LEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYK------------------VPDGAT // 0 ( 1710) LAM-------S-------LIDK---K--------DNTL---GR----VKDL--------- 1 ( 1559) LIL-------S-------KVGV---S--------QQPE---DS----QQDL--------- 2 ( 1855) VAL-------VPCLTKHVLREN---Q--------DYVP---GERTPMLEDV--------- 3 ( 1682) ISR-------T-------SISR---Y--------DSSFRYTGS----PDSLRSRAPMITP 4 ( 1163) VA----------------LVSK---QVTAYNAVNNSTV---SR----TSAS--------- 5 ( 1621) VGLVPQLHRGS-------TISQSLAQ--------RCPL---GEN---IPTLE-------- // 0 ( 1729) DTE---K----Y---------FHLVLPTDEL------AEPK-----------K---S--- 1 ( 1578) PGE---R----HALLEEENRVWHLVRPTDEV------DEGK-----------SKRGS--- 2 ( 1885) DEGGI-R----P---------WHLVKPSDE-------PEPP-----------R---P--- 3 ( 1713) DLESGVK----V---------WHLVKNHDH-------GDQK-----------E---G--- 4 ( 1188) KYE---N----M---------IRYTGSPDSLRSRTPMITPDLESGVKMWHLVK---N--- 5 ( 1652) DGE---EGGVCL---------WHLVKATEEPEG----AKVR-----------C---SSLR // 0 ( 1750) HRQS------HRK------KVLPEIYLTRLLSTKGTLQKFLDDLFKAILSI--REDKP-P 1 ( 1611) VKEK------ERT------KAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP--GHAVP-P 2 ( 1907) RRGSLRGGERERA------KAIPEIYLTRLLSMKGTLQKFVDDLFQVILST----SRPVP 3 ( 1736) DRGS---------------KMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSAL-P 4 ( 1226) HEHG------DQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSAL-P 5 ( 1682) EREP------ARA------KAIPEIYLTRLLSMKGTLQKFVDDTFQAILSV----NRPIP // 0 ( 1795) LAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDAC 1 ( 1656) -AVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDAS 2 ( 1957) LAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAV 3 ( 1780) LAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDAC 4 ( 1279) LAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDAC 5 ( 1726) IAVKYLFDLLDELAEKHGIEDPGTLHIWKTNSLLLRFWVNALKNPQLIFDVRVSDNVDAI // 0 ( 1855) LSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMN 1 ( 1715) LSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMN 2 ( 2017) LLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMN 3 ( 1840) LSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMN 4 ( 1339) LSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMN 5 ( 1786) LAVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMN // 0 ( 1915) AHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALM 1 ( 1775) THLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAAL 2 ( 2077) SVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAV 3 ( 1900) AYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAM 4 ( 1399) AYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLM 5 ( 1846) SALAELSGNYTSAPHCLEALQELYNHIHRYYDQIISALEEDPVGQKLQLACRLQQVAALV // 0 ( 1975) EDNIYECYSEA 1 ( 1835) ENKV....... 2 ( 2137) ENKV....... 3 ( -) ........... 4 ( -) ........... 5 ( 1906) ENKV....... //