# 0 KIAA1262, 1362 aa # 1 KIAA1011 (3541 aa) # 2 KIAA0465 (4433 aa) # 3 KIAA0796 (1876 aa) # 4 KIAA0949 (1559 aa) # 5 KIAA0728 (1637 aa) // exp sw-scr id% from to 1 1.8e-15 612 29.2 26 465 2 1.6e-08 661 19.3 2492 3834 3 1.4e-07 436 19.6 321 1642 4 6.2e-05 304 21.4 41 804 5 8e-05 465 20.2 256 1225 // 0 ( 1) LDLCRQSNNLCLQREEDLQRTRDY-HDCMNVVEVFLEKFTTEWDNLARSDA--ESTAVHL 1 ( -) ............................................................ 2 ( 2492) ............QLEDILVLAKQF-HETAEPISDFLSVTEKKLANSEPVGT--QTAKIQQ 3 ( 321) ..................QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWI 4 ( -) ............................................................ 5 ( -) ............................................................ // 0 ( 58) EALKKLALALQ--ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED-LI 1 ( -) ............................................................ 2 ( 2537) QIIRHKALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VT 3 ( 363) QDCNDLLKGLG--TVKDSLFVLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALC 4 ( -) ............................................................ 5 ( 256) ETIREEIDGLQ--EELDIVINLGSE---LIAACGEPDKPIVKKSIDELNSAWDSLNK-AW // 0 ( 115) KRKIQVSVTNLEELNV-VQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC 1 ( -) ............................................................ 2 ( 2595) SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELK 3 ( 421) KQQTSLQAGVLDYETF-AKS-LEALEAWIVE-----AEEILQGQDPSHSSDLSTIQERM- 4 ( -) ............................................................ 5 ( 310) KDRIDKLEEAMQAAVQ-YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK // 0 ( 174) SELEAKQMLLKSLIKDADRVMADL-G----L-NERQVIQKALSDAQSHVNCLSDLVGQRR 1 ( -) ............................................................ 2 ( 2655) KEVMEHRLVLDT-VNEVSRALLELVP----W-RAREGLDKLVSDANEQYKLVSDTIGQRV 3 ( 473) EELKGQMLKFSSMAPDLDR-LNEL-GYRLPL-NDKEI--KRMQNLNRHWSLISSQTTERF 4 ( -) ............................................................ 5 ( 369) SEAYQQQIEMERLNHQAELLLKKV-T----EESDKHTVQDPLMELKLIWDSLEERIINRQ // 0 ( 228) KYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKT 1 ( -) ............................................................ 2 ( 2709) DEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIR 3 ( 528) SKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFS 4 ( -) ............................................................ 5 ( 424) HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLA // 0 ( 288) YQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRK 1 ( -) ............................................................ 2 ( 2769) HKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 3 ( 586) RQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQ 4 ( -) ............................................................ 5 ( 484) HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK // 0 ( 348) HFKEDFDKACHWLKQ--ADIVTFP-----EINLMNESTELHTQLAKYQNILEQSPEY--- 1 ( -) ............................................................ 2 ( 2829) QFWETYEELSPWIEETRALIAQLP-----SPAIDHE--QLRQQQEEMRQLRESIAEH--- 3 ( 646) RYREMAEKLRKWLVE--VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILT 4 ( -) ............................................................ 5 ( 544) GFHGEIEDLQQWLTD--TERHLLA-----SKPLGGLPETAKEQLNVHMEVCAAFEAK--- // 0 ( 398) ----ENLLLTLQRTGQTILPS-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAI 1 ( -) ............................................................ 2 ( 2879) ----KPHIDKLLKIGPQ-LKE-LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAV 3 ( 704) VEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR-LEEQKKKLAFLLKD-WEKCEKGI 4 ( -) ............................................................ 5 ( 594) ----EETYKSLMQKGQQMLAR-CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL // 0 ( 453) -LARK---E-YASLIELTTQSLS----ELEAQFLRMSK-VP------TDL-AVEEALSLQ 1 ( -) ............................................................ 2 ( 2933) -SQSTQITE-FHDKIEPMLETLE----NLSSR-LRMPPLIP------AEVDKIRECISDN 3 ( 762) -ADSL---EKLRTFKKKLSQSLPDHHEELHAEQMRCKE-LENAVGSWTDD-LTQLSL-LK 4 ( -) ............................................................ 5 ( 649) NLAME---F-HNSLQDFINW-LT----QAE-QTLNVAS-RP------S-L-ILDTVLFQI // 0 ( 496) DGCRAIL--DEVAGLGEAV----DELNQKKEGF-RSTGQPWQPDKML---HLVTLYHR-- 1 ( -) ............................................................ 2 ( 2980) KSATVEL--EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLD---QMVFFWED-- 3 ( 815) DTLSAYISADDISILNERV-----ELLQRQ----------WE--ELC---HQLSLR---- 4 ( -) ............................................................ 5 ( 690) DEHKVFA--NEVNSHREQI----IELDKTGTHL-KYFSQ--KQDVVLIKNLLISVQSRWE // 0 ( 544) --LKRQTEQR-VSLLEDTTSAYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 1 ( -) ............................................................ 2 ( 3033) --IKARAEEREIKFLDVLELA----E---KFWYDMAALLTTIKDTQDIVHD----LESPG 3 ( 851) ---RQQIGER----LNEWAVFSEKNK---ELCEWLTQMESKVSQNGDILIE----EMI-- 4 ( 41) ..LKASETQR--SLLEQDLATYITE------CSSLKRSLEQARMEVSQEDD----KAL-- 5 ( 741) KVVQRLVERG-RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA // 0 ( 594) EEK-----LKMYHSLAGSLQD--SGI--VLKRVTIHLEDLAPHLDPLAYE--KARHQIQS 1 ( -) ............................................................ 2 ( 3080) IDPSI---IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKP--EVRKSIDE 3 ( 895) -EK-----LK------KDYQE--EIA--IAQENKIQLQQMGERLAKASHE--SKASEIEY 4 ( 85) -QL-----LHDIREQSRKLQE----I--KEQEYQAQVEEMRLMMNQLEEDLVSARRRSDL 5 ( 800) QHKEFQKSLGAKHSVYDTTNR--TGR--SLKEKT-SLADDNLKLDDMLSE---LRDK--- // 0 ( 643) WQGEL----K---LLTSAIGETVTECESRMVQSIDFQTEMSRSL----DWLRR--VKAEL 1 ( -) ............................................................ 2 ( 3135) MNNAW----E---NLNKTWKERLEKLEDAMQAAVQYQDTLQAMF----DWLDNTVIKLCT 3 ( 937) KLGKVNDRWQ---HLLDLIAARVKKLKETLVAVQQLDKNMSSLR----TWLAH--IESEL 4 ( 133) YESEL----RESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEY----AKLEK--INAEQ 5 ( 849) WD--------------TICGKSV-ERQNKLEEALLFSGQFTDALQALIDWLYR--VEPQL // 0 ( 690) S--GPVYLD-LN-LQDIQEEI-------R--K-IQIHQE--EVQSSLRIMNALSHKEKEK 1 ( -) ............................................................ 2 ( 3184) M--PPVGTD-LNTVKDQLNEM-------KEFK-VEVYQQ--QIE-----MEKLNHQGELM 3 ( 988) A--KPIVYDSCN-SEEIQRKLNEQQELQR--D-IEKHST--GVASVLNLCEVLLHDCDAC 4 ( 183) Q---------LK-IQELQEKL-------E--KAVKASTEATELLQNIRQAKERAERELEK 5 ( 892) AEDQPVHGD-ID-L--VMNLI-------D--N-HKAFQK--ELGKRTSSVQALKRSAREL // 0 ( 734) FTKAKELISADL-EHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE 1 ( -) ............................................................ 2 ( 3226) LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 3 ( 1040) ATDAE---CDSI-QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 4 ( 224) L-QNREDSSEGI-RKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDN--- 5 ( 936) IEGSRDD-SSWV-KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA // 0 ( 793) DAQEML--QL-AGNGLDVESAEENL-KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPT 1 ( -) ............................................................ 2 ( 3286) HTEELLDAQR-PISG-DPKVIEVEL-AKHHVL---KNDVLAHQATVETVNKAGNELLESS 3 ( 1096) SSERTA--AFPSSSGVIYTVAKEEL-K---KFEAFQRQVHECLTQLELINKQYRRLAREN 4 ( 279) --------QI-KKDLADKETLENMM-QRHEEEAHEKGKI---LSEQKAMINAMDSKIR-- 5 ( 994) EAEQTL--RF-HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD // 0 ( 849) G-----------KED---LEQKVASLELRSQ---RM-SRDSG--AQVDLLQRCTA--QWH 1 ( -) ............................................................ 2 ( 3340) A-----------GDD---ASSLRSRLEAMNQCWESV-LQKTE--EREQQLQSTLQ--QAQ 3 ( 1150) R-----------TDSACSLKQMVHEGNQRWD---NL-QKRVT--SILRRLKHFIG--QRE 4 ( 324) --------------S---LEQRIVELS-EAN---KL-AANSS--L---FTQRN------- 5 ( 1051) SITTIKHWITIIRAR---FEEVLAWAKQHQQ---RLASALAGLIAKQELLEALLAWLQWA // 0 ( 887) DY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEKLSEHKALVSVVNSFHEK 1 ( 26) ...................................SYREALERLEQSKALVSNLISTKEE 2 ( 3381) GF---HSEIEDFLLELTRMESQLSA----SKPTGGLPETAREQLDTHMELYSQLKAKEET 3 ( 1191) EF---ETARDSILVWLTEMDLQLTN---IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQ 4 ( 350) -----MKAQEEMI-----SELRQQK---FYLETQAGKLEAQNRKLEEQ-LEKISHQDHSD 5 ( 1105) ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSH // 0 ( 941) IVA----LEE--------KASQLEKTG--NDASKATLS-RSMT----TVWQRWTR----- 1 ( 51) LMK----LRQIL------RLLRLRCTE--NDG--ICLL-KIVS----ALWEKWLS----- 2 ( 3434) YNQ----LLD--------KGRLMLLSR--DDSGSGSKTEQSVA----LLEQKWHV----- 3 ( 1245) IIAQGEQLIE--------KSEPLDAAI--IEEELDELR-RYCQ----EVFGRVERYHKKL 4 ( 396) KNR----LLE--------LETRLREVSLEHEEQKLELK-RQLTELQLSLQERESQ----- 5 ( 1165) IPV----LDKGRAGRKRFPASSLYPSG--SQTQIETKN-PRVN----LLVSKWQQ----- // 0 ( 977) L------RAVAQDQEKILEDAVDEW--TGF-NNKVKKATEMIDQLQ---DKLP--GSSAE 1 ( 87) L------LEAAKEWEMWCEELKQEW--KFV-SEEIEREAIILDNLQ---EELPEISKTKE 2 ( 3471) V------SSKMEERKSKLEEALNLA--TEF-QNSLQEFINWLTLAE---QSLN--IASPP 3 ( 1290) I------RLPLPDDEHDLSDRELELEDSAA-LSDLHWHDRSADSLL---SPQP--SSNLS 4 ( 438) LTALQAARAALESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALR--NSCTV 5 ( 1209) V------WLLALERRRKLNDALD..................................... // 0 ( 1023) KASKAELLTLLEYHDTFV----LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 1 ( 135) AATTEELSELLDCLCQYG----ENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQE 2 ( 3517) SLILNTVLSQIEEHKVFA----NEVNAHRDQIIEL-DQTGNQLK---FLSQKQDVVLIKN 3 ( 1338) LSLAQPLRSERSGRDTPASVDSIPLEWDHD-YDLSRDLESAMSR--ALPSEDEE------ 4 ( 494) ITDLEEQLNQLTEDNA-------ELNNQNFYLSKQLDEA-SGANDEIVQLRSEVDHLRRE 5 ( -) ............................................................ // 0 ( 1079) I-TAMQDRCLNMQ---EKVKTNGKLVKQELKDREMVETQI-NSVKCWVQETKEYLGN--P 1 ( 191) I-TSMKERCNKLL---QKVQKNKELVQTEIQERHSFTKEI-IALKNFFQQTTTSFQN--M 2 ( 3569) LLVSVQSRWEKVV---QRSIERGRSLDDARKRAKQFHEAW-KKLIDWLEDAESHL-D--S 3 ( 1389) ---GQDDKDFYLR---GAVALSGDHSALESQIRQLGKA-L-DDSRFQIQQTENIIRSKTP 4 ( 546) I-TEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQW-EAWRSVLGD--E 5 ( -) ............................................................ // 0 ( 1132) T-I----EIDAQLEELQILL-TEATNHRQNIEKMAEEQKE--------KYLGLYTILPSE 1 ( 244) A-FQDHPEKSEQFEELQSIL-KKG---KLTFENIMEKLRI--------KYSEMYTIVPAE 2 ( 3622) E-L----EISNDPDKIKLQL-SK---HKEFQKTLGGKQPVYDTTIRTGRALKEKTLLP-E 3 ( 1441) TGP----ELDTSYKGYMKLL-GECSSSIDSVKRLEHKLKE--------EEESL----PGF 4 ( 602) K-S----QFECRVRELQRMLDTEKQSRARADQRITESRQV--------VELAVKEHKAEI 5 ( -) ............................................................ // 0 ( 1178) LSLQLAEVALDLKIRDQIQDKI--KEVEQSKATSQEL--S-----RQIQ-KLA--KDLTT 1 ( 291) IESQVEECR---KALEDIDEKI--SNEVLKSSPSYAM--R-----RKIE-EIN--NGLHN 2 ( 3672) DSQKLDNFLGE--VRDK-WDTVCGKSVERQHKLEEALLFS-----GQFM-DAL--QALVD 3 ( 1484) VNLHSTETQT-----AGVIDRW---ELLQAQALSKEL--RMKQNLQKWQ-QFN--SDLNS 4 ( 649) LALQQALKEQKLKA-ESLSDKL--NDLEKKHAMLEMN--A-----RSLQQKLETERELKQ 5 ( -) ............................................................ // 0 ( 1226) ILTKLKAKT--DNVVQ-AKTD--------Q-----KVLGEELDGCNSKLMELDAAV--QK 1 ( 336) VEKMLQQKS--KNIEK-AQEI--------Q-----KKMWDELDLWHSKLNELDSEV--QD 2 ( 3721) WLYKVEPQLAEDQPVH-GDLDLVMNLMDAH-----KVFQKELGKRTGTVQVLKRSG--RE 3 ( 1531) IWAWLGDTE--EELEQLQRLE--------L-----STDIQTIELQIKKLKELQKAVDHRK 4 ( 699) RLLEEQAKL--QQQMD-LQKN--------HIFRLTQGLQEALD--RADLLKTERSD--LE 5 ( -) ............................................................ // 0 ( 1268) FLEQNGQLGKPLAKKIGKLTELHQQ--TI-RQAENRLSKLN----QAASHLE---EYNEM 1 ( 378) IVEQDPGQAQEWMDNLMIPFQQYQQ--VS-QRAECRTSQLN----KATVKME---EYSDL 2 ( 3773) LIE-NSRDDTTWVK--GQLQELSTRWDTVCKLSVSKQSRLE----QALKQAE---VFRDT 3 ( 1576) AIILSINLCSP------EFTQADSK--ES-RDLQDRLSQMNGRWDRVCSLLE---EWRGL 4 ( 744) YQLENIQVLYS-HEKVKMEGTISQQ--T--KLIDFLQAKMD----QPAKKKKVPLQYNE- 5 ( -) ............................................................ // 0 ( 1318) LELILKWIEKAKVLAHGTIAWNSASQLREQYILHQVTLGKIIFKK 1 ( 428) LKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMAL....... 2 ( 3823) VHMLLEWLSEAE................................. 3 ( 1624) LQDALMQCQGFHEMSHGLL.......................... 4 ( 794) LKLALEK-EKAR................................. 5 ( -) ............................................. //