# 0 KIAA0743, 1205 aa # 1 KIAA0578 (1542 aa) # 2 KIAA0921 (1658 aa) # 3 KIAA0868 (1339 aa) # 4 KIAA1763 (1322 aa) # 5 KIAA1714 (1175 aa) // exp sw-scr id% from to 1 0 6301 76.4 325 1542 2 0 5576 61.4 247 1658 3 1.4e-25 928 24.6 194 1335 4 1.7e-23 879 24.3 192 1318 5 2.3e-22 856 26.7 226 1169 // 0 ( 1) GCAFSGI----CTLHFHSC---SEINSSLAAREENVATFRGSEYLCYDLSQNPIQSSSDE 1 ( 325) ...............................KEEYIATFKGSEYFCYDLSQNPIQSSSDE 2 ( 247) .CSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDE 3 ( 194) ..................................DVINFDGHVVLPYRFRNKKMKTLKDV 4 ( 192) ..............................AYRSEVVDLDGKSSLLYRFDQKSLSPIKDI 5 ( 226) ..............................AYKSEVVYFDGQSALLYRLDKKPLKPIRDV // 0 ( 54) ITLSFKTWQRNGLILH-T-GKSADYVNLALKDGAVSLVINLGSGAFEAI---VEPVN--- 1 ( 354) ITLSFKTLQRNGLMLH-T-GKSADYVNLALKNGAVSLVINLGSGAFEAL---VEPVN--- 2 ( 306) ITLAFRTLQRNGLMLH-T-GKSADYVNLSLKSGAVWLVINLGSGAFEAL---VEPVN--- 3 ( 220) IALNFKTSESEGVILHGE-GQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMT--- 4 ( 222) ISLKFKTMQSDGILLH-REGPNGDHITLQLRRARLFLLINSGEAKLPST---STLVNLTL 5 ( 256) ISLKFKAMQSNGILLH-REGQHGNHITLELIKGKLVFFLNSGNAKLPST---IAPVTLTL // 0 ( 106) GKF-NDNAWHDVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSDDFFYVGG 1 ( 406) GKF-NDNAWHDVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSDDFFYVGG 2 ( 358) GKF-NDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGG 3 ( 276) GSLLDDHHWHSVVIERQGRS--------INLTLDRSMQHF-RTNGEFDYLDLDYEITFGG 4 ( 278) GSLLDDQHWHSVLIQRLGKQ--------VNFTVDE-HRHHFHARGEFNLMNLDYEISFGG 5 ( 312) GSLLDDQHWHSVLIELLDTQ--------VNFTVDK-HTHHFQAKGDSSYLDLNFEISFGG // 0 ( 157) SPSTADLPGSPVS---NNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCEN 1 ( 457) SPSTADLPGSPVS---NNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCEN 2 ( 417) SPNTADLPGSPVS---NNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCED 3 ( 327) IPFSGK-PSSSSR---KNFKGCMESINYNGVNIT-DLARRKKLEPSNV---GNLSFSCVE 4 ( 329) IPA----PGKSVSFPHRNFHGCLENLYYNGVDI-IDLAKQQK---PQIIAMGNVSFSCSQ 5 ( 363) IPT----PGRSRAFRRKSFHGCLENLYYNGVDV----TELAKKHKPQILMMGNVSFSCPQ // 0 ( 214) VATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKN 1 ( 514) VATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQM 2 ( 474) VAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSA 3 ( 379) PYTV-PV-FFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHF-------ADNLGN 4 ( 381) PQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFS--------ELQLISG 5 ( 415) PQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLF--G--ELRRGSGS--- // 0 ( 274) TKVDFFAVELLDGNLYL-LLDMGSGTIKVKATQK-KANDGEWYHVDIQRDGRSGTISVNS 1 ( 574) IKVDFFAIEMLDGHLYL-LLDMGSGTIKIKALLK-KVNDGEWYHVDFQRDGRSGTISVNT 2 ( 534) QRADYFAMELLDGHLYL-LLDMGSGGIKLRASSR-KVNDGEWCHVDFQRDGRKGSISVNS 3 ( 430) VEIDLTESKV--GVHIN-ITQTKMSQIDI-SSGS-GLNDGQWHEVRFLAKENFAILTIDG 4 ( 432) GILLFLSDGKLKSNLYQ------PGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDG 5 ( 467) -----FVLFLKDGKLKLSLFQPGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVVDD // 0 ( 332) RRT--PFTASGESEILDLEGD-MYLGGLPEN-RAGLILPTELWTAMLNYGYVGCIRDLFI 1 ( 632) LRT--PYTAPGESEILDLDDE-LYLGGLPEN-KAGLVFPTEVWTALLNYGYVGCIRDLFI 2 ( 592) RST--PFLATGDSEILDLESE-LYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFI 3 ( 485) DEA--S-AVRTNSPLQVKTGE-KYFFGGFLN-QMN-----NSSHSVLQPSFQGCMQLIQV 4 ( 486) QMA--SAAPLLGPEQIYSGGT-YYFGGCPDK-SFGSKCKSPLG------GFQGCMRLISI 5 ( 520) DTAVQPLVA-----VLIDSGDTYYFGGCLDN-SSGSGCKSPLG------GFQGCLRLITI // 0 ( 388) DGRSKNI--RQLAEMQNAAGV-----K-SSCSRMSA--KQCDSYPCKNNAVCKDGWNRFI 1 ( 688) DGQSKDI--RQMAEVQSTAGV-----K-PSCSKETA--KPCLSNPCKNNGMCRDGWNRYV 2 ( 649) DGRSRDL--RGLAEAQGAVGV-----A-PFCSRETL--KQCASAPCRNGGVCREGWNRFI 3 ( 535) DDQLVNL--YEVAQRKPGSFA-----N-VSID-MCAIIDRCVPNHCEHGGKCSQTWDSFK 4 ( 536) SGKVVDLISVQQGSLGNFSDL-----QIDSCG-ISD--RCLPNY-CEHGGECSQSWSTFH 5 ( 568) G--DKAV--DPILVQQGALGSFRDLQI-DSCG-ITD--RCLPSY-CEHGGECSQSWDTFS // 0 ( 438) CDCTGTGYWGRTCER-------EA-------SILSY--------------DGS------- 1 ( 738) CDCSGTGYLGRSCER-------EA-------TVLSY--------------DGS------- 2 ( 699) CDCIGTGFLGRVCER-------EA-------TVLSY--------------DGS------- 3 ( 586) CTCDETGYSGATCHNSIY----EP-------SCEAYKHLGQTSNYYWIDPDGSGPLGPLK 4 ( 587) CNCTNTGYRGATCHNSIY----EQ-------SCEAYKHRGNT--------SGF------- 5 ( 619) CDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDA-----------DGS------- // 0 ( 463) MYMKI-----IMPMV-MHTEAEDVSFRF----MSQRAYGL--L-VATTSRD--SADTLRL 1 ( 763) MFMKI-----QLPVV-MHTEAEDVSLRF----RSQRAYGI--L-MATTSRD--SADTLRL 2 ( 724) MYMKI-----MLPNA-MHTEAEDVSLRF----MSQRAYGL--M-MATTSRE--SADTLRL 3 ( 635) VYCNM-----TEDKV-WTIVSHDLQMQTPVVGYNPEKYSVTQL-VYSASMDQISAITDSA 4 ( 621) YYIDSDGSGPLEPFL-LYCNMTETAWTI----IQHNGSDL--TRVRNTNPE--NPYAGFF 5 ( 661) GPLGP-----FLVYCNMTADAAWTVVQH----GGPDAVTL--R-GAPSGHPR-SAVSFAY // 0 ( 508) ELDGGRVKLMVNLD----C---IRINCNSSKGPETLYAGQKLN-----DNEWHTVRVVRR 1 ( 808) ELDAGRVKLTVNLD----C---IRINCNSSKGPETLFAGYNLN-----DNEWHTVRVVRR 2 ( 769) ELDGGQMKLTVNL----------------GKGPETLFAGHKLN-----DNEWHTVRVVRR 3 ( 688) EYCEQYVSYFCKMS---------RLLNTPDGSPYTWWVGKA--------NEKH-YYWGGS 4 ( 672) EYVASMEQLQATINRAEHCEQEFTYYCKKSR----LVNKQDGT-----PLSWWVGRTNET 5 ( 708) AAGAGQLRSAVNLAER--CEQRLALRCGTARRPDS-RDGTPLSWWVGRTNETHTYWGVSL // 0 ( 556) -----GKSLKLTVDDDVA-EGTMVG-------DHTRLEFHNIETGIMTEKRYISV--VPS 1 ( 856) -----GKSLKLTVDDQQAMTGQMAG-------DHTRLEFHNIETGIITERRYLSS--VPS 2 ( 808) -----GKSLQLSVDNVTV-EGQMAG-------AHMRLEFHNIETGIMTERRFISV--VPS 3 ( 730) -----GPGIQ-----KCA-CGIERN-------CTDPKYYCNCDADYKQWRK-------DA 4 ( 723) QTYWGGSSPDLQKCTCGL-EGNCIDSQYYCNCDADRNEWTN-DTGLLAYKEHLPVTKIVI 5 ( 765) -----PDAQKCTCG---L-EGNCIDSQYYCNCDAGRNEWTS-DTIVLSQKEHLPVTQIVM // 0 ( 601) SFIG--HLQSLMFNGLLYIDLCKNGD---IDYCELKARFGLRNIIADPVTFKTKSSYLSL 1 ( 902) NFIG--HLQSLTFNGMAYIDLCKNGD---IDYCELNARFGFRNIIADPVTFKTKSSYVAL 2 ( 853) NFIG--HLSGLVFNGQPYMDQCKDGD---ITYCELNARFGLRAIVADPVTFKSRSSYLAL 3 ( 765) GFLS--YKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQ-GDRNYW-NAASFPNPSSYLHF 4 ( 781) TDTG--RLHSEAAYKLGPL-LCR-GD---RSF-------------WNSASFDTEASYLHF 5 ( 815) TDAGRPHSEAAYTLGPL---LCR-GD---QSF-------------WNSASFNTETSYLHF // 0 ( 656) ATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVEL-VKG-Y-IHYVFDLGNGPNVI 1 ( 957) ATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVEL-VKG-Y-LHYVFDLGNGANLI 2 ( 908) ATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIEL-VKG-Y-IHYVFDLGNGPSLM 3 ( 821) STFQGETSADISFYFKTLTPWGVFLENMGK-EDFIKLEL-KSA-TEVSFSFDVGNGPVEI 4 ( 821) PTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIEL-RSPTV-VTFSFDVGNGPFEI 5 ( 855) PAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELHAPT-E-VTFSFDVGNGPCEV // 0 ( 713) KGNSDRPLNDNQWHNVVITRDNSNTHSLKVDT---KVVTQV----INGAKNLDLKGDLYM 1 ( 1014) KGSSNKPLNDNQWHNVMISRDTSNLHTVKIDT---KITTQI----TAGARNLDLKSDLYI 2 ( 965) KGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS---RTVTQH----SNGARNLDLKGELYI 3 ( 878) VVRSPTPLNDDQWHRVTAER-NVKQASLQVD----RLPQQIRKAPTEGHTRLELYSQLFV 4 ( 878) SVQSPTHFNDNQWHHVRVER-NMKEASLQVDQLTPKTQPAP----ADGHVLLQLNSQLFV 5 ( 912) TVQSPTPFNDNQWHHVRAER-NVKGASLQVDQLPQKMQPAP----ADGHVRLQLNSQLFI // 0 ( 766) AGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIKRGCEGPSTTCQ 1 ( 1067) GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ 2 ( 1018) GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCT 3 ( 933) GG-AGG-----------QQGFLGCIRSLRMNGVTLDLEERAKVTSGFIS-GCSGHCTS-Y 4 ( 933) GGTA-----------TRQRGFLGCIRSLQLNGMTLDLEERA-QVTPEVQPGCRGHCSSYG 5 ( 967) GGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVTPG-VEPGCAGHCST-Y // 0 ( 826) EDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN-DPGATYIFGKSGGLILYTW--PA---- 1 ( 1127) EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN-DPGTTYIFSKGGGQITYKW--PP---- 2 ( 1078) EESCANQGVCLQQWDGFTCDCTMTSYGGPVCN-DPGTTYIFGKGGALITYTW--PP---- 3 ( 979) GTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGA---FFEEGMWLRYNFQAPATNAR 4 ( 981) K-LCRNGGKCRERPIGFFCDCTFSAYTGPFCS-NEISAY-FG-SGSSVIYNF--QE---- 5 ( 1014) GHLCRNGGRCREKRRGVTCDCAFSAYDGPFCS-NEISAYF--ATGSSMTYHF--QE---- // 0 ( 879) -------------NDRPSTRSDRLAVGFS---TTVKDG-----ILV--RIDSAPGLGDFL 1 ( 1180) -------------NDRPSTRADRLAIGFS---TVQKEA-----VLV--RVDSSSGLGDYL 2 ( 1131) -------------NDRPSTRMDRLAVGFS---THQRSA-----VLV--RVDSASGLGDYL 3 ( 1036) DSSSRVDNAPDQQNSHPDLAQEEIRFSFS---TTKAPC-----ILL--YISSFTT--DFL 4 ( 1031) -------------NYLLSKNSSSHAASFH---GDMKLSREMIKFSF--RTTRTPSLLLFV 5 ( 1065) -------------HYTLSENSSSLVSSLHRDVTLTREM-----ITLSFRTTRTPSLLLYV // 0 ( 916) QLHIEQ-GKIGVVFNIGTV--DISIKEER--TP---------VNDGKYHVVRFT-RNGGN 1 ( 1217) ELHIHQ-GKIGVKFNVGTD--DIAIEESN--AI---------INDGKYHVVRFT-RSGGN 2 ( 1168) QLHIDQ-GTVGVIFNVGTD--DITIDEPN--AI---------VSDGKYHVVRFT-RSGGN 3 ( 1084) AVLVKPTGSLQIRYNLGGTREPYNIDVDH--RN---------MANGQPHSVNIT-RHEKT 4 ( 1073) SSFYKE-YLSVIIAKNGSL--QIRYKLNK--YQ---------EPD----VVNFDFKNMAD 5 ( 1107) SSFYEE-YLSVILANNGSL--QIRYKLDRHQNPDAFTFDFKNMADGQLHQVKIN-RE--E // 0 ( 961) ATLQVDNWP-VNEHYPTG------------------------------RQLTIFNTQAQI 1 ( 1262) ATLQVDSWP-VIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATI 2 ( 1213) ATLQVDSWP-VNERYPAG------------------------------RQLTIFNSQAAI 3 ( 1132) IFLKLDHYPSVSYHLPSS------------------------------SD-TLFNSPKSL 4 ( 1115) GQL----------HH------------------------------------IMINREEGV 5 ( 1161) AVVMVEVIP................................................... // 0 ( 990) AIGGK-DKGRLFQGQLS-GLYYDGLK--VLNMAAENNPNIKINGSVRLVGE--VPSILGT 1 ( 1321) IIGGK-EQGQPFQGQLS-GLYYNGLK--VLNMAAENDANIAIVGNVRLVGE--VPSSMTT 2 ( 1242) KIGGR-DQGRPFQGQVS-GLYYNGLK--VLALAAESDPNVRTEGHLRLVGE--GPSVLLS 3 ( 1161) FLGKVIETGKIDQ-----------------EIHKYNTPG--------FTG------CLSR 4 ( 1129) VFIEI-DDNRRRQVHLSSGTEFSAVKSLVLGRILEHSD---VDQETALAGAQGFTGCLSA 5 ( -) ............................................................ // 0 ( 1044) TQT-T--SMPPEMSTTVMETTTTMATTTTRKNR--ST----ASIQPTSDD-LVSSAECSS 1 ( 1375) ESTAT--AMQSEMSTSIMETTTTLATSTARRGKPPTK----EPISQTTDDILVASAECPS 2 ( 1296) AET-TATTLLADMATTIMETTTTMATTTTRRGR--SPTLRDSTTQNTDDL-LVASAECPS 3 ( 1190) VQF-N--QIAPLKAALRQTNASAHVHIQGELVE--SN----CGASPLTLS-PMSSA---T 4 ( 1185) VQL-S--HVAP-LKAALHPSHPDPVTVTGHVTE--SS----CMAQPGTD---ATSRERTH 5 ( -) ............................................................ // 0 ( 1094) DDEDFVECEPST------------------------------------------------ 1 ( 1429) DDEDIDPCEPSS------------------------------------------------ 2 ( 1352) DDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPP 3 ( 1237) DPWHLDHLDSAS------------------------------------------------ 4 ( 1232) SFAD----HSGT------------------------------------------------ 5 ( -) ............................................................ // 0 ( -) ------------------------------------------------------------ 1 ( -) ------------------------------------------------------------ 2 ( 1412) PAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTT 3 ( -) ------------------------------------------------------------ 4 ( -) ------------------------------------------------------------ 5 ( -) ............................................................ // 0 ( -) ------------------------------------------------------------ 1 ( -) ------------------------------------------------------------ 2 ( 1472) LLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAP 3 ( -) ------------------------------------------------------------ 4 ( -) ------------------------------------------------------------ 5 ( -) ............................................................ // 0 ( 1106) --------------------------AN-PTEPGIRR-VPGASEVIRESSSTTGMVVGIV 1 ( 1441) --------------------------AN-PTRAGGREPYPGSAEVIRESSSTTGMVVGIV 2 ( 1532) TSFEPRRPPPLRPGVTSAPGFPHLPTAN-PTGPGERG-PPGAVEVIRESSSTTGMVVGIV 3 ( 1249) --------------------------ADFPYNPG--Q-GQAIRNGVNRNSAIIGGVIAVV 4 ( 1240) --------------------------ID-DREP--------LANAIKSDSAVIGGLIAVV 5 ( -) ............................................................ // 0 ( 1138) AAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQS-NGTLMKEKQQSS-KSGHKK 1 ( 1474) AAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQS-NGAVVKEKQPSSAKSSNKN 2 ( 1590) AAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQS-NGAVVKEKAPAAPKTPSKA 3 ( 1280) IFTILCTLVFLI---RYMFRHKGTYHTNEAKG--AESAESADAAIMNNDPNFT-ETIDES 4 ( 1265) IFILLCITAIAVRIYQQKR----LYKRSEAKR--SENVDS-AEAVLKSELNIQ-NAVNEN 5 ( -) ............................................................ // 0 ( 1196) QKNKDREYYV 1 ( 1533) KKNKDKEYYV 2 ( 1649) KKNKDKEYYV 3 ( 1334) KK........ 4 ( 1317) QK........ 5 ( -) .......... //