HUGE

Gene/Protein Characteristic Table for KIAA0046

Link to : Rouge \| GTOP \| SWISS-PROT/TrEMBL \| GeneCards\| RefDIC
Features : DNA sequence \| Protein sequence \| Expression \| Mapping

Product ID :	ORK00383
Accession No. :	D28475
Description :	Chloride channel protein 6.
HUGO Gene Name :	chloride channel 6 (CLCN6)
Clone Name :	ha00519s1 [Vector Info]
Flexi ORF Clone :	pF1KSDA0046
Source :	Myeloblast cell line (KG-1)
Note :	We replaced ha00519, former representative clones for KIAA0046 with ha00519s1. (2002/5/10)

Features of the cloned DNA sequence	Description

Length: 5567 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis) for :
cloned DNA seq.
Warning for N-terminal truncation:
NO

Warning for coding interruption:
NO

Integrity of 3' end

Length of 3'UTR 2905 bp

Genome contig ID gi89161185f_11688855
PolyA signal sequence
(AATAAA,-18)
+----*----+----*----+----*----+----
TAACCCTAACATGTGAGAATAAAATGTCTTCTGTC
Flanking genome sequence
(136919 - 136968)
----+----*----+----*----+----*----+----*----+----*
TCCTCTGTCTCCTTTAGCCTTTTGTCTCCATGCTGCTTTCTTTCTTTCTT

Ensembl ContigView (Add our DAS server as a DAS source)

Chr f/r start end exon identity class

ContigView(URL based/DAS) 1 f 11788855 11825772 23 99.4 Perfect prediction

Features of the protein sequence	Description

Length: 872 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
P51797	100.0	Chloride channe...	Homo sapiens
CAI15895	99.9	chloride channe...	Homo sapiens
XP_001104721	99.4	chloride channe...	Macaca mulatta
EAW71716	99.5	chloride channe...	Homo sapiens
XP_001491791	98.2	similar to Chlo...	Equus caballus

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of homology search against other HUGE database (FASTA output)
No significant homologues
Result of motif / domain search (InterProScan and SOSUI)

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Result of InterProScan

Search method interpro_ID From To Entry Definition

FPrintScan IPR002248 5 17 PR01117 Chloride channel CLC-6

IPR002248 81 90 PR01117 Chloride channel CLC-6

IPR002248 101 113 PR01117 Chloride channel CLC-6

IPR001807 155 172 PR00762 Chloride channel

IPR001807 186 205 PR00762 Chloride channel

IPR002248 206 215 PR01117 Chloride channel CLC-6

IPR002248 217 226 PR01117 Chloride channel CLC-6

IPR001807 250 269 PR00762 Chloride channel

IPR001807 487 507 PR00762 Chloride channel

IPR001807 522 538 PR00762 Chloride channel

IPR001807 540 559 PR00762 Chloride channel

IPR001807 578 592 PR00762 Chloride channel

HMMPfam IPR014743 139 575 PF00654 Chloride channel

IPR000644 606 861 PF00571 Cystathionine beta-synthase

HMMSmart IPR000644 611 660 SM00116 Cystathionine beta-synthase

IPR000644 813 861 SM00116 Cystathionine beta-synthase

Search method	interpro_ID	From	To	Entry	Definition
FPrintScan	IPR002248	5	17	PR01117	Chloride channel CLC-6
IPR002248	81	90	PR01117	Chloride channel CLC-6
IPR002248	101	113	PR01117	Chloride channel CLC-6
IPR001807	155	172	PR00762	Chloride channel
IPR001807	186	205	PR00762	Chloride channel
IPR002248	206	215	PR01117	Chloride channel CLC-6
IPR002248	217	226	PR01117	Chloride channel CLC-6
IPR001807	250	269	PR00762	Chloride channel
IPR001807	487	507	PR00762	Chloride channel
IPR001807	522	538	PR00762	Chloride channel
IPR001807	540	559	PR00762	Chloride channel
IPR001807	578	592	PR00762	Chloride channel
HMMPfam	IPR014743	139	575	PF00654	Chloride channel
IPR000644	606	861	PF00571	Cystathionine beta-synthase
HMMSmart	IPR000644	611	660	SM00116	Cystathionine beta-synthase
IPR000644	813	861	SM00116	Cystathionine beta-synthase

Prediction of transmembrane (TM) segments

Method No. N terminal transmembrane region C terminal type length

SOSUI2 1 6 GCRGSLCCCCRWCCCCG 22 SECONDARY 17

2 84 WMVVFAIGVCTGLVGLFVDFFVR 106 PRIMARY 23

3 130 ALSLLELLGFNLTFVFLASLLVL 152 PRIMARY 23

4 175 PGIVRLRTLLCKVLGVLFSVAGG 197 PRIMARY 23

5 245 VSAGAAAGVAAAFGAPIGGTLFS 267 SECONDARY 23

6 274 FWNQGLTWKVLFCSMSATFTLNF 296 SECONDARY 23

7 333 TAMDLGFFVVMGVIGGLLGATFN 355 PRIMARY 23

8 377 RVLESLLVSLVTTVVVFVASMVL 399 PRIMARY 23

9 462 TFSPVTLALFFVLYFLLACWTY 483 PRIMARY 22

10 490 GLFVPSLLCGAAFGRLVANVLKS 512 SECONDARY 23

11 524 FALIGAAAFLGGVVRMTISLTVI 546 PRIMARY 23

Method	No.	N terminal	transmembrane region	C terminal	type	length
SOSUI2	1	6	GCRGSLCCCCRWCCCCG	22	SECONDARY	17
2	84	WMVVFAIGVCTGLVGLFVDFFVR	106	PRIMARY	23
3	130	ALSLLELLGFNLTFVFLASLLVL	152	PRIMARY	23
4	175	PGIVRLRTLLCKVLGVLFSVAGG	197	PRIMARY	23
5	245	VSAGAAAGVAAAFGAPIGGTLFS	267	SECONDARY	23
6	274	FWNQGLTWKVLFCSMSATFTLNF	296	SECONDARY	23
7	333	TAMDLGFFVVMGVIGGLLGATFN	355	PRIMARY	23
8	377	RVLESLLVSLVTTVVVFVASMVL	399	PRIMARY	23
9	462	TFSPVTLALFFVLYFLLACWTY	483	PRIMARY	22
10	490	GLFVPSLLCGAAFGRLVANVLKS	512	SECONDARY	23
11	524	FALIGAAAFLGGVVRMTISLTVI	546	PRIMARY	23

Expression profile	Description

: Northern blot Description

Northern blot	Description

RH mapping information	Description

Chromosome No.

: 1

Experimental conditions

Panel name	: Stanford G3
Primer_f	: CCAGATAAGCCCAAAGAC
Primer_r	: GTGATGGGGCTGCTAATG
PCR product length	: 124 bp
PCR conditions	: 95 °C15 sec56 °C60 sec30 cycles

How to obtain KIAA clone(s) Back to the HUGE Protein Database homepage

	cloned DNA seq.
Warning for N-terminal truncation:	NO
Warning for coding interruption:	NO

Length of 3'UTR	2905 bp
Genome contig ID	gi89161185f_11688855
PolyA signal sequence (AATAAA,-18)	+--------+--------+----*----+---- TAACCCTAACATGTGAGAATAAAATGTCTTCTGTC
Flanking genome sequence (136919 - 136968)	----+--------+--------+--------+--------+----* TCCTCTGTCTCCTTTAGCCTTTTGTCTCCATGCTGCTTTCTTTCTTTCTT

	Chr	f/r	start	end	exon	identity	class
ContigView(URL based/DAS)	1	f	11788855	11825772	23	99.4	Perfect prediction

Gene/Protein Characteristic Table for KIAA0046

Features of the cloned DNA sequence

Features of the protein sequence

Expression profile

RH mapping information