# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/ha04782.fasta.nr -Q ../query/KIAA0243.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA0243, 699 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7816589 sequences Expectation_n fit: rho(ln(x))= 6.2985+/-0.0002; mu= 8.4314+/- 0.011 mean_var=124.5921+/-24.070, 0's: 41 Z-trim: 74 B-trim: 408 in 2/64 Lambda= 0.114902 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|221044412|dbj|BAH13883.1| unnamed protein produ (1113) 4588 772.2 0 gi|9297077|sp|Q92574.2|TSC1_HUMAN RecName: Full=Ha (1164) 4588 772.2 0 gi|114627341|ref|XP_520334.2| PREDICTED: tuberous (1163) 4583 771.4 0 gi|55725927|emb|CAH89743.1| hypothetical protein [ (1164) 4531 762.8 0 gi|114627347|ref|XP_001168941.1| PREDICTED: tubero ( 710) 4500 757.5 3.7e-216 gi|109109939|ref|XP_001103589.1| PREDICTED: simila (1163) 4479 754.2 5.9e-215 gi|109109945|ref|XP_001103673.1| PREDICTED: simila ( 710) 4396 740.2 5.8e-211 gi|194225970|ref|XP_001498398.2| PREDICTED: tubero (1163) 4182 704.9 3.9e-200 gi|73967838|ref|XP_537808.2| PREDICTED: similar to (1169) 4110 693.0 1.5e-196 gi|9297064|sp|Q9Z136.1|TSC1_RAT RecName: Full=Hama (1163) 3948 666.2 1.9e-188 gi|14388581|dbj|BAB60810.1| hamartin [Mus musculus (1160) 3947 666.0 2.1e-188 gi|12054942|emb|CAC20676.1| hamartin [Mus musculus (1161) 3947 666.0 2.1e-188 gi|126297932|ref|XP_001371107.1| PREDICTED: simila (1151) 3931 663.3 1.3e-187 gi|74184577|dbj|BAE27905.1| unnamed protein produc (1155) 3889 656.4 1.6e-185 gi|149642246|ref|XP_001511515.1| PREDICTED: simila (1165) 3697 624.5 6.3e-176 gi|30851553|gb|AAH52399.1| Tsc1 protein [Mus muscu (1148) 3415 577.8 7.3e-162 gi|118099383|ref|XP_415449.2| PREDICTED: hypotheti (1156) 2785 473.4 2e-130 gi|194033729|ref|XP_001926965.1| PREDICTED: simila ( 380) 1934 331.8 2.6e-88 gi|32766372|gb|AAH55190.1| Tuberous sclerosis 1a [ (1128) 1228 215.3 9.9e-53 gi|122890980|emb|CAM14057.1| novel protein (zgc:63 (1128) 1228 215.3 9.9e-53 gi|26338886|dbj|BAC33114.1| unnamed protein produc ( 221) 1146 201.0 3.7e-49 gi|47212214|emb|CAF94981.1| unnamed protein produc ( 835) 933 166.2 4.2e-38 gi|47210448|emb|CAF91397.1| unnamed protein produc (1198) 924 164.9 1.5e-37 gi|115960743|ref|XP_001190249.1| PREDICTED: simila (1454) 764 138.4 1.7e-29 gi|47199378|emb|CAF88327.1| unnamed protein produc ( 274) 693 126.0 1.8e-26 gi|210112732|gb|EEA60506.1| hypothetical protein B (1434) 549 102.8 9e-19 gi|198418601|ref|XP_002129559.1| PREDICTED: simila ( 971) 511 96.3 5.3e-17 gi|190587558|gb|EDV27600.1| hypothetical protein T (1093) 493 93.4 4.6e-16 gi|91078944|ref|XP_974036.1| PREDICTED: similar to (1047) 456 87.2 3.1e-14 gi|212505770|gb|EEB10150.1| conserved hypothetical ( 851) 454 86.8 3.4e-14 gi|167879453|gb|EDS42836.1| Tsc1 [Culex quinquefas (1136) 396 77.3 3.3e-11 gi|108882026|gb|EAT46251.1| conserved hypothetical ( 969) 384 75.3 1.2e-10 gi|215509780|gb|EEC19233.1| hypothetical protein I ( 874) 363 71.8 1.2e-09 gi|193915397|gb|EDW14264.1| GI24168 [Drosophila mo (1107) 333 66.9 4.5e-08 gi|190628743|gb|EDV44267.1| GF16105 [Drosophila an (1107) 324 65.4 1.3e-07 gi|194142200|gb|EDW58608.1| GJ14201 [Drosophila vi (1112) 320 64.7 2e-07 gi|198131959|gb|EAL27956.2| GA19391 [Drosophila ps (1107) 305 62.2 1.1e-06 gi|194185391|gb|EDW99002.1| GE23448 [Drosophila ya (1100) 304 62.1 1.2e-06 gi|194121392|gb|EDW43435.1| GM26560 [Drosophila se (1100) 304 62.1 1.2e-06 gi|194102386|gb|EDW24429.1| GL23405 [Drosophila pe (1126) 303 61.9 1.4e-06 gi|5726655|gb|AAD48503.1|AF173560_1 tuberous scler (1100) 302 61.7 1.6e-06 gi|194200589|gb|EDX14165.1| GD21066 [Drosophila si (1100) 302 61.7 1.6e-06 gi|7301106|gb|AAF56240.1| Tsc1 [Drosophila melanog (1100) 302 61.7 1.6e-06 gi|193894179|gb|EDV93045.1| GH18494 [Drosophila gr (1146) 302 61.8 1.6e-06 gi|190656680|gb|EDV53912.1| GG11256 [Drosophila er (1100) 297 60.9 2.8e-06 gi|194166293|gb|EDW81194.1| GK11157 [Drosophila wi (1132) 294 60.4 4e-06 gi|158594835|gb|EDP33413.1| hypothetical protein B (1001) 265 55.6 0.0001 gi|190615456|gb|EDV30980.1| GF15126 [Drosophila an (2184) 252 53.7 0.0008 gi|110758387|ref|XP_001119992.1| PREDICTED: simila (1001) 245 52.3 0.001 gi|124422189|emb|CAK87029.1| unnamed protein produ ( 620) 238 50.9 0.0016 >>gi|221044412|dbj|BAH13883.1| unnamed protein product [ (1113 aa) initn: 4588 init1: 4588 opt: 4588 Z-score: 4113.2 bits: 772.2 E(): 0 Smith-Waterman score: 4588; 100.000% identity (100.000% similar) in 699 aa overlap (1-699:415-1113) 10 20 30 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAE :::::::::::::::::::::::::::::: gi|221 HHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISRELSEITTAEAE 390 400 410 420 430 440 40 50 60 70 80 90 KIAA02 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI 450 460 470 480 490 500 100 110 120 130 140 150 KIAA02 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT 510 520 530 540 550 560 160 170 180 190 200 210 KIAA02 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD 570 580 590 600 610 620 220 230 240 250 260 270 KIAA02 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA 630 640 650 660 670 680 280 290 300 310 320 330 KIAA02 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE 690 700 710 720 730 740 340 350 360 370 380 390 KIAA02 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL 750 760 770 780 790 800 400 410 420 430 440 450 KIAA02 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH 810 820 830 840 850 860 460 470 480 490 500 510 KIAA02 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL 870 880 890 900 910 920 520 530 540 550 560 570 KIAA02 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG 930 940 950 960 970 980 580 590 600 610 620 630 KIAA02 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL 990 1000 1010 1020 1030 1040 640 650 660 670 680 690 KIAA02 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMD 1050 1060 1070 1080 1090 1100 KIAA02 YNETHHEHS ::::::::: gi|221 YNETHHEHS 1110 >>gi|9297077|sp|Q92574.2|TSC1_HUMAN RecName: Full=Hamart (1164 aa) initn: 4588 init1: 4588 opt: 4588 Z-score: 4113.0 bits: 772.2 E(): 0 Smith-Waterman score: 4588; 100.000% identity (100.000% similar) in 699 aa overlap (1-699:466-1164) 10 20 30 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAE :::::::::::::::::::::::::::::: gi|929 HHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISRELSEITTAEAE 440 450 460 470 480 490 40 50 60 70 80 90 KIAA02 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI 500 510 520 530 540 550 100 110 120 130 140 150 KIAA02 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT 560 570 580 590 600 610 160 170 180 190 200 210 KIAA02 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD 620 630 640 650 660 670 220 230 240 250 260 270 KIAA02 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA 680 690 700 710 720 730 280 290 300 310 320 330 KIAA02 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE 740 750 760 770 780 790 340 350 360 370 380 390 KIAA02 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL 800 810 820 830 840 850 400 410 420 430 440 450 KIAA02 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH 860 870 880 890 900 910 460 470 480 490 500 510 KIAA02 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL 920 930 940 950 960 970 520 530 540 550 560 570 KIAA02 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG 980 990 1000 1010 1020 1030 580 590 600 610 620 630 KIAA02 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL 1040 1050 1060 1070 1080 1090 640 650 660 670 680 690 KIAA02 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|929 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMD 1100 1110 1120 1130 1140 1150 KIAA02 YNETHHEHS ::::::::: gi|929 YNETHHEHS 1160 >>gi|114627341|ref|XP_520334.2| PREDICTED: tuberous scle (1163 aa) initn: 4583 init1: 4583 opt: 4583 Z-score: 4108.5 bits: 771.4 E(): 0 Smith-Waterman score: 4583; 99.857% identity (100.000% similar) in 699 aa overlap (1-699:465-1163) 10 20 30 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAE :::::::::::::::::::::::::::::: gi|114 HHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISRELSEITTAEAE 440 450 460 470 480 490 40 50 60 70 80 90 KIAA02 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI 500 510 520 530 540 550 100 110 120 130 140 150 KIAA02 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT 560 570 580 590 600 610 160 170 180 190 200 210 KIAA02 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD 620 630 640 650 660 670 220 230 240 250 260 270 KIAA02 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA 680 690 700 710 720 730 280 290 300 310 320 330 KIAA02 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE 740 750 760 770 780 790 340 350 360 370 380 390 KIAA02 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL 800 810 820 830 840 850 400 410 420 430 440 450 KIAA02 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH 860 870 880 890 900 910 460 470 480 490 500 510 KIAA02 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL 920 930 940 950 960 970 520 530 540 550 560 570 KIAA02 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: gi|114 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSTRGSSGSRGG 980 990 1000 1010 1020 1030 580 590 600 610 620 630 KIAA02 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL 1040 1050 1060 1070 1080 1090 640 650 660 670 680 690 KIAA02 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMD 1100 1110 1120 1130 1140 1150 KIAA02 YNETHHEHS ::::::::: gi|114 YNETHHEHS 1160 >>gi|55725927|emb|CAH89743.1| hypothetical protein [Pong (1164 aa) initn: 4531 init1: 4531 opt: 4531 Z-score: 4061.9 bits: 762.8 E(): 0 Smith-Waterman score: 4531; 98.712% identity (99.571% similar) in 699 aa overlap (1-699:466-1164) 10 20 30 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAE :::::::::::::::::::::::::::::: gi|557 HHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISRELSEITTAEAE 440 450 460 470 480 490 40 50 60 70 80 90 KIAA02 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI 500 510 520 530 540 550 100 110 120 130 140 150 KIAA02 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: gi|557 DLPCGSADESPAGDRECQTSLETSILTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT 560 570 580 590 600 610 160 170 180 190 200 210 KIAA02 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD ::::.:::::::::::::::::: :::::::::::::::::::::::::::::::::::: gi|557 AHHFIIRKTEELLKKAKGNTEEDCVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD 620 630 640 650 660 670 220 230 240 250 260 270 KIAA02 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: gi|557 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNTA 680 690 700 710 720 730 280 290 300 310 320 330 KIAA02 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: gi|557 MKDQLKLQEKDIQMWKVSLQKEQARYSQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE 740 750 760 770 780 790 340 350 360 370 380 390 KIAA02 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL 800 810 820 830 840 850 400 410 420 430 440 450 KIAA02 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH 860 870 880 890 900 910 460 470 480 490 500 510 KIAA02 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL 920 930 940 950 960 970 520 530 540 550 560 570 KIAA02 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: gi|557 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSTRGSSGSRGG 980 990 1000 1010 1020 1030 580 590 600 610 620 630 KIAA02 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL 1040 1050 1060 1070 1080 1090 640 650 660 670 680 690 KIAA02 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMD :::::::::::::::::::::::::::::::::::::::::::: ::.::::::::::: gi|557 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHTPPPNPDSVGQLHIMD 1100 1110 1120 1130 1140 1150 KIAA02 YNETHHEHS ::::::::: gi|557 YNETHHEHS 1160 >>gi|114627347|ref|XP_001168941.1| PREDICTED: tuberous s (710 aa) initn: 4500 init1: 4500 opt: 4500 Z-score: 4036.9 bits: 757.5 E(): 3.7e-216 Smith-Waterman score: 4500; 99.854% identity (100.000% similar) in 685 aa overlap (15-699:26-710) 10 20 30 40 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAEPVVPRGGFDSPFYRDSLPG ::::::::::::::::::::::::::::::::::: gi|114 MPPKLPSLSQVEYRLPFLLFPLFLSAAISRELSEITTAEAEPVVPRGGFDSPFYRDSLPG 10 20 30 40 50 60 50 60 70 80 90 100 KIAA02 SQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPIDLPCGSADESPAGDRECQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPIDLPCGSADESPAGDRECQT 70 80 90 100 110 120 110 120 130 140 150 160 KIAA02 SLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGN 130 140 150 160 170 180 170 180 190 200 210 220 KIAA02 TEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQ 190 200 210 220 230 240 230 240 250 260 270 280 KIAA02 LLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSL 250 260 270 280 290 300 290 300 310 320 330 340 KIAA02 QKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIEL 310 320 330 340 350 360 350 360 370 380 390 400 KIAA02 KKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTT 370 380 390 400 410 420 410 420 430 440 450 460 KIAA02 KEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVK 430 440 450 460 470 480 470 480 490 500 510 520 KIAA02 LQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLD 490 500 510 520 530 540 530 540 550 560 570 580 KIAA02 CCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQ :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: gi|114 CCNDGCSDSMVGHNEEASGHNGETKTPRPSSTRGSSGSRGGGGSSSSSSELSTPEKPPHQ 550 560 570 580 590 600 590 600 610 620 630 640 KIAA02 RAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLS 610 620 630 640 650 660 650 660 670 680 690 KIAA02 ESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMDYNETHHEHS :::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMDYNETHHEHS 670 680 690 700 710 >>gi|109109939|ref|XP_001103589.1| PREDICTED: similar to (1163 aa) initn: 4479 init1: 4479 opt: 4479 Z-score: 4015.3 bits: 754.2 E(): 5.9e-215 Smith-Waterman score: 4479; 97.711% identity (99.142% similar) in 699 aa overlap (1-699:465-1163) 10 20 30 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAE :::::::::::::::::::::::::::::: gi|109 HHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISRELSEITTAEAE 440 450 460 470 480 490 40 50 60 70 80 90 KIAA02 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI :::::::::::: :.:::::::::::::::.::::::::::::::::::::::::::::: gi|109 PVVPRGGFDSPFNRESLPGSQRKTHSAASSAQGASVNPEPLHSSLDKLGPDTPKQAFTPI 500 510 520 530 540 550 100 110 120 130 140 150 KIAA02 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT :::::.:.:::::::::::::::::.::::::::: :::::::::::::::::::::::: gi|109 DLPCGGAEESPAGDRECQTSLETSILTPSPCKIPPSTRVGFGSGQPPPYDHLFEVALPKT 560 570 580 590 600 610 160 170 180 190 200 210 KIAA02 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD :::::: :::::::::::.::::::::::::::::::::::::::::::::::::::::: gi|109 AHHFVIGKTEELLKKAKGSTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD 620 630 640 650 660 670 220 230 240 250 260 270 KIAA02 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA 680 690 700 710 720 730 280 290 300 310 320 330 KIAA02 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: gi|109 MKDQLKLQEKDIQMWKVSLQKEQARYSQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE 740 750 760 770 780 790 340 350 360 370 380 390 KIAA02 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL 800 810 820 830 840 850 400 410 420 430 440 450 KIAA02 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH 860 870 880 890 900 910 460 470 480 490 500 510 KIAA02 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL 920 930 940 950 960 970 520 530 540 550 560 570 KIAA02 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: gi|109 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSTRGSSGSRGG 980 990 1000 1010 1020 1030 580 590 600 610 620 630 KIAA02 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL ::::::::::::::::::::::::::::::: :: ::::::::::::::::::::::::: gi|109 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTTGEPSASIPTTVGSLPSSKSFLGMKAREL 1040 1050 1060 1070 1080 1090 640 650 660 670 680 690 KIAA02 FRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMD ::::::::::::::::::::::::::.:::::::: ::::::::::::.::::::::::: gi|109 FRNKSESQCDEDGMTSSLSESLKTELSKDLGVEAKTPLNLDGPHPSPPNPDSVGQLHIMD 1100 1110 1120 1130 1140 1150 KIAA02 YNETHHEHS ::::::::: gi|109 YNETHHEHS 1160 >>gi|109109945|ref|XP_001103673.1| PREDICTED: similar to (710 aa) initn: 4396 init1: 4396 opt: 4396 Z-score: 3943.7 bits: 740.2 E(): 5.8e-211 Smith-Waterman score: 4396; 97.664% identity (99.124% similar) in 685 aa overlap (15-699:26-710) 10 20 30 40 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAEPVVPRGGFDSPFYRDSLPG :::::::::::::::::::::::::::: :.:::: gi|109 MQPKLPSLSKVEYRLPFLLFPVFLSAAISRELSEITTAEAEPVVPRGGFDSPFNRESLPG 10 20 30 40 50 60 50 60 70 80 90 100 KIAA02 SQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPIDLPCGSADESPAGDRECQT :::::::::::.::::::::::::::::::::::::::::::::::.:.::::::::::: gi|109 SQRKTHSAASSAQGASVNPEPLHSSLDKLGPDTPKQAFTPIDLPCGGAEESPAGDRECQT 70 80 90 100 110 120 110 120 130 140 150 160 KIAA02 SLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGN ::::::.::::::::: :::::::::::::::::::::::::::::: :::::::::::. gi|109 SLETSILTPSPCKIPPSTRVGFGSGQPPPYDHLFEVALPKTAHHFVIGKTEELLKKAKGS 130 140 150 160 170 180 170 180 190 200 210 220 KIAA02 TEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 TEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQ 190 200 210 220 230 240 230 240 250 260 270 280 KIAA02 LLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSL 250 260 270 280 290 300 290 300 310 320 330 340 KIAA02 QKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIEL :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 QKEQARYSQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIEL 310 320 330 340 350 360 350 360 370 380 390 400 KIAA02 KKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 KKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTT 370 380 390 400 410 420 410 420 430 440 450 460 KIAA02 KEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 KEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVK 430 440 450 460 470 480 470 480 490 500 510 520 KIAA02 LQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLD 490 500 510 520 530 540 530 540 550 560 570 580 KIAA02 CCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQ :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: gi|109 CCNDGCSDSMVGHNEEASGHNGETKTPRPSSTRGSSGSRGGGGSSSSSSELSTPEKPPHQ 550 560 570 580 590 600 590 600 610 620 630 640 KIAA02 RAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLS :::::::::::: :: :::::::::::::::::::::::::::::::::::::::::::: gi|109 RAGPFSSRWETTTGEPSASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLS 610 620 630 640 650 660 650 660 670 680 690 KIAA02 ESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMDYNETHHEHS :::::::.:::::::: ::::::::::::.:::::::::::::::::::: gi|109 ESLKTELSKDLGVEAKTPLNLDGPHPSPPNPDSVGQLHIMDYNETHHEHS 670 680 690 700 710 >>gi|194225970|ref|XP_001498398.2| PREDICTED: tuberous s (1163 aa) initn: 3743 init1: 3743 opt: 4182 Z-score: 3749.2 bits: 704.9 E(): 3.9e-200 Smith-Waterman score: 4182; 91.000% identity (97.429% similar) in 700 aa overlap (1-699:465-1163) 10 20 30 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAE ::::::::::::::::::.::::::::.:: gi|194 HHLPNDRGPEELPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISKELSEITTADAE 440 450 460 470 480 490 40 50 60 70 80 90 KIAA02 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI .::::::::::::::::: ::::::::. ::.:.:::::.:::::::::::::::::: gi|194 LLVPRGGFDSPFYRDSLPGCPRKTHSAASGPQGTSANPEPLNSSLDKLGPDTPKQAFTPI 500 510 520 530 540 550 100 110 120 130 140 150 KIAA02 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT :::::...:.:.:.: :.::::::.:::::::::: .::::::::::::::::::::: gi|194 DLPCGGSEEGPVGNRGRQASLETSILTPSPCKIPPPRGAGFGSGQPPPYDHLFEVALPKT 560 570 580 590 600 610 160 170 180 190 200 210 KIAA02 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD ::::: .::::::::::::.:::. :::::.::::::::::::::::::::: ::::::: gi|194 AHHFVSKKTEELLKKAKGNAEEDSWPSTSPVEVLDRLIQQGADAHSKELNKLSLPSKSVD 620 630 640 650 660 670 220 230 240 250 260 270 KIAA02 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA :::::::::::::::::.::::::::::::::::::::.::::::::::::::::::::: gi|194 WTHFGGSPPSDEIRTLRNQLLLLHNQLLYERFKRQQHAVRNRRLLRKVIKAAALEEHNAA 680 690 700 710 720 730 280 290 300 310 320 330 KIAA02 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE :::::::::::::.::::::::::::.::::::::.::.::::::::::::::::::::: gi|194 MKDQLKLQEKDIQIWKVSLQKEQARYSQLQEQRDTVVTQLHSQIRQLQHDREEFYNQSQE 740 750 760 770 780 790 340 350 360 370 380 390 KIAA02 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL ::::::::::::::::.:::::..:::::::::::::::::::::::::::::::::::: gi|194 LQTKLEDCRNMIAELRLELKKASSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL 800 810 820 830 840 850 400 410 420 430 440 450 KIAA02 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: gi|194 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQNQRLDTSQKRILELESH 860 870 880 890 900 910 460 470 480 490 500 510 KIAA02 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: gi|194 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQAFELEILDLYGRLEKDGLL 920 930 940 950 960 970 520 530 540 550 560 570 KIAA02 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG :::::::.::::::::: ::::::::::..:::::::::::::: :::.:.::::::::: gi|194 KKLEEEKTEAAEAAEERPDCCNDGCSDSVIGHNEEASGHNGETKPPRPGSTRGSSGSRGG 980 990 1000 1010 1020 1030 580 590 600 610 620 630 KIAA02 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL ::::::: :::::::::.::::::::::::..:: :.::::::::::::::::::::::: gi|194 GGSSSSS-ELSTPEKPPNQRAGPFSSRWETAVGEPSTSIPTTVGSLPSSKSFLGMKAREL 1040 1050 1060 1070 1080 1090 640 650 660 670 680 KIAA02 FRNKSESQCDEDGMT-SSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIM ::::::::::::.:: :::::.:::::::: :::.: :::::::.::::.:::::::::: gi|194 FRNKSESQCDEDSMTISSLSETLKTELGKDSGVEVKTPLNLDGPYPSPPNPDSVGQLHIM 1100 1110 1120 1130 1140 1150 690 KIAA02 DYNETHHEHS :::::::::: gi|194 DYNETHHEHS 1160 >>gi|73967838|ref|XP_537808.2| PREDICTED: similar to tub (1169 aa) initn: 3879 init1: 3411 opt: 4110 Z-score: 3684.7 bits: 693.0 E(): 1.5e-196 Smith-Waterman score: 4110; 89.601% identity (96.154% similar) in 702 aa overlap (1-699:466-1167) 10 20 30 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAE :::.:::.::::::::::.::::::::..: gi|739 HHLPNDRGLEELPGLKGSVTLSDLPGFLGDLASDEDSVEKDKEEAAISKELSEITTADTE 440 450 460 470 480 490 40 50 60 70 80 90 KIAA02 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI :.::::::::::: ::::: ::::::.:. ::.::::::..::::: :::::::::::: gi|739 PLVPRGGFDSPFYPDSLPGCPRKTHSATSGPQGTSVNPEPFNSSLDKRGPDTPKQAFTPI 500 510 520 530 540 550 100 110 120 130 140 150 KIAA02 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT :::::.. :::::::: ::::::.:.::::::::: :::::::::::::::::::::: gi|739 DLPCGGTHESPAGDRERQTSLETNILTPSPCKIPPQRGVGFGSGQPPPYDHLFEVALPKT 560 570 580 590 600 610 160 170 180 190 200 210 KIAA02 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD ::::: .::.::::::::::::: ::::: ::::::::::::::::::..: ::::::: gi|739 AHHFVSKKTKELLKKAKGNTEEDYPPSTSPAEVLDRLIQQGADAHSKELSRLSLPSKSVD 620 630 640 650 660 670 220 230 240 250 260 270 KIAA02 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: gi|739 WTHFGGSPPSDEIRTLRNQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA 680 690 700 710 720 730 280 290 300 310 320 330 KIAA02 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE :::::::::::::.::::::::::::.:::.:::::::.::::::::::::::::::::: gi|739 MKDQLKLQEKDIQIWKVSLQKEQARYSQLQDQRDTMVTQLHSQIRQLQHDREEFYNQSQE 740 750 760 770 780 790 340 350 360 370 380 390 KIAA02 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL ::::::::::::::::.::::::.:::::::::::::::::::::::::::::::::::: gi|739 LQTKLEDCRNMIAELRLELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL 800 810 820 830 840 850 400 410 420 430 440 450 KIAA02 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH ::::::::::::.::::::::::::::: ::::::::::::::.:::::::::::::::: gi|739 GEVNELYLEQLQSKHSDTTKEVEMMKAACRKELEKNRSHVLQQNQRLDTSQKRILELESH 860 870 880 890 900 910 460 470 480 490 500 510 KIAA02 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: gi|739 LAKKDHLLLEQKKYLEDVKVQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL 920 930 940 950 960 970 520 530 540 550 560 570 KIAA02 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG :::::::::::::::::: ::.::::::.. :.::::::::::: :::..:::::::::: gi|739 KKLEEEKAEAAEAAEERLACCKDGCSDSVTDHHEEASGHNGETKPPRPGGARGSSGSRGG 980 990 1000 1010 1020 1030 580 590 600 610 620 KIAA02 GGSSS--SSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAR ::.:: ::::::::::::.:::: ::::::::.:: ..::::::::::::::::::::: gi|739 GGGSSGGSSSELSTPEKPPNQRAGLFSSRWETTVGEPATSIPTTVGSLPSSKSFLGMKAR 1040 1050 1060 1070 1080 1090 630 640 650 660 670 680 KIAA02 ELFRNKSESQCDEDGMT-SSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLH ::::::::::::::..: :::::.:::::::::::::: : .::::::. :.:::::::: gi|739 ELFRNKSESQCDEDSVTISSLSETLKTELGKDLGVEAKTPPTLDGPHPTSPNPDSVGQLH 1100 1110 1120 1130 1140 1150 690 KIAA02 IMDYNETHHEHS :::::::::::: gi|739 IMDYNETHHEHSEG 1160 >>gi|9297064|sp|Q9Z136.1|TSC1_RAT RecName: Full=Hamartin (1163 aa) initn: 3990 init1: 3384 opt: 3948 Z-score: 3539.6 bits: 666.2 E(): 1.9e-188 Smith-Waterman score: 3948; 86.591% identity (94.294% similar) in 701 aa overlap (1-699:466-1163) 10 20 30 KIAA02 LASEEDSIEKDKEEAAISRELSEITTAEAE ::::::::::::::::::.::::::::::. gi|929 QDVPSDRGLEDLPGSKGSVTLRNLPDFLGDLASEEDSIEKDKEEAAISKELSEITTAEAD 440 450 460 470 480 490 40 50 60 70 80 90 KIAA02 PVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPI ::.:::::::::::::: :::::::::::..:: ::::::::::::: :::::::::::: gi|929 PVAPRGGFDSPFYRDSLSGSQRKTHSAASGTQGFSVNPEPLHSSLDKHGPDTPKQAFTPI 500 510 520 530 540 550 100 110 120 130 140 150 KIAA02 DLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKT : : :::: ::::::. ::::::::.::::::::: :.::::: :::::::::::::: gi|929 DPPSGSADASPAGDRDRQTSLETSILTPSPCKIPPQRGVSFGSGQLPPYDHLFEVALPKT 560 570 580 590 600 610 160 170 180 190 200 210 KIAA02 AHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVD : ::: .:::::::::::: ::: :::::::::::::..::: ::::::..: ::::::: gi|929 ACHFVSKKTEELLKKAKGNPEEDCVPSTSPMEVLDRLLEQGAGAHSKELSRLSLPSKSVD 620 630 640 650 660 670 220 230 240 250 260 270 KIAA02 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAA :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: gi|929 WTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRAAALEEHNAA 680 690 700 710 720 730 280 290 300 310 320 330 KIAA02 MKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQE ::::::::::::::::::::::::::.:::.:::::::.::::::::::::::::::::: gi|929 MKDQLKLQEKDIQMWKVSLQKEQARYSQLQQQRDTMVTQLHSQIRQLQHDREEFYNQSQE 740 750 760 770 780 790 340 350 360 370 380 390 KIAA02 LQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL :::::::::.::::::.::::::.:::::::::::::::::::::::::::::::::::: gi|929 LQTKLEDCRSMIAELRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVL 800 810 820 830 840 850 400 410 420 430 440 450 KIAA02 GEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESH ::::::::::::.:: ::::::::::.::::::::::::.:::.::::.::.:.::::: gi|929 GEVNELYLEQLQSKHPDTTKEVEMMKTAYRKELEKNRSHLLQQNQRLDASQRRVLELESL 860 870 880 890 900 910 460 470 480 490 500 510 KIAA02 LAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLL ::::::::::::::::::: :: ::: :::::::::..::.:.::::::::::::::: : gi|929 LAKKDHLLLEQKKYLEDVKSQASGQLLAAESRYEAQRKITRVLELEILDLYGRLEKDGRL 920 930 940 950 960 970 520 530 540 550 560 570 KIAA02 KKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGG .::::..::::::::::::::.::::::..::::::.::::::.: ::...:.: :.: gi|929 QKLEEDRAEAAEAAEERLDCCTDGCSDSLLGHNEEAAGHNGETRTSRPGGTRASCGGRVT 980 990 1000 1010 1020 1030 580 590 600 610 620 630 KIAA02 GGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKAREL :::::::::::::::::.:: :::::: :::: :.:::::::::::::::::::.::: gi|929 GGSSSSSSELSTPEKPPNQR---FSSRWEPTMGEPSSSIPTTVGSLPSSKSFLGMKTREL 1040 1050 1060 1070 1080 1090 640 650 660 670 680 KIAA02 FRNKSESQCDEDGMT-SSLSESLKTELGKD-LGVEAKIPLNLDGPHPSPPTPDSVGQLHI ::::::::::::::: ::.::.:::::::: :.: : : .::.:::: :. ::.::::: gi|929 FRNKSESQCDEDGMTMSSFSETLKTELGKDSAGMENKTPPSLDAPHPSSPSSDSMGQLHI 1100 1110 1120 1130 1140 1150 690 KIAA02 MDYNETHHEHS ::::::::::: gi|929 MDYNETHHEHS 1160 699 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Wed Mar 4 07:07:30 2009 done: Wed Mar 4 07:11:12 2009 Total Scan time: 1561.160 Total Display time: 0.450 Function used was FASTA [version 34.26.5 April 26, 2007]