hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080501/iprscan-20080501-22205650/chunk_1/iprscan-20080501-22205650.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA0279 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00028.8.ls Cadherin domain 763.8 1e-226 8 PF00028.8.fs Cadherin domain 749.1 2.6e-222 8 PF02210.14.ls Laminin G domain 202.2 1.1e-57 2 PF02210.14.fs Laminin G domain 198.5 1.4e-57 2 PF00008.17.ls EGF-like domain 198.6 1.4e-56 6 PF00002.15.fs 7 transmembrane receptor (Secretin family 194.8 4.6e-56 2 PF00002.15.ls 7 transmembrane receptor (Secretin family 192.6 8.5e-55 1 PF00008.17.fs EGF-like domain 191.1 2.5e-54 7 PF01825.11.fs Latrophilin/CL-1-like GPS domain 79.9 5.2e-23 1 PF00053.14.fs Laminin EGF-like (Domains III and V) 77.1 1.1e-21 5 PF01825.11.ls Latrophilin/CL-1-like GPS domain 81.9 1.9e-21 1 PF00054.13.fs Laminin G domain 70.0 9.4e-20 4 PF02793.12.fs Hormone receptor domain 74.2 1.1e-19 2 PF02793.12.ls Hormone receptor domain 74.6 2.9e-19 1 PF07974.3.fs EGF-like domain 72.2 3.8e-19 7 PF00054.13.ls Laminin G domain 68.2 2.5e-17 2 PF07974.3.ls EGF-like domain 60.2 6.2e-15 5 PF00053.14.ls Laminin EGF-like (Domains III and V) 50.7 4.5e-12 1 PF07645.6.fs Calcium binding EGF domain 37.7 1.1e-10 5 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF00028.8.fs 1/8 117 211 .. 1 107 [] 95.5 8.9e-27 PF00028.8.ls 1/8 117 211 .. 1 107 [] 97.4 4.1e-26 PF00028.8.fs 2/8 225 321 .. 1 107 [] 90.5 2.5e-25 PF00028.8.ls 2/8 225 321 .. 1 107 [] 92.3 1.3e-24 PF00028.8.fs 3/8 335 427 .. 1 107 [] 105.3 1.4e-29 PF00028.8.ls 3/8 335 427 .. 1 107 [] 107.1 4.6e-29 PF00028.8.ls 4/8 441 532 .. 1 107 [] 102.6 1.1e-27 PF00028.8.fs 4/8 441 532 .. 1 107 [] 100.8 2.8e-28 PF00028.8.fs 5/8 546 634 .. 1 107 [] 81.6 8.6e-23 PF00028.8.ls 5/8 546 634 .. 1 107 [] 83.4 6.3e-22 PF00028.8.fs 6/8 648 737 .. 1 107 [] 86.6 3.1e-24 PF00028.8.ls 6/8 648 737 .. 1 107 [] 88.5 1.9e-23 PF00028.8.ls 7/8 751 843 .. 1 107 [] 103.5 5.7e-28 PF00028.8.fs 7/8 751 843 .. 1 107 [] 101.7 1.5e-28 PF00028.8.fs 8/8 857 945 .. 1 107 [] 87.1 2.3e-24 PF00028.8.ls 8/8 857 945 .. 1 107 [] 88.9 1.4e-23 PF00008.17.ls 1/6 1163 1216 .. 1 38 [] 27.8 3.5e-05 PF00008.17.fs 1/7 1163 1216 .. 1 38 [] 26.0 2.2e-06 PF00008.17.fs 2/7 1223 1254 .. 1 38 [] 30.1 1.6e-07 PF00008.17.ls 2/6 1223 1254 .. 1 38 [] 31.9 2.1e-06 PF07974.3.ls 1/5 1223 1254 .. 1 37 [] 22.0 0.002 PF00008.17.fs 3/7 1263 1296 .. 1 38 [] 35.2 5.6e-09 PF00008.17.ls 3/6 1263 1296 .. 1 38 [] 37.1 5.7e-08 PF00054.13.ls 1/2 1326 1488 .. 1 159 [] 52.5 1.3e-12 PF00054.13.fs 1/4 1326 1390 .. 1 76 [. 31.3 1.3e-08 PF02210.14.ls 1/2 1326 1485 .. 1 141 [] 124.6 2.5e-34 PF02210.14.fs 1/2 1326 1485 .. 1 141 [] 122.8 1.8e-35 PF00054.13.fs 2/4 1439 1488 .. 102 159 .] 20.7 1.4e-05 PF00008.17.fs 4/7 1509 1540 .. 1 38 [] 37.6 1.2e-09 PF00008.17.ls 4/6 1509 1540 .. 1 38 [] 39.4 1.1e-08 PF02210.14.ls 2/2 1575 1701 .. 1 141 [] 77.5 3.8e-20 PF02210.14.fs 2/2 1575 1701 .. 1 141 [] 75.7 9.7e-22 PF00008.17.ls 5/6 1728 1759 .. 1 38 [] 29.0 1.6e-05 PF00008.17.fs 5/7 1728 1759 .. 1 38 [] 27.2 1e-06 PF00008.17.ls 6/6 1763 1797 .. 1 38 [] 33.4 7.5e-07 PF00008.17.fs 6/7 1763 1797 .. 1 38 [] 31.6 6.1e-08 PF00053.14.ls 1/1 1855 1900 .. 1 59 [] 50.7 4.5e-12 PF00053.14.fs 5/5 1855 1888 .. 1 43 [. 52.0 2.1e-14 PF02793.12.ls 1/1 1904 1961 .. 1 78 [] 74.6 2.9e-19 PF02793.12.fs 2/2 1904 1961 .. 1 78 [] 72.9 2.6e-19 PF01825.11.fs 1/1 2246 2294 .. 1 48 [] 79.9 5.2e-23 PF01825.11.ls 1/1 2246 2294 .. 1 48 [] 81.9 1.9e-21 PF00002.15.ls 1/1 2304 2547 .. 1 293 [] 192.6 8.5e-55 PF00002.15.fs 1/2 2304 2462 .. 1 195 [. 161.1 2.4e-46 PF00002.15.fs 2/2 2496 2547 .. 237 293 .] 33.7 1.2e-09 Alignments of top-scoring domains: PF00028.8.fs: domain 1 of 8, from 117 to 211: score 95.5, E = 8.9e-27 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnp...gg y+a+vpEn+p Gt+v++++A+D+D +g gr+ Y + +++++ KIAA0279 117 YQATVPENQPAGTPVASLRAIDPD--EGEAGRLEYTMDALFDsrsNQ 161 wFrIdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggp F++dp tG ++t+++LDRE+ +++++ v A+D+ g p KIAA0279 162 FFSLDPVTGA----VTTAEELDRETK--STHVFRVTAQDH-------GMP 198 plsstatvtitVl<-* +s+ at+ti V+ KIAA0279 199 RRSALATLTILVT 211 PF00028.8.ls: domain 1 of 8, from 117 to 211: score 97.4, E = 4.1e-26 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnp...gg y+a+vpEn+p Gt+v++++A+D+D +g gr+ Y + +++++ KIAA0279 117 YQATVPENQPAGTPVASLRAIDPD--EGEAGRLEYTMDALFDsrsNQ 161 wFrIdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggp F++dp tG ++t+++LDRE+ +++++ v A+D+ g p KIAA0279 162 FFSLDPVTGA----VTTAEELDRETK--STHVFRVTAQDH-------GMP 198 plsstatvtitVl<-* +s+ at+ti V+ KIAA0279 199 RRSALATLTILVT 211 PF00028.8.fs: domain 2 of 8, from 225 to 321: score 90.5, E = 2.5e-25 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnp...gg y s++En vG evltv+AtD D +pN++i Y++l+g+ ++++ KIAA0279 225 YKESLRENLEVGYEVLTVRATDGD--APPNANILYRLLEGSGgspSE 269 wFrIdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggp F+Idp++G+ i+t+ p+DREe + Y LtveA+D++ + + KIAA0279 270 VFEIDPRSGV----IRTRGPVDREEV--ESYQLTVEASDQGRD-----PG 308 plsstatvtitVl<-* p+s+ta v +V+ KIAA0279 309 PRSTTAAVFLSVE 321 PF00028.8.ls: domain 2 of 8, from 225 to 321: score 92.3, E = 1.3e-24 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnp...gg y s++En vG evltv+AtD D +pN++i Y++l+g+ ++++ KIAA0279 225 YKESLRENLEVGYEVLTVRATDGD--APPNANILYRLLEGSGgspSE 269 wFrIdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggp F+Idp++G+ i+t+ p+DREe + Y LtveA+D++ + + KIAA0279 270 VFEIDPRSGV----IRTRGPVDREEV--ESYQLTVEASDQGRD-----PG 308 plsstatvtitVl<-* p+s+ta v +V+ KIAA0279 309 PRSTTAAVFLSVE 321 PF00028.8.fs: domain 3 of 8, from 335 to 427: score 105.3, E = 1.4e-29 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr y+++v+E++ +G +vl+vtA+D+D g N+ ++Ysi +gn +g+F KIAA0279 335 YVVQVREDVTPGAPVLRVTASDRD--KGSNAVVHYSIMSGNARGQFY 379 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls +d +tG + ++ pLD+E++ eY+L v+A+D+ g ppls KIAA0279 380 LDAQTGA----LDVVSPLDYETT--KEYTLRVRAQDG-------GRPPLS 416 st.atvtitVl<-* ++++ vt++Vl KIAA0279 417 NVsGLVTVQVL 427 PF00028.8.ls: domain 3 of 8, from 335 to 427: score 107.1, E = 4.6e-29 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr y+++v+E++ +G +vl+vtA+D+D g N+ ++Ysi +gn +g+F KIAA0279 335 YVVQVREDVTPGAPVLRVTASDRD--KGSNAVVHYSIMSGNARGQFY 379 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls +d +tG + ++ pLD+E++ eY+L v+A+D+ g ppls KIAA0279 380 LDAQTGA----LDVVSPLDYETT--KEYTLRVRAQDG-------GRPPLS 416 st.atvtitVl<-* ++++ vt++Vl KIAA0279 417 NVsGLVTVQVL 427 PF00028.8.ls: domain 4 of 8, from 441 to 532: score 102.6, E = 1.1e-27 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr ++a+v E +p G vl+v+A+DaD g+N+r+ Y++ g + + F+ KIAA0279 441 FQATVLESVPLGYLVLHVQAIDAD--AGDNARLEYRLAGVGHDFPFT 485 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls I+ tG+ is++++LDREe + Y++ veA+D+ g+p+l+ KIAA0279 486 INNGTGW----ISVAAELDREEV--DFYSFGVEARDH-------GTPALT 522 statvtitVl<-* + a+v +tVl KIAA0279 523 ASASVSVTVL 532 PF00028.8.fs: domain 4 of 8, from 441 to 532: score 100.8, E = 2.8e-28 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr ++a+v E +p G vl+v+A+DaD g+N+r+ Y++ g + + F+ KIAA0279 441 FQATVLESVPLGYLVLHVQAIDAD--AGDNARLEYRLAGVGHDFPFT 485 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls I+ tG+ is++++LDREe + Y++ veA+D+ g+p+l+ KIAA0279 486 INNGTGW----ISVAAELDREEV--DFYSFGVEARDH-------GTPALT 522 statvtitVl<-* + a+v +tVl KIAA0279 523 ASASVSVTVL 532 PF00028.8.fs: domain 5 of 8, from 546 to 634: score 81.6, E = 8.6e-23 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr y++++ E+a+vGt+v tv A+D+D +++ i+Y i++gn ++ F+ KIAA0279 546 YTVRLNEDAAVGTSVVTVSAVDRD----AHSVITYQITSGNTRNRFS 588 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls I++++G g++s++ pLD+ ++Y+L v A+D+ + KIAA0279 589 ITSQSGG--GLVSLALPLDYKLE--RQYVLAVTASDG----------TRQ 624 statvtitVl<-* +ta+++++V+ KIAA0279 625 DTAQIVVNVT 634 PF00028.8.ls: domain 5 of 8, from 546 to 634: score 83.4, E = 6.3e-22 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr y++++ E+a+vGt+v tv A+D+D +++ i+Y i++gn ++ F+ KIAA0279 546 YTVRLNEDAAVGTSVVTVSAVDRD----AHSVITYQITSGNTRNRFS 588 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls I++++G g++s++ pLD+ ++Y+L v A+D+ + KIAA0279 589 ITSQSGG--GLVSLALPLDYKLE--RQYVLAVTASDG----------TRQ 624 statvtitVl<-* +ta+++++V+ KIAA0279 625 DTAQIVVNVT 634 PF00028.8.fs: domain 6 of 8, from 648 to 737: score 86.6, E = 3.1e-24 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr y++ v E+ p Gt+v + AtD D +g N+ri+Y++ p +Fr KIAA0279 648 YTVNVNEDRPAGTTVVLISATDED--TGENARITYFMEDSIP--QFR 690 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls Id dtG ++t+++LD+E + Y+L + A+D+ g p +s KIAA0279 691 IDADTGA----VTTQAELDYEDQ--VSYTLAITARDN-------GIPQKS 727 statvtitVl<-* +t+++ i V KIAA0279 728 DTTYLEILVN 737 PF00028.8.ls: domain 6 of 8, from 648 to 737: score 88.5, E = 1.9e-23 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr y++ v E+ p Gt+v + AtD D +g N+ri+Y++ p +Fr KIAA0279 648 YTVNVNEDRPAGTTVVLISATDED--TGENARITYFMEDSIP--QFR 690 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls Id dtG ++t+++LD+E + Y+L + A+D+ g p +s KIAA0279 691 IDADTGA----VTTQAELDYEDQ--VSYTLAITARDN-------GIPQKS 727 statvtitVl<-* +t+++ i V KIAA0279 728 DTTYLEILVN 737 PF00028.8.ls: domain 7 of 8, from 751 to 843: score 103.5, E = 5.7e-28 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnp.ggwF y++sv E++p+ t+vl++ AtD+D +g+Ngr++Y + gg+ ++g F KIAA0279 751 YQGSVYEDVPPFTSVLQISATDRD--SGLNGRVFYTFQGGDDgDGDF 795 rIdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppl +++ +G ++t ++LDRE +Y+L +A+D g pp KIAA0279 796 IVESTSGI----VRTLRRLDRENV--AQYVLRAYAVDK-------GMPPA 832 sstatvtitVl<-* +++ +vt+tVl KIAA0279 833 RTPMEVTVTVL 843 PF00028.8.fs: domain 7 of 8, from 751 to 843: score 101.7, E = 1.5e-28 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnp.ggwF y++sv E++p+ t+vl++ AtD+D +g+Ngr++Y + gg+ ++g F KIAA0279 751 YQGSVYEDVPPFTSVLQISATDRD--SGLNGRVFYTFQGGDDgDGDF 795 rIdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppl +++ +G ++t ++LDRE +Y+L +A+D g pp KIAA0279 796 IVESTSGI----VRTLRRLDRENV--AQYVLRAYAVDK-------GMPPA 832 sstatvtitVl<-* +++ +vt+tVl KIAA0279 833 RTPMEVTVTVL 843 PF00028.8.fs: domain 8 of 8, from 857 to 945: score 87.1, E = 2.3e-24 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr + + v+En+p+G v++vtAtD+D +g+N++i Y i++gn + F KIAA0279 857 FDVFVEENSPIGLAVARVTATDPD--EGTNAQIMYQIVEGNIPEVFQ 901 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls +d +G+ ++ LD+E + +eY+L++ At a pl KIAA0279 902 LDIFSGE----LTALVDLDYEDR--PEYVLVIQATSA----------PLV 935 statvtitVl<-* s+atv++ +l KIAA0279 936 SRATVHVRLL 945 PF00028.8.ls: domain 8 of 8, from 857 to 945: score 88.9, E = 1.4e-23 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr + + v+En+p+G v++vtAtD+D +g+N++i Y i++gn + F KIAA0279 857 FDVFVEENSPIGLAVARVTATDPD--EGTNAQIMYQIVEGNIPEVFQ 901 IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls +d +G+ ++ LD+E + +eY+L++ At a pl KIAA0279 902 LDIFSGE----LTALVDLDYEDR--PEYVLVIQATSA----------PLV 935 statvtitVl<-* s+atv++ +l KIAA0279 936 SRATVHVRLL 945 PF00008.17.ls: domain 1 of 6, from 1163 to 1216: score 27.8, E = 3.5e-05 *->CspnngpCsngGtCvdtp......................ggytCeC C + pC n +Cv++ + +++ + +++ ++ ++ gg +C+C KIAA0279 1163 CLRE--PCENYMRCVSVLrfdssapfiasssvlfrpihpvGGLRCRC 1207 ppGyfllytGkrC<-* ppG +tG++C KIAA0279 1208 PPG----FTGDYC 1216 PF00008.17.fs: domain 1 of 7, from 1163 to 1216: score 26.0, E = 2.2e-06 *->CspnngpCsngGtCvdtp......................ggytCeC C + pC n +Cv++ + +++ + +++ ++ ++ gg +C+C KIAA0279 1163 CLRE--PCENYMRCVSVLrfdssapfiasssvlfrpihpvGGLRCRC 1207 ppGyfllytGkrC<-* ppG +tG++C KIAA0279 1208 PPG----FTGDYC 1216 PF00008.17.fs: domain 2 of 7, from 1223 to 1254: score 30.1, E = 1.6e-07 *->CspnngpCsngGtCvdtpggytCeCppGyfllytGkrC<-* C + pC +G+C++ +ggytC C G ytG++C KIAA0279 1223 CYSR--PCGPHGRCRSREGGYTCLCRDG----YTGEHC 1254 PF00008.17.ls: domain 2 of 6, from 1223 to 1254: score 31.9, E = 2.1e-06 *->CspnngpCsngGtCvdtpggytCeCppGyfllytGkrC<-* C + pC +G+C++ +ggytC C G ytG++C KIAA0279 1223 CYSR--PCGPHGRCRSREGGYTCLCRDG----YTGEHC 1254 PF07974.3.ls: domain 1 of 5, from 1223 to 1254: score 22.0, E = 0.002 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C +++C+ hG+C+s +g+ C C +g y+G +C KIAA0279 1223 CysrpCGP-HGRCRSREGG----YTCLCRDG----YTGEHC 1254 PF00008.17.fs: domain 3 of 7, from 1263 to 1296: score 35.2, E = 5.6e-09 *->CspnngpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* C+p C+ngGtCv++ gg++C+Cp G ++ ++C KIAA0279 1263 CTPG--VCKNGGTCVNLLvGGFKCDCPSG---DFEKPYC 1296 PF00008.17.ls: domain 3 of 6, from 1263 to 1296: score 37.1, E = 5.7e-08 *->CspnngpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* C+p C+ngGtCv++ gg++C+Cp G ++ ++C KIAA0279 1263 CTPG--VCKNGGTCVNLLvGGFKCDCPSG---DFEKPYC 1296 PF00054.13.ls: domain 1 of 2, from 1326 to 1488: score 52.5, E = 1.3e-12 *->FRTtepsGlLllgYnGtqterrskkeigdDFlaleLvdGrlevsydl F+T+e +GlLl YnG +e+ DF+ale + ++++ ++ KIAA0279 1326 FATKERDGLLL--YNGRFNEKH-------DFVALEVIQEQVQLTFSA 1363 GsgrlrpavvrsgdkvlnDGkWHsveler................ngrsg G + +v + ++DG+WH+v+l++ +++ ++++ ++++++++ + KIAA0279 1364 GES--TTTVSPFVPGGVSDGQWHTVQLKYynkpllgqtglpqgpsEQKVA 1411 tLsVdgearskkt......LgGsvvtgesplgattesttLdvdgkLyvGG ++ Vdg+++ + + +++ G ++ ++ + + + + +Ld++g+L +GG KIAA0279 1412 VVTVDGCDT--GValrfgsVLGNYSCAAQGTQGGS-KKSLDLTGPLLLGG 1458 lPeldqavkarrlaisps.fkGCirdviingkpld<-* P ++++ +++ ++f+GC+r++ ++++ +d KIAA0279 1459 VP-----DLPESFPVRMRqFVGCMRNLQVDSRHID 1488 PF00054.13.fs: domain 1 of 4, from 1326 to 1390: score 31.3, E = 1.3e-08 *->FRTtepsGlLllgYnGtqterrskkeigdDFlaleLvdGrlevsydl F+T+e +GlLl YnG +e+ DF+ale + ++++ ++ KIAA0279 1326 FATKERDGLLL--YNGRFNEKH-------DFVALEVIQEQVQLTFSA 1363 GsgrlrpavvrsgdkvlnDGkWHsveler<-* G + +v + ++DG+WH+v+l++ KIAA0279 1364 GES--TTTVSPFVPGGVSDGQWHTVQLKY 1390 PF02210.14.ls: domain 1 of 2, from 1326 to 1485: score 124.6, E = 2.5e-34 *->FRTatqpnGlLlyaggk.glpdradpksdKflaLeLvdGrlvlrydl F T + +GlLly+g + k+d f+aLe+++ +++l+++ KIAA0279 1326 FAT-KERDGLLLYNGRFnE-------KHD-FVALEVIQEQVQLTFSA 1363 G.sgg.vlltsg.plnDGqWHtVsverngrs................vtL G+s+++v+ + ++ ++DGqWHtV++ + ++ ++++ ++++++++ +++ KIAA0279 1364 GeSTTtVSPFVPgGVSDGQWHTVQLKYYNKPllgqtglpqgpseqkvAVV 1413 sVDgg.vv.g.spgssdtl..............slnlngplylGGlpess +VDg+++ + + gs ++ + +++++++++sl+l+gpl lGG+p+ + KIAA0279 1414 TVDGCdTGvAlRFGSVLGNyscaaqgtqggskkSLDLTGPLLLGGVPDLP 1463 kssllrliaaqnlvtvs.gFvGCirnvringe<-* s ++r + FvGC+rn++++++ KIAA0279 1464 ESFPVR----------MrQFVGCMRNLQVDSR 1485 PF02210.14.fs: domain 1 of 2, from 1326 to 1485: score 122.8, E = 1.8e-35 *->FRTatqpnGlLlyaggk.glpdradpksdKflaLeLvdGrlvlrydl F T + +GlLly+g + k+d f+aLe+++ +++l+++ KIAA0279 1326 FAT-KERDGLLLYNGRFnE-------KHD-FVALEVIQEQVQLTFSA 1363 G.sgg.vlltsg.plnDGqWHtVsverngrs................vtL G+s+++v+ + ++ ++DGqWHtV++ + ++ ++++ ++++++++ +++ KIAA0279 1364 GeSTTtVSPFVPgGVSDGQWHTVQLKYYNKPllgqtglpqgpseqkvAVV 1413 sVDgg.vv.g.spgssdtl..............slnlngplylGGlpess +VDg+++ + + gs ++ + +++++++++sl+l+gpl lGG+p+ + KIAA0279 1414 TVDGCdTGvAlRFGSVLGNyscaaqgtqggskkSLDLTGPLLLGGVPDLP 1463 kssllrliaaqnlvtvs.gFvGCirnvringe<-* s ++r + FvGC+rn++++++ KIAA0279 1464 ESFPVR----------MrQFVGCMRNLQVDSR 1485 PF00054.13.fs: domain 2 of 4, from 1439 to 1488: score 20.7, E = 1.4e-05 *->gesplgattesttLdvdgkLyvGGlPeldqavkarrlaisps.fkGC g++ +++++ Ld++g+L +GG P ++++ +++ ++f+GC KIAA0279 1439 GTQGGSKKS----LDLTGPLLLGGVP-----DLPESFPVRMRqFVGC 1476 irdviingkpld<-* +r++ ++++ +d KIAA0279 1477 MRNLQVDSRHID 1488 PF00008.17.fs: domain 4 of 7, from 1509 to 1540: score 37.6, E = 1.2e-09 *->CspnngpCsngGtCvdtpggytCeCppGyfllytGkrC<-* C++n C+ngGtCv+ ++ ++CeCp G + Gk C KIAA0279 1509 CDSN--TCHNGGTCVNQWDAFSCECPLG----FGGKSC 1540 PF00008.17.ls: domain 4 of 6, from 1509 to 1540: score 39.4, E = 1.1e-08 *->CspnngpCsngGtCvdtpggytCeCppGyfllytGkrC<-* C++n C+ngGtCv+ ++ ++CeCp G + Gk C KIAA0279 1509 CDSN--TCHNGGTCVNQWDAFSCECPLG----FGGKSC 1540 PF02210.14.ls: domain 2 of 2, from 1575 to 1701: score 77.5, E = 3.8e-20 *->FRTatqpnGlLlyaggk.glpdradpksdKflaLeLvdGrlvlrydl FRT +q++G+Ll a ++ + ++L+L++G++ l+++ KIAA0279 1575 FRT-RQADGVLLQAITRgR---------S-TITLQLREGHVMLSVEG 1610 G.sgg.vlltsg.plnDGqWHtVsverngrs....vtLsVDgg.vv.g.s + ++++l + +++ nDG WH+ ++ + +++++ Ls D+g+++ +++ KIAA0279 1611 TgLQAsSLRLEPgRANDGDWHHAQLALGASGgpghAILSFDYGqQRaEgN 1660 pgssdtlslnlngplylGGlpesskssllrliaaqnlvtvs.gFvGCirn g+ + +++ +GG+p ++ +gF+GC+++ KIAA0279 1661 LGPRL--HGLHLSNITVGGIPGPAGGV-------------ArGFRGCLQG 1695 vringe<-* vr+ + KIAA0279 1696 VRVSDT 1701 PF02210.14.fs: domain 2 of 2, from 1575 to 1701: score 75.7, E = 9.7e-22 *->FRTatqpnGlLlyaggk.glpdradpksdKflaLeLvdGrlvlrydl FRT +q++G+Ll a ++ + ++L+L++G++ l+++ KIAA0279 1575 FRT-RQADGVLLQAITRgR---------S-TITLQLREGHVMLSVEG 1610 G.sgg.vlltsg.plnDGqWHtVsverngrs....vtLsVDgg.vv.g.s + ++++l + +++ nDG WH+ ++ + +++++ Ls D+g+++ +++ KIAA0279 1611 TgLQAsSLRLEPgRANDGDWHHAQLALGASGgpghAILSFDYGqQRaEgN 1660 pgssdtlslnlngplylGGlpesskssllrliaaqnlvtvs.gFvGCirn g+ + +++ +GG+p ++ +gF+GC+++ KIAA0279 1661 LGPRL--HGLHLSNITVGGIPGPAGGV-------------ArGFRGCLQG 1695 vringe<-* vr+ + KIAA0279 1696 VRVSDT 1701 PF00008.17.ls: domain 5 of 6, from 1728 to 1759: score 29.0, E = 1.6e-05 *->CspnngpCsngGtCvdtpggytCeCppGyfllytGkrC<-* C++n pC + C + +++y+C C+pG y G++C KIAA0279 1728 CDSN--PCPANSYCSNDWDSYSCSCDPG----YYGDNC 1759 PF00008.17.fs: domain 5 of 7, from 1728 to 1759: score 27.2, E = 1e-06 *->CspnngpCsngGtCvdtpggytCeCppGyfllytGkrC<-* C++n pC + C + +++y+C C+pG y G++C KIAA0279 1728 CDSN--PCPANSYCSNDWDSYSCSCDPG----YYGDNC 1759 PF00008.17.ls: domain 6 of 6, from 1763 to 1797: score 33.4, E = 7.5e-07 *->CspnngpCsngGtCvdtp...ggytCeCppGyfllytGkrC<-* C+ n pC + C++ p+ ++gytCeCpp y G++C KIAA0279 1763 CDLN--PCEHQSVCTRKPsapHGYTCECPPN----YLGPYC 1797 PF00008.17.fs: domain 6 of 7, from 1763 to 1797: score 31.6, E = 6.1e-08 *->CspnngpCsngGtCvdtp...ggytCeCppGyfllytGkrC<-* C+ n pC + C++ p+ ++gytCeCpp y G++C KIAA0279 1763 CDLN--PCEHQSVCTRKPsapHGYTCECPPN----YLGPYC 1797 PF00053.14.ls: domain 1 of 1, from 1855 to 1900: score 50.7, E = 4.5e-12 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrCkpGy CdC p Gsls Cd+ e GqC+ Ckp+v Gr+CdrC + KIAA0279 1855 CDCYPTGSLS-RVCDP-------EDGQCP-CKPGVIGRQCDRCDNPF 1892 yglpsgdpgqgC<-* +gC KIAA0279 1893 AE----VTTNGC 1900 PF00053.14.fs: domain 5 of 5, from 1855 to 1888: score 52.0, E = 2.1e-14 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrC<-* CdC p Gsls Cd+ e GqC+ Ckp+v Gr+CdrC KIAA0279 1855 CDCYPTGSLS-RVCDP-------EDGQCP-CKPGVIGRQCDRC 1888 PF02793.12.ls: domain 1 of 1, from 1904 to 1961: score 74.6, E = 2.9e-19 *->glgCprtwDgitCWPrtpaGqlvvvpCPdyfsgfnydttgdfssgna ++ Cpr ++ +++WPrt +G ++ pCP++ g+ a KIAA0279 1904 YDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGT------------A 1938 yRnClenGwwerhpnsnwpwpnysaCtspey<-* +R+C+e +w +pn+++Cts+++ KIAA0279 1939 VRHCDEHRGWL--------PPNLFNCTSITF 1961 PF02793.12.fs: domain 2 of 2, from 1904 to 1961: score 72.9, E = 2.6e-19 *->glgCprtwDgitCWPrtpaGqlvvvpCPdyfsgfnydttgdfssgna ++ Cpr ++ +++WPrt +G ++ pCP++ g+ a KIAA0279 1904 YDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGT------------A 1938 yRnClenGwwerhpnsnwpwpnysaCtspey<-* +R+C+e +w +pn+++Cts+++ KIAA0279 1939 VRHCDEHRGWL--------PPNLFNCTSITF 1961 PF01825.11.fs: domain 1 of 1, from 2246 to 2294: score 79.9, E = 5.2e-23 *->snptCvfWdese.ggq.GgWstdGCqlgvssndthttClCnHLTsFA ++p+CvfW++s + +GgWs++GC++ v +n++h+ C+CnH+TsFA KIAA0279 2246 TKPICVFWNHSIlVSGtGGWSARGCEV-VFRNESHVSCQCNHMTSFA 2291 vLm<-* vLm KIAA0279 2292 VLM 2294 PF01825.11.ls: domain 1 of 1, from 2246 to 2294: score 81.9, E = 1.9e-21 *->snptCvfWdese.ggq.GgWstdGCqlgvssndthttClCnHLTsFA ++p+CvfW++s + +GgWs++GC++ v +n++h+ C+CnH+TsFA KIAA0279 2246 TKPICVFWNHSIlVSGtGGWSARGCEV-VFRNESHVSCQCNHMTSFA 2291 vLm<-* vLm KIAA0279 2292 VLM 2294 PF00002.15.ls: domain 1 of 1, from 2304 to 2547: score 192.6, E = 8.5e-55 *->lllLkviytVGyslSLvaLllAiaifllFRkLhCtRNyIHlNLfaSf l Lk +++V +++ L+aLll+++ + l+R L+++ + I NL a++ KIAA0279 2304 ILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSNQHGIRRNLTAAL 2350 iLraisflikdavlfnsvglseadqlsweeslhcsasagkitmivvVgCk L++++fl+++++ + + + C+ KIAA0279 2351 GLAQLVFLLGINQADLPFA-----------------------------CT 2371 vvavflhYfflaNFfWmLvEGlYLhtLlvvtVevffserkylwwYlliGW v+a++lh+ +l++F W L+E+l+L+++l +ev+ ++ +++Y+ +GW KIAA0279 2372 VIAILLHFLYLCTFSWALLEALHLYRAL---TEVRDVNTGPMRFYYMLGW 2418 GvPavfVgiWaivrpdkagygnegCCWlsnedngyfwWiikGPvllvilv GvPa ++g++++++p+ gygn+++CWls+ + ++W+++GPv++++ + KIAA0279 2419 GVPAFITGLAVGLDPE--GYGNPDFCWLSI--YDTLIWSFAGPVAFAVSM 2464 NfilFinilriLvqKlridslspdmgetdqyrkkrlaKStLlLlPLLGit ++l i+ r ++ r + + + + + ++++l+LL t KIAA0279 2465 SVFLYILAARASCAAQR-----QGFEKKGPVS---GLQPSFAVLLLLSAT 2506 wvlflfapeddarGvssivflylflilnSfQGFfVavlYCFLNgEV<-* w+l+l+ +++d + +f+ylf+ n+ QG f+++ Y +L +EV KIAA0279 2507 WLLALLSVNSD-----TLLFHYLFATCNCIQGPFIFLSYVVLSKEV 2547 PF00002.15.fs: domain 1 of 2, from 2304 to 2462: score 161.1, E = 2.4e-46 *->lllLkviytVGyslSLvaLllAiaifllFRkLhCtRNyIHlNLfaSf l Lk +++V +++ L+aLll+++ + l+R L+++ + I NL a++ KIAA0279 2304 ILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSNQHGIRRNLTAAL 2350 iLraisflikdavlfnsvglseadqlsweeslhcsasagkitmivvVgCk L++++fl+++++ + + + C+ KIAA0279 2351 GLAQLVFLLGINQADLPFA-----------------------------CT 2371 vvavflhYfflaNFfWmLvEGlYLhtLlvvtVevffserkylwwYlliGW v+a++lh+ +l++F W L+E+l+L+++l +ev+ ++ +++Y+ +GW KIAA0279 2372 VIAILLHFLYLCTFSWALLEALHLYRAL---TEVRDVNTGPMRFYYMLGW 2418 GvPavfVgiWaivrpdkagygnegCCWlsnedngyfwWiikGPvllvi<- GvPa ++g++++++p+ gygn+++CWls+ + ++W+++GPv++++ KIAA0279 2419 GVPAFITGLAVGLDPE--GYGNPDFCWLSI--YDTLIWSFAGPVAFAV 2462 * KIAA0279 - - PF00002.15.fs: domain 2 of 2, from 2496 to 2547: score 33.7, E = 1.2e-09 *->tLlLlPLLGitwvlflfapeddarGvssivflylflilnSfQGFfVa ++++l+LL tw+l+l+ +++d + +f+ylf+ n+ QG f++ KIAA0279 2496 SFAVLLLLSATWLLALLSVNSD-----TLLFHYLFATCNCIQGPFIF 2537 vlYCFLNgEV<-* + Y +L +EV KIAA0279 2538 LSYVVLSKEV 2547 //