hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080502/iprscan-20080502-18230723/chunk_1/iprscan-20080502-18230723.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA0973 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF08926.1.ls Domain of unknown function (DUF1908) 720.5 1.1e-213 1 PF08926.1.fs Domain of unknown function (DUF1908) 718.6 4e-213 1 PF00069.15.ls Protein kinase domain 273.1 5.1e-79 1 PF00069.15.fs Protein kinase domain 271.2 1.9e-78 1 PF00595.14.fs PDZ domain (Also known as DHR or GLGF) 35.9 2e-09 1 PF07714.7.fs Protein tyrosine kinase 31.7 4.3e-09 1 PF00595.14.ls PDZ domain (Also known as DHR or GLGF) 38.0 3.1e-08 1 PF00433.14.fs Protein kinase C terminal domain 26.2 3.8e-07 1 PF00433.14.ls Protein kinase C terminal domain 28.2 2.7e-05 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF08926.1.fs 1/1 72 351 .. 1 317 [] 718.6 4e-213 PF08926.1.ls 1/1 72 351 .. 1 317 [] 720.5 1.1e-213 PF00069.15.ls 1/1 387 660 .. 1 287 [] 273.1 5.1e-79 PF00069.15.fs 1/1 387 660 .. 1 287 [] 271.2 1.9e-78 PF07714.7.fs 1/1 459 533 .. 81 161 .. 31.7 4.3e-09 PF00433.14.fs 1/1 678 723 .. 1 47 [] 26.2 3.8e-07 PF00433.14.ls 1/1 678 723 .. 1 47 [] 28.2 2.7e-05 PF00595.14.ls 1/1 980 1065 .. 1 86 [] 38.0 3.1e-08 PF00595.14.fs 1/1 1015 1065 .. 33 86 .] 35.9 2e-09 Alignments of top-scoring domains: PF08926.1.fs: domain 1 of 1, from 72 to 351: score 718.6, E = 4e-213 *->sSpldSprnfststsanFsfarssslradraDgRRWSLASLPStSGY sSpldSprnfs++t+a+Fsfa+ ++raDgRRWSLASLPS SGY KIAA0973 72 SSPLDSPRNFSPNTPAHFSFAS-----SRRADGRRWSLASLPS-SGY 112 GTpgntpsStvSSssSSqErLhqmLpyqptsdelhflskhFrSteSvtde GT ntpsStvSSs+SSqErLhq Lpyqpt+delhflskhF SteS+tde KIAA0973 113 GT--NTPSSTVSSSCSSQERLHQ-LPYQPTVDELHFLSKHFGSTESITDE 159 dgh.rspavqnaflnRPRSRSLtSPgrslsefdnEiVmmnhVYkERFPkA dg++rspav RPRSRSL SPgrs+s++dnEiVmmnhVYkERFPkA KIAA0973 160 DGGrRSPAV------RPRSRSL-SPGRSPSSYDNEIVMMNHVYKERFPKA 202 taQMEerLkeiiteysPvmrsrrdtvLpaesyadrsllrlLADGvlgFih taQMEe+L+++ ++y+P d+vLp LADGvl+Fih KIAA0973 203 TAQMEEKLRDFTRAYEP------DSVLP------------LADGVLSFIH 234 HQivELArDCLdKSkdgLiTsrYFlELqekLEklLqeAyerseseevafi HQi+ELArDCL+KS+dgLiT++YF+ELqe+LEklLq+Ayerses evaf+ KIAA0973 235 HQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFV 284 skLVkKlLiiisRPARLLECLEFDPeeFYhLLEaAEGvakegqGikTarv ++LVkKlLiiisRPARLLECLEF+PeeFYhLLEaAEG+akeg+++kT KIAA0973 285 TQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKT--- 331 pDiPrYIIsqLGLtrDPLeem<-* DiPrYII+qLGLtrDP++++ KIAA0973 332 -DIPRYIIRQLGLTRDPFPDV 351 PF08926.1.ls: domain 1 of 1, from 72 to 351: score 720.5, E = 1.1e-213 *->sSpldSprnfststsanFsfarssslradraDgRRWSLASLPStSGY sSpldSprnfs++t+a+Fsfa+ ++raDgRRWSLASLPS SGY KIAA0973 72 SSPLDSPRNFSPNTPAHFSFAS-----SRRADGRRWSLASLPS-SGY 112 GTpgntpsStvSSssSSqErLhqmLpyqptsdelhflskhFrSteSvtde GT ntpsStvSSs+SSqErLhq Lpyqpt+delhflskhF SteS+tde KIAA0973 113 GT--NTPSSTVSSSCSSQERLHQ-LPYQPTVDELHFLSKHFGSTESITDE 159 dgh.rspavqnaflnRPRSRSLtSPgrslsefdnEiVmmnhVYkERFPkA dg++rspav RPRSRSL SPgrs+s++dnEiVmmnhVYkERFPkA KIAA0973 160 DGGrRSPAV------RPRSRSL-SPGRSPSSYDNEIVMMNHVYKERFPKA 202 taQMEerLkeiiteysPvmrsrrdtvLpaesyadrsllrlLADGvlgFih taQMEe+L+++ ++y+P d+vLp LADGvl+Fih KIAA0973 203 TAQMEEKLRDFTRAYEP------DSVLP------------LADGVLSFIH 234 HQivELArDCLdKSkdgLiTsrYFlELqekLEklLqeAyerseseevafi HQi+ELArDCL+KS+dgLiT++YF+ELqe+LEklLq+Ayerses evaf+ KIAA0973 235 HQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFV 284 skLVkKlLiiisRPARLLECLEFDPeeFYhLLEaAEGvakegqGikTarv ++LVkKlLiiisRPARLLECLEF+PeeFYhLLEaAEG+akeg+++kT KIAA0973 285 TQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKT--- 331 pDiPrYIIsqLGLtrDPLeem<-* DiPrYII+qLGLtrDP++++ KIAA0973 332 -DIPRYIIRQLGLTRDPFPDV 351 PF00069.15.ls: domain 1 of 1, from 387 to 660: score 273.1, E = 5.1e-79 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar + +++ + G++G Vy+ +h++t++++A+K+i+k++ + ++ ++a+ KIAA0973 387 FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQnLILRNQIQQAF 433 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E il p++v ++++fe+++hl++V+Ey+egG d ++l+ KIAA0973 434 V--ERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGG----DCATLLK 477 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng + g+l + + a++++ +++ +leYLH+ gi+HRDLKP+N+L+ + g KIAA0973 478 ---NIGAL--PVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMG 522 vvdaflKiaDFGlAkkls............t.sss.l..ttfvGTpwYmA ++ K++DFGl+k + +++ +++ ++ +++ ++ ++GTp+Y+A KIAA0973 523 HI----KLTDFGLSKMGLmslttnlyeghiEkDAReFldKQVCGTPEYIA 568 PEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirki PEv+l ++gyg++vD+W++G+ilye+l G PF g+ ++ +l+ ++ KIAA0973 569 PEVIL-RQGYGKPVDWWAMGIILYEFLVGCVPFFGD-----TPEELFGQV 612 lgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt... + ++ +++ + +l+ ea+ Li+++L+ +P Rl+ ++ KIAA0973 613 ISDDILWPEGDE------------ALPTEAQLLISSLLQTNPLVRLGagg 650 aeeilqHPwf<-* a e++qH +f KIAA0973 651 AFEVKQHSFF 660 PF00069.15.fs: domain 1 of 1, from 387 to 660: score 271.2, E = 1.9e-78 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar + +++ + G++G Vy+ +h++t++++A+K+i+k++ + ++ ++a+ KIAA0973 387 FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQnLILRNQIQQAF 433 rlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdyls E il p++v ++++fe+++hl++V+Ey+egG d ++l+ KIAA0973 434 V--ERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGG----DCATLLK 477 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnng + g+l + + a++++ +++ +leYLH+ gi+HRDLKP+N+L+ + g KIAA0973 478 ---NIGAL--PVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMG 522 vvdaflKiaDFGlAkkls............t.sss.l..ttfvGTpwYmA ++ K++DFGl+k + +++ +++ ++ +++ ++ ++GTp+Y+A KIAA0973 523 HI----KLTDFGLSKMGLmslttnlyeghiEkDAReFldKQVCGTPEYIA 568 PEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirki PEv+l ++gyg++vD+W++G+ilye+l G PF g+ ++ +l+ ++ KIAA0973 569 PEVIL-RQGYGKPVDWWAMGIILYEFLVGCVPFFGD-----TPEELFGQV 612 lgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt... + ++ +++ + +l+ ea+ Li+++L+ +P Rl+ ++ KIAA0973 613 ISDDILWPEGDE------------ALPTEAQLLISSLLQTNPLVRLGagg 650 aeeilqHPwf<-* a e++qH +f KIAA0973 651 AFEVKQHSFF 660 PF07714.7.fs: domain 1 of 1, from 459 to 533: score 31.7, E = 4.3e-09 *->ggpglyiVtEymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMe + l++V+Ey+egGd + L++ ++L++++ + ++ ++e KIAA0973 459 H---LCMVMEYVEGGDCATLLKN---IGALPVEMARMYFAETVLALE 499 YLesknfvHRDLAARNcLVsenlvVKIsDFGLaR<-* YL++ ++vHRDL N L+++ +++K +DFGL++ KIAA0973 500 YLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK 533 PF00433.14.fs: domain 1 of 1, from 678 to 723: score 26.2, E = 3.8e-07 *->kvksptDTsNFDpeFTsepptltpppdsr.lssgkqleFrGFtYvnp +++s++DTs+FD+ ++++++ + d+++ ++++ e r+F+ ++p KIAA0973 678 HLESEDDTSYFDTRSDRYHHVNS--YDEDdTTEEEPVEIRQFSSCSP 722 e<-* KIAA0973 723 R 723 PF00433.14.ls: domain 1 of 1, from 678 to 723: score 28.2, E = 2.7e-05 *->kvksptDTsNFDpeFTsepptltpppdsr.lssgkqleFrGFtYvnp +++s++DTs+FD+ ++++++ + d+++ ++++ e r+F+ ++p KIAA0973 678 HLESEDDTSYFDTRSDRYHHVNS--YDEDdTTEEEPVEIRQFSSCSP 722 e<-* KIAA0973 723 R 723 PF00595.14.ls: domain 1 of 1, from 980 to 1065: score 38.0, E = 3.1e-08 *->evtlekedkrgglGfsikggsdkga.....dkgifvsevlpGsgaAe +t+++ ++ + Gf+++ ++++ + +v +v +G g+A+ KIAA0973 980 PITIQR--SGKKYGFTLRAIRVYMGdtdvySVHHIVWHVEEG-GPAQ 1023 agGrLqaGDqIlsvNGqdlenlsheeavlalkgsggsevtLtvl<-* +G L+aGD I+ vNG+++ ++ h e+v+++ +sg+ +v++t KIAA0973 1024 EAG-LCAGDLITHVNGEPVHGMVHPEVVELILKSGN-KVAVTTT 1065 PF00595.14.fs: domain 1 of 1, from 1015 to 1065: score 35.9, E = 2e-09 *->evlpGsgaAeagGrLqaGDqIlsvNGqdlenlsheeavlalkgsggs +v +G g+A+ +G L+aGD I+ vNG+++ ++ h e+v+++ +sg+ KIAA0973 1015 HVEEG-GPAQEAG-LCAGDLITHVNGEPVHGMVHPEVVELILKSGN- 1058 evtLtvl<-* +v++t KIAA0973 1059 KVAVTTT 1065 //