# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/hk07196mrp1.fasta.nr -Q ../query/KIAA1118.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1118, 1165 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7801847 sequences Expectation_n fit: rho(ln(x))= 6.7791+/-0.000209; mu= 8.3735+/- 0.012 mean_var=167.5043+/-32.305, 0's: 44 Z-trim: 142 B-trim: 432 in 1/66 Lambda= 0.099097 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 39, opt: 27, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|77416379|sp|Q9UPN4.2|AZI1_HUMAN RecName: Full=5 (1083) 6964 1008.8 0 gi|187952407|gb|AAI36581.1| 5-azacytidine induced (1080) 6933 1004.3 0 gi|187953283|gb|AAI36579.1| 5-azacytidine induced (1080) 6923 1002.9 0 gi|111955084|ref|NP_055799.2| 5-azacytidine induce (1080) 6918 1002.2 0 gi|109119008|ref|XP_001111529.1| PREDICTED: simila ( 992) 5885 854.4 0 gi|111955162|ref|NP_001009811.2| 5-azacytidine ind (1044) 5130 746.5 1.8e-212 gi|39645061|gb|AAH11615.2| AZI1 protein [Homo sapi ( 739) 4711 686.5 1.5e-194 gi|73964833|ref|XP_540478.2| PREDICTED: similar to (1097) 4366 637.3 1.4e-179 gi|149054995|gb|EDM06812.1| 5-azacytidine induced (1069) 3851 563.7 2e-157 gi|118099826|ref|XP_420077.2| PREDICTED: hypotheti (1086) 3548 520.4 2.2e-144 gi|76645428|ref|XP_592864.2| PREDICTED: similar to (1089) 3494 512.7 4.7e-142 gi|123229683|emb|CAM22595.1| 5-azacytidine induced (1059) 3351 492.2 6.6e-136 gi|25089760|sp|Q62036.1|AZI1_MOUSE RecName: Full=5 (1060) 3349 491.9 8e-136 gi|123229684|emb|CAM22596.1| 5-azacytidine induced (1060) 3345 491.3 1.2e-135 gi|194216562|ref|XP_001490072.2| PREDICTED: 5-azac (1158) 3244 476.9 2.8e-131 gi|89268162|emb|CAJ81461.1| Novel protein containi (1085) 3119 459.0 6.4e-126 gi|189526186|ref|XP_001339858.2| PREDICTED: simila (1076) 2522 373.7 3.2e-100 gi|189526194|ref|XP_001920137.1| PREDICTED: pre-ac (1018) 2466 365.7 7.8e-98 gi|119912647|ref|XP_001251898.1| PREDICTED: simila (1053) 2246 334.2 2.4e-88 gi|198430021|ref|XP_002131173.1| PREDICTED: simila ( 937) 2098 313.0 5.1e-82 gi|116487428|gb|AAI25763.1| LOC734011 protein [Xen (1095) 1976 295.6 1e-76 gi|115313145|gb|AAI24168.1| LOC563066 protein [Dan ( 783) 1776 266.9 3.3e-68 gi|47217655|emb|CAG03052.1| unnamed protein produc (1069) 1700 256.2 7.5e-65 gi|119610037|gb|EAW89631.1| 5-azacytidine induced ( 231) 1430 216.8 1.1e-53 gi|156215874|gb|EDO36823.1| predicted protein [Nem (1081) 1129 174.5 2.8e-40 gi|194192822|gb|EDX06398.1| GD10050 [Drosophila si (1100) 822 130.7 4.7e-27 gi|221118025|ref|XP_002157020.1| PREDICTED: simila ( 509) 816 129.4 5e-27 gi|194175944|gb|EDW89555.1| GE22050 [Drosophila ya (1127) 820 130.4 5.8e-27 gi|221128377|ref|XP_002165639.1| PREDICTED: simila ( 548) 811 128.8 8.7e-27 gi|190661016|gb|EDV58208.1| GG25261 [Drosophila er (1134) 812 129.2 1.3e-26 gi|7303851|gb|AAF58897.1| CG1625, isoform A [Droso (1127) 811 129.1 1.4e-26 gi|220902155|gb|ACL83083.1| CG1625, isoform B [Dro (1160) 811 129.1 1.4e-26 gi|190621799|gb|EDV37323.1| GF11477 [Drosophila an (1155) 810 129.0 1.6e-26 gi|194125113|gb|EDW47156.1| GM20578 [Drosophila se (1134) 800 127.5 4.2e-26 gi|194144103|gb|EDW60499.1| GJ20828 [Drosophila vi (1182) 794 126.7 7.9e-26 gi|194113642|gb|EDW35685.1| GL17395 [Drosophila pe (1181) 792 126.4 9.6e-26 gi|194160070|gb|EDW74971.1| GK15613 [Drosophila wi (1148) 781 124.8 2.8e-25 gi|193911792|gb|EDW10659.1| GI21224 [Drosophila mo (1189) 781 124.8 2.9e-25 gi|54636112|gb|EAL25515.1| GA14055 [Drosophila pse (1190) 779 124.5 3.5e-25 gi|193899260|gb|EDV98126.1| GH22846 [Drosophila gr (1136) 754 121.0 4e-24 gi|108878714|gb|EAT42939.1| autotransporter adhesi (1217) 735 118.3 2.8e-23 gi|163776710|gb|EDQ90329.1| predicted protein [Mon ( 978) 700 113.2 7.7e-22 gi|167882366|gb|EDS45749.1| autotransporter adhesi (1214) 664 108.1 3.2e-20 gi|221505058|gb|EEE30712.1| conserved hypothetical ( 591) 628 102.6 6.9e-19 gi|158276581|gb|EDP02353.1| predicted protein [Chl (1739) 634 104.0 7.8e-19 gi|211965454|gb|EEB00650.1| hypothetical protein, ( 591) 626 102.3 8.4e-19 gi|110758989|ref|XP_001121847.1| PREDICTED: simila ( 631) 626 102.4 8.8e-19 gi|89291949|gb|EAR89937.1| hypothetical protein TT ( 657) 621 101.7 1.5e-18 gi|124430248|emb|CAK95036.1| unnamed protein produ ( 660) 609 100.0 4.9e-18 gi|124421981|emb|CAK86829.1| unnamed protein produ ( 659) 583 96.2 6.4e-17 >>gi|77416379|sp|Q9UPN4.2|AZI1_HUMAN RecName: Full=5-aza (1083 aa) initn: 6964 init1: 6964 opt: 6964 Z-score: 5387.7 bits: 1008.8 E(): 0 Smith-Waterman score: 6964; 100.000% identity (100.000% similar) in 1083 aa overlap (83-1165:1-1083) 60 70 80 90 100 110 KIAA11 PSPPAESAGPARQAGFAAAPPARAGPALSTMKGTRAIGSVPERSPAGVDLSLTGLPPPVS :::::::::::::::::::::::::::::: gi|774 MKGTRAIGSVPERSPAGVDLSLTGLPPPVS 10 20 30 120 130 140 150 160 170 KIAA11 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP 40 50 60 70 80 90 180 190 200 210 220 230 KIAA11 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS 100 110 120 130 140 150 240 250 260 270 280 290 KIAA11 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN 160 170 180 190 200 210 300 310 320 330 340 350 KIAA11 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ 220 230 240 250 260 270 360 370 380 390 400 410 KIAA11 AAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 AAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE 280 290 300 310 320 330 420 430 440 450 460 470 KIAA11 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ 340 350 360 370 380 390 480 490 500 510 520 530 KIAA11 ALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 ALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS 400 410 420 430 440 450 540 550 560 570 580 590 KIAA11 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVTTEDDASSLTADNLEKFGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVTTEDDASSLTADNLEKFGK 460 470 480 490 500 510 600 610 620 630 640 650 KIAA11 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 520 530 540 550 560 570 660 670 680 690 700 710 KIAA11 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH 580 590 600 610 620 630 720 730 740 750 760 770 KIAA11 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA 640 650 660 670 680 690 780 790 800 810 820 830 KIAA11 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR 700 710 720 730 740 750 840 850 860 870 880 890 KIAA11 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 760 770 780 790 800 810 900 910 920 930 940 950 KIAA11 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE 820 830 840 850 860 870 960 970 980 990 1000 1010 KIAA11 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR 880 890 900 910 920 930 1020 1030 1040 1050 1060 1070 KIAA11 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS 940 950 960 970 980 990 1080 1090 1100 1110 1120 1130 KIAA11 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|774 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA 1000 1010 1020 1030 1040 1050 1140 1150 1160 KIAA11 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK ::::::::::::::::::::::::::::::::: gi|774 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1060 1070 1080 >>gi|187952407|gb|AAI36581.1| 5-azacytidine induced 1 [H (1080 aa) initn: 3705 init1: 3705 opt: 6933 Z-score: 5363.8 bits: 1004.3 E(): 0 Smith-Waterman score: 6933; 99.723% identity (99.723% similar) in 1083 aa overlap (83-1165:1-1080) 60 70 80 90 100 110 KIAA11 PSPPAESAGPARQAGFAAAPPARAGPALSTMKGTRAIGSVPERSPAGVDLSLTGLPPPVS :::::::::::::::::::::::::::::: gi|187 MKGTRAIGSVPERSPAGVDLSLTGLPPPVS 10 20 30 120 130 140 150 160 170 KIAA11 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP 40 50 60 70 80 90 180 190 200 210 220 230 KIAA11 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS 100 110 120 130 140 150 240 250 260 270 280 290 KIAA11 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN 160 170 180 190 200 210 300 310 320 330 340 350 KIAA11 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ 220 230 240 250 260 270 360 370 380 390 400 410 KIAA11 AAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 AAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE 280 290 300 310 320 330 420 430 440 450 460 470 KIAA11 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ 340 350 360 370 380 390 480 490 500 510 520 530 KIAA11 ALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 ALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS 400 410 420 430 440 450 540 550 560 570 580 590 KIAA11 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVTTEDDASSLTADNLEKFGK :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: gi|187 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASE---EDDASSLTADNLEKFGK 460 470 480 490 500 600 610 620 630 640 650 KIAA11 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 510 520 530 540 550 560 660 670 680 690 700 710 KIAA11 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH 570 580 590 600 610 620 720 730 740 750 760 770 KIAA11 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA 630 640 650 660 670 680 780 790 800 810 820 830 KIAA11 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR 690 700 710 720 730 740 840 850 860 870 880 890 KIAA11 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 750 760 770 780 790 800 900 910 920 930 940 950 KIAA11 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE 810 820 830 840 850 860 960 970 980 990 1000 1010 KIAA11 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR 870 880 890 900 910 920 1020 1030 1040 1050 1060 1070 KIAA11 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS 930 940 950 960 970 980 1080 1090 1100 1110 1120 1130 KIAA11 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA 990 1000 1010 1020 1030 1040 1140 1150 1160 KIAA11 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK ::::::::::::::::::::::::::::::::: gi|187 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1050 1060 1070 1080 >>gi|187953283|gb|AAI36579.1| 5-azacytidine induced 1 [H (1080 aa) initn: 3705 init1: 3705 opt: 6923 Z-score: 5356.1 bits: 1002.9 E(): 0 Smith-Waterman score: 6923; 99.538% identity (99.723% similar) in 1083 aa overlap (83-1165:1-1080) 60 70 80 90 100 110 KIAA11 PSPPAESAGPARQAGFAAAPPARAGPALSTMKGTRAIGSVPERSPAGVDLSLTGLPPPVS :::::::::::::::::::::::::::::: gi|187 MKGTRAIGSVPERSPAGVDLSLTGLPPPVS 10 20 30 120 130 140 150 160 170 KIAA11 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP 40 50 60 70 80 90 180 190 200 210 220 230 KIAA11 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS 100 110 120 130 140 150 240 250 260 270 280 290 KIAA11 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN 160 170 180 190 200 210 300 310 320 330 340 350 KIAA11 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ 220 230 240 250 260 270 360 370 380 390 400 410 KIAA11 AAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 ATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE 280 290 300 310 320 330 420 430 440 450 460 470 KIAA11 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ 340 350 360 370 380 390 480 490 500 510 520 530 KIAA11 ALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 ALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS 400 410 420 430 440 450 540 550 560 570 580 590 KIAA11 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVTTEDDASSLTADNLEKFGK :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: gi|187 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASE---EDDASSLTADNLEKFGK 460 470 480 490 500 600 610 620 630 640 650 KIAA11 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 510 520 530 540 550 560 660 670 680 690 700 710 KIAA11 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH 570 580 590 600 610 620 720 730 740 750 760 770 KIAA11 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA 630 640 650 660 670 680 780 790 800 810 820 830 KIAA11 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR 690 700 710 720 730 740 840 850 860 870 880 890 KIAA11 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 750 760 770 780 790 800 900 910 920 930 940 950 KIAA11 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE 810 820 830 840 850 860 960 970 980 990 1000 1010 KIAA11 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR 870 880 890 900 910 920 1020 1030 1040 1050 1060 1070 KIAA11 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS 930 940 950 960 970 980 1080 1090 1100 1110 1120 1130 KIAA11 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA 990 1000 1010 1020 1030 1040 1140 1150 1160 KIAA11 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK ::::::::::::::::::::::::::::::::: gi|187 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1050 1060 1070 1080 >>gi|111955084|ref|NP_055799.2| 5-azacytidine induced 1 (1080 aa) initn: 3705 init1: 3705 opt: 6918 Z-score: 5352.2 bits: 1002.2 E(): 0 Smith-Waterman score: 6918; 99.446% identity (99.723% similar) in 1083 aa overlap (83-1165:1-1080) 60 70 80 90 100 110 KIAA11 PSPPAESAGPARQAGFAAAPPARAGPALSTMKGTRAIGSVPERSPAGVDLSLTGLPPPVS :::::::::::::::::::::::::::::: gi|111 MKGTRAIGSVPERSPAGVDLSLTGLPPPVS 10 20 30 120 130 140 150 160 170 KIAA11 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP 40 50 60 70 80 90 180 190 200 210 220 230 KIAA11 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS 100 110 120 130 140 150 240 250 260 270 280 290 KIAA11 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN 160 170 180 190 200 210 300 310 320 330 340 350 KIAA11 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ 220 230 240 250 260 270 360 370 380 390 400 410 KIAA11 AAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 ATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE 280 290 300 310 320 330 420 430 440 450 460 470 KIAA11 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ 340 350 360 370 380 390 480 490 500 510 520 530 KIAA11 ALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 ALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS 400 410 420 430 440 450 540 550 560 570 580 590 KIAA11 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVTTEDDASSLTADNLEKFGK ::::::::::::::::::::::.::::::::::::::::: ::::::::::::::::: gi|111 AKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASE---EDDASSLTADNLEKFGK 460 470 480 490 500 600 610 620 630 640 650 KIAA11 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 510 520 530 540 550 560 660 670 680 690 700 710 KIAA11 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH 570 580 590 600 610 620 720 730 740 750 760 770 KIAA11 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA 630 640 650 660 670 680 780 790 800 810 820 830 KIAA11 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR 690 700 710 720 730 740 840 850 860 870 880 890 KIAA11 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ 750 760 770 780 790 800 900 910 920 930 940 950 KIAA11 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE 810 820 830 840 850 860 960 970 980 990 1000 1010 KIAA11 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR 870 880 890 900 910 920 1020 1030 1040 1050 1060 1070 KIAA11 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS 930 940 950 960 970 980 1080 1090 1100 1110 1120 1130 KIAA11 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA 990 1000 1010 1020 1030 1040 1140 1150 1160 KIAA11 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK ::::::::::::::::::::::::::::::::: gi|111 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1050 1060 1070 1080 >>gi|109119008|ref|XP_001111529.1| PREDICTED: similar to (992 aa) initn: 4713 init1: 4713 opt: 5885 Z-score: 4554.5 bits: 854.4 E(): 0 Smith-Waterman score: 5885; 93.173% identity (96.285% similar) in 996 aa overlap (174-1165:1-992) 150 160 170 180 190 200 KIAA11 TGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPSE :.:::::: ::::::::::::::::::::: gi|109 PAEPTDFLTLFEGSPSGKKRPASLSTAPSE 10 20 30 210 220 230 240 250 260 KIAA11 KGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGNC :::::::::::::.:::: :::::::::::::::::::::::::::::::::::::.::: gi|109 KGATWNVLDDQPRSFTLPPNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAMGNC 40 50 60 70 80 90 270 280 290 300 310 320 KIAA11 VTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSAR ::::::::::::::::::::::::::::::::::::::::::::::: :::::::.:::: gi|109 VTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKPPKNVSSASHSAR 100 110 120 130 140 150 330 340 350 360 370 KIAA11 NNTGGSTGLPRRKEVTEEEAERFIHQVNQAAVTIQRWYRHQVQRRGAGAARLEHLL---- ::.::.:::::::::::::::::::::::::::::::::.:: . :. :: . gi|109 NNAGGTTGLPRRKEVTEEEAERFIHQVNQAAVTIQRWYRRQVFQSGS-RFRLPDVYTTWH 160 170 180 190 200 380 390 400 410 420 430 KIAA11 QAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTA : .::::: :::::::::::::::::::::::::::::::::::::::::::::: :: gi|109 QLLWQEQRQRPGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKAITA 210 220 230 240 250 260 440 450 460 470 480 490 KIAA11 ERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNAGGGLPAAGPGDRCLPTSDSS :: :::: :::.:: :.:::::::::: :::::::: :.:.::::::::: :::::.:: gi|109 ERRLPENPGETRAPGTRRPAQELSPTPGDTAHQALKAINTGAGLPAAGPGDCCLPTSSSS 270 280 290 300 310 320 500 510 520 530 540 550 KIAA11 PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDALPRP ::::::::::::::::::::::::: .::::::.::::::::::::::::::::. :::: gi|109 PEPQQPPEDRTQDVLAQDAAGDNLETVAPSRGSTKSRGPLEELLHTLQLLEKEPEPLPRP 330 340 350 360 370 380 560 570 580 590 600 610 KIAA11 RTHHRGRYAWASEVTTEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLD :.::::::::::: :::::::::::::::::::::::::::::::::::::::::::: gi|109 RAHHRGRYAWASE---EDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLD 390 400 410 420 430 440 620 630 640 650 660 670 KIAA11 EMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQ ::::::::: : :::::: ::::::::::::.:::::::::::::::::::::::::::: gi|109 EMEKSGQDQPDPQQEGWVLEAGPGPLELGSEASTSVMRLKLEVEEKKQAMLLLQRALAQQ 450 460 470 480 490 500 680 690 700 710 720 730 KIAA11 RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQ ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 RDLTVRRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQ 510 520 530 540 550 560 740 750 760 770 780 790 KIAA11 EDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQK :::::::::::.::::::::::::::::::::.::::::::::::::::::::::::::: gi|109 EDQRCTERVAQVQAQHELEIKKLKELMSATEKVRREKWISEKTKKIKEVTVRGLEPEIQK 570 580 590 600 610 620 800 810 820 830 840 850 KIAA11 LIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQR 630 640 650 660 670 680 860 870 880 890 900 910 KIAA11 FQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 FQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALR 690 700 710 720 730 740 920 930 940 950 960 970 KIAA11 AEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRD ::::::::::::::::::..::::::::::::::: .::::::::::::::::::::::: gi|109 AEFEKGREEQERRHQMELKALKQQLELERQAWEAGCARKEEAWLLNREQELREEIRKGRD 750 760 770 780 790 800 980 990 1000 1010 1020 1030 KIAA11 KEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQ ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: gi|109 KEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLHERCSELKGQ 810 820 830 840 850 860 1040 1050 1060 1070 1080 1090 KIAA11 LGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQ ::::::::::::::::::::::::.::.:::::::::::::::::::::::::::::::: gi|109 LGEAEGENLRLQGLVRQKERALEDTQAMNEQLSSERSNLAQVIRQEFEDRLAASEEETRQ 870 880 890 900 910 920 1100 1110 1120 1130 1140 1150 KIAA11 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 AKAELAALQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 930 940 950 960 970 980 1160 KIAA11 PTPSTK :: ::: gi|109 PTLSTK 990 >>gi|111955162|ref|NP_001009811.2| 5-azacytidine induced (1044 aa) initn: 4900 init1: 3236 opt: 5130 Z-score: 3970.9 bits: 746.5 E(): 1.8e-212 Smith-Waterman score: 6596; 96.122% identity (96.399% similar) in 1083 aa overlap (83-1165:1-1044) 60 70 80 90 100 110 KIAA11 PSPPAESAGPARQAGFAAAPPARAGPALSTMKGTRAIGSVPERSPAGVDLSLTGLPPPVS :::::::::::::::::::::::::::::: gi|111 MKGTRAIGSVPERSPAGVDLSLTGLPPPVS 10 20 30 120 130 140 150 160 170 KIAA11 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP 40 50 60 70 80 90 180 190 200 210 220 230 KIAA11 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS 100 110 120 130 140 150 240 250 260 270 280 290 KIAA11 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN 160 170 180 190 200 210 300 310 320 330 340 350 KIAA11 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ 220 230 240 250 260 270 360 370 380 390 400 410 KIAA11 AAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 ATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE 280 290 300 310 320 330 420 430 440 450 460 470 KIAA11 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ 340 350 360 370 380 390 480 490 500 510 520 530 KIAA11 ALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 ALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS 400 410 420 430 440 450 540 550 560 570 580 590 KIAA11 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVTTEDDASSLTADNLEKFGK ::::::::::::::::::::::.::::::::::::::::: ::::::::::::::::: gi|111 AKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASE---EDDASSLTADNLEKFGK 460 470 480 490 500 600 610 620 630 640 650 KIAA11 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 510 520 530 540 550 560 660 670 680 690 700 710 KIAA11 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH 570 580 590 600 610 620 720 730 740 750 760 770 KIAA11 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA 630 640 650 660 670 680 780 790 800 810 820 830 KIAA11 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR 690 700 710 720 730 740 840 850 860 870 880 890 KIAA11 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ :::::::::::::::::::::::::: gi|111 QAEELREQLEREKEALGQQERERARQ---------------------------------- 750 760 770 900 910 920 930 940 950 KIAA11 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 --RQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE 780 790 800 810 820 830 960 970 980 990 1000 1010 KIAA11 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR 840 850 860 870 880 890 1020 1030 1040 1050 1060 1070 KIAA11 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS 900 910 920 930 940 950 1080 1090 1100 1110 1120 1130 KIAA11 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|111 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA 960 970 980 990 1000 1010 1140 1150 1160 KIAA11 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK ::::::::::::::::::::::::::::::::: gi|111 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1020 1030 1040 >>gi|39645061|gb|AAH11615.2| AZI1 protein [Homo sapiens] (739 aa) initn: 3705 init1: 3705 opt: 4711 Z-score: 3648.9 bits: 686.5 E(): 1.5e-194 Smith-Waterman score: 4711; 99.596% identity (99.596% similar) in 742 aa overlap (424-1165:1-739) 400 410 420 430 440 450 KIAA11 TLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVP :::::::::::::::::::::::::::::: gi|396 ELQQKRALRAQKASTAERGPPENPRETRVP 10 20 30 460 470 480 490 500 510 KIAA11 GMRQPAQELSPTPGGTAHQALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 GMRQPAQELSPTPGGTAHQALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDV 40 50 60 70 80 90 520 530 540 550 560 570 KIAA11 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASE- 100 110 120 130 140 580 590 600 610 620 630 KIAA11 TTEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 --EDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQ 150 160 170 180 190 200 640 650 660 670 680 690 KIAA11 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA 210 220 230 240 250 260 700 710 720 730 740 750 KIAA11 LSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 LSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQA 270 280 290 300 310 320 760 770 780 790 800 810 KIAA11 QHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 QHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKS 330 340 350 360 370 380 820 830 840 850 860 870 KIAA11 LHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 LHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQ 390 400 410 420 430 440 880 890 900 910 920 930 KIAA11 QRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 QRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRH 450 460 470 480 490 500 940 950 960 970 980 990 KIAA11 QMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 QMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADM 510 520 530 540 550 560 1000 1010 1020 1030 1040 1050 KIAA11 ALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 ALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGL 570 580 590 600 610 620 1060 1070 1080 1090 1100 1110 KIAA11 VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 VRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQL 630 640 650 660 670 680 1120 1130 1140 1150 1160 KIAA11 ELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|396 ELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 690 700 710 720 730 >>gi|73964833|ref|XP_540478.2| PREDICTED: similar to 5-a (1097 aa) initn: 3785 init1: 2466 opt: 4366 Z-score: 3380.3 bits: 637.3 E(): 1.4e-179 Smith-Waterman score: 4530; 67.444% identity (82.063% similar) in 1115 aa overlap (83-1165:1-1097) 60 70 80 90 100 KIAA11 PSPPAESAGPARQAGFAAAPPARAGPALSTMKGTRAIG---SVPERSPAGVDLSLTGLPP :::.: . :.:: : ::::::::::: gi|739 MKGSRPASRPASTPEGSSEGVDLSLTGLPP 10 20 30 110 120 130 140 150 160 KIAA11 PVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPR- ::: ::.::.:::::.: :::.::: .::. . :::::...:::::::::::: :: gi|739 PVSWRPNSASTTKPIAR-FSVVAGSEPRRKAPVSEGPGGSRTVNNLRRSNSTTQVHQPPA 40 50 60 70 80 170 180 190 200 210 220 KIAA11 ----SGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNA .:.:::.: : : ::::.:::: :.:: .::::.:::::::::::.:. : .. gi|739 NQAWTGAPRPAESPHVLTLSEGSPGGKKRAAGLSKTPSEKAATWNVLDDQPRAFASPPDS 90 100 110 120 130 140 230 240 250 260 270 280 KIAA11 RSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSS :: :.. .:.::::.:::: :::.::::::::::.:::::::::::.::: ::::: ::: gi|739 RSPSTVGAPVGPRRRECTVPLAPSFTANNRSNKGTVGNCVTTMVHNHYTPPERAPPPKSS 150 160 170 180 190 200 290 300 310 320 330 340 KIAA11 NQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAE :.::::::::.:::: :. :..::: . ... : :.:::::. : ::::::::::: gi|739 NHTAPSLNNILKAATGAGG-SGSFGKPHGDQAGSKHVAQNNTGGAPGPLRRKEVTEEEAE 210 220 230 240 250 260 350 360 370 380 390 400 KIAA11 RFIHQVNQAAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEA :::::::.:::::::::::::::: : ::::::: ...::::.. : .::: ::.::: gi|739 RFIHQVNRAAVTIQRWYRHQVQRRQARAARLEHLPASNQEEQRRQLGGDSLLDQHQKKEA 270 280 290 300 310 320 410 420 430 440 450 460 KIAA11 ARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSP :::::::::::::::::::::::::: .. : ::.:: ::::: : gi|739 ARRKAREEKARQARRAAIQELQQKRAQKSGDPELKEAWGPEKPR---------PAQELPP 330 340 350 360 370 470 480 490 500 510 KIAA11 TPGGTAH--QALKANNAGGGLPAAGPGDRCL-PTSDS----SPEPQQ---PPEDRTQDVL ::::.: :. :::::: : :: :: :. . .: : . :: . ::. gi|739 RPGGTTHTPQTHKANNAGEHSRARGP-HFCLRPVHPQGHQPTPTPVEDMVPPTTQKQDAS 380 390 400 410 420 430 520 530 540 550 560 570 KIAA11 AQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVT :: :..::. .:... :::: :.::: ::.:::.::. :::::.... .:.:..: gi|739 AQGMPGEDLEVGGPAQSRAKSRVTLDELLDTLKLLEEEPEPLPRPRAYRKDKYSWTDE-- 440 450 460 470 480 490 580 590 600 610 620 630 KIAA11 TEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEME--KSGQDQLDSQ :::::.:::::::.:::::. : :::::::::::::::::: ::: . :::. : gi|739 -EDDASNLTADNLERFGKLSTCDGPSEDGTLLSEAKLQSIMSFLHEMEMEQLGQDRPASA 500 510 520 530 540 550 640 650 660 670 680 690 KIAA11 QEGWVPEAG-PGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETE .: . : : : : :: ::::::::::::::::::. :::::: ::::::.::::::: gi|739 PQGLALEDGRPEP---GSTVSTSVMRLKLEVEEKKQAVGLLQRALMQQRDLTVRRVKETE 560 570 580 590 600 610 700 710 720 730 740 750 KIAA11 KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQA : :.:::..::.::::::::::.::::. : :.. . . .: .: .. gi|739 KELGRQLRQQRDHYEATIQRHLSFIDQVPPPGKGAPAAGEGTGTCWAHGVSRALNRPSHQ 620 630 640 650 660 670 760 770 780 790 800 810 KIAA11 QAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRL ::. ::::::::::::::.::::::.:::.::::.:::: :::::::::::::::..: gi|739 APQHQHEIKKLKELMSATEKVRREKWINEKTRKIKEITVRGKEPEIQKLIARHKQEVKKL 680 690 700 710 720 730 820 830 840 850 860 870 KIAA11 KSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWAL ::.:::::::.: ::.::: ::.::::::::::::::::::::::.:::.::.:::: :: gi|739 KSVHEAELLQADARAAQRCARQVEELREQLEREKEALGQQERERAQQRFEQHVEQEQRAL 740 750 760 770 780 790 880 890 900 910 920 930 KIAA11 QQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQER ::::.:::.:::::.::::::::::::::::::.::::::.: :::::::::::::::: gi|739 QQQRRRLYGEVAEEKERLGQQAARQRAELEELRRQLEESSAAEGRALRAEFEKGREEQER 800 810 820 830 840 850 940 950 960 970 980 990 KIAA11 RHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEA :::::...::.::: ::: :::. ..:::::::.::.:::::.:.::::::::::::::: gi|739 RHQMEMKALKDQLEAERQMWEANCAKKEEAWLLTRERELREEVRRGRDKEIELVIHRLEA 860 870 880 890 900 910 1000 1010 1020 1030 1040 1050 KIAA11 DMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQ ::. :.::::.:::::..::::::.::::::::::::::.::.::::.:::::::.:::: gi|739 DMTRAREESERAAESRVQRLRDKYDAELSELEQSERKLQDRCTELKGRLGEAEGEGLRLQ 920 930 940 950 960 970 1060 1070 1080 1090 1100 1110 KIAA11 GLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ ::.:.::. : . :::::: .:::.::.:.:.:: ::::::::.:: :.:::: :.::: gi|739 GLLRHKEKELARVTAVNEQLVGERSGLAEVLRREFADRLAASEEDTRVARAELAELRARQ 980 990 1000 1010 1020 1030 1120 1130 1140 1150 1160 KIAA11 QLELE-----------EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRP .:::: :::.::: ::..::::: ::: ::::::::::::::::::.. : gi|739 RLELEQLSREKQAELEEVHQRVKLALTKKEEAVRSLRKQHEAAVKRADHLEELLEQRKWP 1040 1050 1060 1070 1080 1090 KIAA11 TPSTK :.: gi|739 LSSAK >>gi|149054995|gb|EDM06812.1| 5-azacytidine induced gene (1069 aa) initn: 4606 init1: 2969 opt: 3851 Z-score: 2982.5 bits: 563.7 E(): 2e-157 Smith-Waterman score: 4923; 72.392% identity (88.827% similar) in 1083 aa overlap (83-1165:1-1069) 60 70 80 90 100 110 KIAA11 PSPPAESAGPARQAGFAAAPPARAGPALSTMKGTRAIGSVPERSPAGVDLSLTGLPPPVS :::.:.:...:: :: :.:::: ::: :.: gi|149 MKGSRTISATPEGSPEGMDLSLIGLPLPMS 10 20 30 120 130 140 150 160 170 KIAA11 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP .:::::...: : :::::.:::: ..:.:::::::: .::::::::::::::.: .::: gi|149 QRPGSASAAKSIFRSVSVATGSEPRKKALEATGPGGPRAINNLRRSNSTTQVNQSWTGSP 40 50 60 70 80 90 180 190 200 210 220 230 KIAA11 RPTEPTDFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDS ::.:::::::::::: ::..: ::.: . ::::::::::::::: :. :.:..: :.::: gi|149 RPAEPTDFLMLFEGSTSGRRRVASFSKVSSEKGATWNVLDDQPRDFASPANSQSPSTLDS 100 110 120 130 140 150 240 250 260 270 280 290 KIAA11 PAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLN :::::::. :::.::::::::::::::::::::::.:. :... : ::::::::::: gi|149 ALGPRRKECS--LAPSFTANNRSNKGAVGNCVTTMVHNHYASSKKVSPPKSSNQTAPSLN 160 170 180 190 200 300 310 320 330 340 350 KIAA11 NIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQ ::.:::. ::.:.: ::: :: ::...:.: :.::: ::::::::::::::.:::: gi|149 NIVKAAAREGGEGSDFGKPRKNFSSVSQSTR----GTTGLLRRKEVTEEEAERFIQQVNQ 210 220 230 240 250 260 360 370 380 390 400 410 KIAA11 AAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREE :::::::::: ::::: .::: ::::: .::: :::: : :.:::::.:.::::.::::: gi|149 AAVTIQRWYRCQVQRRRTGAASLEHLLASKREGQRQRLGSGNLLDLHRQEEAARKKAREE 270 280 290 300 310 320 420 430 440 450 460 470 KIAA11 KARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQ ::::::.::::::::: ::::: .:. ::.. :::. . .:.:: :....: gi|149 KARQARQAAIQELQQK---RAQKAREVEHRPPKERPETRALEQPRPTQEPPSMPSSVTHP 330 340 350 360 370 380 480 490 500 510 520 530 KIAA11 ALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS ::::::..: .::.: : :.:.: :: : ::. ::. .: : ..: .: .:.. gi|149 --KANNAGASLYPTGPADPCPPASESFPERQPSLEDKPQDAHSQVEAREDLAALASTRSK 390 400 410 420 430 540 550 560 570 580 590 KIAA11 AKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVTTEDDASSLTADNLEKFGK ...:. :..:: ::.:::.::. : .:..... :::: .: :.:.. ::::::::::: gi|149 TRARATLDDLLDTLKLLEEEPEPLLHPKAYRQDRYAWMDE---EEDTNPLTADNLEKFGK 440 450 460 470 480 490 600 610 620 630 640 650 KIAA11 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS ::: : ::.::::::::::::::.::::::::::.. .:. : :::: :::::: . gi|149 LSAAPGPPDDGTLLSEAKLQSIMTFLDEMEKSGQERPAPWRESLVLEAGPRSLELGSEGT 500 510 520 530 540 550 660 670 680 690 700 710 KIAA11 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH :::::::::.:::::::.::::::::::::..:::::::: :::::..:.:.:::::::: gi|149 TSVMRLKLELEEKKQAMVLLQRALAQQRDLATRRVKETEKELSRQLRQQKEQYEATIQRH 560 570 580 590 600 610 720 730 740 750 760 770 KIAA11 LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKA :.::::::::::::::::::::::::: :::: :::::.: :::::::::::::::::: gi|149 LSFIDQLIEDKKVLSEKCEAVVAELKQGDQRCRERVAQVQEQHELEIKKLKELMSATEKI 620 630 640 650 660 670 780 790 800 810 820 830 KIAA11 RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR ::::::.::::::::.::::::::::::::.::::::::..:::::: : .:.:.:: :: gi|149 RREKWINEKTKKIKEITVRGLEPEIQKLIAKHKQEVRRLRGLHEAELQQREEQAAQRHLR 680 690 700 710 720 730 840 850 860 870 880 890 KIAA11 QAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQ :::::::.::::.:::::::::::.::..::::::: ::.:::.:::.:::::.:::::: gi|149 QAEELREHLEREREALGQQERERAQQRLEQHLEQEQRALEQQRRRLYTEVAEEKERLGQQ 740 750 760 770 780 790 900 910 920 930 940 950 KIAA11 AARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWE :::::.:::::::::::::.:::::::::::..::::::::::::..::.::: ::::: gi|149 AARQRVELEELRQQLEESSAALTRALRAEFERSREEQERRHQMELKALKDQLEAERQAWV 800 810 820 830 840 850 960 970 980 990 1000 1010 KIAA11 AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLR :. ..:::::::.::.::.::::::::.:::::::::::::.:::::::.:::.:.::.: gi|149 ASCAKKEEAWLLTRERELKEEIRKGRDQEIELVIHRLEADMTLAKEESERAAENRVKRVR 860 870 880 890 900 910 1020 1030 1040 1050 1060 1070 KIAA11 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS ::::.::::::::::::::::.::::.:::::::. :::.:.::::. :.: ..:: :. gi|149 DKYETELSELEQSERKLQERCTELKGRLGEAEGEKERLQSLLRQKEKELDDLRVVNTQMC 920 930 940 950 960 970 1080 1090 1100 1110 1120 1130 KIAA11 SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEA :::..::::.:::: ..::::.:::...::::: :.::::.::.:::::::::::::: : gi|149 SERASLAQVVRQEFAEQLAASQEETQRVKAELAELRARQQMELDEVHRRVKTALARKEAA 980 990 1000 1010 1020 1030 1140 1150 1160 KIAA11 VSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK :.::: ::::: :::::::::::::. :. :.: gi|149 VNSLRKQHEAAEKRADHLEELLEQHKGPSLSSK 1040 1050 1060 >>gi|118099826|ref|XP_420077.2| PREDICTED: hypothetical (1086 aa) initn: 3101 init1: 2115 opt: 3548 Z-score: 2748.3 bits: 520.4 E(): 2.2e-144 Smith-Waterman score: 3939; 60.866% identity (81.064% similar) in 1109 aa overlap (83-1165:1-1086) 60 70 80 90 100 110 KIAA11 PSPPAESAGPARQAGFAAAPPARAGPALSTMKGTRAIGSVPERSPAGVDLSLTGLPPPVS :...:. : : ..:.::::::: ::. gi|118 MRSARSSCSCP---GGAVELSLTGLPVPVA 10 20 120 130 140 150 160 170 KIAA11 RRPGSAATTKPIVRSVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSP :::.::. .: .::::::: ...::..:: .::.::::::::::::::.: :... gi|118 RRPSSASPAKHVVRSVSVVGDGKSKRNALE---DAGSRAINNLRRSNSTTQVNQ-RANGT 30 40 50 60 70 80 180 190 200 210 220 230 KIAA11 RPTEPT-DFLMLFEGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALD : .: : ::: .::.: .:.:. ::.: . :: .:::.::::::.: ::..: : . gi|118 RSSEQTGDFLTFFESSSGGRKKVASVSKTSLEKKTTWNILDDQPRAFPGPSSSR---AAE 90 100 110 120 130 140 240 250 260 270 280 290 KIAA11 SPAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSL ::: :.:: :: :: ::::::::::::.:::::::::: :. ....: :::::. :: gi|118 PPAGMRKKEATVLLAANFTANNRSNKGAMGNCVTTMVHNNYSTTDKGPAPKSSNQAPSSL 150 160 170 180 190 200 300 310 320 330 340 350 KIAA11 NNIIKAATCEGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVN ::.:::.. : .:::.: : :: :: . ..:: ...::::.:::::::::::.::: gi|118 NNVIKATANEDNESSSFMKSQKNFSSNNIMTHNN---NSSLPRRREVTEEEAERFIQQVN 210 220 230 240 250 360 370 380 390 400 410 KIAA11 QAAVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKARE ::::::::::.. ::: :::: : .:: ::::: ::.. : ..:::...:. ::: :: gi|118 LAAVTIQRWYRRHSQRRRAGAAALGRLLAAKREE-RQQQEERNVLDLRDKKDEERRKIRE 260 270 280 290 300 310 420 430 440 450 460 KIAA11 EKARQARRAAIQELQQKRALRAQKASTAERGPPEN---PRETRVPGMRQPAQELSPTPGG :::: :::::::::.:: :::::: ..: :. .:.: . ..::. : :. gi|118 EKARLARRAAIQELHQK---RAQKASDTKRLAEEELAQVKESRRVAKKKPAKPASARNGS 320 330 340 350 360 370 470 480 490 500 510 520 KIAA11 TAHQALKANNAGGGLPAAGPGDRCLPTSDSSPEPQQPP--EDRTQDVLAQDAAGDNLEMM : ...:::::: .: ..: : .. :: : : ::. : : .....:..:: . gi|118 PASSSIKANNAGEALLQVSPEASGL--AELSPVPAQDRGVEDKLQVVSSRETGGEDLETV 380 390 400 410 420 430 530 540 550 560 570 580 KIAA11 APSRGSAKSRGPLEELLHTLQLLEKEPDALPRPRTHHRGRYAWASEVTTEDDASSLTADN . . . : :. : ::: ::.:::.::. :: :. .. .:.:.. ..:::::: gi|118 VTAVSRAPSKVTLSELLDTLRLLEEEPELLPPPKLFKKDKYTWVDG----PGSNSLTADN 440 450 460 470 480 590 600 610 620 630 640 KIAA11 LEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDS-----QQEGWVPEAG :::::::. : ::::.::::::::::.::::::::: :.. : :.:: . : gi|118 LEKFGKLNHSPGVPEDGALLSEAKLQSIISFLDEMEKSEQERPRSATSATQREGLLSEEE 490 500 510 520 530 540 650 660 670 680 690 KIAA11 PGPLELGS----EVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQ . :: .: ::..:.:::::::::::.:. ::: ::::::.::.:.::.::: :..: gi|118 LAHLEQASAVATEVTSSIMRLKLEVEEKKRAISLLQTALAQQRELTVRHVKQTEKELGHQ 550 560 570 580 590 600 700 710 720 730 740 750 KIAA11 LQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHEL :: :::.:::.::::::::::::.::::::::::.::::::: ::. ....: : :::: gi|118 LQLQREQYEAAIQRHLAFIDQLIDDKKVLSEKCETVVAELKQVDQKYGKKLTQMQEQHEL 610 620 630 640 650 660 760 770 780 790 800 810 KIAA11 EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA :::::::::::::: ::::::.::::::::.::.::::::::::..:.:....:: :::: gi|118 EIKKLKELMSATEKIRREKWIDEKTKKIKEITVKGLEPEIQKLITKHRQDIQKLKMLHEA 670 680 690 700 710 720 820 830 840 850 860 870 KIAA11 ELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQR :::::::::.:: ::::::: ::..:: .:.::: :::. ...::::. ::::::.: gi|118 ELLQSDERAAQRYCRQAEELRGLLEQQKEEQSQRERELARQQCEKQLEQEEQALQQQRRR 730 740 750 760 770 780 880 890 900 910 920 930 KIAA11 LYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMEL ::.:::::.:::.:::::::::.::::.::: :: :.: ::. :. . .:::::::: :. gi|118 LYAEVAEEKERLSQQAARQRAEVEELRRQLEASSLAVTTALKEEYAREKEEQERRHQTEV 790 800 810 820 830 840 940 950 960 970 980 990 KIAA11 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK ..::..::::.:::::. ..:::::::.::.:::::.:: :::::::::.::::::. :: gi|118 KVLKDRLELEKQAWEASYVKKEEAWLLSRERELREEVRKERDKEIELVIQRLEADMSSAK 850 860 870 880 890 900 1000 1010 1020 1030 1040 1050 KIAA11 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK :: :.:::.::::.:::::.::.:::.:::::::::.::::.: : :::..:::::...: gi|118 EECERAAENRIKRIRDKYEVELQELERSERKLQERCKELKGRLVELEGESIRLQGLLKHK 910 920 930 940 950 960 1060 1070 1080 1090 1100 1110 KIAA11 ERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL-- :. .:... : .:::.:::.::.:::::: :::...:::.:. :::.: :..::.::: gi|118 EQEVEETRKVRDQLSQERSSLAEVIRQEFADRLVGTEEENRRLKAEMAELRTRQRLELDR 970 980 990 1000 1010 1020 1120 1130 1140 1150 1160 KIAA11 ---------EEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK ::::::::::.::::: ::::: :.::::.:::::: ::::.:: ..: gi|118 VVREKDRELEEVHRRVKTAVARKEENVSSLRKQYEAAVQRADHLEALLEQQRRQLLAAK 1030 1040 1050 1060 1070 1080 1165 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Tue Mar 3 20:14:16 2009 done: Tue Mar 3 20:18:07 2009 Total Scan time: 1826.330 Total Display time: 0.930 Function used was FASTA [version 34.26.5 April 26, 2007]