hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080501/iprscan-20080501-18032082/chunk_1/iprscan-20080501-18032082.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA1124 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00780.12.ls CNH domain 348.3 1.2e-101 1 PF00780.12.fs CNH domain 346.6 3.9e-101 1 PF00069.15.ls Protein kinase domain 220.1 4.7e-63 1 PF00069.15.fs Protein kinase domain 218.2 1.8e-62 1 PF08826.1.fs DMPK coiled coil domain like 121.4 1.4e-33 3 PF08826.1.ls DMPK coiled coil domain like 114.5 2.9e-31 1 PF00130.12.fs Phorbol esters/diacylglycerol binding dom 58.9 1.2e-15 1 PF00130.12.ls Phorbol esters/diacylglycerol binding dom 60.8 4e-15 1 PF07714.7.fs Protein tyrosine kinase 43.0 2.2e-12 2 PF00433.14.fs Protein kinase C terminal domain 40.7 1.7e-11 1 PF00433.14.ls Protein kinase C terminal domain 42.7 1.2e-09 1 PF02370.7.ls M protein repeat 40.4 5.8e-09 6 PF00169.19.fs PH domain 25.6 2.6e-07 1 PF02370.7.fs M protein repeat 31.1 3.9e-07 5 PF00169.19.ls PH domain 27.6 4.2e-05 1 PF00786.18.fs P21-Rho-binding domain 18.0 0.00021 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF07714.7.fs 1/2 125 139 .. 1 15 [. 11.8 0.0025 PF00069.15.fs 1/1 125 391 .. 1 287 [] 218.2 1.8e-62 PF00069.15.ls 1/1 125 391 .. 1 287 [] 220.1 4.7e-63 PF07714.7.fs 2/2 194 344 .. 82 233 .. 31.2 5.7e-09 PF00433.14.fs 1/1 409 456 .. 1 47 [] 40.7 1.7e-11 PF00433.14.ls 1/1 409 456 .. 1 47 [] 42.7 1.2e-09 PF08826.1.fs 3/3 927 988 .. 1 61 [] 112.5 4.5e-31 PF08826.1.ls 1/1 927 988 .. 1 61 [] 114.5 2.9e-31 PF00130.12.fs 1/1 1075 1127 .. 1 55 [] 58.9 1.2e-15 PF00130.12.ls 1/1 1075 1127 .. 1 55 [] 60.8 4e-15 PF00169.19.ls 1/1 1145 1263 .. 1 92 [] 27.6 4.2e-05 PF00169.19.fs 1/1 1145 1263 .. 1 92 [] 25.6 2.6e-07 PF00780.12.ls 1/1 1290 1562 .. 1 363 [] 348.3 1.2e-101 PF00780.12.fs 1/1 1290 1562 .. 1 363 [] 346.6 3.9e-101 PF00786.18.fs 1/1 1631 1645 .. 1 16 [. 18.0 0.00021 Alignments of top-scoring domains: PF07714.7.fs: domain 1 of 2, from 125 to 139: score 11.8, E = 0.0025 *->lklgkkLGeGaFGeV<-* ++++k++G+GaFGeV KIAA1124 125 FEIIKVIGRGAFGEV 139 PF00069.15.fs: domain 1 of 1, from 125 to 391: score 218.2, E = 1.8e-62 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e+++++G+G+fG+V k k+t++i+A+Ki++k + + + + +r KIAA1124 125 FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFR 171 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E +l + ++ I l+++f+d++hlylV++y gG dL ++ls KIAA1124 172 E-ERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGG----DLLTLLS- 215 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + + +l +ed a++++ +++ +++ +H+ +HRD+KP+N+Lld ng+ KIAA1124 216 -KFEDKL--PEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGH 262 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll....ggngyg + ++aDFG++ k++ + ++ ++ vGTp+Y++PE+l+ ++g +yg KIAA1124 263 I----RLADFGSCLKMNDdGTVqSSVAVGTPDYISPEILQamedGMGKYG 308 tkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspe +++D+WSlGv +ye+l G++PF+ e + + + ki+ + +f +p KIAA1124 309 PECDWWSLGVCMYEMLYGETPFYAE-----SLVETYGKIMNHEERFQFPS 353 wdsisrsefrrlpnlseeakdLikkcLnkDPskRlt...aeeilqHPwf< + +seeakdLi ++++ ++Rl+++++e+ ++H +f KIAA1124 354 HVT----------DVSEEAKDLIQRLIC-SRERRLGqngIEDFKKHAFF 391 -* KIAA1124 - - PF00069.15.ls: domain 1 of 1, from 125 to 391: score 220.1, E = 4.7e-63 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e+++++G+G+fG+V k k+t++i+A+Ki++k + + + + +r KIAA1124 125 FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFR 171 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E +l + ++ I l+++f+d++hlylV++y gG dL ++ls KIAA1124 172 E-ERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGG----DLLTLLS- 215 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv + + +l +ed a++++ +++ +++ +H+ +HRD+KP+N+Lld ng+ KIAA1124 216 -KFEDKL--PEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGH 262 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvll....ggngyg + ++aDFG++ k++ + ++ ++ vGTp+Y++PE+l+ ++g +yg KIAA1124 263 I----RLADFGSCLKMNDdGTVqSSVAVGTPDYISPEILQamedGMGKYG 308 tkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspe +++D+WSlGv +ye+l G++PF+ e + + + ki+ + +f +p KIAA1124 309 PECDWWSLGVCMYEMLYGETPFYAE-----SLVETYGKIMNHEERFQFPS 353 wdsisrsefrrlpnlseeakdLikkcLnkDPskRlt...aeeilqHPwf< + +seeakdLi ++++ ++Rl+++++e+ ++H +f KIAA1124 354 HVT----------DVSEEAKDLIQRLIC-SRERRLGqngIEDFKKHAFF 391 -* KIAA1124 - - PF07714.7.fs: domain 2 of 2, from 194 to 344: score 31.2, E = 5.7e-09 *->gpg.lyiVtEymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMe ++++ly+V+ y gGdLl+ L k +++L+ + + + + + KIAA1124 194 DENhLYLVMDYYVGGDLLTLLSKF--EDKLPEDMARFYIGEMVLAID 238 YLesknfvHRDLAARNcLVsenlvVKIsDFGLaRdiynddyYvrkkgggk ++ ++vHRD+ N+L++ n++++ +DFG + + ndd ++++ + KIAA1124 239 SIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKM-NDDGT-VQSSVAV 286 lPvkWmAPEslkygk.....FtskSDVWSFGVlLWEiftlGeqPFYpgms +PE l+ ++++ +++ + D WS GV+++E++ Ge+P ++ s KIAA1124 287 GTPDYISPEILQAMEdgmgkYGPECDWWSLGVCMYEMLY-GETP-FYAES 334 neevlellyed<-* e++ ++ ++ KIAA1124 335 LVETYGKI-MN 344 PF00433.14.fs: domain 1 of 1, from 409 to 456: score 40.7, E = 1.7e-11 *->kvksptDTsNFDpeFTsepptltpppdsr.lssgkqleFrGFtYvnp v+sp DTsNFD++++ t+ pp s + +sg +l+F+GFt++ + KIAA1124 409 DVSSPSDTSNFDVDDDVLRNTEILPPGSHtGFSGLHLPFIGFTFTTE 455 e<-* + KIAA1124 456 S 456 PF00433.14.ls: domain 1 of 1, from 409 to 456: score 42.7, E = 1.2e-09 *->kvksptDTsNFDpeFTsepptltpppdsr.lssgkqleFrGFtYvnp v+sp DTsNFD++++ t+ pp s + +sg +l+F+GFt++ + KIAA1124 409 DVSSPSDTSNFDVDDDVLRNTEILPPGSHtGFSGLHLPFIGFTFTTE 455 e<-* + KIAA1124 456 S 456 PF08826.1.fs: domain 3 of 3, from 927 to 988: score 112.5, E = 4.5e-31 *->eLQsALEaEIRAKQslqeeLekVkaanlafeskLqeaEkkNreLeae eLQsALEaEIRAKQ++qeeL+kVk+anl eskL+++E+kNreL++e KIAA1124 927 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEE 973 leqLkkemEe.lRar<-* +e Lkk mEe++Ra+ KIAA1124 974 MEILKKKMEEkFRAD 988 PF08826.1.ls: domain 1 of 1, from 927 to 988: score 114.5, E = 2.9e-31 *->eLQsALEaEIRAKQslqeeLekVkaanlafeskLqeaEkkNreLeae eLQsALEaEIRAKQ++qeeL+kVk+anl eskL+++E+kNreL++e KIAA1124 927 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEE 973 leqLkkemEe.lRar<-* +e Lkk mEe++Ra+ KIAA1124 974 MEILKKKMEEkFRAD 988 PF00130.12.fs: domain 1 of 1, from 1075 to 1127: score 58.9, E = 1.2e-15 *->HhFvhrwtfkqptfCdhCgeflwgslgkqGlkCswCklnvHkrChek H+F + +f +pt C+hC +++ g l++qG+ C++C + +H C KIAA1124 1075 HQFSIK-SFSSPTQCSHCTSLMVG-LIRQGYACEVCSFACHVSCKDG 1119 VppeCgcg<-* +p C+ KIAA1124 1120 APQVCPIP 1127 PF00130.12.ls: domain 1 of 1, from 1075 to 1127: score 60.8, E = 4e-15 *->HhFvhrwtfkqptfCdhCgeflwgslgkqGlkCswCklnvHkrChek H+F + +f +pt C+hC +++ g l++qG+ C++C + +H C KIAA1124 1075 HQFSIK-SFSSPTQCSHCTSLMVG-LIRQGYACEVCSFACHVSCKDG 1119 VppeCgcg<-* +p C+ KIAA1124 1120 APQVCPIP 1127 PF00169.19.ls: domain 1 of 1, from 1145 to 1263: score 27.6, E = 4.2e-05 *->vikeGwLlkkg...gkkswkkRyfvLfddvLlyykdkk.kkpkgsip ++G++++ ++++ kk+w++ y+v++d +L++y+ + +k+ + + KIAA1124 1145 TAYKGHVKVPKptgVKKGWQRAYAVVCDCKLFLYDLPEgKSTQPGVI 1191 Lsgi.qvtkvpdn...............krkncFeirt.dr......etl s++ +++++ + ++ ++ + ++++ +++F+++ + + ++++ +l KIAA1124 1192 ASQVlDLRDDEFSvssvlasdvihatrrDIPCIFRVTAsLLgapsktSSL 1241 llqaeseeerkeWvkaiqsair<-* l+ +e+e e+k+Wv ++ +++ KIAA1124 1242 LILTENENEKKKWVGILEGLQS 1263 PF00169.19.fs: domain 1 of 1, from 1145 to 1263: score 25.6, E = 2.6e-07 *->vikeGwLlkkg...gkkswkkRyfvLfddvLlyykdkk.kkpkgsip ++G++++ ++++ kk+w++ y+v++d +L++y+ + +k+ + + KIAA1124 1145 TAYKGHVKVPKptgVKKGWQRAYAVVCDCKLFLYDLPEgKSTQPGVI 1191 Lsgi.qvtkvpdn...............krkncFeirt.dr......etl s++ +++++ + ++ ++ + ++++ +++F+++ + + ++++ +l KIAA1124 1192 ASQVlDLRDDEFSvssvlasdvihatrrDIPCIFRVTAsLLgapsktSSL 1241 llqaeseeerkeWvkaiqsair<-* l+ +e+e e+k+Wv ++ +++ KIAA1124 1242 LILTENENEKKKWVGILEGLQS 1263 PF00780.12.ls: domain 1 of 1, from 1290 to 1562: score 348.3, E = 1.2e-101 *->kvnwihaitggqnLLvGTeeGLYvlnrsdqhdaflgklvkiigrrsv k+ +++ai ++++++vG eeGLYv++++++ +v+++++++v KIAA1124 1290 KAILTAAIVDADRIAVGLEEGLYVIEVTRD------VIVRAADCKKV 1330 tqlevieelnlLllLseGKkrhLylhpLsaLetekkdtaqgsskilrlpe +q+e+ +++++++lL+ G+++h++l+p+s+L KIAA1124 1331 HQIELAPREKIVILLC-GRNHHVHLYPWSSL------------------- 1360 ktlarrfavskKipetkghCklccvgfiaegycggtkFLcvvAlksddls + ++ +++K+petkg C+l+++ + + + +g+++F vA+k+ KIAA1124 1361 --DGAEGSFDIKLPETKG-CQLMATATLKRN-SGTCLF---VAVKR---- 1399 tsillyeWPlkeyklpnnyekllkfinrkktrfrkpkeldvpepvqsief il+ye i+r+k+++rk++e++ p+ vq+ ++ KIAA1124 1400 -LILCYE------------------IQRTKPFHRKFNEIVAPGSVQCLAV 1430 lkpslcvGcskgfeillvlfgssgfhsldleGqseaaldlllPsndlsle l+++lcvG+++gf+ l+++++ Gq l l++P+++ sl+ KIAA1124 1431 LRDRLCVGYPSGFCLLSIQGD----------GQ---PLNLVNPNDP-SLA 1466 fakkls.QsvdalrakevvsaiqidrdeyLLCfsefgvfVNlqGrrsrkk f ls+Qs+dal+a+e+ +++eyLLCfs++g++V++qGrr r + KIAA1124 1467 F---LSqQSFDALCAVEL------ESEEYLLCFSHMGLYVDPQGRRARAQ 1507 kdiselmWegaPesfayslypyllafhdngieIrsletgeltqeladrvq elmW++aP ++ +s + ++++++++g+++++++t+e+ vq KIAA1124 1508 ----ELMWPAAPVACSCS-PTHVTVYSEYGVDVFDVRTMEW-------VQ 1545 tillnkirllvslrsls<-* ti+l++ir+l+s+++l+ KIAA1124 1546 TIGLRRIRPLNSEGTLN 1562 PF00780.12.fs: domain 1 of 1, from 1290 to 1562: score 346.6, E = 3.9e-101 *->kvnwihaitggqnLLvGTeeGLYvlnrsdqhdaflgklvkiigrrsv k+ +++ai ++++++vG eeGLYv++++++ +v+++++++v KIAA1124 1290 KAILTAAIVDADRIAVGLEEGLYVIEVTRD------VIVRAADCKKV 1330 tqlevieelnlLllLseGKkrhLylhpLsaLetekkdtaqgsskilrlpe +q+e+ +++++++lL+ G+++h++l+p+s+L KIAA1124 1331 HQIELAPREKIVILLC-GRNHHVHLYPWSSL------------------- 1360 ktlarrfavskKipetkghCklccvgfiaegycggtkFLcvvAlksddls + ++ +++K+petkg C+l+++ + + + +g+++F vA+k+ KIAA1124 1361 --DGAEGSFDIKLPETKG-CQLMATATLKRN-SGTCLF---VAVKR---- 1399 tsillyeWPlkeyklpnnyekllkfinrkktrfrkpkeldvpepvqsief il+ye i+r+k+++rk++e++ p+ vq+ ++ KIAA1124 1400 -LILCYE------------------IQRTKPFHRKFNEIVAPGSVQCLAV 1430 lkpslcvGcskgfeillvlfgssgfhsldleGqseaaldlllPsndlsle l+++lcvG+++gf+ l+++++ Gq l l++P+++ sl+ KIAA1124 1431 LRDRLCVGYPSGFCLLSIQGD----------GQ---PLNLVNPNDP-SLA 1466 fakkls.QsvdalrakevvsaiqidrdeyLLCfsefgvfVNlqGrrsrkk f ls+Qs+dal+a+e+ +++eyLLCfs++g++V++qGrr r + KIAA1124 1467 F---LSqQSFDALCAVEL------ESEEYLLCFSHMGLYVDPQGRRARAQ 1507 kdiselmWegaPesfayslypyllafhdngieIrsletgeltqeladrvq elmW++aP ++ +s + ++++++++g+++++++t+e+ vq KIAA1124 1508 ----ELMWPAAPVACSCS-PTHVTVYSEYGVDVFDVRTMEW-------VQ 1545 tillnkirllvslrsls<-* ti+l++ir+l+s+++l+ KIAA1124 1546 TIGLRRIRPLNSEGTLN 1562 PF00786.18.fs: domain 1 of 1, from 1631 to 1645: score 18.0, E = 0.00021 *->eIStPLtnFkHvvHVG<-* +IS+P tnF Hv+H G KIAA1124 1631 MISNP-TNFNHVAHMG 1645 //