hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080501/iprscan-20080501-18164782/chunk_1/iprscan-20080501-18164782.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA1132 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00041.11.ls Fibronectin type III domain 364.8 1.3e-106 6 PF00041.11.fs Fibronectin type III domain 354.5 1.6e-103 6 PF07679.6.fs Immunoglobulin I-set domain 331.7 1.2e-96 10 PF07679.6.ls Immunoglobulin I-set domain 307.9 1.7e-89 8 PF00047.15.ls Immunoglobulin domain 288.3 1.4e-83 10 PF00047.15.fs Immunoglobulin domain 270.7 2.7e-78 10 PF07686.7.fs Immunoglobulin V-set domain 99.9 1.3e-27 7 PF07686.7.ls Immunoglobulin V-set domain 70.7 4.4e-18 6 PF08205.3.fs CD80-like C2-set immunoglobulin domain 23.8 3.9e-06 4 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF07679.6.ls 1/8 265 350 .. 1 96 [] 80.5 4.7e-21 PF07679.6.fs 3/10 265 350 .. 1 96 [] 78.6 2.5e-22 PF07686.7.ls 1/6 273 351 .. 1 141 [] 32.2 1.7e-06 PF07686.7.fs 2/7 279 351 .. 29 141 .] 34.2 3.7e-09 PF00047.15.ls 3/10 279 335 .. 1 65 [] 55.3 1.8e-13 PF00047.15.fs 3/10 279 335 .. 1 65 [] 53.5 6.4e-14 PF07679.6.ls 2/8 354 442 .. 1 96 [] 29.3 3.8e-06 PF07679.6.fs 4/10 354 428 .. 1 82 [. 33.2 4.4e-09 PF00047.15.ls 4/10 368 427 .. 1 65 [] 34.4 3.8e-07 PF00047.15.fs 4/10 368 427 .. 1 65 [] 32.5 3.7e-08 PF07679.6.fs 5/10 447 541 .. 1 96 [] 50.3 4.6e-14 PF07679.6.ls 3/8 447 541 .. 1 96 [] 52.2 1.6e-12 PF00047.15.fs 5/10 461 526 .. 1 65 [] 29.5 2.4e-07 PF00047.15.ls 5/10 461 526 .. 1 65 [] 31.4 2.8e-06 PF07686.7.ls 3/6 538 633 .. 1 141 [] 11.2 0.0037 PF07679.6.ls 4/8 544 632 .. 1 96 [] 15.0 6.1e-05 PF07679.6.fs 6/10 544 614 .. 1 79 [. 25.3 9e-07 PF00047.15.ls 6/10 558 616 .. 1 65 [] 32.2 1.7e-06 PF00047.15.fs 6/10 558 616 .. 1 65 [] 30.3 1.4e-07 PF07679.6.ls 5/8 635 725 .. 1 96 [] 21.2 1.8e-05 PF00047.15.fs 7/10 649 710 .. 1 65 [] 37.6 1.5e-09 PF00047.15.ls 7/10 649 710 .. 1 65 [] 39.5 1.1e-08 PF07679.6.fs 7/10 664 725 .. 29 96 .] 26.9 3e-07 PF07679.6.fs 8/10 729 824 .. 1 96 [] 47.6 2.8e-13 PF07679.6.ls 6/8 729 824 .. 1 96 [] 49.5 1e-11 PF00047.15.fs 8/10 743 808 .. 1 65 [] 26.2 2e-06 PF00047.15.ls 8/10 743 808 .. 1 65 [] 28.1 2.9e-05 PF07679.6.ls 7/8 828 923 .. 1 96 [] 19.7 2.5e-05 PF00047.15.fs 9/10 842 908 .. 1 65 [] 19.3 0.00015 PF00047.15.ls 9/10 842 908 .. 1 65 [] 21.2 0.0034 PF00041.11.fs 1/6 926 1013 .. 1 84 [] 66.3 2.1e-18 PF00041.11.ls 1/6 926 1013 .. 1 84 [] 68.3 2.3e-17 PF00041.11.fs 2/6 1025 1117 .. 1 84 [] 64.5 7.2e-18 PF00041.11.ls 2/6 1025 1117 .. 1 84 [] 66.5 8e-17 PF00041.11.fs 3/6 1129 1218 .. 1 84 [] 63.9 1e-17 PF00041.11.ls 3/6 1129 1218 .. 1 84 [] 65.9 1.2e-16 PF00041.11.ls 4/6 1230 1316 .. 1 84 [] 71.2 3.1e-18 PF00041.11.fs 4/6 1230 1316 .. 1 84 [] 69.2 3.2e-19 PF07679.6.ls 8/8 1329 1419 .. 1 96 [] 40.4 5.9e-09 PF00047.15.fs 10/10 1343 1404 .. 1 65 [] 28.6 4.2e-07 PF00047.15.ls 10/10 1343 1404 .. 1 65 [] 30.5 5.3e-06 PF07679.6.fs 10/10 1344 1419 .. 16 96 .] 46.9 4.5e-13 PF00041.11.ls 5/6 1423 1506 .. 1 84 [] 76.1 1e-19 PF00041.11.fs 5/6 1423 1506 .. 1 84 [] 74.1 1.2e-20 PF00041.11.ls 6/6 1520 1602 .. 1 84 [] 16.8 0.0031 Alignments of top-scoring domains: PF07679.6.ls: domain 1 of 8, from 265 to 350: score 80.5, E = 4.7e-21 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+++ +++eV G ++++ C+++G+P P + W+KdG+pl++ KIAA1132 265 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA---- 307 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++r + +g LtIs+ +DsG+Y C +tN +G+aea+ L V KIAA1132 308 DSRWTKRITG------LTISDLRTEDSGTYICEVTNTFGSAEATGILMV 350 -* KIAA1132 - - PF07679.6.fs: domain 3 of 10, from 265 to 350: score 78.6, E = 2.5e-22 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+++ +++eV G ++++ C+++G+P P + W+KdG+pl++ KIAA1132 265 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA---- 307 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++r + +g LtIs+ +DsG+Y C +tN +G+aea+ L V KIAA1132 308 DSRWTKRITG------LTISDLRTEDSGTYICEVTNTFGSAEATGILMV 350 -* KIAA1132 - - PF07686.7.ls: domain 1 of 6, from 273 to 351: score 32.2, E = 1.7e-06 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss +++v++ G +v+LpCt s ++ KIAA1132 273 SQEVWA----------------------GHTVELPCTAS----GY-- 291 ssgtfsiyWyrq.qppgkgpeliiisyysyystsegngtvgerfkgrvtl ++ i+W ++++p+ + +++ ++ KIAA1132 292 --PIPAIRWLKDgRPL------------------------PADSRWTKRI 315 sgnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* +g LtIs+l+ +DsGtY C v n+ +++ ++ L+V KIAA1132 316 TG--------LTISDLRTEDSGTYICEVTNT-FGSAEATGILMVI 351 PF07686.7.fs: domain 2 of 7, from 279 to 351: score 34.2, E = 3.7e-09 *->GgsvtLpCtysGtfddsssssgtfsiyWyrq.qppgkgpeliiisyy G +v+LpCt s ++ ++ i+W ++++p+ KIAA1132 279 GHTVELPCTAS----GY----PIPAIRWLKDgRPL------------ 305 syystsegngtvgerfkgrvtlsgnpskgdfsLtIsnlqlsDsGtYyCav + +++ +++g LtIs+l+ +DsGtY C v KIAA1132 306 ------------PADSRWTKRITG--------LTISDLRTEDSGTYICEV 335 snsnelvfgggtrLtVl<-* n+ +++ ++ L+V KIAA1132 336 TNT-FGSAEATGILMVI 351 PF00047.15.ls: domain 3 of 10, from 279 to 335: score 55.3, E = 1.8e-13 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G++v L+C++ +g p + ++Wl++g +l+ + + t ++ KIAA1132 279 GHTVELPCTA--SGYPIPAIRWLKDGRpLPaDSRWTKRITG------ 317 tsLtitnvtpeDggtYtCvv<-* Lti++++ eD+gtY C+v KIAA1132 318 --LTISDLRTEDSGTYICEV 335 PF00047.15.fs: domain 3 of 10, from 279 to 335: score 53.5, E = 6.4e-14 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G++v L+C++ +g p + ++Wl++g +l+ + + t ++ KIAA1132 279 GHTVELPCTA--SGYPIPAIRWLKDGRpLPaDSRWTKRITG------ 317 tsLtitnvtpeDggtYtCvv<-* Lti++++ eD+gtY C+v KIAA1132 318 --LTISDLRTEDSGTYICEV 335 PF07679.6.ls: domain 2 of 8, from 354 to 442: score 29.3, E = 3.8e-06 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp + t pk ++ +G+++ ++C tG+Pe t+ W+++ + + + KIAA1132 354 LHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP---- 396 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< ++ ++++ + tL I +q++ sG Y C At +a +a+ a KIAA1132 397 DEAISIRGLS---NETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIAL 442 -* KIAA1132 - - PF07679.6.fs: domain 4 of 10, from 354 to 428: score 33.2, E = 4.4e-09 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp + t pk ++ +G+++ ++C tG+Pe t+ W+++ + + + KIAA1132 354 LHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP---- 396 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAt<-* ++ ++++ + tL I +q++ sG Y C At KIAA1132 397 DEAISIRGLS---NETLLITSAQKSHSGAYQCFAT 428 PF00047.15.ls: domain 4 of 10, from 368 to 427: score 34.4, E = 3.8e-07 *->GesvtLtCsvsgfgppdvtvtWlrngklt.gvlvtssenngdstyqt G++v L+C +g+p+ t++W+rn l ++++ s + ++ t KIAA1132 368 GSTVILSCAL--TGSPEFTIRWYRNTELVlPDEAISIRGLSNET--- 409 sLtitnvtpeDggtYtCvv<-* L it+++++++g Y C + KIAA1132 410 -LLITSAQKSHSGAYQCFA 427 PF00047.15.fs: domain 4 of 10, from 368 to 427: score 32.5, E = 3.7e-08 *->GesvtLtCsvsgfgppdvtvtWlrngklt.gvlvtssenngdstyqt G++v L+C +g+p+ t++W+rn l ++++ s + ++ t KIAA1132 368 GSTVILSCAL--TGSPEFTIRWYRNTELVlPDEAISIRGLSNET--- 409 sLtitnvtpeDggtYtCvv<-* L it+++++++g Y C + KIAA1132 410 -LLITSAQKSHSGAYQCFA 427 PF07679.6.fs: domain 5 of 10, from 447 to 541: score 50.3, E = 4.6e-14 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+++ + +V+ Ge ++ C ++G P+PtV+W d++p+ KIAA1132 447 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVR---- 489 sdrfkvtydg...GsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeL ++ ++ ++G ++ + + q++D G+Y+C+A+N +G+ae a+ KIAA1132 490 DGSHRTNQYTmsdGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI 539 tV<-* +V KIAA1132 540 NV 541 PF07679.6.ls: domain 3 of 8, from 447 to 541: score 52.2, E = 1.6e-12 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+++ + +V+ Ge ++ C ++G P+PtV+W d++p+ KIAA1132 447 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVR---- 489 sdrfkvtydg...GsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeL ++ ++ ++G ++ + + q++D G+Y+C+A+N +G+ae a+ KIAA1132 490 DGSHRTNQYTmsdGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI 539 tV<-* +V KIAA1132 540 NV 541 PF00047.15.fs: domain 5 of 10, from 461 to 526: score 29.5, E = 2.4e-07 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge ++L C ++ g p++tvtW ++ ++ ++ ++++ ++ + ++ KIAA1132 461 GEQFSLMCAAK--GAPPPTVTWALDDEpIVrDGSHRTNQYTMSDGTT 505 t.sLtitnvtpeDggtYtCvv<-* +++ ++t + Dgg+Y+C++ KIAA1132 506 IsHMNVTGPQIRDGGVYRCTA 526 PF00047.15.ls: domain 5 of 10, from 461 to 526: score 31.4, E = 2.8e-06 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge ++L C ++ g p++tvtW ++ ++ ++ ++++ ++ + ++ KIAA1132 461 GEQFSLMCAAK--GAPPPTVTWALDDEpIVrDGSHRTNQYTMSDGTT 505 t.sLtitnvtpeDggtYtCvv<-* +++ ++t + Dgg+Y+C++ KIAA1132 506 IsHMNVTGPQIRDGGVYRCTA 526 PF07686.7.ls: domain 3 of 6, from 538 to 633: score 11.2, E = 0.0037 *->qsqvtqepprWGLLLASLfWpt.....svtvaeGgsvtLpCtysGtf ++v + p+ + + + +t++ G + +++C + KIAA1132 538 RINVRG--PP-----------SiramrNITAVAGRDTLINCRVI--- 568 ddsssssgtfsiyWyrq.qppgkgpeliiisyysyystsegngtvgerfk ++ + +si Wy++ + +++++ f KIAA1132 569 -GY----PYYSIKWYKDaLLLPDNHRQVV-------------------FE 594 grvtlsgnpskgdfsLtIsnlqls.DsGtYyCavsnsnelvfgggtrLtV + + L+++++q D+G Y C v + l+ + +++ V KIAA1132 595 NGT------------LKLTDVQKGmDEGEYLCSVLIQPQLSISQSVHVAV 632 l<-* + KIAA1132 633 K 633 PF07679.6.ls: domain 4 of 8, from 544 to 632: score 15.0, E = 6.1e-05 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P ++ +++++ G + C+V+G+P ++ W+Kd l+ KIAA1132 544 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD---- 586 sdrfkvtydgGsgtytLtIsnvqpd.DsGkYtCvAtNs.aGeaeasaeLt +r v ++g tL+ +vq++ D+G+Y C + + + + s+++ KIAA1132 587 NHRQVVFENG-----TLKLTDVQKGmDEGEYLCSVLIQpQLSISQSVHVA 631 V<-* V KIAA1132 632 V 632 PF07679.6.fs: domain 6 of 10, from 544 to 614: score 25.3, E = 9e-07 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P ++ +++++ G + C+V+G+P ++ W+Kd l+ KIAA1132 544 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD---- 586 sdrfkvtydgGsgtytLtIsnvqpd.DsGkYtC<-* +r v ++g tL+ +vq++ D+G+Y C KIAA1132 587 NHRQVVFENG-----TLKLTDVQKGmDEGEYLC 614 PF00047.15.ls: domain 6 of 10, from 558 to 616: score 32.2, E = 1.7e-06 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G + ++C+v g p +++ W+++ l++ +++ ++en++ KIAA1132 558 GRDTLINCRV--IGYPYYSIKWYKDALlLPdNHRQVVFENGT----- 597 tsLtitnvtpe.DggtYtCvv<-* L +t+v+++ D+g+Y C v KIAA1132 598 --LKLTDVQKGmDEGEYLCSV 616 PF00047.15.fs: domain 6 of 10, from 558 to 616: score 30.3, E = 1.4e-07 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G + ++C+v g p +++ W+++ l++ +++ ++en++ KIAA1132 558 GRDTLINCRV--IGYPYYSIKWYKDALlLPdNHRQVVFENGT----- 597 tsLtitnvtpe.DggtYtCvv<-* L +t+v+++ D+g+Y C v KIAA1132 598 --LKLTDVQKGmDEGEYLCSV 616 PF07679.6.ls: domain 5 of 8, from 635 to 725: score 21.2, E = 1.8e-05 *->PkFtqkpkdveVqeGesarfeCkV.tGtPePtVsWfKdGqplssvll P +q+ + +++G+ + C V++G+ + ++W KdGq + s KIAA1132 635 PPLIQPFEFPPASIGQLLYIPCVVsSGDMPIRITWRKDGQVIIS--- 678 psdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV ++ + + ++ ++L Is v G YtC+A+N a +++ + +L+V KIAA1132 679 -GSGVTIESKE--FMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIV 725 <-* KIAA1132 - - PF00047.15.fs: domain 7 of 10, from 649 to 710: score 37.6, E = 1.5e-09 *->GesvtLtCsvsgfgppdvtvtWlrngklt.gvlvtssenngdstyqt G+ + ++C vs +g+ ++++tW+++g+++ + ++ + e++ ++ KIAA1132 649 GQLLYIPCVVS-SGDMPIRITWRKDGQVIiSGSGVTIESKEFMSS-- 692 sLtitnvtpeDggtYtCvv<-* L+i++v+ ++g+YtC + KIAA1132 693 -LQISSVSLKHNGNYTCIA 710 PF00047.15.ls: domain 7 of 10, from 649 to 710: score 39.5, E = 1.1e-08 *->GesvtLtCsvsgfgppdvtvtWlrngklt.gvlvtssenngdstyqt G+ + ++C vs +g+ ++++tW+++g+++ + ++ + e++ ++ KIAA1132 649 GQLLYIPCVVS-SGDMPIRITWRKDGQVIiSGSGVTIESKEFMSS-- 692 sLtitnvtpeDggtYtCvv<-* L+i++v+ ++g+YtC + KIAA1132 693 -LQISSVSLKHNGNYTCIA 710 PF07679.6.fs: domain 7 of 10, from 664 to 725: score 26.9, E = 3e-07 *->ePtVsWfKdGqplssvllpsdrfkvtydgGsgtytLtIsnvqpdDsG + ++W KdGq + s ++ + + ++ ++L Is v G KIAA1132 664 PIRITWRKDGQVIIS----GSGVTIESKE--FMSSLQISSVSLKHNG 704 kYtCvAtNsaGeaeasaeLtV<-* YtC+A+N a +++ + +L+V KIAA1132 705 NYTCIASNAAATVSRERQLIV 725 PF07679.6.fs: domain 8 of 10, from 729 to 824: score 47.6, E = 2.8e-13 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKd.Gq....... P+F+ +p ++ G++ ++ C V+G+P+P+V W++ +G++++++ + KIAA1132 729 PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAkGSgnpqqyh 775 plssvllpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGea. p++ ++r+++ + +L I+ v +D G Y C+A+N +G++ KIAA1132 776 PVPL----TGRIQILPNS-----SLLIRHVLEEDIGYYLCQASNGVGTDi 816 easaeLtV<-* ++s +LtV KIAA1132 817 SKSMFLTV 824 PF07679.6.ls: domain 6 of 8, from 729 to 824: score 49.5, E = 1e-11 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKd.Gq....... P+F+ +p ++ G++ ++ C V+G+P+P+V W++ +G++++++ + KIAA1132 729 PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAkGSgnpqqyh 775 plssvllpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGea. p++ ++r+++ + +L I+ v +D G Y C+A+N +G++ KIAA1132 776 PVPL----TGRIQILPNS-----SLLIRHVLEEDIGYYLCQASNGVGTDi 816 easaeLtV<-* ++s +LtV KIAA1132 817 SKSMFLTV 824 PF00047.15.fs: domain 8 of 10, from 743 to 808: score 26.2, E = 2e-06 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+ L+Csv g p+++v W++++++ + +++ ++ ++++++ KIAA1132 743 GKAGVLNCSV--DGYPPPKVMWKHAKGsGNpQQYH--PVPLTGRIQI 785 t...sLtitnvtpeDggtYtCvv<-* +++sL i+ v +eD g+Y C++ KIAA1132 786 LpnsSLLIRHVLEEDIGYYLCQA 808 PF00047.15.ls: domain 8 of 10, from 743 to 808: score 28.1, E = 2.9e-05 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+ L+Csv g p+++v W++++++ + +++ ++ ++++++ KIAA1132 743 GKAGVLNCSV--DGYPPPKVMWKHAKGsGNpQQYH--PVPLTGRIQI 785 t...sLtitnvtpeDggtYtCvv<-* +++sL i+ v +eD g+Y C++ KIAA1132 786 LpnsSLLIRHVLEEDIGYYLCQA 808 PF07679.6.ls: domain 7 of 8, from 828 to 923: score 19.7, E = 2.5e-05 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp +t +p + G + ++ C+++G+ + + W K++ + + KIAA1132 828 AMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDP---- 870 sd..rfkvtydg..GsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasae ++ r+ + ++++ +tL+ + ++++Ds +C A Ns+Ge+ ++ KIAA1132 871 DRvmRYAIATKDngDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQ 920 LtV<-* LtV KIAA1132 921 LTV 923 PF00047.15.fs: domain 9 of 10, from 842 to 908: score 19.3, E = 0.00015 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvt.ssenngdsty G+ L+C++ g ++ ++W ++++ + ++ + + ++++++ KIAA1132 842 GHAKELNCTA--RGERPIIIRWEKGDTvIDpDRVMRyAIATKDNGDE 886 qt.sLtitnvtpeDggtYtCvv<-* ++L +++++++D+ +++C++ KIAA1132 887 VVsTLKLKPADRGDSVFFSCHA 908 PF00047.15.ls: domain 9 of 10, from 842 to 908: score 21.2, E = 0.0034 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvt.ssenngdsty G+ L+C++ g ++ ++W ++++ + ++ + + ++++++ KIAA1132 842 GHAKELNCTA--RGERPIIIRWEKGDTvIDpDRVMRyAIATKDNGDE 886 qt.sLtitnvtpeDggtYtCvv<-* ++L +++++++D+ +++C++ KIAA1132 887 VVsTLKLKPADRGDSVFFSCHA 908 PF00041.11.fs: domain 1 of 6, from 926 to 1013: score 66.3, E = 2.1e-18 *->PsaPtnltvtdvtstsltlsWspPt.gngpitgYevtyRqpkngge. P+ P l +++v + s+ l+W+ ++gn+ itg+ ++y ++k+++++ KIAA1132 926 PPDPPELEIREVKARSMNLRWTQRFdGNSIITGFDIEY-KNKSDSWd 971 ..wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* + ++++++t +++++ +L P + Y++r ++ n +G++++S KIAA1132 972 fkQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGrSEPS 1013 PF00041.11.ls: domain 1 of 6, from 926 to 1013: score 68.3, E = 2.3e-17 *->PsaPtnltvtdvtstsltlsWspPt.gngpitgYevtyRqpkngge. P+ P l +++v + s+ l+W+ ++gn+ itg+ ++y ++k+++++ KIAA1132 926 PPDPPELEIREVKARSMNLRWTQRFdGNSIITGFDIEY-KNKSDSWd 971 ..wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* + ++++++t +++++ +L P + Y++r ++ n +G++++S KIAA1132 972 fkQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGrSEPS 1013 PF00041.11.fs: domain 2 of 6, from 1025 to 1117: score 64.5, E = 7.2e-18 *->P.saPtnltvtdvtstsltlsWspPt...gngpitgYevtyR..qpk P+++P ++t +vts s++++W++P+++ ng+i gY++ yR+++p KIAA1132 1025 PdGPPMDVTLQPVTSQSIQVTWKAPKkelQNGVIRGYQIGYRenSPG 1071 ngge..wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* ++g+ + +e +g++ ytl +Lk +Y v VqA n++G+Gp S KIAA1132 1072 SNGQysIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGtGPSS 1117 PF00041.11.ls: domain 2 of 6, from 1025 to 1117: score 66.5, E = 8e-17 *->P.saPtnltvtdvtstsltlsWspPt...gngpitgYevtyR..qpk P+++P ++t +vts s++++W++P+++ ng+i gY++ yR+++p KIAA1132 1025 PdGPPMDVTLQPVTSQSIQVTWKAPKkelQNGVIRGYQIGYRenSPG 1071 ngge..wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* ++g+ + +e +g++ ytl +Lk +Y v VqA n++G+Gp S KIAA1132 1072 SNGQysIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGtGPSS 1117 PF00041.11.fs: domain 3 of 6, from 1129 to 1218: score 63.9, E = 1e-17 *->PsaP.tnltvtdvtstsltlsWspPt...gngpitgYevtyRqpkng Ps+P++n+++ ++ts+ +++sWs P++++ ng++ gY+v ++ KIAA1132 1129 PSQPpENVRALSITSDVAVISWSEPPrstLNGVLKGYRVIF-WSLYV 1174 ge....wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* ++ ++ +++t+++ ++l+g + t+Y+v+V A++++G+G +S KIAA1132 1175 DGewgeMQNITTTRER--VELRGMEKFTNYSVQVLAYTQAGdGVRS 1218 PF00041.11.ls: domain 3 of 6, from 1129 to 1218: score 65.9, E = 1.2e-16 *->PsaP.tnltvtdvtstsltlsWspPt...gngpitgYevtyRqpkng Ps+P++n+++ ++ts+ +++sWs P++++ ng++ gY+v ++ KIAA1132 1129 PSQPpENVRALSITSDVAVISWSEPPrstLNGVLKGYRVIF-WSLYV 1174 ge....wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* ++ ++ +++t+++ ++l+g + t+Y+v+V A++++G+G +S KIAA1132 1175 DGewgeMQNITTTRER--VELRGMEKFTNYSVQVLAYTQAGdGVRS 1218 PF00041.11.ls: domain 4 of 6, from 1230 to 1316: score 71.2, E = 3.1e-18 *->PsaPtnltvtdvtstsltlsWspPt.gngpitgYevtyRqpkngge. P++P ++++ + +++s+++sW pPt++ng+i +Y++ + ++ ++g++ KIAA1132 1230 PGPPAGIKAVPSSASSVVVSWLPPTkPNGVIRKYTIFC-SSPGSGQp 1275 .wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* + e+ +++ + y + L+ g +Y ++V+Av+ +G+G S KIAA1132 1276 aPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGrGNSS 1316 PF00041.11.fs: domain 4 of 6, from 1230 to 1316: score 69.2, E = 3.2e-19 *->PsaPtnltvtdvtstsltlsWspPt.gngpitgYevtyRqpkngge. P++P ++++ + +++s+++sW pPt++ng+i +Y++ + ++ ++g++ KIAA1132 1230 PGPPAGIKAVPSSASSVVVSWLPPTkPNGVIRKYTIFC-SSPGSGQp 1275 .wkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* + e+ +++ + y + L+ g +Y ++V+Av+ +G+G S KIAA1132 1276 aPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGrGNSS 1316 PF07679.6.ls: domain 8 of 8, from 1329 to 1419: score 40.4, E = 5.9e-09 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKd..Gqplssvl k++ v+ +++r+ C+ G+P P V W+Kd++++ +++ KIAA1132 1329 AKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDseDSAIPV-- 1373 lpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLt +++ ++ +g tL + v+ +DsG YtC+AtN +G ++ ++L KIAA1132 1374 SMDGHRLIHTNG-----TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLL 1418 V<-* V KIAA1132 1419 V 1419 PF00047.15.fs: domain 10 of 10, from 1343 to 1404: score 28.6, E = 4.2e-07 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvt.ssenngdsty ++v+L+C + g+p + v W++++ + +v+ ++ ++++t KIAA1132 1343 MKDVRLPCNS--VGDPAPAVKWTKDSEdSAiPVSMDgHRLIHTNGT- 1386 qtsLtitnvtpeDggtYtCvv<-* L +++v+ eD+g+YtC++ KIAA1132 1387 ---LLLRAVKAEDSGYYTCTA 1404 PF00047.15.ls: domain 10 of 10, from 1343 to 1404: score 30.5, E = 5.3e-06 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvt.ssenngdsty ++v+L+C + g+p + v W++++ + +v+ ++ ++++t KIAA1132 1343 MKDVRLPCNS--VGDPAPAVKWTKDSEdSAiPVSMDgHRLIHTNGT- 1386 qtsLtitnvtpeDggtYtCvv<-* L +++v+ eD+g+YtC++ KIAA1132 1387 ---LLLRAVKAEDSGYYTCTA 1404 PF07679.6.fs: domain 10 of 10, from 1344 to 1419: score 46.9, E = 4.5e-13 *->esarfeCkVtGtPePtVsWfKd..GqplssvllpsdrfkvtydgGsg +++r+ C+ G+P P V W+Kd++++ +++ +++ ++ +g KIAA1132 1344 KDVRLPCNSVGDPAPAVKWTKDseDSAIPV--SMDGHRLIHTNG--- 1385 tytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV<-* tL + v+ +DsG YtC+AtN +G ++ ++L V KIAA1132 1386 --TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1419 PF00041.11.ls: domain 5 of 6, from 1423 to 1506: score 76.1, E = 1e-19 *->PsaPtnltvtdvtstsltlsWspPt.gngpitgYevtyRqpknggew P++P+ ltv+ ++++s+tl+W p ++g++ i g+ ++y + +n++ew KIAA1132 1423 PDQPR-LTVSKTSASSITLTWIPGDnGGSSIRGFVLQY-SVDNSEEW 1467 keltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* k + ++++++s+ l Lk gt Y+v+++A n +G+G+ S KIAA1132 1468 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGsGRIS 1506 PF00041.11.fs: domain 5 of 6, from 1423 to 1506: score 74.1, E = 1.2e-20 *->PsaPtnltvtdvtstsltlsWspPt.gngpitgYevtyRqpknggew P++P+ ltv+ ++++s+tl+W p ++g++ i g+ ++y + +n++ew KIAA1132 1423 PDQPR-LTVSKTSASSITLTWIPGDnGGSSIRGFVLQY-SVDNSEEW 1467 keltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* k + ++++++s+ l Lk gt Y+v+++A n +G+G+ S KIAA1132 1468 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGsGRIS 1506 PF00041.11.ls: domain 6 of 6, from 1520 to 1602: score 16.8, E = 0.0031 *->PsaPtnltvtdvtstsltlsWspPt.gngpitgYevtyRqpknggew s+ + l +t ++st ++l+ + +g+ pit ++yR pk g + KIAA1132 1520 FSKDQHL-FTHINSTHARLNLQGWNnGGCPITAIVLEYR-PK-GTWA 1563 keltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* + +++ ++ lt L++ t Y++r +A n +G G e+ KIAA1132 1564 WQGLRANSSGEVFLTELREATWYELRMRACNSAGcGNET 1602 //