hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/smart.HMMs.bin Sequence file: /db/iprscan/tmp/20080501/iprscan-20080501-18164782/chunk_1/iprscan-20080501-18164782.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA1132 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- SM00408 359.7 1.9e-103 9 SM00409 321.6 5.2e-92 10 SM00060 253.5 1.7e-71 6 SM00406 38.8 7.3e-07 2 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- SM00409 1/10 71 161 .. 1 58 [] 6.2 40 SM00408 1/9 77 149 .. 1 56 [] 6.2 1.3 SM00409 2/10 170 258 .. 1 58 [] 26.8 0.0031 SM00409 3/10 271 351 .. 1 58 [] 57.4 1.8e-12 SM00408 2/9 277 340 .. 1 56 [] 63.5 2.8e-14 SM00406 1/2 281 335 .. 1 76 [] 33.0 4e-05 SM00409 4/10 360 442 .. 1 58 [] 35.3 8.5e-06 SM00408 3/9 366 432 .. 1 56 [] 57.9 1.3e-12 SM00409 5/10 453 542 .. 1 58 [] 35.8 5.9e-06 SM00408 4/9 459 531 .. 1 56 [] 45.6 6.8e-09 SM00409 6/10 550 633 .. 1 58 [] 27.6 0.0017 SM00408 5/9 556 621 .. 1 56 [] 38.2 1.1e-06 SM00409 7/10 641 726 .. 1 58 [] 36.9 2.7e-06 SM00408 6/9 647 715 .. 1 56 [] 35.6 6.7e-06 SM00409 8/10 735 825 .. 1 58 [] 39.3 5.1e-07 SM00408 7/9 741 813 .. 1 56 [] 48.7 7.8e-10 SM00409 9/10 834 924 .. 1 58 [] 27.1 0.0025 SM00408 8/9 840 913 .. 1 56 [] 10.1 0.49 SM00060 1/6 926 1010 .. 1 69 [] 38.5 8.8e-07 SM00060 2/6 1026 1114 .. 1 69 [] 54.6 1.3e-11 SM00060 3/6 1129 1215 .. 1 69 [] 45.7 6e-09 SM00060 4/6 1230 1313 .. 1 69 [] 49.4 4.7e-10 SM00409 10/10 1338 1420 .. 1 58 [] 29.3 0.00053 SM00408 9/9 1344 1409 .. 1 56 [] 54.0 1.9e-11 SM00406 2/2 1345 1404 .. 1 76 [] 5.8 0.77 SM00060 5/6 1423 1503 .. 1 69 [] 46.1 4.6e-09 SM00060 6/6 1518 1599 .. 1 69 [] 19.1 0.6 Alignments of top-scoring domains: SM00409: domain 1 of 10, from 71 to 161: score 6.2, E = 40 *->pp.vtvkeGesvtLtC.as.....titWy.................. ++vt + v+ +C+a+++++ ++Wy ++++ + ++ ++ + KIAA1132 71 LQqVTFSSSVGVVVPCpAAgspsaALRWYlatgddiydvphirhvha 117 ...LtI.nvtpeDse....sgGtYtCaat..sgsasseqgttLtVl<-* +++L++ + +p+ + ++ +Y+C+a++ +g++ s ++++++ KIAA1132 118 ngtLQLyPFSPSAFNsfihD-NDYFCTAEnaAGKIRS-PNIRVKAV 161 SM00408: domain 1 of 9, from 77 to 149: score 6.2, E = 1.3 *->leGqsVtLtCpasgdpvpnItWlk..gkplp.........sgstLti + V+ +Cpa+g+p + +W+ +g + + ++ ++ + ++tL++ KIAA1132 77 SSSVGVVVPCPAAGSPSAALRWYLatGDDIYdvphirhvhANGTLQL 123 knvsle......DsGlYtCvArNsvg<-* ++s++ ++ ++ Y C+A+N++g KIAA1132 124 YPFSPSafnsfiHDNDYFCTAENAAG 149 SM00409: domain 2 of 10, from 170 to 258: score 26.8, E = 0.0031 *->pp.vtvkeGesvtLtC.as........titWy............... +++ ++G ++++C ++++ + ++W +++ + + ++ + KIAA1132 170 VEdQRSMRGNVAVFKClIPssvqeyvsVVSWEkdtvsiipenrffit 216 ....LtI.nvtpeDsesgGtYtCaat....sgsasseqgttLtVl<-* +++L I++v++eD+ tY+C +++ ++ + +s +g++L+V+ KIAA1132 217 yhggLYIsDVQKEDA--LSTYRCITKhkysGETRQS-NGARLSVT 258 SM00409: domain 3 of 10, from 271 to 351: score 57.4, E = 1.8e-12 *->pp.vtvkeGesvtLtC.as.....titWy.................. +++v +G +v+L+C+as+ + + i+W++++++ + +++ +++ ++ KIAA1132 271 FHsQEVWAGHTVELPCtASgypipAIRWLkdgrplpadsrwtkritg 317 LtI.nvtpeDsesgGtYtCaat..sgsasseqgttLtVl<-* LtI++++ eDs GtY C++t++ gsa++ + L V KIAA1132 318 LTIsDLRTEDS---GTYICEVTntFGSAEA--TGILMVI 351 SM00408: domain 2 of 9, from 277 to 340: score 63.5, E = 2.8e-14 *->leGqsVtLtCpasgdpvpnItWlk.gkplp.......sgstLtiknv G +V+L+C asg+p p I+Wlk+g plp +++ ++ Lti++ KIAA1132 277 WAGHTVELPCTASGYPIPAIRWLKdGRPLPadsrwtkRITGLTISDL 323 sleDsGlYtCvArNsvg<-* + eDsG+Y C+++N g KIAA1132 324 RTEDSGTYICEVTNTFG 340 SM00406: domain 1 of 2, from 281 to 335: score 33.0, E = 4e-05 *->svtLsCkaSgftf.yvsWvrqpPsstgkgkglewlgysykgRvtisk +v+L+C+aSg+ + + W++ g++l KIAA1132 281 TVELPCTASGYPIpAIRWLKD-------GRPL-------------PA 307 dtltraskndvsLtisnLrpeDtgtYyCar<-* d+ r+ k+ Ltis+Lr eD+gtY+C++ KIAA1132 308 DS--RWTKRITGLTISDLRTEDSGTYICEV 335 SM00409: domain 4 of 10, from 360 to 442: score 35.3, E = 8.5e-06 *->pp.vtvkeGesvtLtC.as.....titWy.................. p+++ G++v L+C ++++ ti+Wy+++ ++ + ++ + KIAA1132 360 PKkLKTGIGSTVILSCaLTgspefTIRWYrntelvlpdeaisirgls 406 ...LtI.nvtpeDsesgGtYtCaat.sgsasseqgttLtVl<-* + +L I+++++++s G Y+C at++ ++ + + ++ l KIAA1132 407 netLLItSAQKSHS---GAYQCFATrKAQTAQ--DFAIIAL 442 SM00408: domain 3 of 9, from 366 to 432: score 57.9, E = 1.3e-12 *->leGqsVtLtCpasgdpvpnItWlk..gkplp.........sgstLti +G +V+L C +g+p+ +I+W+++++ lp++ + ++ s+ tL i KIAA1132 366 GIGSTVILSCALTGSPEFTIRWYRntELVLPdeaisirglSNETLLI 412 knvsleDsGlYtCvArNsvg<-* +++++++sG Y+C+A+ ++ KIAA1132 413 TSAQKSHSGAYQCFATRKAQ 432 SM00409: domain 5 of 10, from 453 to 542: score 35.8, E = 5.9e-06 *->pp.vtvkeGesvtLtC.as.....titWy.................. ++ +v++Ge +L C a++ +++t+tW ++ + +++++++++ + KIAA1132 453 FSeKVVNPGEQFSLMCaAKgapppTVTWAlddepivrdgshrtnqyt 499 .........LtI.nvtpeDsesgGtYtCaat..sgsasseqgttLtVl<- +++++ +++++++ + D G+Y+C+a++ gsa+ +++ V+ KIAA1132 500 msdgttishMNVtGPQIRDG---GVYRCTARnlVGSAEY--QARINVR 542 * KIAA1132 - - SM00408: domain 4 of 9, from 459 to 531: score 45.6, E = 6.8e-09 *->leGqsVtLtCpasgdpvpnItWlk.gkplp................s ++G++++L C a g+p p++tW +++p+ +++++++++ + +++++ KIAA1132 459 NPGEQFSLMCAAKGAPPPTVTWALdDEPIVrdgshrtnqytmsdgtT 505 gstLtiknvsleDsGlYtCvArNsvg<-* s+ +++ + D G+Y+C+ArN vg KIAA1132 506 ISHMNVTGPQIRDGGVYRCTARNLVG 531 SM00409: domain 6 of 10, from 550 to 633: score 27.6, E = 0.0017 *->pp.vtvkeGesvtLtC.as.....titWy.................. +++t+++G + ++C++ + + +i+Wy++ ++++++ ++ KIAA1132 550 MRnITAVAGRDTLINCrVIgypyySIKWYkdalllpdnhrqvvfeng 596 .LtI.nvtpeDsesgGtYtCaat...sgsasseqgttLtVl<-* +L +++v++ +G+Y C + + s+s+ ++++ V+ KIAA1132 597 tLKLtDVQKGMD--EGEYLCSVLiqpQLSISQ--SVHVAVK 633 SM00408: domain 5 of 9, from 556 to 621: score 38.2, E = 1.1e-06 *->leGqsVtLtCpasgdpvpnItWlk.gkplp........sgstLtikn G++ ++C++ g+p ++I+W+k+ lp+++++ ++tL++++ KIAA1132 556 VAGRDTLINCRVIGYPYYSIKWYKdALLLPdnhrqvvfENGTLKLTD 602 vs.leDsGlYtCvArNsvg<-* v++ D+G+Y C++ KIAA1132 603 VQkGMDEGEYLCSVLIQPQ 621 SM00409: domain 7 of 10, from 641 to 726: score 36.9, E = 2.7e-06 *->pp.vtvkeGesvtLtC.as......titWy................. + ++ G+ + ++C +s+++ + +itW+++++ ++++ + ++ KIAA1132 641 FEfPPASIGQLLYIPCvVSsgdmpiRITWRkdgqviisgsgvtiesk 687 .....LtI.nvtpeDsesgGtYtCaat..sgsasseqgttLtVl<-* ++L+I++v++ + G+YtC a++ + ++s + +L+V+ KIAA1132 688 efmssLQIsSVSLKHN---GNYTCIASnaAATVSR--ERQLIVR 726 SM00408: domain 6 of 9, from 647 to 715: score 35.6, E = 6.7e-06 *->leGqsVtLtCp.asgdpvpnItWlk.gkplp...........sgstL +Gq + ++C sgd ItW+k+g+ + ++++ + ++++ s+L KIAA1132 647 SIGQLLYIPCVvSSGDMPIRITWRKdGQVIIsgsgvtieskeFMSSL 693 tiknvsleDsGlYtCvArNsvg<-* +i++vsl + G+YtC+A+N++ KIAA1132 694 QISSVSLKHNGNYTCIASNAAA 715 SM00409: domain 8 of 10, from 735 to 825: score 39.3, E = 5.1e-07 *->pp.vtvkeGesvtLtC.as.....titWy.................. p ++ + G +L+C++ + +++ + W++ ++++++++ ++ + ++ KIAA1132 735 PNnQDGIYGKAGVLNCsVDgypppKVMWKhakgsgnpqqyhpvpltg 781 .........LtI.nvtpeDsesgGtYtCaat..sgsasseqgttLtVl<- + + ++++L I++v +eD G Y C+a+++ g++ s ++ LtV+ KIAA1132 782 riqilpnssLLIrHVLEEDI---GYYLCQASngVGTDIS-KSMFLTVK 825 * KIAA1132 - - SM00408: domain 7 of 9, from 741 to 813: score 48.7, E = 7.8e-10 *->leGqsVtLtCpasgdpvpnItWlk..gkplp...............s + G + +L+C ++g+p p ++W++ +g+ p++ ++ + +++ + KIAA1132 741 IYGKAGVLNCSVDGYPPPKVMWKHakGSGNPqqyhpvpltgriqilP 787 gstLtiknvsleDsGlYtCvArNsvg<-* +s+L i++v +eD G+Y C+A+N vg KIAA1132 788 NSSLLIRHVLEEDIGYYLCQASNGVG 813 SM00409: domain 9 of 10, from 834 to 924: score 27.1, E = 0.0025 *->pp.vtvkeGesvtLtC.as.....titWy.................. p ++ + G +L+C+a + + i+W ++++ ++++ + + KIAA1132 834 PNtTIAIKGHAKELNCtARgerpiIIRWEkgdtvidpdrvmryaiat 880 ..........LtI.nvtpeDsesgGtYtCaat..sgsasseqgttLtVl< +++++ ++L ++++ + Ds + C a +++g++ + ++LtV+ KIAA1132 881 kdngdevvstLKLkPADRGDS---VFFSCHAInsYGEDRG--LIQLTVQ 924 -* KIAA1132 - - SM00408: domain 8 of 9, from 840 to 913: score 10.1, E = 0.49 *->leGqsVtLtCpasgdpvpnItWlk.gkplp................. + G + +L+C a+g I+W k+++ +++++ + +++++++ KIAA1132 840 IKGHAKELNCTARGERPIIIRWEKgDTVIDpdrvmryaiatkdngde 886 sgstLtiknvsleDsGlYtCvArNsvg<-* stL++k++ ++Ds +C A Ns g KIAA1132 887 VVSTLKLKPADRGDSVFFSCHAINSYG 913 SM00060: domain 1 of 6, from 926 to 1010: score 38.5, E = 8.8e-07 *->PgpPsnptelrvtdvtststsdltsvtlsWepP..........ivgY P+ P+ l++++v ++ s++l+W+ ++++ + ++Y KIAA1132 926 PPDPPE---LEIREVKAR------SMNLRWTQRfdgnsiitgfDIEY 963 r.....................ytltgLkPgaepwteYefrVrAvngnda ++++++++ ++++++ +++ +++ + +L+P + Y++r + +n+ KIAA1132 964 KnksdswdfkqstrnisptinqANIVDLHPA----SVYSIRMYSFNK--I 1007 Geg<-* G++ KIAA1132 1008 GRS 1010 SM00060: domain 2 of 6, from 1026 to 1114: score 54.6, E = 1.3e-11 *->PgpPsnptelrvtdvtststsdltsvtlsWepP............iv gpP + +++ +vts s++++W++P+++ ++ ++ + KIAA1132 1026 DGPPMD---VTLQPVTSQ------SIQVTWKAPkkelqngvirgyQI 1063 gYr.......................ytltgLkPgaepwteYefrVrAvn gYr+++++++++ + ++ + ++++++ytl++Lk +Y + V+A+n KIAA1132 1064 GYRenspgsngqysivemkatgdsevYTLDNLKKF----AQYGVVVQAFN 1109 gndaGeg<-* + aG g KIAA1132 1110 R--AGTG 1114 SM00060: domain 3 of 6, from 1129 to 1215: score 45.7, E = 6e-09 *->PgpPsnptelrvtdvtststsdltsvtlsWepP........ivgYr. P+ P+ + +r+ ++ts+ +++sW++P+ + ++ gYr+ KIAA1132 1129 PSQPPEN--VRALSITSD------VAVISWSEPprstlngvLKGYRv 1167 .......................ytltgLkPgaepwteYefrVrAvngnd ++ +++++++ ++ +++++++ l+g + t+Y+++V A++ KIAA1132 1168 ifwslyvdgewgemqnitttrerVELRGMEKF----TNYSVQVLAYTQ-- 1211 aGeg<-* aG g KIAA1132 1212 AGDG 1215 SM00060: domain 4 of 6, from 1230 to 1313: score 49.4, E = 4.7e-10 *->PgpPsnptelrvtdvtststsdltsvtlsWepP......ivgYr... PgpP + +++++ +++ sv++sW pP ++++ i Y+ KIAA1132 1230 PGPPAG---IKAVPSSAS------SVVVSWLPPtkpngvIRKYTifc 1267 .....................ytltgLkPgaepwteYefrVrAvngndaG ++++++++ +++ ++++++ y++ +L g ++Y +V+Av++ aG KIAA1132 1268 sspgsgqpapseyetspeqlfYRIAHLNRG----QQYLLWVAAVTS--AG 1311 eg<-* +g KIAA1132 1312 RG 1313 SM00409: domain 10 of 10, from 1338 to 1420: score 29.3, E = 0.00053 *->pp.vtvkeGesvtLtC.as.....titWy.................. + + k +v+L+C+ +++ + ++W++++ ++ + + ++++ KIAA1132 1338 VTtPWMK---DVRLPCnSVgdpapAVKWTkdsedsaipvsmdghrli 1381 .....LtI.nvtpeDsesgGtYtCaat..sgsasseqgttLtVl<-* +++++L ++ v++eDs G YtC+at+++g ++ ++L V+ KIAA1132 1382 htngtLLLrAVKAEDS---GYYTCTATntGGFDTI--IVNLLVQ 1420 SM00408: domain 9 of 9, from 1344 to 1409: score 54.0, E = 1.9e-11 *->leGqsVtLtCpasgdpvpnItWlk...gkplp..........sgstL +V+L+C gdp+p ++W+k+++++ +p + ++++ ++++tL KIAA1132 1344 ---KDVRLPCNSVGDPAPAVKWTKdseDSAIPvsmdghrlihTNGTL 1387 tiknvsleDsGlYtCvArNsvg<-* ++ v+ eDsG+YtC+A+N g KIAA1132 1388 LLRAVKAEDSGYYTCTATNTGG 1409 SM00406: domain 2 of 2, from 1345 to 1404: score 5.8, E = 0.77 *->svtLsCkaSgftf.yvsWvrqpPsstgkgkglewlgysykgRvtisk +v+L+C g+ + v W + ++ R+ + KIAA1132 1345 DVRLPCNSVGDPApAVKWTKD-------SEDSAIPVSMDGHRLIHTN 1384 dtltraskndvsLtisnLrpeDtgtYyCar<-* +L ++ +++eD+g+Y+C KIAA1132 1385 ----------GTLLLRAVKAEDSGYYTCTA 1404 SM00060: domain 5 of 6, from 1423 to 1503: score 46.1, E = 4.6e-09 *->PgpPsnptelrvtdvtststsdltsvtlsWepP..........ivgY P+ P+ l+v+ ++++ s+tl+W p ++++++ + +++Y KIAA1132 1423 PDQPR----LTVSKTSAS------SITLTWIPGdnggssirgfVLQY 1459 r..................ytltgLkPgaepwteYefrVrAvngndaGeg +++++++++++ ++++++++l+ Lk g t Y+++++A+n+ +G+g KIAA1132 1460 SvdnseewkdvfisssersFKLDSLKCG----TWYKVKLAAKNS--VGSG 1503 <-* KIAA1132 - - SM00060: domain 6 of 6, from 1518 to 1599: score 19.1, E = 0.6 *->PgpPsnptelrvtdvtststsdltsvtlsWepP...........ivg P+ ++ +t+++st +++l + ++++ + +++ KIAA1132 1518 PSFSKDQ--HLFTHINST------HARLNLQ-GwnnggcpitaiVLE 1555 Yr.................ytltgLkPgaepwteYefrVrAvngndaGeg Yr+++++ +++ + ++++++ lt L++ t Ye r rA n+ aG g KIAA1132 1556 YRpkgtwawqglranssgeVFLTELREA----TWYELRMRACNS--AGCG 1599 <-* KIAA1132 - - //