hmmpfam - search one or more sequences against HMM database
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file:                 /db/iprscan/data/Pfam.bin
Sequence file:            /db/iprscan/tmp/20080501/iprscan-20080501-20415549/chunk_1/iprscan-20080501-20415549.nocrc
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Query sequence: KIAA1220
Accession:      [none]
Description:    [none]

Scores for sequence family classification (score includes all domains):
Model        Description                                Score    E-value  N 
--------     -----------                                -----    ------- ---
PF00060.17.ls Ligand-gated ion channel                   434.2   1.7e-127   1
PF00060.17.fs Ligand-gated ion channel                   432.3   5.9e-127   1
PF01094.18.fs Receptor family ligand binding region       83.3    1.7e-22   1
PF00497.10.fs Bacterial extracellular solute-binding p    62.9    1.4e-16   2

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
PF01094.18.fs   1/1       1   183 [.   202   421 .]    83.3  1.7e-22
PF00497.10.fs   1/2     245   329 ..    23    98 ..    59.4  1.2e-15
PF00060.17.fs   1/1     344   634 ..     1   304 []   432.3 5.9e-127
PF00060.17.ls   1/1     344   634 ..     1   304 []   434.2 1.7e-127

Alignments of top-scoring domains:
PF01094.18.fs: domain 1 of 1, from 1 to 183: score 83.3, E = 1.7e-22
                   *->likskarvivlcgssddlgllkrqilrqarelGlmsggYvwiltdlw
                      + +++ r  +l  s++ +    ++++ +a e +l+s + +w++++  
    KIAA1220     1    RYRDTLRRAILLLSPQGA----HSFINEAVETNLASKDSHWVFVNEE 43   

                   sdsldsqgdgsdlpwariagadeGlltartfpfqldndkareaakgvlgi
                    ++                               +  d  + a++ ++++
    KIAA1220    44 ISDP------------------------------EILDLVHSALGRMTVV 63   

                   tlk.p.spefqeflerlkk...........sdtevnayallaYDAVyllA
                   ++  p+ +++q+ ++++++ ++   ++++++ + + +  l++YD+V++lA
    KIAA1220    64 RQIfPsAKDNQKCTRNNHRissllcdpqegYLQMLQISNLYLYDSVLMLA 113  

                   hAlnealrddpngtaglcnacrdsrvddasnalgglnlglmkw.dGsqll
                   +A+++ l+d+++++ ++ n++r+s                ++w+ G ++l
    KIAA1220   114 NAFHRKLEDRKWHSMASLNCIRKST---------------KPWnGGRSML 148  

                   eylrnkvnFeGltGdvqfddnggrrpdyslvilnwdg<-*
                   + +++ ++++GltG + f + +  +p  +++il +++   
    KIAA1220   149 DTIKK-GHITGLTGVMEFRE-DSSNPYVQFEILGTTY    183  

PF00497.10.fs: domain 1 of 2, from 245 to 329: score 59.4, E = 1.2e-15
                   *->lvGFDvDlakAiakklkgvKvef............vptdwdglipaL
                      ++GF +D++ A+ak l g+K e+ + ++++ +++  +t+w+g+i  L
    KIAA1220   245    YKGFSIDVLDALAKAL-GFKYEIyqapdgryghqlHNTSWNGMIGEL 290  

                   qsgkvDviiagmtiTpeRkkkvdFFSdPYytsgavlvtvkk<-*
                    s+++D++i+++tiTpeR+ +vdF S  Y++ + +++  kk   
    KIAA1220   291 ISKRADLAISAITITPERESVVDF-SKRYMDYSVGIL-IKK    329  

PF00060.17.fs: domain 1 of 1, from 344 to 634: score 432.3, E = 5.9e-127
                   *->slevWlcilaayllvsvvlflverwfsPyewrgnrqprpcneddqsp
                      + +vW+ci+aa+ +v+v++f+++r +     +   qprp        
    KIAA1220   344    DFAVWACIAAAIPVVGVLIFVLNR-IQAVRAQSAAQPRP-------- 381  

                   eeepnqftlsnslWFsfgalmqQGcdelPrslSgRivvgvWwfFaLilis
                      + + tl++++W ++ga++qQG++ ++ s+ +Riv+g Ww+F+Li++s
    KIAA1220   382 ---SASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCS 428  

                   SYTANLAAFLTvermqspIesleDLakqnpkieYGtlrggstftffkesk
                   SYTANLAAFLTv+rm+ pI++++DL+kq  +++YGt+r+++++++f+ + 
    KIAA1220   429 SYTANLAAFLTVSRMDNPIRTFQDLSKQV-EMSYGTVRDSAVYEYFRAKG 477  

                   ......iptyrrmweymnsrkgrskaPsvfvksyeeGvqrVrngpengly
                   +++ ++++t+  +w+ ++++ g     +++v+s+ eG++++++g  n  y
    KIAA1220   478 tnpleqDSTFAELWRTISKNGG----ADNCVSSPSEGIRKAKKG--N--Y 519  

                   AFlmEstyleyevarnpdCdLttvGevlfgtkGYGIAlpkgSPlrdklsl
                   AFl++++++ey++ +++dC  t +G+ ++ +kGYGIAl++gSP+rd++s+
    KIAA1220   520 AFLWDVAVVEYAALTDDDCSVTVIGN-SISSKGYGIALQHGSPYRDLFSQ 568  

                   AILeLsEsGelekLenKWwkkkgkCpsesta...vsssqLglenfaGlFl
                   +ILeL+ +G+l+ L++KWw++ g C+++s+a+ + ++++L l++faG+F+
    KIAA1220   569 RILELQDTGDLDVLKQKWWPHMGRCDLTSHAsaqADGKSLKLHSFAGVFC 618  

                   iLgiGlvLallvalfE<-*
                   iL+iGl+La+lva++E   
    KIAA1220   619 ILAIGLLLACLVAALE    634  

PF00060.17.ls: domain 1 of 1, from 344 to 634: score 434.2, E = 1.7e-127
                   *->slevWlcilaayllvsvvlflverwfsPyewrgnrqprpcneddqsp
                      + +vW+ci+aa+ +v+v++f+++r +     +   qprp        
    KIAA1220   344    DFAVWACIAAAIPVVGVLIFVLNR-IQAVRAQSAAQPRP-------- 381  

                   eeepnqftlsnslWFsfgalmqQGcdelPrslSgRivvgvWwfFaLilis
                      + + tl++++W ++ga++qQG++ ++ s+ +Riv+g Ww+F+Li++s
    KIAA1220   382 ---SASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCS 428  

                   SYTANLAAFLTvermqspIesleDLakqnpkieYGtlrggstftffkesk
                   SYTANLAAFLTv+rm+ pI++++DL+kq  +++YGt+r+++++++f+ + 
    KIAA1220   429 SYTANLAAFLTVSRMDNPIRTFQDLSKQV-EMSYGTVRDSAVYEYFRAKG 477  

                   ......iptyrrmweymnsrkgrskaPsvfvksyeeGvqrVrngpengly
                   +++ ++++t+  +w+ ++++ g     +++v+s+ eG++++++g  n  y
    KIAA1220   478 tnpleqDSTFAELWRTISKNGG----ADNCVSSPSEGIRKAKKG--N--Y 519  

                   AFlmEstyleyevarnpdCdLttvGevlfgtkGYGIAlpkgSPlrdklsl
                   AFl++++++ey++ +++dC  t +G+ ++ +kGYGIAl++gSP+rd++s+
    KIAA1220   520 AFLWDVAVVEYAALTDDDCSVTVIGN-SISSKGYGIALQHGSPYRDLFSQ 568  

                   AILeLsEsGelekLenKWwkkkgkCpsesta...vsssqLglenfaGlFl
                   +ILeL+ +G+l+ L++KWw++ g C+++s+a+ + ++++L l++faG+F+
    KIAA1220   569 RILELQDTGDLDVLKQKWWPHMGRCDLTSHAsaqADGKSLKLHSFAGVFC 618  

                   iLgiGlvLallvalfE<-*
                   iL+iGl+La+lva++E   
    KIAA1220   619 ILAIGLLLACLVAALE    634  

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