hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080502/iprscan-20080502-00030881/chunk_1/iprscan-20080502-00030881.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA1338 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00069.15.fs Protein kinase domain 280.0 4.1e-81 4 PF00069.15.ls Protein kinase domain 218.4 1.5e-62 2 PF07714.7.fs Protein tyrosine kinase 91.7 1.6e-26 4 PF00587.15.ls tRNA synthetase class II core domain (G, -29.4 0.0017 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF00069.15.ls 1/2 161 385 .. 1 287 [] 32.4 1.6e-10 PF00069.15.fs 1/4 178 289 .. 31 156 .. 59.6 8.5e-17 PF07714.7.fs 1/4 198 289 .. 60 156 .. 37.5 8.3e-11 PF00069.15.fs 2/4 343 385 .. 232 287 .] 24.5 8e-07 PF00069.15.fs 3/4 436 503 .. 1 71 [. 50.4 3.4e-14 PF07714.7.fs 2/4 436 498 .. 1 71 [. 19.8 1.2e-05 PF00069.15.ls 2/2 436 847 .. 1 287 [] 186.0 8.4e-53 PF00069.15.fs 4/4 643 847 .. 74 287 .] 145.6 3e-41 PF07714.7.fs 3/4 680 719 .. 124 163 .. 31.6 4.5e-09 PF00587.15.ls 1/1 909 1069 .. 1 226 [] -29.4 0.0017 Alignments of top-scoring domains: PF00069.15.ls: domain 1 of 2, from 161 to 385: score 32.4, E = 1.6e-10 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ++ +k G ++ ++ +i+k+k+ + +t KIAA1338 161 LQWQKKMGP------FLTSQEKE-------KIDKCKKQIQGTET--- 191 lsEiqilkrLsHpNIvrlidvfed..kdhly..lVlEycegGLrvldLfd E l +LsHpN+vr++ + +++d++ ++ E+ g +L + KIAA1338 192 --EFNSLVKLSHPNVVRYLAMNLKeqDDSIVvdILVEHISGV----SLAA 235 ylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld +ls +gp+ + ++++++ Q+l+gl+YLHsn+++H L +N+L+d KIAA1338 236 HLS---HSGPI--PVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVD 280 nngvvdaflKiaDFGlAkkls........t.sss.lttfvGTpwYmAPEv +g+v Ki+D ++k l + +++ ++ +++++ + KIAA1338 281 AEGTV----KITDYSISKRLAdickedvfEqTRVrFSDNA---------- 316 llggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgp l + g+k DvW lG++l l G +++ + i +l+ KIAA1338 317 -L-PYKTGKKGDVWRLGLLLLSLSQG----QEC----GEYPVTIPSDLP- 355 plefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilq +++d++kkc ++D ++R++++++l+ KIAA1338 356 ------------------------ADFQDFLKKCVCLDDKERWSPQQLLK 381 HPwf<-* H ++ KIAA1338 382 HSFI 385 PF00069.15.fs: domain 1 of 4, from 178 to 289: score 59.6, E = 8.5e-17 *->iikkrkekskkdktarrlsEiqilkrLsHpNIvrlidvfed..kdhl +i+k+k+ + +t E l +LsHpN+vr++ + +++d++ KIAA1338 178 KIDKCKKQIQGTET-----EFNSLVKLSHPNVVRYLAMNLKeqDDSI 219 y..lVlEycegGLrvldLfdylsetrrkgpllfsedeakkialQilrgle ++ E+ g +L ++ls +gp+ + ++++++ Q+l+gl+ KIAA1338 220 VvdILVEHISGV----SLAAHLS---HSGPI--PVHQLRRYTAQLLSGLD 260 YLHsngiiHRDLKPeNILldnngvvdaflKiaD<-* YLHsn+++H L +N+L+d +g+v Ki+D KIAA1338 261 YLHSNSVVHKVLSASNVLVDAEGTV----KITD 289 PF07714.7.fs: domain 1 of 4, from 198 to 289: score 37.5, E = 8.3e-11 *->klGdHpNiVrLlGvctkegePggpg.lyiVtEymegGdLldfLrkhr kl +HpN+Vr+l+ +k ++ ++ + i +E+ g +L +L + KIAA1338 198 KL-SHPNVVRYLAMNLK-EQD-DSIvVDILVEHISGVSLAAHLSH-- 239 egrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVsenlvVKIs +p+++++L + +Q +G++YL+s+ vH L A N+LV+ +++VKI+ KIAA1338 240 -SGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKIT 288 D<-* D KIAA1338 289 D 289 PF00069.15.fs: domain 2 of 4, from 343 to 385: score 24.5, E = 8e-07 *->gpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlta +++++ +p + + +++d++kkc ++D ++R+++ KIAA1338 343 CGEYPVTIPSDLP-------------ADFQDFLKKCVCLDDKERWSP 376 eeilqHPwf<-* +++l+H ++ KIAA1338 377 QQLLKHSFI 385 PF00069.15.fs: domain 3 of 4, from 436 to 503: score 50.4, E = 3.4e-14 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e l+ lG+G+fG V k ++k +g+ +AvK+i+ ++ ++++++ KIAA1338 436 FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKG- 481 lsEiqilkrLsHpNIvrlidvfed<-* E+ +l rL+H+NIvr++ ++ + KIAA1338 482 --EVTLLSRLHHENIVRYYNAWIE 503 PF07714.7.fs: domain 2 of 4, from 436 to 498: score 19.8, E = 1.2e-05 *->lklgkkLGeGaFGeVyk......GtlkgsgdgteikVAVKtLkeiga ++ ++ LG+GaFG V k +++ +G ++ AVK ++ + KIAA1338 436 FEELQLLGKGAFGAVIKvqnkldGCCY----------AVKRIPI-NP 471 seeeieredFlrEAsiMkklGdHpNiVrLl<-* +++ + E+ ++++l +H+NiVr++ KIAA1338 472 ASRQ--FRRIKGEVTLLSRL-HHENIVRYY 498 PF00069.15.ls: domain 2 of 2, from 436 to 847: score 186.0, E = 8.4e-53 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e l+ lG+G+fG V k ++k +g+ +AvK+i+ ++ ++++++ KIAA1338 436 FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKG- 481 lsEiqilkrLsHpNIvrlidvfed.......................... E+ +l rL+H+NIvr++ ++ ++++++ +++++++++++ ++++ + KIAA1338 482 --EVTLLSRLHHENIVRYYNAWIErherpagpgtpppdsgplakddraar 529 .................................................. +++ +++++ ++ + +++ +++ + +++++++ + + + ++++++++ KIAA1338 530 gqpasdtdgldsveaaapppilsssvewstsgersasarfpatgpgssdd 579 .................................................. ++++++++++ +++ + ++++++ +++++++++++++++ +++++ KIAA1338 580 edddedehggvfsqsflpasdsesdiifdnedensksqnqdedcnekngc 629 ...........kdhlylVlEycegGLrvldLfdylsetrrkgpllfsede ++++++ +++ +ly+ +Eyce+ L d + ++ + KIAA1338 630 hesepsvtteaVHYLYIQMEYCEKS----TLRDTID---QGLYR--DTVR 670 akkialQilrgleYLHsngiiHRDLKPeNILldnngvvdaflKiaDFGlA + + +++il gl+Y+H++g iHRDLKP NI+ld++++v Ki+DFGlA KIAA1338 671 LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHV----KIGDFGLA 716 kkls.................t.sss.lttfvGTpwYmAPEvll.ggngy + + ++++++++++ + ++s++lt+ vGT Y++PEv ++ + y KIAA1338 717 TDHLafsadskqddqtgdlikSdPSGhLTGMVGTALYVSPEVQGsTKSAY 766 gtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdsp +kvD +SlG+i++e+ +e + ++l +++ +++++f+++ KIAA1338 767 NQKVDLFSLGIIFFEMSYHPMVTASE-----RIFVLNQLRDPTSPKFPED 811 ewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +d + k++i+++Ln DP+kR+ta+e+l+++ + KIAA1338 812 FDDGEH-----------AKQKSVISWLLNHDPAKRPTATELLKSELL 847 PF00069.15.fs: domain 4 of 4, from 643 to 847: score 145.6, E = 3e-41 *->hlylVlEycegGLrvldLfdylsetrrkgpllfsedeakkialQilr +ly+ +Eyce+ L d + ++ + + + +++il KIAA1338 643 YLYIQMEYCEKS----TLRDTID---QGLYR--DTVRLWRLFREILD 680 gleYLHsngiiHRDLKPeNILldnngvvdaflKiaDFGlAkkls...... gl+Y+H++g iHRDLKP NI+ld++++v Ki+DFGlA + + ++ KIAA1338 681 GLAYIHEKGMIHRDLKPVNIFLDSDDHV----KIGDFGLATDHLafsads 726 ...........t.sss.lttfvGTpwYmAPEvll.ggngygtkvDvWSlG ++++++++ + ++s++lt+ vGT Y++PEv ++ + y +kvD +SlG KIAA1338 727 kqddqtgdlikSdPSGhLTGMVGTALYVSPEVQGsTKSAYNQKVDLFSLG 776 vilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsisrsef +i++e+ +e + ++l +++ +++++f+++ +d + KIAA1338 777 IIFFEMSYHPMVTASE-----RIFVLNQLRDPTSPKFPEDFDDGEH---- 817 rrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* k++i+++Ln DP+kR+ta+e+l+++ + KIAA1338 818 -------AKQKSVISWLLNHDPAKRPTATELLKSELL 847 PF07714.7.fs: domain 3 of 4, from 680 to 719: score 31.6, E = 4.5e-09 *->kGMeYLesknfvHRDLAARNcLVsenlvVKIsDFGLaRdi<-* +G++Y ++k+++HRDL N+ ++++ +VKI+DFGLa d+ KIAA1338 680 DGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDH 719 PF00587.15.ls: domain 1 of 1, from 909 to 1069: score -29.4, E = 0.0017 *->lrnalenfareeftkryGyqevdtPilepkelwerksGhwddyvdee +++ +++ +++ f+ r+G++ + tP l p+ h e KIAA1338 909 MQQHVCETIIRIFK-RHGAVQLCTPLLLPRNRQIY-E-H-----NE- 946 kmykfkdrggrfRaDHliekheldElasiaknkcgcGLtprFNLMFTIGP f+d++g + KIAA1338 947 -AALFMDHSG--------M--LV--------------------------- 958 gegyLrPtaevgitrlfkneilssyreLPlklyqigpcFRyEagsaGrpr +L +++ +++r+++++ + L lk+y i ++F rpr KIAA1338 959 ---MLPFDLRIPFARYVARNNI-----LNLKRYCIERVF--------RPR 992 rGlgRvR..eFtqvdaeiFgtpeqHPFsseeedeellklaeeilkdL.Gl + l R +++e + ++i ++ s +e++ ++ei ++++ l KIAA1338 993 K-LDRFHpkELLECAFDIVTSTTN----SFLPTAEIIYTIYEIIQEFpAL 1037 seepyrvvlsdrGdlggyasktgdleawlpae<-* e++y ++l+++ l + ++g e++l + KIAA1338 1038 QERNYSIYLNHTMLLKAILLHCGIPEDKLSQV 1069 //