hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080502/iprscan-20080502-08322456/chunk_1/iprscan-20080502-08322456.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA1639 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00069.15.ls Protein kinase domain 384.3 1.7e-112 2 PF00069.15.fs Protein kinase domain 383.2 3.7e-112 2 PF07679.6.fs Immunoglobulin I-set domain 360.0 3.6e-105 5 PF07679.6.ls Immunoglobulin I-set domain 343.8 2.7e-100 5 PF00047.15.ls Immunoglobulin domain 183.1 6.1e-52 5 PF00047.15.fs Immunoglobulin domain 178.0 2.2e-50 5 PF07686.7.fs Immunoglobulin V-set domain 53.3 1.5e-14 5 PF00169.19.fs PH domain 38.6 2.8e-11 1 PF07686.7.ls Immunoglobulin V-set domain 47.1 5.5e-11 3 PF07714.7.fs Protein tyrosine kinase 34.9 4.9e-10 2 PF00621.11.fs RhoGEF domain 31.8 3.7e-09 1 PF00169.19.ls PH domain 40.6 5.1e-09 1 PF00621.11.ls RhoGEF domain 33.6 2.5e-07 1 PF07654.6.ls Immunoglobulin C1-set domain 9.4 0.0003 1 PF08205.3.fs CD80-like C2-set immunoglobulin domain 16.8 0.00037 3 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF07679.6.ls 1/5 1 81 [. 1 96 [] 28.4 4.6e-06 PF07679.6.fs 1/5 1 81 [. 16 96 .] 45.9 8.8e-13 PF00621.11.fs 1/1 312 492 .. 1 207 [] 31.8 3.7e-09 PF00621.11.ls 1/1 312 492 .. 1 207 [] 33.6 2.5e-07 PF00169.19.ls 1/1 512 620 .. 1 92 [] 40.6 5.1e-09 PF00169.19.fs 1/1 512 620 .. 1 92 [] 38.6 2.8e-11 PF07679.6.fs 2/5 630 703 .. 1 79 [. 74.6 3.8e-21 PF07679.6.ls 2/5 630 722 .. 1 96 [] 74.4 3.3e-19 PF00047.15.ls 2/5 644 705 .. 1 65 [] 44.9 2.6e-10 PF00047.15.fs 2/5 644 705 .. 1 65 [] 43.0 4.9e-11 PF07679.6.fs 3/5 724 815 .. 1 96 [] 77.1 7.2e-22 PF07679.6.ls 3/5 724 815 .. 1 96 [] 79.0 1.4e-20 PF00047.15.ls 3/5 738 800 .. 1 65 [] 41.7 2.3e-09 PF00047.15.fs 3/5 738 800 .. 1 65 [] 39.8 3.7e-10 PF07679.6.fs 4/5 973 1062 .. 1 96 [] 88.5 3.4e-25 PF07679.6.ls 4/5 973 1062 .. 1 96 [] 90.4 5e-24 PF07686.7.fs 4/5 974 1063 .. 1 141 [] 22.8 5.6e-06 PF07686.7.ls 2/3 974 1063 .. 1 141 [] 24.5 0.00017 PF00047.15.ls 4/5 987 1047 .. 1 65 [] 39.9 8.3e-09 PF00047.15.fs 4/5 987 1047 .. 1 65 [] 38.0 1.1e-09 PF00069.15.fs 1/2 1084 1337 .. 1 287 [] 254.2 2.5e-73 PF00069.15.ls 1/2 1084 1337 .. 1 287 [] 256.1 6.7e-74 PF07679.6.fs 5/5 2079 2164 .. 1 91 [. 73.9 5.9e-21 PF07679.6.ls 5/5 2079 2169 .. 1 96 [] 71.6 2.4e-18 PF07686.7.ls 3/3 2079 2169 .. 1 141 [] 13.8 0.002 PF07654.6.ls 1/1 2086 2163 .. 1 92 [] 9.4 0.0003 PF00047.15.ls 5/5 2093 2154 .. 1 65 [] 46.6 7.8e-11 PF00047.15.fs 5/5 2093 2154 .. 1 65 [] 44.7 1.7e-11 PF00069.15.fs 2/2 2288 2490 .. 1 222 [. 129.0 1.6e-36 PF00069.15.ls 2/2 2288 2540 .. 1 287 [] 128.2 2.1e-35 PF07714.7.fs 2/2 2288 2409 .. 1 140 [. 26.5 1.3e-07 Alignments of top-scoring domains: PF07679.6.ls: domain 1 of 5, from 1 to 81: score 28.4, E = 4.6e-06 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqp.....ls +s++f +kV+G P PtV W++ +++ + KIAA1639 1 ---------------SSITFFVKVEGRPVPTVHWLREEAErgvlwIG 32 svllpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasa + +++ + v + + ++L+ ++v + G+YtC+A+N aG+a +sa KIAA1639 33 P---DTPGYTVASSA--QQHSLVLLDVGRQHQGTYTCIASNAAGQALCSA 77 eLtV<-* +L+V KIAA1639 78 SLHV 81 PF07679.6.fs: domain 1 of 5, from 1 to 81: score 45.9, E = 8.8e-13 *->esarfeCkVtGtPePtVsWfKdGqp.....lssvllpsdrfkvtydg +s++f +kV+G P PtV W++ +++ + + +++ + v + KIAA1639 1 SSITFFVKVEGRPVPTVHWLREEAErgvlwIGP---DTPGYTVASSA 44 GsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV<-* + ++L+ ++v + G+YtC+A+N aG+a +sa+L+V KIAA1639 45 --QQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHV 81 PF00621.11.fs: domain 1 of 1, from 312 to 492: score 31.8, E = 3.7e-09 *->vlkElleTEkkYvrdLeildnvymkpLreaaisskplLtpddietiF v+ Ell +E ++v++L l+ + ++ L ++ ++ + + ++ iF KIAA1639 312 VIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP--IAVAGQKAVIF 356 sNiediyefh.reFLkssLearisssnfedlDekkiepsaqrlGdlFlel N+ di +fh+++FL+ +L ++ + ++ +F++ KIAA1639 357 RNVRDIGRFHsSSFLQ-ELQQCDTDD---------------DVAMCFIKN 390 kaeflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAk ++++ Y e+++ + A+ ++ + ++ +ef +++ +++ A+ KIAA1639 391 -QAAFEQYLEFLVGRVQAESVVVS-------TAIQEFYKKYAEEAL-LAG 431 d..davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedssesedLkka d++ Lq++L +Pv R+ rY+ LLkeL+ +++ ++L++a KIAA1639 432 DpsQPPPPPLQHYLEQPVERVQRYQALLKELIRNKAR--NRQNCALLEQA 479 ldalqdlaksiNe<-* ++ + l+++ KIAA1639 480 YAVVSALPQRAEN 492 PF00621.11.ls: domain 1 of 1, from 312 to 492: score 33.6, E = 2.5e-07 *->vlkElleTEkkYvrdLeildnvymkpLreaaisskplLtpddietiF v+ Ell +E ++v++L l+ + ++ L ++ ++ + + ++ iF KIAA1639 312 VIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP--IAVAGQKAVIF 356 sNiediyefh.reFLkssLearisssnfedlDekkiepsaqrlGdlFlel N+ di +fh+++FL+ +L ++ + ++ +F++ KIAA1639 357 RNVRDIGRFHsSSFLQ-ELQQCDTDD---------------DVAMCFIKN 390 kaeflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAk ++++ Y e+++ + A+ ++ + ++ +ef +++ +++ A+ KIAA1639 391 -QAAFEQYLEFLVGRVQAESVVVS-------TAIQEFYKKYAEEAL-LAG 431 d..davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedssesedLkka d++ Lq++L +Pv R+ rY+ LLkeL+ +++ ++L++a KIAA1639 432 DpsQPPPPPLQHYLEQPVERVQRYQALLKELIRNKAR--NRQNCALLEQA 479 ldalqdlaksiNe<-* ++ + l+++ KIAA1639 480 YAVVSALPQRAEN 492 PF00169.19.ls: domain 1 of 1, from 512 to 620: score 40.6, E = 5.1e-09 *->vikeGwLlkkg......gkkswkkRyfvLfddvLlyykdkk...... +i++G++ ++++ ++ + + + R+++Lf+++L+++k++ ++++++ KIAA1639 512 PIRQGHFIVWEgapgarMPWKGHNRHVFLFRNHLVICKPRRdsrtdt 558 ..kkpkgsipLsgiqvtkvpdnkrkncFeirt.dr...etlllqaeseee ++ + ++ Ls+i + + +++ ++ +Fe++ + +++ +++llqa ++ KIAA1639 559 vsYVFRNMMKLSSIDLNDQVEG-DDRAFEVWQeREdsvRKYLLQARTAII 607 rkeWvkaiqsair<-* + +Wvk i+ + KIAA1639 608 KSSWVKEICGIQQ 620 PF00169.19.fs: domain 1 of 1, from 512 to 620: score 38.6, E = 2.8e-11 *->vikeGwLlkkg......gkkswkkRyfvLfddvLlyykdkk...... +i++G++ ++++ ++ + + + R+++Lf+++L+++k++ ++++++ KIAA1639 512 PIRQGHFIVWEgapgarMPWKGHNRHVFLFRNHLVICKPRRdsrtdt 558 ..kkpkgsipLsgiqvtkvpdnkrkncFeirt.dr...etlllqaeseee ++ + ++ Ls+i + + +++ ++ +Fe++ + +++ +++llqa ++ KIAA1639 559 vsYVFRNMMKLSSIDLNDQVEG-DDRAFEVWQeREdsvRKYLLQARTAII 607 rkeWvkaiqsair<-* + +Wvk i+ + KIAA1639 608 KSSWVKEICGIQQ 620 PF07679.6.fs: domain 2 of 5, from 630 to 703: score 74.6, E = 3.8e-21 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F+ ++ d ++ Ge++++ C+VtGtP+P +sW+KdG+ +++ KIAA1639 630 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQV---- 672 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtC<-* ++++ +d +g + L+ + + DsG+Y C KIAA1639 673 DPHHILIEDP-DGSCALILDSLTGVDSGQYMC 703 PF07679.6.ls: domain 2 of 5, from 630 to 722: score 74.4, E = 3.3e-19 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P F+ ++ d ++ Ge++++ C+VtGtP+P +sW+KdG+ +++ KIAA1639 630 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQV---- 672 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaea..saeLt ++++ +d +g + L+ + + DsG+Y C A aG +++ +++ ++ KIAA1639 673 DPHHILIEDP-DGSCALILDSLTGVDSGQYMCFAASAAGNCSTlgKILVQ 721 V<-* V KIAA1639 722 V 722 PF00047.15.ls: domain 2 of 5, from 644 to 705: score 44.9, E = 2.6e-10 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge+v+L C+v +g+p + ++W+++gk ++ + ++ e+ ++s KIAA1639 644 GETVKLACRV--TGTPKPVISWYKDGKaVQvDPHHILIEDPDGSCA- 687 tsLtitnvtpeDggtYtCvv<-* L + ++t D+g Y+C + KIAA1639 688 --LILDSLTGVDSGQYMCFA 705 PF00047.15.fs: domain 2 of 5, from 644 to 705: score 43.0, E = 4.9e-11 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge+v+L C+v +g+p + ++W+++gk ++ + ++ e+ ++s KIAA1639 644 GETVKLACRV--TGTPKPVISWYKDGKaVQvDPHHILIEDPDGSCA- 687 tsLtitnvtpeDggtYtCvv<-* L + ++t D+g Y+C + KIAA1639 688 --LILDSLTGVDSGQYMCFA 705 PF07679.6.fs: domain 3 of 5, from 724 to 815: score 77.1, E = 7.2e-22 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F+ k + eGe+a f+C+++G P P++ W+KdG l+ KIAA1639 724 PRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTT---- 766 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< + +f+ + sg L+I+ + ++D G+Y C N+ G+a asaeL + KIAA1639 767 GNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 815 -* KIAA1639 - - PF07679.6.ls: domain 3 of 5, from 724 to 815: score 79.0, E = 1.4e-20 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F+ k + eGe+a f+C+++G P P++ W+KdG l+ KIAA1639 724 PRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTT---- 766 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< + +f+ + sg L+I+ + ++D G+Y C N+ G+a asaeL + KIAA1639 767 GNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 815 -* KIAA1639 - - PF00047.15.ls: domain 3 of 5, from 738 to 800: score 41.7, E = 2.3e-09 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge++ +tC+ +g p ++++W+++g lt+g++ + + ++ KIAA1639 738 GEDAQFTCTI--EGAPYPQIRWYKDGAlLTtGNKFQTLSEPRSGLLV 782 tsLtitnvtpeDggtYtCvv<-* L+i+++++eD g Y C+ KIAA1639 783 --LVIRAASKEDLGLYECEL 800 PF00047.15.fs: domain 3 of 5, from 738 to 800: score 39.8, E = 3.7e-10 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge++ +tC+ +g p ++++W+++g lt+g++ + + ++ KIAA1639 738 GEDAQFTCTI--EGAPYPQIRWYKDGAlLTtGNKFQTLSEPRSGLLV 782 tsLtitnvtpeDggtYtCvv<-* L+i+++++eD g Y C+ KIAA1639 783 --LVIRAASKEDLGLYECEL 800 PF07679.6.fs: domain 4 of 5, from 973 to 1062: score 88.5, E = 3.4e-25 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+ ++dv++q G +a fe ++G+P+P+V+W+Kd +l KIAA1639 973 PSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVD---- 1015 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s r++ +g ty+L+ + v + D+G+YtC A+N +G++ ++aeL V KIAA1639 1016 STRLSQQQEG--TTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLV 1062 -* KIAA1639 - - PF07679.6.ls: domain 4 of 5, from 973 to 1062: score 90.4, E = 5e-24 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+ ++dv++q G +a fe ++G+P+P+V+W+Kd +l KIAA1639 973 PSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVD---- 1015 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s r++ +g ty+L+ + v + D+G+YtC A+N +G++ ++aeL V KIAA1639 1016 STRLSQQQEG--TTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLV 1062 -* KIAA1639 - - PF07686.7.fs: domain 4 of 5, from 974 to 1063: score 22.8, E = 5.6e-06 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss + qvt e v +++Gg++ + +d+ KIAA1639 974 SMQVTIE---------------DVQAQTGGTAQFEAIIE---GDP-- 1000 ssgtfsiyWyrqqppgkgpeliiisyysyystsegngtvgerfkgrvtls ++ s++Wy+ + ++ ++++ls KIAA1639 1001 --QP-SVTWYK-DSV--------------------------QLVDSTRLS 1020 gnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* ++ ++++sL ++++ + D G+Y+C n+ +++ +L Vl KIAA1639 1021 QQQEGTTYSLVLRHVASKDAGVYTCLAQNT-GGQVLCKAELLVL 1063 PF07686.7.ls: domain 2 of 3, from 974 to 1063: score 24.5, E = 0.00017 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss + qvt e v +++Gg++ + +d+ KIAA1639 974 SMQVTIE---------------DVQAQTGGTAQFEAIIE---GDP-- 1000 ssgtfsiyWyrqqppgkgpeliiisyysyystsegngtvgerfkgrvtls ++ s++Wy+ + ++ ++++ls KIAA1639 1001 --QP-SVTWYK-DSV--------------------------QLVDSTRLS 1020 gnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* ++ ++++sL ++++ + D G+Y+C n+ +++ +L Vl KIAA1639 1021 QQQEGTTYSLVLRHVASKDAGVYTCLAQNT-GGQVLCKAELLVL 1063 PF00047.15.ls: domain 4 of 5, from 987 to 1047: score 39.9, E = 8.3e-09 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+++ + +g+p+++vtW++++ +l ++++ + +++++ + KIAA1639 987 GGTAQFEAII--EGDPQPSVTWYKDSVqLVdSTRLSQQQEGTTYS-- 1029 tsLtitnvtpeDggtYtCvv<-* L+++ v + D+g+YtC + KIAA1639 1030 --LVLRHVASKDAGVYTCLA 1047 PF00047.15.fs: domain 4 of 5, from 987 to 1047: score 38.0, E = 1.1e-09 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+++ + +g+p+++vtW++++ +l ++++ + +++++ + KIAA1639 987 GGTAQFEAII--EGDPQPSVTWYKDSVqLVdSTRLSQQQEGTTYS-- 1029 tsLtitnvtpeDggtYtCvv<-* L+++ v + D+g+YtC + KIAA1639 1030 --LVLRHVASKDAGVYTCLA 1047 PF00069.15.fs: domain 1 of 2, from 1084 to 1337: score 254.2, E = 2.5e-73 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ye++e +G+G fG V++ +hkg+ ++ A K i++r++ + ++ KIAA1639 1084 YEVKEEIGRGVFGFVKRVQHKGNKILCAAKFIPLRSRTRAQAYR--- 1127 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E il+ LsHp + l+d fe+++ l l+lE+c +L d+l KIAA1639 1128 --ERDILAALSHPLVTGLLDQFETRKTLILILELCSSE----ELLDRLY- 1170 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld..nn rkg++ +e e+k ++ Q+++gl YLHs+g++H D+KP+NIL++++ + KIAA1639 1171 --RKGVV--TEAEVKVYIQQLVEGLHYLHSHGVLHLDIKPSNILMVhpAR 1216 gvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtk ++ Ki+DFG+A +++ + + G+p++++PE+++ +n+ + + KIAA1639 1217 EDI----KICDFGFAQN--ItPAElQFSQYGSPEFVSPEIIQ-QNPVSEA 1259 vDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewd +D+W++Gvi y lt PF ge ++++ + ++l+++++++sp KIAA1639 1260 SDIWAMGVISYLSLTCSSPFAGE-----SDRATLLNVLEGRVSWSSPMAA 1304 sisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s e+akd+ik L++ P+ R++a+++l HPwf KIAA1639 1305 HLS-----------EDAKDFIKATLQRAPQARPSAAQCLSHPWF 1337 PF00069.15.ls: domain 1 of 2, from 1084 to 1337: score 256.1, E = 6.7e-74 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr ye++e +G+G fG V++ +hkg+ ++ A K i++r++ + ++ KIAA1639 1084 YEVKEEIGRGVFGFVKRVQHKGNKILCAAKFIPLRSRTRAQAYR--- 1127 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E il+ LsHp + l+d fe+++ l l+lE+c +L d+l KIAA1639 1128 --ERDILAALSHPLVTGLLDQFETRKTLILILELCSSE----ELLDRLY- 1170 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld..nn rkg++ +e e+k ++ Q+++gl YLHs+g++H D+KP+NIL++++ + KIAA1639 1171 --RKGVV--TEAEVKVYIQQLVEGLHYLHSHGVLHLDIKPSNILMVhpAR 1216 gvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtk ++ Ki+DFG+A +++ + + G+p++++PE+++ +n+ + + KIAA1639 1217 EDI----KICDFGFAQN--ItPAElQFSQYGSPEFVSPEIIQ-QNPVSEA 1259 vDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewd +D+W++Gvi y lt PF ge ++++ + ++l+++++++sp KIAA1639 1260 SDIWAMGVISYLSLTCSSPFAGE-----SDRATLLNVLEGRVSWSSPMAA 1304 sisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* s e+akd+ik L++ P+ R++a+++l HPwf KIAA1639 1305 HLS-----------EDAKDFIKATLQRAPQARPSAAQCLSHPWF 1337 PF07679.6.fs: domain 5 of 5, from 2079 to 2164: score 73.9, E = 5.9e-21 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F+++++d +V G+s+++ C+V+ P + +W KdG pl s KIAA1639 2079 PTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLES---- 2121 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeas<-* s+r+ ++++ ++ + LtI+ v +D G+YtC ++N G+++++ KIAA1639 2122 SSRVLISATL-KNFQLLTILVVVAEDLGVYTCSVSNALGTVTTT 2164 PF07679.6.ls: domain 5 of 5, from 2079 to 2169: score 71.6, E = 2.4e-18 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F+++++d +V G+s+++ C+V+ P + +W KdG pl s KIAA1639 2079 PTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLES---- 2121 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV< s+r+ ++++ ++ + LtI+ v +D G+YtC ++N G+++++ L KIAA1639 2122 SSRVLISATL-KNFQLLTILVVVAEDLGVYTCSVSNALGTVTTTGVLRK 2169 -* KIAA1639 - - PF07686.7.ls: domain 3 of 3, from 2079 to 2169: score 13.8, E = 0.002 *->qsqvtqepprWGLLLASLfWptsvtvaeGgsvtLpCtysGtfddsss + + + + tv++G+svtL C++s KIAA1639 2079 PTFLRE--LS------------DETVVLGQSVTLACQVS-------- 2103 ssgtfsiyWyrq.qppgkgpeliiisyysyystsegngtvgerfkgrvtl ++ + +W++++ p+ ++ + +i + tl KIAA1639 2104 AQPAAQATWSKDgAPLESSSRVLI----------------------SATL 2131 sgnpskgdfsLtIsnlqlsDsGtYyCavsnsnelvfgggtrLtVl<-* + LtI + ++D G+Y+C vsn l + t + + KIAA1639 2132 KNFQL-----LTILVVVAEDLGVYTCSVSN--ALGTVTTTGVLRK 2169 PF07654.6.ls: domain 1 of 1, from 2086 to 2163: score 9.4, E = 0.0003 *->ppgspepelgkpntLvClVtgFyPpdItVtWlkNGqev..tegvest + ++ lg+++tL C V+ p + tW k+G ++++++ v + KIAA1639 2086 SD-ETV-VLGQSVTLACQVSA--QPAAQATWSKDGAPLesSSRVLIS 2128 eplpkngDgtYqlsSyLtftasepesgdtYtCrVeHesLkvenePlt<-* +l+ n +ql+ L + e+ +YtC+V +L +t KIAA1639 2129 ATLK-N----FQLLTILVVV---AEDLGVYTCSVSN-ALG---TVTT 2163 PF00047.15.ls: domain 5 of 5, from 2093 to 2154: score 46.6, E = 7.8e-11 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+svtL C+v ++ p ++ tW ++g +l+++ +v +s + + + KIAA1639 2093 GQSVTLACQV--SAQPAAQATWSKDGApLEsSSRVLISATLKNFQL- 2136 tsLtitnvtpeDggtYtCvv<-* Lti++v eD g+YtC v KIAA1639 2137 --LTILVVVAEDLGVYTCSV 2154 PF00047.15.fs: domain 5 of 5, from 2093 to 2154: score 44.7, E = 1.7e-11 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+svtL C+v ++ p ++ tW ++g +l+++ +v +s + + + KIAA1639 2093 GQSVTLACQV--SAQPAAQATWSKDGApLEsSSRVLISATLKNFQL- 2136 tsLtitnvtpeDggtYtCvv<-* Lti++v eD g+YtC v KIAA1639 2137 --LTILVVVAEDLGVYTCSV 2154 PF00069.15.fs: domain 2 of 2, from 2288 to 2490: score 129.0, E = 1.6e-36 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + + ++ +G f++V+++ +k +g+ A Kii+++ +++ ta++ KIAA1639 2288 FAFQTQIQRGRFSVVRQCWEKASGRALAAKIIPYHPKDK----TAVL 2330 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E + lk L+Hp+ +l+ ++ +++hl l+lE+c g +L l KIAA1639 2331 R-EYEALKGLRHPHLAQLHAAYLSPRHLVLILELCSGP----ELLPCLA- 2374 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++ ++ se e+k++++Q+l++ +YLH++ i+H DL +eN + +++ KIAA1639 2375 --ERASY--SESEVKDYLWQMLSATQYLHNQHILHLDLRSENMIIT-EYN 2419 vdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEvllggngygt + lK+ D G A ls+++ +s +++++ ++ mAPE+l g+g + KIAA1639 2420 L---LKVVDLGNAQSLSqekVlPSDkFKDY---LETMAPELLE-GQGAVP 2462 kvDvWSlGvilyelltGkpPFsgevqds.ld<-* D+W++Gv+ +++l+ + P s+e + +d KIAA1639 2463 QTDIWAIGVTAFIMLSAEYPVSSE---GaRD 2490 PF00069.15.ls: domain 2 of 2, from 2288 to 2540: score 128.2, E = 2.1e-35 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + + ++ +G f++V+++ +k +g+ A Kii+++ +++ ta++ KIAA1639 2288 FAFQTQIQRGRFSVVRQCWEKASGRALAAKIIPYHPKDK----TAVL 2330 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse + E + lk L+Hp+ +l+ ++ +++hl l+lE+c g +L l KIAA1639 2331 R-EYEALKGLRHPHLAQLHAAYLSPRHLVLILELCSGP----ELLPCLA- 2374 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++ ++ se e+k++++Q+l++ +YLH++ i+H DL +eN + +++ KIAA1639 2375 --ERASY--SESEVKDYLWQMLSATQYLHNQHILHLDLRSENMIIT-EYN 2419 vdaflKiaDFGlAkkls...t.sss.lttfvGTpwYmAPEvllggngygt + lK+ D G A ls+++ +s +++++ ++ mAPE+l g+g + KIAA1639 2420 L---LKVVDLGNAQSLSqekVlPSDkFKDY---LETMAPELLE-GQGAVP 2462 kvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspew D+W++Gv+ +++l+ + P s+e ++++lq+ +++ +l++ + KIAA1639 2463 QTDIWAIGVTAFIMLSAEYPVSSE---GARDLQRGLRKGLVRLSRCYA-- 2507 dsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* ls a ++++ L+ P R+ a +lq Pw+ KIAA1639 2508 ------------GLSGGAVAFLRSTLCAQPWGRPCASSCLQCPWL 2540 PF07714.7.fs: domain 2 of 2, from 2288 to 2409: score 26.5, E = 1.3e-07 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie + ++ ++ +G F +V ++ k + A K++ +++++ KIAA1639 2288 FAFQTQIQRGRFSVVRQCWEK----ASGRALAAKII---PYHPKD-- 2325 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL + + lrE + +k l +Hp++ +L+++ + + + l +++E++ g L KIAA1639 2326 KTAVLREYEALKGL-RHPHLAQLHAAYL--SPRH---LVLILELCSGPEL 2369 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLA<-* l L + + + + ++ ++ +Q ++ +YL+++++ H DL+ KIAA1639 2370 LPCLAE---RASYSESEVKDYLWQMLSATQYLHNQHILHLDLR 2409 //