# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fg02852mrp1.fasta.nr -Q ../query/KIAA1832.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1832, 694 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7826334 sequences Expectation_n fit: rho(ln(x))= 5.4794+/-0.000193; mu= 12.3927+/- 0.011 mean_var=94.0865+/-17.893, 0's: 30 Z-trim: 34 B-trim: 0 in 0/64 Lambda= 0.132224 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|55749600|ref|NP_115827.1| spire homolog 2 [Homo ( 714) 4210 813.6 0 gi|172045735|sp|Q8WWL2.2|SPIR2_HUMAN RecName: Full ( 714) 4210 813.6 0 gi|17932848|emb|CAD19439.1| Spir-2 protein [Homo s ( 728) 4210 813.6 0 gi|21740110|emb|CAD39070.1| hypothetical protein [ ( 662) 4202 812.1 0 gi|141796932|gb|AAI39733.1| SPIRE2 protein [Homo s ( 581) 3938 761.6 0 gi|73956894|ref|XP_536746.2| PREDICTED: similar to ( 626) 3648 706.4 7.9e-201 gi|149038446|gb|EDL92806.1| rCG51060 [Rattus norve ( 714) 3637 704.3 3.7e-200 gi|187469025|gb|AAI66756.1| Spire2 protein [Rattus ( 714) 3626 702.2 1.6e-199 gi|81878461|sp|Q8K1S6.1|SPIR2_MOUSE RecName: Full= ( 718) 3595 696.3 9.6e-198 gi|20072945|gb|AAH26502.1| SPIRE2 protein [Mus mus ( 618) 3575 692.4 1.2e-196 gi|114664214|ref|XP_511239.2| PREDICTED: spire hom ( 622) 3417 662.3 1.4e-187 gi|119587085|gb|EAW66681.1| spire homolog 2 (Droso ( 499) 3411 661.1 2.7e-187 gi|83404912|gb|AAI11031.1| SPIRE2 protein [Homo sa ( 666) 3394 657.9 3.2e-186 gi|119587084|gb|EAW66680.1| spire homolog 2 (Droso ( 465) 3172 615.4 1.4e-173 gi|194674961|ref|XP_001787790.1| PREDICTED: simila ( 700) 2830 550.4 8e-154 gi|194208924|ref|XP_001488450.2| PREDICTED: spire ( 637) 2808 546.1 1.4e-152 gi|119587086|gb|EAW66682.1| spire homolog 2 (Droso ( 378) 2593 504.9 2.1e-140 gi|193787751|dbj|BAG52954.1| unnamed protein produ ( 298) 2057 402.6 1.1e-109 gi|149411926|ref|XP_001510997.1| PREDICTED: simila ( 694) 1953 383.1 1.8e-103 gi|118096608|ref|XP_414215.2| PREDICTED: similar t ( 639) 1928 378.3 4.7e-102 gi|126304997|ref|XP_001377808.1| PREDICTED: simila ( 745) 1870 367.3 1.1e-98 gi|39794327|gb|AAH63706.1| SPIRE2 protein [Homo sa ( 269) 1863 365.5 1.4e-98 gi|82179906|sp|Q5U3H9.1|SPIR2_DANRE RecName: Full= ( 606) 1553 306.7 1.6e-80 gi|168269700|dbj|BAG09977.1| spire homolog 1 [synt ( 756) 1516 299.7 2.4e-78 gi|215273889|sp|Q08AE8.2|SPIR1_HUMAN RecName: Full ( 756) 1513 299.2 3.6e-78 gi|73962225|ref|XP_547684.2| PREDICTED: similar to ( 694) 1505 297.6 9.8e-78 gi|47221923|emb|CAF98935.1| unnamed protein produc ( 829) 1403 278.2 8e-72 gi|123889259|sp|Q1LYM3.1|SPIR1_DANRE RecName: Full ( 761) 1392 276.1 3.2e-71 gi|167736382|ref|NP_001038312.2| spire homolog 1 [ ( 722) 1383 274.3 1e-70 gi|35193148|gb|AAH58669.1| SPIRE1 protein [Mus mus ( 605) 1357 269.3 2.8e-69 gi|115527932|gb|AAI25207.1| SPIRE1 protein [Homo s ( 597) 1356 269.1 3.2e-69 gi|81882269|sp|Q52KF3.1|SPIR1_MOUSE Protein spire ( 598) 1330 264.2 9.8e-68 gi|149064533|gb|EDM14736.1| spire homolog 1 (Droso ( 691) 1190 237.5 1.2e-59 gi|148677693|gb|EDL09640.1| spire homolog 1 (Droso ( 620) 1185 236.5 2.1e-59 gi|191250771|ref|NP_064533.3| spire homolog 1 isof ( 742) 1170 233.7 1.8e-58 gi|119621951|gb|EAX01546.1| spire homolog 1 (Droso ( 622) 1160 231.7 5.8e-58 gi|8920230|emb|CAB96370.1| Spir-1 protein [Homo sa ( 620) 1139 227.7 9.4e-57 gi|148677692|gb|EDL09639.1| spire homolog 1 (Droso ( 678) 1106 221.5 7.8e-55 gi|149064532|gb|EDM14735.1| spire homolog 1 (Droso ( 749) 1102 220.8 1.4e-54 gi|149410899|ref|XP_001508511.1| PREDICTED: simila ( 680) 1099 220.1 2e-54 gi|119621950|gb|EAX01545.1| spire homolog 1 (Droso ( 497) 1096 219.4 2.4e-54 gi|148677694|gb|EDL09641.1| spire homolog 1 (Droso ( 573) 1043 209.4 2.9e-51 gi|149064534|gb|EDM14737.1| spire homolog 1 (Droso ( 644) 1035 207.9 9e-51 gi|115528597|gb|AAI24675.1| Zgc:153436 [Danio reri ( 396) 1030 206.8 1.2e-50 gi|75076554|sp|Q4R707.1|SPIR1_MACFA RecName: Full= ( 584) 1031 207.1 1.4e-50 gi|92098118|gb|AAI15006.1| Spire homolog 1 (Drosop ( 583) 1010 203.1 2.3e-49 gi|194214503|ref|XP_001489382.2| PREDICTED: simila ( 699) 968 195.2 6.7e-47 gi|37595748|ref|NP_919336.1| Spir-1 protein isofor ( 643) 957 193.0 2.7e-46 gi|21739264|emb|CAD38680.1| hypothetical protein [ ( 458) 946 190.8 9.1e-46 gi|194377242|dbj|BAG63182.1| unnamed protein produ ( 545) 940 189.7 2.3e-45 >>gi|55749600|ref|NP_115827.1| spire homolog 2 [Homo sap (714 aa) initn: 4201 init1: 4201 opt: 4210 Z-score: 4340.4 bits: 813.6 E(): 0 Smith-Waterman score: 4210; 96.909% identity (97.836% similar) in 647 aa overlap (49-694:73-714) 20 30 40 50 60 70 KIAA18 PAGNILFIRSMSCLCLGLLWTDSCCLPGRVLGPLHPPAAFSPPHPPAVP-PSDRAPVPQT .: .: :: : .:: :..: :: gi|557 VCFQGCRGLRGSPGRRLRDTGDLLLRGDGSVGAREPEAA--EPATMVVPLASSEA---QT 50 60 70 80 90 80 90 100 110 120 130 KIAA18 VQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 VQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEE 100 110 120 130 140 150 140 150 160 170 180 190 KIAA18 AEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 AEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEML 160 170 180 190 200 210 200 210 220 230 240 250 KIAA18 QKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 QKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLT 220 230 240 250 260 270 260 270 280 290 300 310 KIAA18 PFEMLMQDIRARNYKLRKVMVDGDIPPRVEKDAHELILDFIRSRPPLKQVSERRLRPLPP :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: gi|557 PFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPP 280 290 300 310 320 330 320 330 340 350 360 370 KIAA18 KQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 KQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAG 340 350 360 370 380 390 380 390 400 410 420 430 KIAA18 GSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 GSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGL 400 410 420 430 440 450 440 450 460 470 480 490 KIAA18 QSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 QSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMT 460 470 480 490 500 510 500 510 520 530 540 550 KIAA18 PDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 PDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA 520 530 540 550 560 570 560 570 580 590 600 610 KIAA18 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRR 580 590 600 610 620 630 620 630 640 650 660 670 KIAA18 DIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 DIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRS 640 650 660 670 680 690 680 690 KIAA18 RQTQSLYIPNTRTLDFK ::::::::::::::::: gi|557 RQTQSLYIPNTRTLDFK 700 710 >>gi|172045735|sp|Q8WWL2.2|SPIR2_HUMAN RecName: Full=Pro (714 aa) initn: 4201 init1: 4201 opt: 4210 Z-score: 4340.4 bits: 813.6 E(): 0 Smith-Waterman score: 4210; 96.909% identity (97.836% similar) in 647 aa overlap (49-694:73-714) 20 30 40 50 60 70 KIAA18 PAGNILFIRSMSCLCLGLLWTDSCCLPGRVLGPLHPPAAFSPPHPPAVP-PSDRAPVPQT .: .: :: : .:: :..: :: gi|172 VCFQGCRGLRGSPGRRLRDTGDLLLRGDGSVGAREPEAA--EPATMVVPLASSEA---QT 50 60 70 80 90 80 90 100 110 120 130 KIAA18 VQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 VQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEE 100 110 120 130 140 150 140 150 160 170 180 190 KIAA18 AEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 AEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEML 160 170 180 190 200 210 200 210 220 230 240 250 KIAA18 QKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 QKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLT 220 230 240 250 260 270 260 270 280 290 300 310 KIAA18 PFEMLMQDIRARNYKLRKVMVDGDIPPRVEKDAHELILDFIRSRPPLKQVSERRLRPLPP :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: gi|172 PFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPP 280 290 300 310 320 330 320 330 340 350 360 370 KIAA18 KQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 KQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAG 340 350 360 370 380 390 380 390 400 410 420 430 KIAA18 GSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 GSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGL 400 410 420 430 440 450 440 450 460 470 480 490 KIAA18 QSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 QSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMT 460 470 480 490 500 510 500 510 520 530 540 550 KIAA18 PDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 PDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA 520 530 540 550 560 570 560 570 580 590 600 610 KIAA18 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRR 580 590 600 610 620 630 620 630 640 650 660 670 KIAA18 DIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 DIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRS 640 650 660 670 680 690 680 690 KIAA18 RQTQSLYIPNTRTLDFK ::::::::::::::::: gi|172 RQTQSLYIPNTRTLDFK 700 710 >>gi|17932848|emb|CAD19439.1| Spir-2 protein [Homo sapie (728 aa) initn: 4201 init1: 4201 opt: 4210 Z-score: 4340.3 bits: 813.6 E(): 0 Smith-Waterman score: 4210; 96.909% identity (97.836% similar) in 647 aa overlap (49-694:87-728) 20 30 40 50 60 70 KIAA18 PAGNILFIRSMSCLCLGLLWTDSCCLPGRVLGPLHPPAAFSPPHPPAVP-PSDRAPVPQT .: .: :: : .:: :..: :: gi|179 VCFQGCRGLRGSPGRRLRDTGDLLLRGDGSVGAREPEAA--EPATMVVPLASSEA---QT 60 70 80 90 100 110 80 90 100 110 120 130 KIAA18 VQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 VQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEE 120 130 140 150 160 170 140 150 160 170 180 190 KIAA18 AEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 AEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEML 180 190 200 210 220 230 200 210 220 230 240 250 KIAA18 QKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 QKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLT 240 250 260 270 280 290 260 270 280 290 300 310 KIAA18 PFEMLMQDIRARNYKLRKVMVDGDIPPRVEKDAHELILDFIRSRPPLKQVSERRLRPLPP :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: gi|179 PFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPP 300 310 320 330 340 350 320 330 340 350 360 370 KIAA18 KQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 KQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAG 360 370 380 390 400 410 380 390 400 410 420 430 KIAA18 GSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 GSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGL 420 430 440 450 460 470 440 450 460 470 480 490 KIAA18 QSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 QSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMT 480 490 500 510 520 530 500 510 520 530 540 550 KIAA18 PDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 PDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA 540 550 560 570 580 590 560 570 580 590 600 610 KIAA18 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRR 600 610 620 630 640 650 620 630 640 650 660 670 KIAA18 DIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|179 DIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRS 660 670 680 690 700 710 680 690 KIAA18 RQTQSLYIPNTRTLDFK ::::::::::::::::: gi|179 RQTQSLYIPNTRTLDFK 720 >>gi|21740110|emb|CAD39070.1| hypothetical protein [Homo (662 aa) initn: 4193 init1: 4193 opt: 4202 Z-score: 4332.6 bits: 812.1 E(): 0 Smith-Waterman score: 4202; 96.754% identity (97.682% similar) in 647 aa overlap (49-694:21-662) 20 30 40 50 60 70 KIAA18 PAGNILFIRSMSCLCLGLLWTDSCCLPGRVLGPLHPPAAFSPPHPPAVP-PSDRAPVPQT .: .: :: : .:: :..: :: gi|217 GSPGRRLRDTGDLLLRGDGSVGAREPEAA--EPATMVVPLASSEA---QT 10 20 30 40 80 90 100 110 120 130 KIAA18 VQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 VQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEE 50 60 70 80 90 100 140 150 160 170 180 190 KIAA18 AEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : gi|217 AEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKETL 110 120 130 140 150 160 200 210 220 230 240 250 KIAA18 QKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 QKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLT 170 180 190 200 210 220 260 270 280 290 300 310 KIAA18 PFEMLMQDIRARNYKLRKVMVDGDIPPRVEKDAHELILDFIRSRPPLKQVSERRLRPLPP :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: gi|217 PFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPP 230 240 250 260 270 280 320 330 340 350 360 370 KIAA18 KQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 KQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAG 290 300 310 320 330 340 380 390 400 410 420 430 KIAA18 GSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 GSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGL 350 360 370 380 390 400 440 450 460 470 480 490 KIAA18 QSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 QSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMT 410 420 430 440 450 460 500 510 520 530 540 550 KIAA18 PDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 PDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA 470 480 490 500 510 520 560 570 580 590 600 610 KIAA18 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRR 530 540 550 560 570 580 620 630 640 650 660 670 KIAA18 DIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 DIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRS 590 600 610 620 630 640 680 690 KIAA18 RQTQSLYIPNTRTLDFK ::::::::::::::::: gi|217 RQTQSLYIPNTRTLDFK 650 660 >>gi|141796932|gb|AAI39733.1| SPIRE2 protein [Homo sapie (581 aa) initn: 2853 init1: 2853 opt: 3938 Z-score: 4061.1 bits: 761.6 E(): 0 Smith-Waterman score: 3938; 99.314% identity (99.657% similar) in 583 aa overlap (112-694:1-581) 90 100 110 120 130 140 KIAA18 GFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGV :::::::::::::::::::::::::::::: gi|141 MANNDSEDSGCGAADEGYGGPEEEEEAEGV 10 20 30 150 160 170 180 190 200 KIAA18 PRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|141 PRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLR 40 50 60 70 80 90 210 220 230 240 250 260 KIAA18 EDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|141 EDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEM 100 110 120 130 140 150 270 280 290 300 310 320 KIAA18 LMQDIRARNYKLRKVMVDGDIPPRVEKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRS ::::::::::::::: ::::::::.:::::::::::::::::::::::::::::::::: gi|141 LMQDIRARNYKLRKV--DGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRS 160 170 180 190 200 330 340 350 360 370 380 KIAA18 LHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|141 LHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQ 210 220 230 240 250 260 390 400 410 420 430 440 KIAA18 RPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|141 RPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSAT 270 280 290 300 310 320 450 460 470 480 490 500 KIAA18 HPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTPDAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|141 HPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTPDAK 330 340 350 360 370 380 510 520 530 540 550 560 KIAA18 HLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|141 HLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPL 390 400 410 420 430 440 570 580 590 600 610 620 KIAA18 FSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|141 FSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQ 450 460 470 480 490 500 630 640 650 660 670 680 KIAA18 SLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|141 SLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQ 510 520 530 540 550 560 690 KIAA18 SLYIPNTRTLDFK :::::::::.::: gi|141 SLYIPNTRTFDFK 570 580 >>gi|73956894|ref|XP_536746.2| PREDICTED: similar to spi (626 aa) initn: 3650 init1: 2391 opt: 3648 Z-score: 3761.7 bits: 706.4 E(): 7.9e-201 Smith-Waterman score: 3648; 86.473% identity (94.364% similar) in 621 aa overlap (74-694:7-626) 50 60 70 80 90 100 KIAA18 LPGRVLGPLHPPAAFSPPHPPAVPPSDRAPVPQTVQSLGFAIYRALDWGLDESEERELSP ::: :::::::::::::::::.:::::::: gi|739 MTLWLLVPQMVQSLGFAIYRALDWGLDDSEERELSP 10 20 30 110 120 130 140 150 160 KIAA18 QLERLIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGVPRSVRTFAQAMRLCAARLTDPR :::.::::::::: :::.:::::::::::::::::.: ::.::::::::::::::::::: gi|739 QLEQLIDLMANNDCEDSSCGAADEGYGGPEEEEEADGGPRAVRTFAQAMRLCAARLTDPR 40 50 60 70 80 90 170 180 190 200 210 220 KIAA18 GAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDEPHLETPRAELDSLGHTDWA ::::::::::::::::::::::::::::::::::::::::: . : : ::::.::::::: gi|739 GAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDELQAEKPLAELDNLGHTDWA 100 110 120 130 140 150 230 240 250 260 270 280 KIAA18 RLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIP :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: gi|739 RLWVQLMRELRHGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIP 160 170 180 190 200 210 290 300 310 320 330 340 KIAA18 PRVEKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHEKILEEIKQERRLRPVRGEG :::.::::::::::::::::::::::::::::: :::.:::::::::::::::::: :. gi|739 PRVKKDAHELILDFIRSRPPLKQVSERRLRPLPQKQRTLHEKILEEIKQERRLRPVGGQC 220 230 240 250 260 270 350 360 370 380 390 400 KIAA18 WAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQRPRPRVLLKAPTLAEMEEMNTS :..::::::::::::::::.:::::::::.::::...::::::::::::::::::::::: gi|739 WGGRGFGSLPCILNACSGDSKSTSCINLSITDAGNNSQRPRPRVLLKAPTLAEMEEMNTS 280 290 300 310 320 330 410 420 430 440 450 460 KIAA18 EEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHPPGGTEPPRPRAGSAHVWRPG :::::::::::::::::::::::.::::::::.:: ::.: :: : ::::::.: :::. gi|739 EEEESPCGEVTLKRDRSFSEHDLVQLRSEVASSLQPATQPQGGLESSRPRAGSVHSWRPS 340 350 360 370 380 390 470 480 490 500 510 520 KIAA18 SRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTPDAKHLWLEFSHPVESLALTVEEVMD ...:: :. .. : : :. :. :.: :: .::..:::::::::::::::::::::: gi|739 TQEQGKVQAQPDSSSLPP-SDLDSAEDKPAASAAPDTNHLWLEFSHPVESLALTVEEVMD 400 410 420 430 440 450 530 540 550 560 570 580 KIAA18 VRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLFSWPPSCLFCKRAVCTSCSIKM :::::::::::::::.::: :::::::::::::.:::::::::.:::::::::::::::: gi|739 VRRVLVKAEMEKFLQDKELVSSLKKGKICCCCRTKFPLFSWPPTCLFCKRAVCTSCSIKM 460 470 480 490 500 510 590 600 610 620 630 640 KIAA18 KMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQSLQGPQWQSVEEAFPHIYSHGC :::::::.::::::::::::.:::..: .: :::: ::::::::::::::::::::.::: gi|739 KMPSKKFAHIPVYTLGFESPRRVSTTKPTPSQRRDAFQSLQGPQWQSVEEAFPHIYTHGC 520 530 540 550 560 570 650 660 670 680 690 KIAA18 VLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQSLYIPNTRTLDFK . :::::.:::::::::::::::::.:::::::.::::::::::: ::.:: gi|739 IRKDVCSDCTSFVADVVRSSRKSVDALNTTPRRTRQTQSLYIPNTWTLNFK 580 590 600 610 620 >>gi|149038446|gb|EDL92806.1| rCG51060 [Rattus norvegicu (714 aa) initn: 3642 init1: 2397 opt: 3637 Z-score: 3749.7 bits: 704.3 E(): 3.7e-200 Smith-Waterman score: 3637; 84.688% identity (92.656% similar) in 640 aa overlap (56-694:81-714) 30 40 50 60 70 80 KIAA18 IRSMSCLCLGLLWTDSCCLPGRVLGPLHPPAAFSP-PHPPAVPPSDRAPVPQTVQSLGFA : . : : .:::.. : ::::::: gi|149 GCRGLRGEPGGVRRIRDTADILLRRDGSVGARLEPEPSTMVVPPANSE--AQMVQSLGFA 60 70 80 90 100 90 100 110 120 130 140 KIAA18 IYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGVPRS :::::::::::.::::::::::::::::::.: :::.::::::::::::::::::: ::. gi|149 IYRALDWGLDENEERELSPQLERLIDLMANSDCEDSSCGAADEGYGGPEEEEEAEGGPRA 110 120 130 140 150 160 150 160 170 180 190 200 KIAA18 VRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDE ::::::::::::.:::::.::::::::::::::::::::::::::::::::::::: ::: gi|149 VRTFAQAMRLCASRLTDPHGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLGEDE 170 180 190 200 210 220 210 220 230 240 250 260 KIAA18 PHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQ :..: : :::: ::::::::::::::::::.:::::::::.::::::::::::::::::: gi|149 PRVEKPLAELDHLGHTDWARLWVQLMRELRHGVKLKKVQEKEFNPLPTEFQLTPFEMLMQ 230 240 250 260 270 280 270 280 290 300 310 320 KIAA18 DIRARNYKLRKVMVDGDIPPRVEKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHE ::::::::::::::::::::::.:::::::::::::::::::::::::::.: :::.::: gi|149 DIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPVPQKQRTLHE 290 300 310 320 330 340 330 340 350 360 370 380 KIAA18 KILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQRPR ::::::::::::::: .: .::::::::::::::::: ::::::::::::::...:::: gi|149 KILEEIKQERRLRPVGAEHLGARGFGSLPCILNACSGDIKSTSCINLSVTDAGSGSQRPR 350 360 370 380 390 400 390 400 410 420 430 440 KIAA18 PRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHPP ::::::::::::::::.: ::::::::::.::::::::::::::::::..:::::::.:: gi|149 PRVLLKAPTLAEMEEMSTPEEEESPCGEVALKRDRSFSEHDLAQLRSEMGSGLQSATQPP 410 420 430 440 450 460 450 460 470 480 490 500 KIAA18 GGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTPDAKHLW ::::::: :::: : :::..:::: : ::: :.: :: ::.: :::: .:::.::: gi|149 GGTEPPRVRAGSMHSWRPSTRDQGLC--SVSGQSQPHPSNL-SSADGPEAS-APDARHLW 470 480 490 500 510 520 510 520 530 540 550 560 KIAA18 LEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLFSW :::::::::::::::::.::::::::::::::::.::::::::.::::::::.::::::: gi|149 LEFSHPVESLALTVEEVVDVRRVLVKAEMEKFLQDKELFSSLKRGKICCCCRTKFPLFSW 530 540 550 560 570 580 570 580 590 600 610 620 KIAA18 PPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQSLQ ::.:::::::::::::.:::::::: :::::::::::: ::: ..:..: ::: :: :: gi|149 PPTCLFCKRAVCTSCSVKMKMPSKKHGHIPVYTLGFESLQRVPTTKASPALRRDAFQCLQ 590 600 610 620 630 640 630 640 650 660 670 680 KIAA18 GPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQSLY ::.:.:::: :::::.::::::::::.::::::::: ::::::::::.:::::::::::: gi|149 GPKWRSVEEEFPHIYAHGCVLKDVCSDCTSFVADVVCSSRKSVDVLNATPRRSRQTQSLY 650 660 670 680 690 700 690 KIAA18 IPNTRTLDFK .::::::.:. gi|149 VPNTRTLNFQ 710 >>gi|187469025|gb|AAI66756.1| Spire2 protein [Rattus nor (714 aa) initn: 3631 init1: 2393 opt: 3626 Z-score: 3738.3 bits: 702.2 E(): 1.6e-199 Smith-Waterman score: 3626; 84.375% identity (92.656% similar) in 640 aa overlap (56-694:81-714) 30 40 50 60 70 80 KIAA18 IRSMSCLCLGLLWTDSCCLPGRVLGPLHPPAAFSP-PHPPAVPPSDRAPVPQTVQSLGFA : . : : .:::.. : ::::::: gi|187 GCRGLRGEPGGVRRIRDTADILLRRDGSVGARLEPEPSTMVVPPANSE--AQMVQSLGFA 60 70 80 90 100 90 100 110 120 130 140 KIAA18 IYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGVPRS :::::::::::.::::::::::::::::::.: :::.::::::::::::::::::: ::. gi|187 IYRALDWGLDENEERELSPQLERLIDLMANSDCEDSSCGAADEGYGGPEEEEEAEGGPRA 110 120 130 140 150 160 150 160 170 180 190 200 KIAA18 VRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDE ::::::::::::.:::::.::::::::::::::::::::::::::::::::::::: ::: gi|187 VRTFAQAMRLCASRLTDPHGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLGEDE 170 180 190 200 210 220 210 220 230 240 250 260 KIAA18 PHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQ :..: : :::: ::::::::::::::::::.:::::::::.::::::::::::::::::: gi|187 PRVEKPLAELDHLGHTDWARLWVQLMRELRHGVKLKKVQEKEFNPLPTEFQLTPFEMLMQ 230 240 250 260 270 280 270 280 290 300 310 320 KIAA18 DIRARNYKLRKVMVDGDIPPRVEKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHE ::::::::::::::::::::::.:::::::::::::::::::::::::::.: :::.::: gi|187 DIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPVPQKQRTLHE 290 300 310 320 330 340 330 340 350 360 370 380 KIAA18 KILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQRPR ::::::::::::::: .. .::::::::::::::::: ::::::::::::::...:::: gi|187 KILEEIKQERRLRPVGAQHLGARGFGSLPCILNACSGDIKSTSCINLSVTDAGSGSQRPR 350 360 370 380 390 400 390 400 410 420 430 440 KIAA18 PRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHPP ::::::::::::::::.: ::::::::::.::::::::::::::::::..:::::::.:: gi|187 PRVLLKAPTLAEMEEMSTPEEEESPCGEVALKRDRSFSEHDLAQLRSEMGSGLQSATQPP 410 420 430 440 450 460 450 460 470 480 490 500 KIAA18 GGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTPDAKHLW ::::::: :::: : :::..:::: : ::: :.: :: ::.: :::: .:::.::: gi|187 GGTEPPRVRAGSMHSWRPSTRDQGLC--SVSGQSQPHPSNL-SSADGPEAS-APDARHLW 470 480 490 500 510 520 510 520 530 540 550 560 KIAA18 LEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLFSW :::::::::::::::::.::::::::::::::::.::::::::.::::::::.::::::: gi|187 LEFSHPVESLALTVEEVVDVRRVLVKAEMEKFLQDKELFSSLKRGKICCCCRTKFPLFSW 530 540 550 560 570 580 570 580 590 600 610 620 KIAA18 PPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQSLQ ::.:::::::::::::.:::::::: :::::::::::: ::: ..:..: ::: :: :: gi|187 PPTCLFCKRAVCTSCSVKMKMPSKKHGHIPVYTLGFESLQRVPTTKASPALRRDAFQCLQ 590 600 610 620 630 640 630 640 650 660 670 680 KIAA18 GPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQSLY ::.:.:::: :::::.::::::::::.::::::::: ::::::::::.:::::.:::::: gi|187 GPKWRSVEEEFPHIYAHGCVLKDVCSDCTSFVADVVCSSRKSVDVLNATPRRSHQTQSLY 650 660 670 680 690 700 690 KIAA18 IPNTRTLDFK .::::::.:. gi|187 VPNTRTLNFQ 710 >>gi|81878461|sp|Q8K1S6.1|SPIR2_MOUSE RecName: Full=Prot (718 aa) initn: 3270 init1: 1662 opt: 3595 Z-score: 3706.3 bits: 696.3 E(): 9.6e-198 Smith-Waterman score: 3595; 83.906% identity (92.500% similar) in 640 aa overlap (61-694:85-718) 40 50 60 70 80 KIAA18 CLCLGLLWTDSCCLPGRVLGPLHPPAAFSPPHPPA--VPPSDRAPVPQTVQSLGFAIYRA :.: . :::.. : ::::::::::: gi|818 LRGEPGGVRRIRDTADILLRRDGSVGARLEPEPTTMVVPPASSE--AQMVQSLGFAIYRA 60 70 80 90 100 110 90 100 110 120 130 140 KIAA18 LDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGVPRSVRTF :::::::.::::::::::::::::::.: :::.:::::::: :::::::::: ::.:::: gi|818 LDWGLDENEERELSPQLERLIDLMANSDCEDSSCGAADEGYVGPEEEEEAEGGPRAVRTF 120 130 140 150 160 170 150 160 170 180 190 200 KIAA18 AQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDEPHLE :::::::: :::::.::::::::::::::::::::::::::::::::::.:: :.::. : gi|818 AQAMRLCALRLTDPHGAQAHYQAVCRALFVETLELRAFLARVREAKEMLKKLGEEEPR-E 180 190 200 210 220 230 210 220 230 240 250 260 KIAA18 TPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRA : :::: ::::::::::::::::::.:::::::::.::::::::::::::::::::::: gi|818 KPLAELDHLGHTDWARLWVQLMRELRHGVKLKKVQEKEFNPLPTEFQLTPFEMLMQDIRA 240 250 260 270 280 290 270 280 290 300 310 320 KIAA18 RNYKLRKVMVDGDIPPRVEKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHEKILE ::::::::::::::::::.:::::::::::::::::::::::.:::.: :::.::::::: gi|818 RNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERQLRPVPQKQRTLHEKILE 300 310 320 330 340 350 330 340 350 360 370 380 KIAA18 EIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQRPRPRVL ::::::::::: .. ..:::::::::::::::: ::::::::::::.:...:::::::: gi|818 EIKQERRLRPVGAQHLGGRGFGSLPCILNACSGDIKSTSCINLSVTDTGSGSQRPRPRVL 360 370 380 390 400 410 390 400 410 420 430 440 KIAA18 LKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHPPGGTE :::::::::::::::::::::::::.::::::::::::::::::.:::::::..:::::: gi|818 LKAPTLAEMEEMNTSEEEESPCGEVALKRDRSFSEHDLAQLRSEMASGLQSAAQPPGGTE 420 430 440 450 460 470 450 460 470 480 490 500 KIAA18 PPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPL----LSNRGSSGDRPEASMTPDAKHLW ::: :::: : :::.::::: :: :: :.:: : . :: : :::. .::..::: gi|818 PPRARAGSMHSWRPSSRDQGFCP--VSGQSQPLPSSALPSSLSSVDGPEAA-SPDTRHLW 480 490 500 510 520 510 520 530 540 550 560 KIAA18 LEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLFSW :::::::::::::::::.::::::::::::.:::.::::::::.:::::::::::::::: gi|818 LEFSHPVESLALTVEEVVDVRRVLVKAEMERFLQDKELFSSLKRGKICCCCRAKFPLFSW 530 540 550 560 570 580 570 580 590 600 610 620 KIAA18 PPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQSLQ ::.:::::::::::::.::::::::.:::::::::::: ::: ..:..: ::: ::::: gi|818 PPTCLFCKRAVCTSCSVKMKMPSKKYGHIPVYTLGFESLQRVPTTKATPTLRRDAFQSLQ 590 600 610 620 630 640 630 640 650 660 670 680 KIAA18 GPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQSLY ::.:.:::: :::::.::::::::::.::::::::: ::::::::::.:::::::::::: gi|818 GPKWRSVEEEFPHIYAHGCVLKDVCSDCTSFVADVVCSSRKSVDVLNATPRRSRQTQSLY 650 660 670 680 690 700 690 KIAA18 IPNTRTLDFK :::::::.:. gi|818 IPNTRTLNFQ 710 >>gi|20072945|gb|AAH26502.1| SPIRE2 protein [Mus musculu (618 aa) initn: 3270 init1: 1662 opt: 3575 Z-score: 3686.6 bits: 692.4 E(): 1.2e-196 Smith-Waterman score: 3575; 85.507% identity (93.720% similar) in 621 aa overlap (78-694:2-618) 50 60 70 80 90 100 KIAA18 VLGPLHPPAAFSPPHPPAVPPSDRAPVPQTVQSLGFAIYRALDWGLDESEERELSPQLER ::::::::::::::::::.::::::::::: gi|200 MVQSLGFAIYRALDWGLDENEERELSPQLER 10 20 30 110 120 130 140 150 160 KIAA18 LIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGVPRSVRTFAQAMRLCAARLTDPRGAQA :::::::.: :::.:::::::: :::::::::: ::.:::::::::::: :::::.:::: gi|200 LIDLMANSDCEDSSCGAADEGYVGPEEEEEAEGGPRAVRTFAQAMRLCALRLTDPHGAQA 40 50 60 70 80 90 170 180 190 200 210 220 KIAA18 HYQAVCRALFVETLELRAFLARVREAKEMLQKLREDEPHLETPRAELDSLGHTDWARLWV ::::::::::::::::::::::::::::::.:: :.::. : : :::: ::::::::::: gi|200 HYQAVCRALFVETLELRAFLARVREAKEMLKKLGEEEPR-EKPLAELDHLGHTDWARLWV 100 110 120 130 140 150 230 240 250 260 270 280 KIAA18 QLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVE :::::::.:::::::::.:::::::::::::::::::::::::::::::::::::::::. gi|200 QLMRELRHGVKLKKVQEKEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVK 160 170 180 190 200 210 290 300 310 320 330 340 KIAA18 KDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHEKILEEIKQERRLRPVRGEGWAAR :::::::::::::::::::::::.:::.: :::.:::::::::::::::::: .. ..: gi|200 KDAHELILDFIRSRPPLKQVSERQLRPVPQKQRTLHEKILEEIKQERRLRPVGAQHLGGR 220 230 240 250 260 270 350 360 370 380 390 400 KIAA18 GFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQRPRPRVLLKAPTLAEMEEMNTSEEEE ::::::::::::::: ::::::::::::.:...::::::::::::::::::::::::::: gi|200 GFGSLPCILNACSGDIKSTSCINLSVTDTGSGSQRPRPRVLLKAPTLAEMEEMNTSEEEE 280 290 300 310 320 330 410 420 430 440 450 460 KIAA18 SPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHPPGGTEPPRPRAGSAHVWRPGSRDQ ::::::.::::::::::::::::::.:::::::..::::::::: :::: : :::.:::: gi|200 SPCGEVALKRDRSFSEHDLAQLRSEMASGLQSAAQPPGGTEPPRARAGSMHSWRPSSRDQ 340 350 360 370 380 390 470 480 490 500 510 520 KIAA18 GTCPASVSDPSHPL----LSNRGSSGDRPEASMTPDAKHLWLEFSHPVESLALTVEEVMD : :: :: :.:: : . :: : :::. .::..::::::::::::::::::::.: gi|200 GFCP--VSGQSQPLPSSALPSSLSSVDGPEAA-SPDTRHLWLEFSHPVESLALTVEEVVD 400 410 420 430 440 530 540 550 560 570 580 KIAA18 VRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLFSWPPSCLFCKRAVCTSCSIKM :::::::::::.:::.::::::::.::::::::::::::::::.:::::::::::::.:: gi|200 VRRVLVKAEMERFLQDKELFSSLKRGKICCCCRAKFPLFSWPPTCLFCKRAVCTSCSVKM 450 460 470 480 490 500 590 600 610 620 630 640 KIAA18 KMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQSLQGPQWQSVEEAFPHIYSHGC ::::::.:::::::::::: ::: ..:..: ::: :::::::.:.:::: :::::.::: gi|200 KMPSKKYGHIPVYTLGFESLQRVPTTKATPTLRRDAFQSLQGPKWRSVEEEFPHIYAHGC 510 520 530 540 550 560 650 660 670 680 690 KIAA18 VLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQSLYIPNTRTLDFK :::::::.::::::::: ::::::::::.:::::::::::::::::::.:. gi|200 VLKDVCSDCTSFVADVVCSSRKSVDVLNATPRRSRQTQSLYIPNTRTLNFQ 570 580 590 600 610 694 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 21:29:07 2009 done: Thu Mar 5 21:32:45 2009 Total Scan time: 1522.600 Total Display time: 0.360 Function used was FASTA [version 34.26.5 April 26, 2007]