# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fh12206mrp1.fasta.nr -Q ../query/KIAA1836.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1836, 718 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7820989 sequences Expectation_n fit: rho(ln(x))= 6.8229+/-0.000203; mu= 6.1108+/- 0.011 mean_var=135.6409+/-26.095, 0's: 36 Z-trim: 50 B-trim: 0 in 0/66 Lambda= 0.110123 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|119627191|gb|EAX06786.1| coiled-coil and C2 dom ( 838) 4706 759.4 1.2e-216 gi|74744295|sp|Q5T0F9.1|C2D1B_HUMAN RecName: Full= ( 858) 4706 759.4 1.2e-216 gi|114556602|ref|XP_513407.2| PREDICTED: coiled-co ( 858) 4685 756.1 1.2e-215 gi|55960617|emb|CAI12284.1| coiled-coil and C2 dom ( 852) 4634 748.0 3.2e-213 gi|119627192|gb|EAX06787.1| coiled-coil and C2 dom ( 821) 4453 719.2 1.4e-204 gi|114556600|ref|XP_001144134.1| PREDICTED: hypoth ( 841) 4432 715.9 1.5e-203 gi|149693619|ref|XP_001490702.1| PREDICTED: coiled ( 860) 4131 668.1 3.7e-189 gi|119890209|ref|XP_588670.3| PREDICTED: similar t ( 861) 4109 664.6 4.2e-188 gi|55960614|emb|CAI12281.1| coiled-coil and C2 dom ( 627) 3992 645.9 1.3e-182 gi|73977519|ref|XP_539614.2| PREDICTED: similar to ( 909) 3963 641.4 4.2e-181 gi|55960615|emb|CAI12282.1| coiled-coil and C2 dom ( 771) 3782 612.6 1.7e-172 gi|16877234|gb|AAH16880.1| CC2D1B protein [Homo sa ( 532) 3356 544.8 3e-152 gi|148877237|sp|Q5FVK6.2|C2D1B_RAT RecName: Full=C ( 850) 3301 536.2 1.8e-149 gi|81897220|sp|Q8BRN9.1|C2D1B_MOUSE RecName: Full= ( 848) 3262 530.0 1.3e-147 gi|149035714|gb|EDL90395.1| coiled-coil and C2 dom ( 598) 3256 528.9 2e-147 gi|148698789|gb|EDL30736.1| coiled-coil and C2 dom ( 851) 3254 528.7 3.2e-147 gi|74144615|dbj|BAE27295.1| unnamed protein produc ( 848) 3253 528.6 3.6e-147 gi|148698788|gb|EDL30735.1| coiled-coil and C2 dom ( 869) 3229 524.8 5.2e-146 gi|123247258|emb|CAM23503.1| coiled-coil and C2 do ( 769) 3224 523.9 8.2e-146 gi|32967615|gb|AAH55068.1| Cc2d1b protein [Mus mus ( 773) 3224 523.9 8.2e-146 gi|109004984|ref|XP_001105514.1| PREDICTED: simila ( 798) 2997 487.9 6e-135 gi|39644790|gb|AAH07912.2| CC2D1B protein [Homo sa ( 391) 2522 412.2 1.8e-112 gi|118094658|ref|XP_001235393.1| PREDICTED: hypoth ( 875) 2329 381.8 5.7e-103 gi|82187160|sp|Q6PF54.1|C2D1B_XENLA RecName: Full= ( 864) 2207 362.4 3.9e-97 gi|148725390|emb|CAN88230.1| novel protein similar ( 790) 1946 320.9 1.1e-84 gi|189515755|ref|XP_692169.3| PREDICTED: si:ch211- ( 859) 1946 320.9 1.2e-84 gi|148743922|gb|AAI42502.1| CC2D1A protein [Bos ta ( 951) 1729 286.5 3e-74 gi|114675699|ref|XP_524131.2| PREDICTED: hypotheti ( 950) 1727 286.2 3.8e-74 gi|73986396|ref|XP_542027.2| PREDICTED: similar to ( 950) 1700 281.9 7.4e-73 gi|22671723|gb|AAN04488.1| hypothetical protein [H ( 950) 1693 280.8 1.6e-72 gi|74737148|sp|Q6P1N0.1|C2D1A_HUMAN RecName: Full= ( 951) 1692 280.6 1.8e-72 gi|31455459|dbj|BAC77355.1| putative NFkB activati ( 951) 1692 280.6 1.8e-72 gi|149037875|gb|EDL92235.1| similar to cDNA sequen ( 918) 1611 267.7 1.3e-68 gi|22268085|gb|AAH27028.1| Cc2d1a protein [Mus mus ( 874) 1603 266.5 3e-68 gi|108935962|sp|Q8K1A6.2|C2D1A_MOUSE RecName: Full ( 943) 1603 266.5 3.2e-68 gi|148678987|gb|EDL10934.1| mCG5898, isoform CRA_a ( 950) 1603 266.5 3.2e-68 gi|148678988|gb|EDL10935.1| mCG5898, isoform CRA_b ( 919) 1591 264.6 1.2e-67 gi|47223860|emb|CAG06037.1| unnamed protein produc ( 911) 1557 259.2 4.9e-66 gi|114675701|ref|XP_001171190.1| PREDICTED: coiled ( 801) 1550 258.0 9.7e-66 gi|18921439|gb|AAH16188.1| Coiled-coil and C2 doma ( 595) 1528 254.4 8.7e-65 gi|84372143|gb|ABC56419.1| Freud-1 [Mus musculus] ( 595) 1528 254.4 8.7e-65 gi|123247259|emb|CAM23504.1| coiled-coil and C2 do ( 233) 1471 245.0 2.3e-62 gi|170285117|gb|AAI61089.1| LOC100145460 protein [ ( 973) 1423 237.9 1.3e-59 gi|194191088|gb|EDX04664.1| GD23762 [Drosophila si ( 836) 1362 228.2 9.8e-57 gi|51858870|gb|AAH81948.1| Coiled-coil and C2 doma ( 896) 1342 225.0 9.4e-56 gi|108935961|sp|Q66HA5.2|C2D1A_RAT RecName: Full=C ( 941) 1337 224.2 1.7e-55 gi|126323162|ref|XP_001366597.1| PREDICTED: simila ( 967) 1319 221.4 1.2e-54 gi|126323160|ref|XP_001366548.1| PREDICTED: simila ( 949) 1301 218.5 8.9e-54 gi|119604786|gb|EAW84380.1| coiled-coil and C2 dom ( 736) 1298 217.9 1e-53 gi|10435321|dbj|BAB14561.1| unnamed protein produc ( 387) 1293 216.9 1.1e-53 >>gi|119627191|gb|EAX06786.1| coiled-coil and C2 domain (838 aa) initn: 4706 init1: 4706 opt: 4706 Z-score: 4046.0 bits: 759.4 E(): 1.2e-216 Smith-Waterman score: 4706; 100.000% identity (100.000% similar) in 718 aa overlap (1-718:121-838) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL :::::::::::::::::::::::::::::: gi|119 EVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALL 100 110 120 130 140 150 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR 160 170 180 190 200 210 100 110 120 130 140 150 KIAA18 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY 220 230 240 250 260 270 160 170 180 190 200 210 KIAA18 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP 280 290 300 310 320 330 220 230 240 250 260 270 KIAA18 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK 340 350 360 370 380 390 280 290 300 310 320 330 KIAA18 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE 400 410 420 430 440 450 340 350 360 370 380 390 KIAA18 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS 460 470 480 490 500 510 400 410 420 430 440 450 KIAA18 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK 520 530 540 550 560 570 460 470 480 490 500 510 KIAA18 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET 580 590 600 610 620 630 520 530 540 550 560 570 KIAA18 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN 640 650 660 670 680 690 580 590 600 610 620 630 KIAA18 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK 700 710 720 730 740 750 640 650 660 670 680 690 KIAA18 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV 760 770 780 790 800 810 700 710 KIAA18 KVRLREPLSGQDVQMVTENWLVLEPRGL :::::::::::::::::::::::::::: gi|119 KVRLREPLSGQDVQMVTENWLVLEPRGL 820 830 >>gi|74744295|sp|Q5T0F9.1|C2D1B_HUMAN RecName: Full=Coil (858 aa) initn: 4706 init1: 4706 opt: 4706 Z-score: 4045.9 bits: 759.4 E(): 1.2e-216 Smith-Waterman score: 4706; 100.000% identity (100.000% similar) in 718 aa overlap (1-718:141-858) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL :::::::::::::::::::::::::::::: gi|747 EVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALL 120 130 140 150 160 170 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR 180 190 200 210 220 230 100 110 120 130 140 150 KIAA18 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY 240 250 260 270 280 290 160 170 180 190 200 210 KIAA18 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP 300 310 320 330 340 350 220 230 240 250 260 270 KIAA18 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK 360 370 380 390 400 410 280 290 300 310 320 330 KIAA18 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE 420 430 440 450 460 470 340 350 360 370 380 390 KIAA18 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS 480 490 500 510 520 530 400 410 420 430 440 450 KIAA18 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK 540 550 560 570 580 590 460 470 480 490 500 510 KIAA18 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET 600 610 620 630 640 650 520 530 540 550 560 570 KIAA18 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN 660 670 680 690 700 710 580 590 600 610 620 630 KIAA18 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK 720 730 740 750 760 770 640 650 660 670 680 690 KIAA18 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV 780 790 800 810 820 830 700 710 KIAA18 KVRLREPLSGQDVQMVTENWLVLEPRGL :::::::::::::::::::::::::::: gi|747 KVRLREPLSGQDVQMVTENWLVLEPRGL 840 850 >>gi|114556602|ref|XP_513407.2| PREDICTED: coiled-coil a (858 aa) initn: 4685 init1: 4685 opt: 4685 Z-score: 4027.9 bits: 756.1 E(): 1.2e-215 Smith-Waterman score: 4685; 99.721% identity (99.861% similar) in 718 aa overlap (1-718:141-858) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL :::::::::::::::::::::::::::::: gi|114 EVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALL 120 130 140 150 160 170 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR 180 190 200 210 220 230 100 110 120 130 140 150 KIAA18 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY 240 250 260 270 280 290 160 170 180 190 200 210 KIAA18 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP 300 310 320 330 340 350 220 230 240 250 260 270 KIAA18 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK 360 370 380 390 400 410 280 290 300 310 320 330 KIAA18 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE 420 430 440 450 460 470 340 350 360 370 380 390 KIAA18 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS 480 490 500 510 520 530 400 410 420 430 440 450 KIAA18 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK ::::::::::::::::::::::::::::::::::::::::: :::::::::::::.:::: gi|114 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKCLEAQIIQARSGRPIDLSK 540 550 560 570 580 590 460 470 480 490 500 510 KIAA18 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET 600 610 620 630 640 650 520 530 540 550 560 570 KIAA18 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN 660 670 680 690 700 710 580 590 600 610 620 630 KIAA18 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK 720 730 740 750 760 770 640 650 660 670 680 690 KIAA18 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV 780 790 800 810 820 830 700 710 KIAA18 KVRLREPLSGQDVQMVTENWLVLEPRGL :::::::::::::::::::::::::::: gi|114 KVRLREPLSGQDVQMVTENWLVLEPRGL 840 850 >>gi|55960617|emb|CAI12284.1| coiled-coil and C2 domain (852 aa) initn: 2434 init1: 2434 opt: 4634 Z-score: 3984.1 bits: 748.0 E(): 3.2e-213 Smith-Waterman score: 4634; 99.164% identity (99.164% similar) in 718 aa overlap (1-718:141-852) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL :::::::::::::::::::::::::::::: gi|559 EVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALL 120 130 140 150 160 170 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR 180 190 200 210 220 230 100 110 120 130 140 150 KIAA18 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY 240 250 260 270 280 290 160 170 180 190 200 210 KIAA18 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP 300 310 320 330 340 350 220 230 240 250 260 270 KIAA18 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK 360 370 380 390 400 410 280 290 300 310 320 330 KIAA18 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE 420 430 440 450 460 470 340 350 360 370 380 390 KIAA18 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS ::::::::::::::::: ::::::::::::::::::::::::::::::::::::: gi|559 KLASAEDSAPADKDEDE------GEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS 480 490 500 510 520 400 410 420 430 440 450 KIAA18 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK 530 540 550 560 570 580 460 470 480 490 500 510 KIAA18 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET 590 600 610 620 630 640 520 530 540 550 560 570 KIAA18 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN 650 660 670 680 690 700 580 590 600 610 620 630 KIAA18 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK 710 720 730 740 750 760 640 650 660 670 680 690 KIAA18 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV 770 780 790 800 810 820 700 710 KIAA18 KVRLREPLSGQDVQMVTENWLVLEPRGL :::::::::::::::::::::::::::: gi|559 KVRLREPLSGQDVQMVTENWLVLEPRGL 830 840 850 >>gi|119627192|gb|EAX06787.1| coiled-coil and C2 domain (821 aa) initn: 2265 init1: 2265 opt: 4453 Z-score: 3828.9 bits: 719.2 E(): 1.4e-204 Smith-Waterman score: 4453; 99.132% identity (99.132% similar) in 691 aa overlap (1-691:121-805) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL :::::::::::::::::::::::::::::: gi|119 EVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALL 100 110 120 130 140 150 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR 160 170 180 190 200 210 100 110 120 130 140 150 KIAA18 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY 220 230 240 250 260 270 160 170 180 190 200 210 KIAA18 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP 280 290 300 310 320 330 220 230 240 250 260 270 KIAA18 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK 340 350 360 370 380 390 280 290 300 310 320 330 KIAA18 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE 400 410 420 430 440 450 340 350 360 370 380 390 KIAA18 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS ::::::::::::::::: ::::::::::::::::::::::::::::::::::::: gi|119 KLASAEDSAPADKDEDE------GEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS 460 470 480 490 500 400 410 420 430 440 450 KIAA18 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK 510 520 530 540 550 560 460 470 480 490 500 510 KIAA18 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET 570 580 590 600 610 620 520 530 540 550 560 570 KIAA18 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN 630 640 650 660 670 680 580 590 600 610 620 630 KIAA18 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK 690 700 710 720 730 740 640 650 660 670 680 690 KIAA18 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV 750 760 770 780 790 800 700 710 KIAA18 KVRLREPLSGQDVQMVTENWLVLEPRGL : gi|119 KPMASTRRGVRPRLCRR 810 820 >>gi|114556600|ref|XP_001144134.1| PREDICTED: hypothetic (841 aa) initn: 2265 init1: 2265 opt: 4432 Z-score: 3810.7 bits: 715.9 E(): 1.5e-203 Smith-Waterman score: 4432; 98.842% identity (98.987% similar) in 691 aa overlap (1-691:141-825) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL :::::::::::::::::::::::::::::: gi|114 EVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALL 120 130 140 150 160 170 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR 180 190 200 210 220 230 100 110 120 130 140 150 KIAA18 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREY 240 250 260 270 280 290 160 170 180 190 200 210 KIAA18 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP 300 310 320 330 340 350 220 230 240 250 260 270 KIAA18 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK 360 370 380 390 400 410 280 290 300 310 320 330 KIAA18 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE 420 430 440 450 460 470 340 350 360 370 380 390 KIAA18 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS ::::::::::::::::: ::::::::::::::::::::::::::::::::::::: gi|114 KLASAEDSAPADKDEDE------GEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS 480 490 500 510 520 400 410 420 430 440 450 KIAA18 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK ::::::::::::::::::::::::::::::::::::::::: :::::::::::::.:::: gi|114 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKCLEAQIIQARSGRPIDLSK 530 540 550 560 570 580 460 470 480 490 500 510 KIAA18 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET 590 600 610 620 630 640 520 530 540 550 560 570 KIAA18 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN 650 660 670 680 690 700 580 590 600 610 620 630 KIAA18 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK 710 720 730 740 750 760 640 650 660 670 680 690 KIAA18 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV 770 780 790 800 810 820 700 710 KIAA18 KVRLREPLSGQDVQMVTENWLVLEPRGL : gi|114 KPMASTRRGVRPRLCRS 830 840 >>gi|149693619|ref|XP_001490702.1| PREDICTED: coiled-coi (860 aa) initn: 3157 init1: 2310 opt: 4131 Z-score: 3552.2 bits: 668.1 E(): 3.7e-189 Smith-Waterman score: 4131; 87.724% identity (95.448% similar) in 725 aa overlap (1-718:140-860) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL . :::::::.::::.::::::. :.:.::: gi|149 EVLGADEEAGPLDGSETASPGVPEEEKGQENIEPPVQTALLTASVPAAQAGGPQALQALL 110 120 130 140 150 160 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :.::::::::::::::::::::::::::::::::::::.::.:::::::::::::::::: gi|149 EDRIHNYREAAASAKEAGEAAKARRCERGLKTLESQLAAVRKGRKINEDEIPPPVALGKR 170 180 190 200 210 220 100 110 120 130 140 KIAA18 PLAPQEPANRSPETDPPAPPALESDNPSQPETSL---PGISAQPVSDLDPDPRALLSSRQ :::::. .:::::.: :.::..: :::::::::: : ::: : : :::::::: .:: gi|149 PLAPQKTTNRSPEADSPGPPTVEPDNPSQPETSLLGSPRISAPP--DSDPDPRALLLARQ 230 240 250 260 270 280 150 160 170 180 190 200 KIAA18 REYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLK--PQQ ::::.:::.:::::.::::::::: ::.::::::::::::::::::::::::::: :: gi|149 REYKTAALNAKRAGHLDRARELMRTGKKFGAVLEALEKGQPVDLSAMPPAPEDLKLLPQ- 290 300 310 320 330 340 210 220 230 240 250 260 KIAA18 ASQAPTAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSG ::.:::::::. ::::::::..:::.:::: :::: :::::::::::.::::::.:::.. gi|149 ASKAPTAPSVVSPAVERVQPLLAPDTPATP-APTEPQTVLDALQQRLSKYREAGLQARGS 350 360 370 380 390 400 270 280 290 300 310 320 KIAA18 GDERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAAT :::::::::::::::::::::::.:::::.::::::::::::::::: : .:::::::: gi|149 GDERKARMHERIAKQYQDAIRAHHAGRKVDFAELPVPPGFPPIPGLEPTTVTEEDAVAAT 410 420 430 440 450 460 330 340 350 360 370 380 KIAA18 LAAAEKLASAEDSAPADKDEDE--PPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRAS ::::.::::.::.:::..:::: : :::: : :::::::::::.: ::::. ::::.:: gi|149 LAAAQKLASSEDAAPAEEDEDENEPLGHLQDESPAQAPVAKKPAQPLVPSSRSLPEPKAS 470 480 490 500 510 520 390 400 410 420 430 440 KIAA18 SSKESPSPSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSG ::::: :::::::::.::.::::::::::::::.::::::::..:::: :::::.:.:.: gi|149 SSKESLSPSVREQLAVLETRKLQYQRAALQAKRGQDLEQAKAHMRVAKCLEAQIVQVRAG 530 540 550 560 570 580 450 460 470 480 490 500 KIAA18 RPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMH :::::::::::::::::::::::::::::::::::::::::::::::.:::::.:::::: gi|149 RPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQHEKCLLYSKQFMH 590 600 610 620 630 640 510 520 530 540 550 560 KIAA18 QGNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHL ::::.::::::::::::.:::::::::::::::::.:::::::::::::::::::::::: gi|149 QGNVTETTRFEKLAQDRRKQLEILQLAQAQGLDPPSHHFELKTFQTVRIFSELNSTEMHL 650 660 670 680 690 700 570 580 590 600 610 620 KIAA18 IIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNIN ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: gi|149 IIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSEQAQKSKTAVVKNTNSPEFDQLFKLNIN 710 720 730 740 750 760 630 640 650 660 670 680 KIAA18 RNHRGFKRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKP ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 RNHRGFRRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKP 770 780 790 800 810 820 690 700 710 KIAA18 TGGKLEVKVRLREPLSGQDVQMVTENWLVLEPRGL :::::::::::::::::::::.::::::::::::: gi|149 TGGKLEVKVRLREPLSGQDVQIVTENWLVLEPRGL 830 840 850 860 >>gi|119890209|ref|XP_588670.3| PREDICTED: similar to co (861 aa) initn: 2979 init1: 2300 opt: 4109 Z-score: 3533.3 bits: 664.6 E(): 4.2e-188 Smith-Waterman score: 4109; 86.326% identity (95.580% similar) in 724 aa overlap (1-718:140-861) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL ..:: ::.:.::: .::::::. .::.::: gi|119 EVLGTDEEAGALDGDETASLGGPEEEKEQENVEPLVQAALLTAPVPAAQAGGPRGLQALL 110 120 130 140 150 160 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :.::.::.::::::::::::::::::::::::::::::.::.:.::.:::::::::::.: gi|119 EDRIRNYQEAAASAKEAGEAAKARRCERGLKTLESQLAAVRKGKKISEDEIPPPVALGRR 170 180 190 200 210 220 100 110 120 130 140 KIAA18 PLAPQEPANRSPETDPPAPPALESDNPSQPETSL---PGISAQPVSDLDPDPRALLSSRQ ::.::: .:.:::..::: :..: :::::::::: ::::: : : :::::::: .:: gi|119 PLVPQETTNKSPEAEPPAAPSVEPDNPSQPETSLLGSPGISAPP--DSDPDPRALLLARQ 230 240 250 260 270 280 150 160 170 180 190 200 KIAA18 REYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKP-QQA ::::::::.:::::.:::::::::.::::.:::::::::::::::::::.:::::: :: gi|119 REYKVAALNAKRAGDLDRARELMRVGKRFAAVLEALEKGQPVDLSAMPPSPEDLKPLPQA 290 300 310 320 330 340 210 220 230 240 250 260 KIAA18 SQAPTAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGG :::::::: ::::::..:::: :.::.::::.: :::::::::::::::::: :::..: gi|119 SQAPTAPSDAPPAVERMHPVMASDIPAAPVAPAEPQTVLDALQQRLNKYREAGTQARGSG 350 360 370 380 390 400 270 280 290 300 310 320 KIAA18 DERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATL ::::::::::::::::::::::::::::.::::::::::::::::: :...::: .:::: gi|119 DERKARMHERIAKQYQDAIRAHRAGRKVDFAELPVPPGFPPIPGLEPTVATEEDMMAATL 410 420 430 440 450 460 330 340 350 360 370 380 KIAA18 AAAEKLASAEDSAPADKDED--EPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASS :::.:::::::.::....:: .:::::: :::::::::::::.: .:::. ::::..:: gi|119 AAAQKLASAEDTAPVEEEEDNNKPPGHLQDEPPAQAPVAKKPAQPLAPSSRSLPEPKTSS 470 480 490 500 510 520 390 400 410 420 430 440 KIAA18 SKESPSPSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGR ::: :::.:::::::::::::::::::::::..:::::::.::::: ::::: :.:.:: gi|119 SKEVLSPSAREQLALLEARKLQYQRAALQAKRGRDLEQAKAHLRVAKSLEAQITQVRAGR 530 540 550 560 570 580 450 460 470 480 490 500 KIAA18 PVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQ ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: gi|119 PVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQHEKCLLFSKQFMHQ 590 600 610 620 630 640 510 520 530 540 550 560 KIAA18 GNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLI :::::::::::::::::.::::::::::::::::.::::::::::::::.:::::::::: gi|119 GNVAETTRFEKLAQDRKQQLEILQLAQAQGLDPPSHHFELKTFQTVRIFAELNSTEMHLI 650 660 670 680 690 700 570 580 590 600 610 620 KIAA18 IVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINR .:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|119 VVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKNKTAVVKNTNSPEFDQLFKLNINR 710 720 730 740 750 760 630 640 650 660 670 680 KIAA18 NHRGFKRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPT :::::.::::.::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NHRGFRRVIQNKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPT 770 780 790 800 810 820 690 700 710 KIAA18 GGKLEVKVRLREPLSGQDVQMVTENWLVLEPRGL :::::::::::::::::::::::::::::::::: gi|119 GGKLEVKVRLREPLSGQDVQMVTENWLVLEPRGL 830 840 850 860 >>gi|55960614|emb|CAI12281.1| coiled-coil and C2 domain (627 aa) initn: 2253 init1: 2253 opt: 3992 Z-score: 3434.7 bits: 645.9 E(): 1.3e-182 Smith-Waterman score: 3992; 99.028% identity (99.028% similar) in 617 aa overlap (75-691:1-611) 50 60 70 80 90 100 KIAA18 KEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKRPLAPQEPANRSPET :::::::::::::::::::::::::::::: gi|559 KINEDEIPPPVALGKRPLAPQEPANRSPET 10 20 30 110 120 130 140 150 160 KIAA18 DPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREYKVAALSAKRAGELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 DPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREYKVAALSAKRAGELD 40 50 60 70 80 90 170 180 190 200 210 220 KIAA18 RARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAPTAPSVIPPAVERVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 RARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAPTAPSVIPPAVERVQ 100 110 120 130 140 150 230 240 250 260 270 280 KIAA18 PVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERKARMHERIAKQYQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 PVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERKARMHERIAKQYQDA 160 170 180 190 200 210 290 300 310 320 330 340 KIAA18 IRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAEKLASAEDSAPADKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 IRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAEKLASAEDSAPADKD 220 230 240 250 260 270 350 360 370 380 390 400 KIAA18 EDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPSPSVREQLALLEARK ::: ::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 EDE------GEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPSPSVREQLALLEARK 280 290 300 310 320 410 420 430 440 450 460 KIAA18 LQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSKVPSPLTDEEGDFIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 LQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSKVPSPLTDEEGDFIL 330 340 350 360 370 380 470 480 490 500 510 520 KIAA18 IHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAETTRFEKLAQDRKKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 IHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAETTRFEKLAQDRKKQL 390 400 410 420 430 440 530 540 550 560 570 580 KIAA18 EILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 EILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDA 450 460 470 480 490 500 590 600 610 620 630 640 KIAA18 FVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFKRVIQSKGIKFEIFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 FVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFKRVIQSKGIKFEIFH 510 520 530 540 550 560 650 660 670 680 690 700 KIAA18 KGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEVKVRLREPLSGQDVQ ::::::::::::::::::::::::::::::::::::::::::::::: gi|559 KGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEVKPMASTRRGVRPRL 570 580 590 600 610 620 710 KIAA18 MVTENWLVLEPRGL gi|559 CRR >>gi|73977519|ref|XP_539614.2| PREDICTED: similar to coi (909 aa) initn: 3263 init1: 2259 opt: 3963 Z-score: 3407.6 bits: 641.4 E(): 4.2e-181 Smith-Waterman score: 3963; 84.848% identity (93.113% similar) in 726 aa overlap (1-718:186-909) 10 20 30 KIAA18 DTEPPVQTAVLTASAPAAQAGASQGLHALL ::: : :::.::::.::::::. .::.::: gi|739 QEVLGVDEAGPQDGDETASPGGSEEEKGQEDTEAPGQTALLTASVPAAQAGGPRGLQALL 160 170 180 190 200 210 40 50 60 70 80 90 KIAA18 EERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKR :.::::::::::::::::::::::::::::::::.:::.::.:.::.:::::::::.::: gi|739 EDRIHNYREAAASAKEAGEAAKARRCERGLKTLEAQLAAVRKGKKISEDEIPPPVAVGKR 220 230 240 250 260 270 100 110 120 130 140 KIAA18 PLAPQEPANRSPET--DPPAPPALESDNPSQPETSLPG---ISAQPVSDLDPDPRALLSS :::: :.:.::. : ::: . : :.:::::::: : ::: : : :::::::::. gi|739 QPAPQEAADRNPEAEADAPAPFTKEPDKPSQPETSLSGSLGISAPP--DSDPDPRALLSA 280 290 300 310 320 330 150 160 170 180 190 200 KIAA18 RQREYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKP-Q ::::::.:::.:::::.:.::::::::::::::::::: ::::::::::::::.::: gi|739 RQREYKLAALNAKRAGDLNRARELMRIGKRFGAVLEALGKGQPVDLSAMPPAPKDLKALP 340 350 360 370 380 390 210 220 230 240 250 260 KIAA18 QASQAPTAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARS :::.: ::: :.: :.:::::: . :.::.::. .: :::::::::::::::::::::. gi|739 QASKAVTAPPVVPLALERVQPVTGSDTPAAPVVAAEPPTVLDALQQRLNKYREAGIQARG 400 410 420 430 440 450 270 280 290 300 310 320 KIAA18 GGDERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAA .:::::::::::::::::::::::::::.:.:::::::::::::::: ..:.::::::: gi|739 SGDERKARMHERIAKQYQDAIRAHRAGRRVDFAELPVPPGFPPIPGLAPAVGTEEDAVAA 460 470 480 490 500 510 330 340 350 360 370 380 KIAA18 TLAAAEKLASAEDSAPADKDEDEP--PGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRA :::::.:::: :: :::...:.: ::::: :::::::::::::.:.: : . ::.:.: gi|739 TLAAAQKLASLEDPAPAEEEEEEEDVPGHLQDEPPAQAPVAKKPAKPAVLSFEALPDPKA 520 530 540 550 560 570 390 400 410 420 430 440 KIAA18 SSSKESPSPSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARS :::::: ::::::::::::::.::::::::::::.::::::::.::::: ::::: :.:. gi|739 SSSKESLSPSVREQLALLEARRLQYQRAALQAKRGQDLEQAKAHLRVAKRLEAQITQVRA 580 590 600 610 620 630 450 460 470 480 490 500 KIAA18 GRPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFM :::::::::::::::::::::::::::::::::.::::::::::::::.:::.::::::: gi|739 GRPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKTEEVYAQLQKMLLEQHEKCVLFSKQFM 640 650 660 670 680 690 510 520 530 540 550 560 KIAA18 HQGNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMH ::::::::::::.:::::::::::::::::::::::.::::::::: ::::::::::::: gi|739 HQGNVAETTRFENLAQDRKKQLEILQLAQAQGLDPPSHHFELKTFQIVRIFSELNSTEMH 700 710 720 730 740 750 570 580 590 600 610 620 KIAA18 LIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNI :::::::::::: ::::::::::::::::::::.:::::::::::::::::::::::::: gi|739 LIIVRGMNLPAPSGVTPDDLDAFVRFEFHYPNSEQAQKSKTAVVKNTNSPEFDQLFKLNI 760 770 780 790 800 810 630 640 650 660 670 680 KIAA18 NRNHRGFKRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRK :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 NRNHRGFRRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRK 820 830 840 850 860 870 690 700 710 KIAA18 PTGGKLEVKVRLREPLSGQDVQMVTENWLVLEPRGL :::::::::::::::::::::: : ::::::::::: gi|739 PTGGKLEVKVRLREPLSGQDVQTVLENWLVLEPRGL 880 890 900 718 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 21:44:15 2009 done: Thu Mar 5 21:48:04 2009 Total Scan time: 1670.860 Total Display time: 0.430 Function used was FASTA [version 34.26.5 April 26, 2007]