# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fk04261.fasta.nr -Q ../query/KIAA1893.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1893, 800 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7812078 sequences Expectation_n fit: rho(ln(x))= 6.9961+/-0.000209; mu= 4.7626+/- 0.012 mean_var=146.2005+/-27.699, 0's: 32 Z-trim: 76 B-trim: 117 in 1/64 Lambda= 0.106072 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|168278979|dbj|BAG11369.1| G protein-regulated i ( 798) 5350 830.9 0 gi|119605471|gb|EAW85065.1| G protein-regulated in (1008) 5023 781.0 0 gi|74738655|sp|Q7Z2K8.1|GRIN1_HUMAN RecName: Full= (1008) 5016 779.9 0 gi|109079842|ref|XP_001085023.1| PREDICTED: simila (1013) 4518 703.7 9.2e-200 gi|21739648|emb|CAD38868.1| hypothetical protein [ ( 707) 3662 572.6 1.9e-160 gi|97051843|sp|Q3UNH4.2|GRIN1_MOUSE RecName: Full= ( 932) 1104 181.2 1.6e-42 gi|74188195|dbj|BAE25773.1| unnamed protein produc ( 932) 1104 181.2 1.6e-42 gi|149264149|ref|XP_001476403.1| PREDICTED: simila ( 779) 1066 175.4 8e-41 gi|73954008|ref|XP_546216.2| PREDICTED: similar to ( 439) 1055 173.5 1.7e-40 gi|109505477|ref|XP_001070221.1| PREDICTED: simila ( 870) 934 155.2 1e-34 gi|109504667|ref|XP_344572.3| PREDICTED: similar t ( 914) 934 155.2 1.1e-34 gi|5901688|gb|AAD55371.1| GRIN1 [Mus musculus] ( 827) 702 119.7 4.9e-24 gi|148709213|gb|EDL41159.1| mCG148421 [Mus musculu ( 587) 686 117.1 2.1e-23 gi|126291564|ref|XP_001380934.1| PREDICTED: simila ( 820) 653 112.2 8.8e-22 gi|187020927|emb|CAP39508.1| Hypothetical protein (2035) 624 108.1 3.7e-20 gi|160677|gb|AAA29761.1| S-antigen ( 593) 577 100.4 2.2e-18 gi|220976661|gb|EED94988.1| predicted protein [Tha (1964) 578 101.0 4.8e-18 gi|94730422|sp|Q03400.2|SANT_PLAF7 RecName: Full=S ( 585) 560 97.8 1.3e-17 gi|70905642|gb|AAZ14281.1| proteophosphoglycan 5 [ (17392) 568 100.3 7e-17 gi|198151215|gb|EDY74106.1| GA28568 [Drosophila ps (1997) 533 94.1 5.7e-16 gi|134073236|emb|CAM71958.1| proteophosphoglycan p (5967) 540 95.6 6.1e-16 gi|134065504|emb|CAM43271.1| proteophosphoglycan p (5384) 507 90.5 1.9e-14 gi|168335570|ref|ZP_02693633.1| hypothetical prote (1666) 432 78.6 2.3e-11 gi|149449580|ref|XP_001519142.1| PREDICTED: hypoth ( 594) 424 77.0 2.4e-11 gi|18157524|dbj|BAB83839.1| COL11A2 [Oryzias latip (1827) 421 77.0 7.7e-11 gi|161086926|ref|NP_067375.3| proteoglycan 4 isofo (1221) 418 76.4 7.9e-11 gi|62122588|dbj|BAD93256.1| COL11A2 [Oryzias latip (1827) 418 76.5 1.1e-10 gi|330421|gb|AAA45896.1| LF3 gene product gi|2 ( 924) 413 75.5 1.1e-10 gi|109512076|ref|XP_001070045.1| PREDICTED: simila ( 612) 407 74.4 1.5e-10 gi|40743552|gb|EAA62742.1| hypothetical protein AN (1720) 411 75.4 2.1e-10 gi|49647578|emb|CAG82021.1| YALI0C11165p [Yarrowia (1114) 405 74.3 2.9e-10 gi|70905641|gb|AAZ14280.1| proteophosphoglycan ppg (7194) 417 76.9 3.3e-10 gi|3242649|dbj|BAA29028.1| alpha 1 type I collagen (1445) 393 72.6 1.3e-09 gi|109510922|ref|XP_580214.2| PREDICTED: similar t ( 543) 383 70.7 1.8e-09 gi|121885042|gb|EAX90717.1| ATPase, AAA family pro (2005) 389 72.1 2.5e-09 gi|198136317|gb|EAL25587.2| GA14075 [Drosophila ps ( 577) 378 70.0 3.1e-09 gi|109891947|sp|P02453.3|CO1A1_BOVIN RecName: Full (1463) 381 70.8 4.6e-09 gi|70905643|gb|AAZ14282.1| proteophosphoglycan ppg (2425) 384 71.4 4.8e-09 gi|38173761|gb|AAH60753.1| MGC69046 protein [Xenop (1464) 379 70.5 5.7e-09 gi|1572721|gb|AAB09089.1| megakaryocyte stimulatin (1404) 377 70.1 6.8e-09 gi|189181720|ref|NP_001121180.1| proteoglycan 4 is (1363) 376 70.0 7.4e-09 gi|83288393|sp|Q92954.2|PRG4_HUMAN RecName: Full=P (1404) 376 70.0 7.5e-09 gi|152031574|sp|P02457.3|CO1A1_CHICK RecName: Full (1453) 376 70.0 7.7e-09 gi|1174415|sp|P46804.1|SPD2_NEPCL RecName: Full=Sp ( 627) 366 68.2 1.2e-08 gi|169218117|ref|XP_001724802.1| PREDICTED: simila ( 642) 364 67.9 1.5e-08 gi|148725310|emb|CAK04962.2| collagen type XI alph (1877) 371 69.3 1.6e-08 gi|38570069|gb|AAR24536.1| chihuahua [Danio rerio] (1447) 367 68.6 2e-08 gi|221043636|dbj|BAH13495.1| unnamed protein produ ( 904) 363 67.8 2.2e-08 gi|26339398|dbj|BAC33370.1| unnamed protein produc (1464) 366 68.5 2.2e-08 gi|8134352|sp|O46392.2|CO1A2_CANFA RecName: Full=C (1366) 365 68.3 2.4e-08 >>gi|168278979|dbj|BAG11369.1| G protein-regulated induc (798 aa) initn: 5350 init1: 5350 opt: 5350 Z-score: 4432.1 bits: 830.9 E(): 0 Smith-Waterman score: 5350; 100.000% identity (100.000% similar) in 798 aa overlap (3-800:1-798) 10 20 30 40 50 60 KIAA18 GQMDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPR 10 20 30 40 50 70 80 90 100 110 120 KIAA18 HTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 HTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASIS 60 70 80 90 100 110 130 140 150 160 170 180 KIAA18 GTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 GTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKAD 120 130 140 150 160 170 190 200 210 220 230 240 KIAA18 PMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 PMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL 180 190 200 210 220 230 250 260 270 280 290 300 KIAA18 RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD 240 250 260 270 280 290 310 320 330 340 350 360 KIAA18 PVPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 PVPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASV 300 310 320 330 340 350 370 380 390 400 410 420 KIAA18 GNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 GNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDP 360 370 380 390 400 410 430 440 450 460 470 480 KIAA18 VSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 VSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEK 420 430 440 450 460 470 490 500 510 520 530 540 KIAA18 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPT 480 490 500 510 520 530 550 560 570 580 590 600 KIAA18 ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKA 540 550 560 570 580 590 610 620 630 640 650 660 KIAA18 EAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 EAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVC 600 610 620 630 640 650 670 680 690 700 710 720 KIAA18 LKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 LKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKT 660 670 680 690 700 710 730 740 750 760 770 780 KIAA18 KPSSSSRQLDRKALGSARSPEGARGSEGRQASARPVPRAAAECAPAAVLLAGGTHGRVIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 KPSSSSRQLDRKALGSARSPEGARGSEGRQASARPVPRAAAECAPAAVLLAGGTHGRVIC 720 730 740 750 760 770 790 800 KIAA18 PHFVRPSFRPSQAPFLITGP :::::::::::::::::::: gi|168 PHFVRPSFRPSQAPFLITGP 780 790 >>gi|119605471|gb|EAW85065.1| G protein-regulated induce (1008 aa) initn: 4989 init1: 4989 opt: 5023 Z-score: 4160.3 bits: 781.0 E(): 0 Smith-Waterman score: 5023; 96.071% identity (97.338% similar) in 789 aa overlap (3-790:1-788) 10 20 30 40 50 60 KIAA18 GQMDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPR 10 20 30 40 50 70 80 90 100 110 120 KIAA18 HTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASIS 60 70 80 90 100 110 130 140 150 160 170 180 KIAA18 GTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKAD 120 130 140 150 160 170 190 200 210 220 230 240 KIAA18 PMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL 180 190 200 210 220 230 250 260 270 280 290 300 KIAA18 RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD 240 250 260 270 280 290 310 320 330 340 350 360 KIAA18 PVPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASV :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASV 300 310 320 330 340 350 370 380 390 400 410 420 KIAA18 GNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDP 360 370 380 390 400 410 430 440 450 460 470 480 KIAA18 VSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEK 420 430 440 450 460 470 490 500 510 520 530 540 KIAA18 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPT 480 490 500 510 520 530 550 560 570 580 590 600 KIAA18 ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKA 540 550 560 570 580 590 610 620 630 640 650 660 KIAA18 EAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVC 600 610 620 630 640 650 670 680 690 700 710 720 KIAA18 LKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKT 660 670 680 690 700 710 730 740 750 760 770 KIAA18 KPSSSSRQLDRKALGSARSPEGARGSEGR-QASARPVPRAAAECAPAAVLLAGGTHGRVI ::::::::::::::::::::::::::::: . .:.:: . : : :.:.. : gi|119 KPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAE-RSP 720 730 740 750 760 770 780 790 800 KIAA18 CPHFVRPSFRPSQAPFLITGP ::. . : : gi|119 CPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGG 780 790 800 810 820 830 >>gi|74738655|sp|Q7Z2K8.1|GRIN1_HUMAN RecName: Full=G pr (1008 aa) initn: 4982 init1: 4982 opt: 5016 Z-score: 4154.5 bits: 779.9 E(): 0 Smith-Waterman score: 5016; 96.071% identity (97.212% similar) in 789 aa overlap (3-790:1-788) 10 20 30 40 50 60 KIAA18 GQMDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPR 10 20 30 40 50 70 80 90 100 110 120 KIAA18 HTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 HTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASIS 60 70 80 90 100 110 130 140 150 160 170 180 KIAA18 GTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKAD :: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 GTTEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKAD 120 130 140 150 160 170 190 200 210 220 230 240 KIAA18 PMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 PMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL 180 190 200 210 220 230 250 260 270 280 290 300 KIAA18 RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD 240 250 260 270 280 290 310 320 330 340 350 360 KIAA18 PVPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 PVPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASV 300 310 320 330 340 350 370 380 390 400 410 420 KIAA18 GNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 GNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDP 360 370 380 390 400 410 430 440 450 460 470 480 KIAA18 VSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 VSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEK 420 430 440 450 460 470 490 500 510 520 530 540 KIAA18 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPT 480 490 500 510 520 530 550 560 570 580 590 600 KIAA18 ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKA 540 550 560 570 580 590 610 620 630 640 650 660 KIAA18 EAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 EAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVC 600 610 620 630 640 650 670 680 690 700 710 720 KIAA18 LKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|747 LKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKT 660 670 680 690 700 710 730 740 750 760 770 KIAA18 KPSSSSRQLDRKALGSARSPEGARGSEGR-QASARPVPRAAAECAPAAVLLAGGTHGRVI ::::::::::::::::::::::::::::: . .:.:: . : : :.:.. : gi|747 KPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAE-RSP 720 730 740 750 760 770 780 790 800 KIAA18 CPHFVRPSFRPSQAPFLITGP ::. . : : gi|747 CPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGG 780 790 800 810 820 830 >>gi|109079842|ref|XP_001085023.1| PREDICTED: similar to (1013 aa) initn: 3712 init1: 2883 opt: 4518 Z-score: 3742.6 bits: 703.7 E(): 9.2e-200 Smith-Waterman score: 4518; 90.157% identity (94.882% similar) in 762 aa overlap (3-762:1-760) 10 20 30 40 50 60 KIAA18 GQMDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPR : ::::::::::::::::::::::::::::::::::::. :::::::::::::::::: gi|109 MGTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGGPAMRDYCPSQQKASPAPPR 10 20 30 40 50 70 80 90 100 110 120 KIAA18 HTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASIS .::.:::::::::::::::::::::::::::::::::::::::::.::.::::::::::: gi|109 YTPNQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQEAPSEETLEAHGASIS 60 70 80 90 100 110 130 140 150 160 170 180 KIAA18 GTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKAD ::::.: :::::::::::::::::::: :::::::: :::::::::: ::::::::.::: gi|109 GTPETTMSGKPEPVSSVKTEPKSSDDRIPMFLEKMDSKSSKQADSTSTGKEDPGSSQKAD 120 130 140 150 160 170 190 200 210 220 230 240 KIAA18 PMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSL :::::::::::::::::::::::::::.:::::::::::: ::::: :::::::::::: gi|109 PMFTGKAEPEILGKGDPVAPGRMDPMTLRKEDLGSLGKVDSLCSSKMDTVSPRKEDPGSL 180 190 200 210 220 230 250 260 270 280 290 300 KIAA18 RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD ::.:::::::::::::::::::::::::::::::::::::::::::::::::::: :.:: gi|109 RKMDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPLGNAD 240 250 260 270 280 290 310 320 330 340 350 360 KIAA18 PVPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASV :: ::::::.::::::::::::: ::::.:::::::::::: : :::::::::::::.:: gi|109 PVSLESMDSVSTGKTEPGLLGKLTPGSSSKNGPVSSGTGAPRSSGRLDPTCLGMADPVSV 300 310 320 330 340 350 370 380 390 400 410 420 KIAA18 GNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDP :: ::::.::::::.::::: :::::::::::::::::::::::::.:.:::.::::::: gi|109 GNGETVPTTKEDSRLLGKMDAASSGEGRPVSGHTDTTASAKTDLTSFKKVDPVSSGKVDP 360 370 380 390 400 410 430 440 450 460 470 480 KIAA18 VSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEK ::::::::::::::::::::::: :::::::::: ::::::::: :::::. ::::::: gi|109 VSLGKMDPMCSGKPELLSPGQAECVSVGKAGTVSSGKEDPVSSR-EDPISVESRKTSSET 420 430 440 450 460 470 490 500 510 520 530 540 KIAA18 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPT ::::: :::::::::::: ::::::::::::::::::::::::::::::::.:::::::: gi|109 VNPESLGKTNPVSSGPGDTRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLAASGKAAPT 480 490 500 510 520 530 550 560 570 580 590 600 KIAA18 ASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKA :::::.:::::::::::.:::::.::::::::: :::::::::.:::::::::::::::: gi|109 ASGKAKPLAVGKEDPVSRGKADAAPSGQGDSVSRGKVVSTPGKAVPVPSGKVDPVSLGKA 540 550 560 570 580 590 610 620 630 640 650 660 KIAA18 EAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVC ::::::::::::::::.::.::::::.:::::. ::::::::::::::::.:::::::: gi|109 EAIPEGKVGSLPLEKGNPVNTTKADPKASGKAEAQSGGKAETKLPGQEGATAPGEAGAVS 600 610 620 630 640 650 670 680 690 700 710 KIAA18 LKKETPQASEKVDPGSCRKAEP--LASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLE ::::: ::::::::::::::: ::::::::::::::::::::: ::::::::. :.:: gi|109 LKKETLQASEKVDPGSCRKAESISLASGKGEPVSLGKADSAPSRKMESPSLGKVASLTLE 660 670 680 690 700 710 720 730 740 750 760 770 KIAA18 KTKPSSSSRQLDRKALGSARSPEGARGSEGRQASARPVPRAAAECAPAAVLLAGGTHGRV :::: ::::::: :::::::::::::::::: . .: : ...: gi|109 KTKPPSSSRQLDGKALGSARSPEGARGSEGR-VEPKPEPVSSTEASSLGQKDLEAAGAER 720 730 740 750 760 770 780 790 800 KIAA18 ICPHFVRPSFRPSQAPFLITGP gi|109 SPRPEAAAPPPGPRTRDNFTKAPSWEASALPPPREDAGTQAGAQACVSVAVSPMSPQDGA 780 790 800 810 820 830 >>gi|21739648|emb|CAD38868.1| hypothetical protein [Homo (707 aa) initn: 3365 init1: 3365 opt: 3662 Z-score: 3036.7 bits: 572.6 E(): 1.9e-160 Smith-Waterman score: 3662; 93.575% identity (95.058% similar) in 607 aa overlap (185-790:1-598) 160 170 180 190 200 210 KIAA18 MDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLG :::::::::::::::::::::::::::::: gi|217 GKAEPEILGKGDPVAPGRMDPMTVRKEDLG 10 20 30 220 230 240 250 260 270 KIAA18 SLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEK :::::::::::::::::: :::::::::::::::::::::::::::::::::: gi|217 SLGKVDPLCSSKTYTVSP--------RKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEK 40 50 60 70 80 280 290 300 310 320 330 KIAA18 VAPTSAEKVDLVLSGKRDPGPSGKADPVPLESMDSASTGKTEPGLLGKLIPGSSGKNGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 VAPTSAEKVDLVLSGKRDPGPSGKADPVPLESMDSASTGKTEPGLLGKLIPGSSGKNGPV 90 100 110 120 130 140 340 350 360 370 380 390 KIAA18 SSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 SSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHT 150 160 170 180 190 200 400 410 420 430 440 450 KIAA18 DTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 DTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVS 210 220 230 240 250 260 460 470 480 490 500 510 KIAA18 PGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 PGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAE 270 280 290 300 310 320 520 530 540 550 560 570 KIAA18 PATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 PATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSI 330 340 350 360 370 380 580 590 600 610 620 630 KIAA18 GKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 GKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQP 390 400 410 420 430 440 640 650 660 670 680 690 KIAA18 QSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLG ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: gi|217 QSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEALASGKGEPVSLG 450 460 470 480 490 500 700 710 720 730 740 750 KIAA18 KADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGR-QASA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: . .: gi|217 KADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKA 510 520 530 540 550 560 760 770 780 790 800 KIAA18 RPVPRAAAECAPAAVLLAGGTHGRVICPHFVRPSFRPSQAPFLITGP .:: . : : :.:.. : ::. . : : gi|217 EPVSSTEASSLGQKDLEAAGAE-RSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPRED 570 580 590 600 610 620 gi|217 AGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSV 630 640 650 660 670 680 >>gi|97051843|sp|Q3UNH4.2|GRIN1_MOUSE RecName: Full=G pr (932 aa) initn: 1059 init1: 487 opt: 1104 Z-score: 919.6 bits: 181.2 E(): 1.6e-42 Smith-Waterman score: 1751; 47.376% identity (66.622% similar) in 743 aa overlap (44-767:1-694) 20 30 40 50 60 70 KIAA18 LLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRH ::: : :. :: ::::::. ::: ::. :: gi|970 MRDCC-SSPKAIPAPPRHALDQSLGMDPRH 10 20 80 90 100 110 120 130 KIAA18 RSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEP : :::.::::::. : ::::::::.: :: :: .:::: : . .: ::::: gi|970 TSSSGAAEGASCSERPAGSLACPSPNC-----SPLPETPRAHGALTSDNSGTTLFGKPEP 30 40 50 60 70 80 140 150 160 170 180 190 KIAA18 VSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILG .::... : .:. :::.: ::: .: ::::::: ::. :: :. . :. ::::: : : gi|970 MSSAEATPTASEIRNPVFSGKMDGNSLKQADSTSTRKEEAGSLRNEESMLKGKAEPMIYG 90 100 110 120 130 140 200 210 220 230 240 250 KIAA18 KGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDP ::.: . ::.: . :. ::::::: ::::. ::: .. ::::::. .:: :.:: gi|970 KGEPGTVGRVDCTASGAENSGSLGKVDMPCSSKVDIVSPGGDNAGSLRKVETISSGKMDP 150 160 170 180 190 200 260 270 280 290 300 310 KIAA18 VFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPVPLESMDSASTG . :. .: .:.: :. :. : . : : .. ::::: gi|970 ---KTENVMHSRRERPGST----------------GEGDLVSLRENDMKPPDNTDSASTK 210 220 230 240 320 330 340 350 360 370 KIAA18 KTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDS ::.: . ::: ::::::. ::: : :: . ..:.: : : ::.::: ::. ..:.: gi|970 KTDPEFSGKLTPGSSGKTELVSSVTVAPVTSENVNPVCSGGAGPAAVGNSETLSSVKKDP 250 260 270 280 290 300 380 390 400 410 420 KIAA18 RFLGKMDPASSGEGRPVSGHTDTTASA---------KTDLTSLKNVDPMSSGKVDPVSLG ..::: . .::::: :: . :.:: ::: :: ... : ::..::::: gi|970 QLLGKKEAVSSGEGGSVSVRMAETVSARQPEGMFPAKTDSTSSNSTGP--SGRADPVSLR 310 320 330 340 350 360 430 440 450 460 470 480 KIAA18 KMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPE . . . ::: :: :::::::. :. :.: ::::: :::: : .. . .:.: ::: gi|970 NSELVSPVKPERLSSGQAERVSLVKTETLSSGKEDPRSSRRVDHTTVTGNMQTSQKGNPE 370 380 390 400 410 420 490 500 510 520 530 540 KIAA18 SSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGK :::::. ::. :: ::::: : ::.::: .: ::::: .::.: :: :. : ::.: gi|970 SSGKTDLGSSSSGDTRSLGTWGSLSAAKAE-VTEGKGDPQPWKKASLPASEKTDPLASSK 430 440 450 460 470 480 550 560 570 580 590 600 KIAA18 AEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTP-GKTVPVPSGKVDPVSLGKAEAI : . :: . :: :..:: ...::.: : :::. : :::: .. .::.: gi|970 AGSASQGKAETVSPGEVDA--------MTLGKTVPTSSGKTALVSPGKVDLMTSERAEGI 490 500 510 520 530 610 620 630 640 650 660 KIAA18 PEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKK :: ... :::.::..:..: :.:...:.:: :. :..:: :..::.. . :.: gi|970 PELQAS----EKGNPVNSTRVDTGATGSTEPKSGVKVITQIPG---ATSPGKVETPSLQK 540 550 560 570 580 670 680 690 700 710 720 KIAA18 ETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSA-PS-RKTESPSLGKVVPLSLEKTK : :: :::.::. ::..: .. ::::::::::: :: ::.:: . .:.:: . .:. gi|970 EQPQLSEKTDPS--RKVDPPTTV--EPVSLGKADSASPSPRKAESQTSAKTVPQAPDKA- 590 600 610 620 630 640 730 740 750 760 770 KIAA18 PSSSSRQLDRKALGSARSPEGAR--GS-EGRQASA----RPVPRAAAECAPAAVLLAGGT .:: :: : .::. . .: :: :. :: . . :::. .:.: gi|970 -TSSLRQSDGTPYSSAQPQRDTRSIGSLPEREPSASTSQKDLAAAAAQKSPSAEAAAPPP 650 660 670 680 690 700 780 790 800 KIAA18 HGRVICPHFVRPSFRPSQAPFLITGP gi|970 GPRTRDNFTKAPSWDAGAPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGPAFSFQAAPR 710 720 730 740 750 760 >>gi|74188195|dbj|BAE25773.1| unnamed protein product [M (932 aa) initn: 1156 init1: 487 opt: 1104 Z-score: 919.6 bits: 181.2 E(): 1.6e-42 Smith-Waterman score: 1748; 47.241% identity (66.622% similar) in 743 aa overlap (44-767:1-694) 20 30 40 50 60 70 KIAA18 LLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRH ::: : :. :: ::::::. ::: ::. :: gi|741 MRDCC-SSPKAIPAPPRHALDQSLGMDPRH 10 20 80 90 100 110 120 130 KIAA18 RSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEP : :::.::::::. : ::::::::.: :: :: .:::: : . .: ::::: gi|741 TSSSGAAEGASCSERPAGSLACPSPNC-----SPLPETPRAHGALTSDNSGTTLFGKPEP 30 40 50 60 70 80 140 150 160 170 180 190 KIAA18 VSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILG .::... : .:. :::.: ::: .: ::::::: ::. :: :. . :. ::::: : : gi|741 MSSAEATPTASEIRNPVFSGKMDGNSLKQADSTSTRKEEAGSLRNEESMLKGKAEPMIYG 90 100 110 120 130 140 200 210 220 230 240 250 KIAA18 KGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDP ::.: . ::.: . :. ::::::: ::::. ::: .. ::::::. .:: :.:: gi|741 KGEPGTVGRVDCTASGAENSGSLGKVDMPCSSKVDIVSPGGDNAGSLRKVETISSGKMDP 150 160 170 180 190 200 260 270 280 290 300 310 KIAA18 VFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPVPLESMDSASTG . :. .: .:.: :. :. : . : : .. ::::: gi|741 ---KTENVMHSRRERPGST----------------GEGDLVSLRENDMKPPDNTDSASTK 210 220 230 240 320 330 340 350 360 370 KIAA18 KTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDS ::.: . ::: ::::::. ::: : :: . ..:.: : : ::.::: ::. ..:.: gi|741 KTDPEFSGKLTPGSSGKTELVSSVTVAPVTSENVNPVCSGGAGPAAVGNSETLSSVKKDP 250 260 270 280 290 300 380 390 400 410 420 KIAA18 RFLGKMDPASSGEGRPVSGHTDTTASA---------KTDLTSLKNVDPMSSGKVDPVSLG ..::: . .::::: :: . :.:: ::: :: ... : ::..::::: gi|741 QLLGKKEAVSSGEGGSVSVRMAETVSARQPEGMFPAKTDSTSSNSTGP--SGRADPVSLR 310 320 330 340 350 360 430 440 450 460 470 480 KIAA18 KMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPE . . . ::: :: :::::::. :. :.: ::::: :::: : .. . .:.: ::: gi|741 NSELVSPVKPERLSSGQAERVSLVKTETLSSGKEDPRSSRRVDHTTVTGNMQTSQKGNPE 370 380 390 400 410 420 490 500 510 520 530 540 KIAA18 SSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGK :::::. ::. :: ::::: : ::.::: .: :.::: .::.: :: :. : ::.: gi|741 SSGKTDLGSSSSGDTRSLGTWGSLSAAKAE-VTEGRGDPQPWKKASLPASEKTDPLASSK 430 440 450 460 470 480 550 560 570 580 590 600 KIAA18 AEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTP-GKTVPVPSGKVDPVSLGKAEAI : . :: . :: :..:: ...::.: : :::. : :::: .. .::.: gi|741 AGSASQGKAETVSPGEVDA--------MTLGKTVPTSSGKTALVSPGKVDLMTSERAEGI 490 500 510 520 530 610 620 630 640 650 660 KIAA18 PEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKK :: ... :::.::..:..: :.:...:.:: :. :..:: :..::.. . :.: gi|741 PELQAS----EKGNPVNSTRVDTGATGSTEPKSGVKVITQIPG---ATSPGKVETPSLQK 540 550 560 570 580 670 680 690 700 710 720 KIAA18 ETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSA-PS-RKTESPSLGKVVPLSLEKTK : :: :::.::. ::..: .. ::::::::::: :: ::.:: . .:.:: . .:. gi|741 EQPQLSEKTDPS--RKVDPPTTV--EPVSLGKADSASPSPRKAESQTSAKTVPQAPDKA- 590 600 610 620 630 640 730 740 750 760 770 KIAA18 PSSSSRQLDRKALGSARSPEGAR--GS-EGRQASA----RPVPRAAAECAPAAVLLAGGT .:: :: : .::. . .: :: :. :: . . :::. .:.: gi|741 -TSSLRQSDGTPYSSAQPQRDTRSIGSLPEREPSASTSQKDLAAAAAQKSPSAEAAAPPP 650 660 670 680 690 700 780 790 800 KIAA18 HGRVICPHFVRPSFRPSQAPFLITGP gi|741 GPRTRDNFTKAPSWDAGAPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGPAFSFQAAPR 710 720 730 740 750 760 >>gi|149264149|ref|XP_001476403.1| PREDICTED: similar to (779 aa) initn: 1059 init1: 487 opt: 1066 Z-score: 889.2 bits: 175.4 E(): 8e-41 Smith-Waterman score: 1747; 46.588% identity (65.486% similar) in 762 aa overlap (44-785:1-713) 20 30 40 50 60 70 KIAA18 LLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRH ::: : :. :: ::::::. ::: ::. :: gi|149 MRDCC-SSPKAIPAPPRHALDQSLGMDPRH 10 20 80 90 100 110 120 130 KIAA18 RSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEP : :::.::::::. : ::::::::.: :: :: .:::: : . .: ::::: gi|149 TSSSGAAEGASCSERPAGSLACPSPNC-----SPLPETPRAHGALTSDNSGTTLFGKPEP 30 40 50 60 70 80 140 150 160 170 180 190 KIAA18 VSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILG .::... : .:. :::.: ::: .: ::::::: ::. :: :. . :. ::::: : : gi|149 MSSAEATPTASEIRNPVFSGKMDGNSLKQADSTSTRKEEAGSLRNEESMLKGKAEPMIYG 90 100 110 120 130 140 200 210 220 230 240 250 KIAA18 KGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDP ::.: . ::.: . :. ::::::: ::::. ::: .. ::::::. .:: :.: gi|149 KGEPGTVGRVDCTASGAENSGSLGKVDMPCSSKVDIVSPGGDNAGSLRKVETISSGKMD- 150 160 170 180 190 200 260 270 280 290 300 310 KIAA18 VFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPVPLESMDSASTG :. :. .: .:.: :. :. : . : : .. ::::: gi|149 --PKTENVMHSRRERPGST----------------GEGDLVSLRENDMKPPDNTDSASTK 210 220 230 240 320 330 340 350 360 370 KIAA18 KTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDS ::.: . ::: ::::::. ::: : :: . ..:.: : : ::.::: ::. ..:.: gi|149 KTDPEFSGKLTPGSSGKTELVSSVTVAPVTSENVNPVCSGGAGPAAVGNSETLSSVKKDP 250 260 270 280 290 300 380 390 400 410 420 KIAA18 RFLGKMDPASSGEGRPVSGHTDTTASA---------KTDLTSLKNVDPMSSGKVDPVSLG ..::: . .::::: :: . :.:: ::: :: ... : ::..::::: gi|149 QLLGKKEAVSSGEGGSVSVRMAETVSARQPEGMFPAKTDSTSSNSTGP--SGRADPVSLR 310 320 330 340 350 360 430 440 450 460 470 480 KIAA18 KMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPE . . . ::: :: :::::::. :. :.: ::::: :::: : .. . .:.: ::: gi|149 NSELVSPVKPERLSSGQAERVSLVKTETLSSGKEDPRSSRRVDHTTVTGNMQTSQKGNPE 370 380 390 400 410 420 490 500 510 520 530 540 KIAA18 SSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGK :::::. ::. :: ::::: : ::.::: .: ::::: .::.: :: :. : ::.: gi|149 SSGKTDLGSSSSGDTRSLGTWGSLSAAKAE-VTEGKGDPQPWKKASLPASEKTDPLASSK 430 440 450 460 470 480 550 560 570 580 590 600 KIAA18 AEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTP-GKTVPVPSGKVDPVSLGKAEAI : . :: . :: :..:: ...::.: : :::. : :::: .. .::.: gi|149 AGSASQGKAETVSPGEVDA--------MTLGKTVPTSSGKTALVSPGKVDLMTSERAEGI 490 500 510 520 530 610 620 630 640 650 660 KIAA18 PEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKK :: ... :::.::..:..: :.:...:.:: :. :..:: :..::.. . :.: gi|149 PELQAS----EKGNPVNSTRVDTGATGSTEPKSGVKVITQIPG---ATSPGKVETPSLQK 540 550 560 570 580 670 680 690 700 710 720 KIAA18 ETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSA-PS-RKTESPSLGKVVPLSLEKTK : :: :::.::. ::..: .. ::::::::::: :: ::.:: . .:.:: . .:. gi|149 EQPQLSEKTDPS--RKVDPPTTV--EPVSLGKADSASPSPRKAESQTSAKTVPQAPDKA- 590 600 610 620 630 640 730 740 750 760 770 KIAA18 PSSSSRQLDRKALGSARSPEGAR--GSEGRQ-ASARPVPRAAAECAPAAVLLAGGTH--- .:: :: : .::. . .: :: .: ::: . : : . :.. gi|149 -TSSLRQSDGTPYSSAQPQRDTRSIGSPARAGASASTSQKDLAAAAAQKREVYGASMEVE 650 660 670 680 690 700 780 790 800 KIAA18 --GRVICPHFVRPSFRPSQAPFLITGP : .: :. : gi|149 VLGMAIQKHLERQIEEHGRQGAPAPAPPPAVRAGPGRAGSVRTAPAEGAAKRPPGLFRAL 710 720 730 740 750 760 >>gi|73954008|ref|XP_546216.2| PREDICTED: similar to G p (439 aa) initn: 962 init1: 962 opt: 1055 Z-score: 883.4 bits: 173.5 E(): 1.7e-40 Smith-Waterman score: 1115; 45.291% identity (60.721% similar) in 499 aa overlap (44-542:1-417) 20 30 40 50 60 70 KIAA18 LLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRH ::: ::::::.::.: ::. :::::.::: gi|739 MRDCCPSQQKTSPVPLRHNLVQSPGMDSRH 10 20 30 80 90 100 110 120 130 KIAA18 RSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEP ::::::::.:::.:: :: :::: ::. :::. .:::: .: : :::: :.: :::::: gi|739 SSPSGAGEGTSCSEGPGGSSACPSLTCIPPQEAATKETLGTHRALISGTTETTFSGKPEP 40 50 60 70 80 90 140 150 160 170 180 190 KIAA18 VSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILG :::::::: : ..:::.:::::: ::::::::::::::: :: ::::: : :.:: .:: gi|739 VSSVKTEPTSLENRNPVFLEKMDPKSSKQADSTSIGKEDAGSLRKADPTFIVKTEPVVLG 100 110 120 130 140 150 200 210 220 230 240 250 KIAA18 KGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDP ::::.: :::::.: :::: ::::::::.::.:. :::: ::: :::: :: gi|739 KGDPMASGRMDPVTPRKEDPGSLGKVDPVCSDKVDTVSPGKED--------PVSSAKVG- 160 170 180 190 200 260 270 280 290 300 310 KIAA18 VFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPVPLESMDSASTG :.: :. : .. : :. : . :::.::. .. . . :.: gi|739 -----------------STETVSSTEEDRQIL---GQIDNASSGKGDPMSMRVIKTMSAG 210 220 230 240 320 330 340 350 360 370 KIAA18 KTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDS ...: :. :.. : :.: :: :: : :.:. ::: ::. gi|739 QVDP------------KEKPLAREKGEPASCGRADPIVSGKAEPV-------VPAQAEDA 250 260 270 280 380 390 400 410 420 430 KIAA18 RFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGK . .:.:::. :. . .::.. .:.:: : . : : .: gi|739 APPRRAEPSSSGKLAPLPLKKAGAASSR-----------QSDGK--PCGPG---PSPAGA 290 300 310 320 440 450 460 470 480 490 KIAA18 PELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVS : :. : . :: :. : . :.. .::.. : :.: : : . gi|739 PAGPPPAPRTRDNFTKA----PSWEASAPPREDAGTQAGAQACVSVAVSPMS-----P-Q 330 340 350 360 370 500 510 520 530 540 550 KIAA18 SGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKE .: :. :. .: : : . : :.: : . ::: .: . : : gi|739 DGAGSAFSFQAA--PRAPSPAP-----GSP-SRRDAGLQVSLDLSSTPSRPHWVISGLCS 380 390 400 410 420 560 570 580 590 600 610 KIAA18 DPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPL gi|739 AGPHLRAEAGS 430 >>gi|109505477|ref|XP_001070221.1| PREDICTED: similar to (870 aa) initn: 1072 init1: 331 opt: 934 Z-score: 779.4 bits: 155.2 E(): 1e-34 Smith-Waterman score: 1624; 45.760% identity (64.738% similar) in 743 aa overlap (44-771:1-672) 20 30 40 50 60 70 KIAA18 LLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRH ::: : :. :: :::::: ::: ::.::: gi|109 MRDRC-SSPKAIPAPPRHILDQSLGMDSRH 10 20 80 90 100 110 120 130 KIAA18 RSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEP : :::::::::.. : ::::: :: ::..:::: : . :.: ::::: gi|109 SSSSGAGEGASCAEKPVGSLAC----------SPLPETVRAHGALTSEASETTLFGKPEP 30 40 50 60 70 140 150 160 170 180 190 KIAA18 VSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILG .:::.. :.... ::: :::: .: :: :::: :: :: :: . :..::.:: : : gi|109 MSSVEA-PSAAEVRNPSSSEKMDSNSLKQEDSTSSRKEGAGSLRKEESMLVGKTEPLICG 80 90 100 110 120 130 200 210 220 230 240 250 KIAA18 KGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDP :: . :.. . .::. :::: :: ::::. : : :. ::::::. ..: :.: gi|109 KGASETGVRVECSAPKKEESGSLGTVDTACSSKVDIVPPGGENAGSLRKVETIASGKMD- 140 150 160 170 180 190 260 270 280 290 300 310 KIAA18 VFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPVPLESMDSASTG ::::. :: .:.: :. . ::: : : ::: gi|109 --PRKENLMYSRREYPESTG--------EGDLVSPRGNDMKPPDKAD------------- 200 210 220 230 320 330 340 350 360 370 KIAA18 KTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDS ::. :.: ::::::. ::: . :: . ..:. :..::.. :..::. . : : gi|109 ---PGFSGELPPGSSGKTKHVSSVAVAPVTSENVNPASSGITDPVASGDTETLSSGKGDP 240 250 260 270 280 290 380 390 400 410 420 KIAA18 RFLGKMDPASSGEGRPVS---------GHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLG ::::: .:.:.::. ::: :. . . :: : :: ... : ::.:: ::: gi|109 RFLGKKEPVSTGESGPVSVRMAEPVSAGQPEGMVPAKKDPTSANSTGP--SGRVDSVSLR 300 310 320 330 340 430 440 450 460 470 480 KIAA18 KMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPE . . . ::: :: :::::::. :. :. ::::: :: : . .:. :: .: ::: gi|109 NSELVSPVKPEHLSSGQAERVSLVKTETLFSGKEDPRSSGRVETTVTGNIKTF-QKGNPE 350 360 370 380 390 400 490 500 510 520 530 540 KIAA18 SSGKTNPVSS-GPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASG :::::.:::: . :: :::: : ::.:.: .: ::::: : ::: .:::: gi|109 SSGKTDPVSSFSSGDAGSLGTLGSLSAAKTETVTEGKGDPQSLEKA--------SPTASE 410 420 430 440 450 460 550 560 570 580 590 600 KIAA18 KAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTP-GKTVPVPSGKVDPVSLGKAEA ::.:::. ::. .:.:::.. :::. :...::..:: :::. : :::: .. .::. gi|109 KADPLALCKESSASQGKAETVPSGEVGSTTLGKTASTSSGKTALVSPGKVDLTASERAEG 470 480 490 500 510 520 610 620 630 640 650 660 KIAA18 IPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLK .:: .. : :::.: ..:..: ..:.:: :. :.:: ::..::.. : :. gi|109 VPELRA---P-EKGNPGNSTRVDT-----TEPKSGVKVVTQLP---GATSPGKVEAPSLQ 530 540 550 560 670 680 690 700 710 KIAA18 KETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSA---PS-RKTESPSLGKVVPLSLE :: :: :::.::.. :..: :: ::::::::::: :: ::.:: . .:.:: . . gi|109 KEQPQPSEKTDPSG--KVDPTASV--EPVSLGKADSASTSPSPRKAESQTSAKTVPQAPD 570 580 590 600 610 620 720 730 740 750 760 770 KIAA18 KTKPSSSSRQLDRKALGSARSPEGARGSEGRQASARPVPRAAAECAPAAVLLAGGTHGRV :. .:. :: : .::. :. : ... : .: : :.. :.. : gi|109 KA--TSAFRQSDGTPYSSAQ-PR--RDTRSIGALPEPEPSASTSQKDLAAVAAQKSPSAE 630 640 650 660 670 780 790 800 KIAA18 ICPHFVRPSFRPSQAPFLITGP gi|109 GAAPPPGPRTRDNFTKAPSWDAGAPPPREDAGTQAGAQACVSVAVSPMSPQDGAVGPAFS 680 690 700 710 720 730 800 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Fri Mar 6 01:32:54 2009 done: Fri Mar 6 01:36:29 2009 Total Scan time: 1645.250 Total Display time: 0.450 Function used was FASTA [version 34.26.5 April 26, 2007]