# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fj08985mrp1.fasta.nr -Q ../query/KIAA1929.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1929, 410 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7826693 sequences Expectation_n fit: rho(ln(x))= 5.3431+/-0.000189; mu= 10.1691+/- 0.011 mean_var=75.4671+/-14.891, 0's: 31 Z-trim: 35 B-trim: 1515 in 1/65 Lambda= 0.147637 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 37, opt: 25, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|119602662|gb|EAW82256.1| rhophilin, Rho GTPase ( 413) 2738 592.4 6.4e-167 gi|30173334|sp|Q8TCX5.1|RHPN1_HUMAN RecName: Full= ( 695) 2569 556.5 6.6e-156 gi|119602657|gb|EAW82251.1| rhophilin, Rho GTPase ( 440) 2426 525.9 6.8e-147 gi|19343951|gb|AAH25767.1| Rhophilin, Rho GTPase b ( 670) 2422 525.2 1.7e-146 gi|119602661|gb|EAW82255.1| rhophilin, Rho GTPase ( 400) 2061 448.2 1.6e-123 gi|194672727|ref|XP_875821.2| PREDICTED: similar t ( 652) 1892 412.3 1.6e-112 gi|119602658|gb|EAW82252.1| rhophilin, Rho GTPase ( 338) 1844 401.9 1.1e-109 gi|6093970|sp|Q61085.1|RHPN1_MOUSE RecName: Full=R ( 643) 1827 398.5 2.3e-108 gi|30354357|gb|AAH52010.1| Rhpn1 protein [Mus musc ( 451) 1825 397.9 2.4e-108 gi|148697538|gb|EDL29485.1| rhophilin, Rho GTPase ( 472) 1825 397.9 2.4e-108 gi|149066183|gb|EDM16056.1| rhophilin, Rho GTPase ( 643) 1805 393.8 6e-107 gi|109480881|ref|XP_216954.4| PREDICTED: similar t ( 661) 1805 393.8 6.1e-107 gi|149571566|ref|XP_001518976.1| PREDICTED: simila ( 694) 1574 344.6 4.1e-92 gi|126323112|ref|XP_001373228.1| PREDICTED: simila ( 651) 1524 333.9 6.3e-89 gi|118087436|ref|XP_418410.2| PREDICTED: similar t ( 676) 1512 331.4 3.8e-88 gi|51703751|gb|AAH81320.1| Rhpn1 protein [Xenopus ( 706) 1475 323.5 9.3e-86 gi|189533546|ref|XP_001338978.2| PREDICTED: simila ( 659) 1367 300.5 7.4e-79 gi|220672693|emb|CAX14137.1| novel protein similar ( 364) 1344 295.4 1.4e-77 gi|73974832|ref|XP_539197.2| PREDICTED: similar to ( 623) 1264 278.5 2.8e-72 gi|72009278|ref|XP_785878.1| PREDICTED: similar to ( 687) 1214 267.9 4.9e-69 gi|215498838|gb|EEC08332.1| rhophilin-2, putative ( 665) 1192 263.2 1.2e-67 gi|118096400|ref|XP_414133.2| PREDICTED: similar t ( 679) 1172 259.0 2.4e-66 gi|156537498|ref|XP_001607370.1| PREDICTED: simila ( 713) 1167 257.9 5.2e-66 gi|27882117|gb|AAH44556.1| Rhophilin, Rho GTPase b ( 683) 1164 257.3 7.9e-66 gi|126296046|ref|XP_001367255.1| PREDICTED: simila ( 765) 1161 256.7 1.3e-65 gi|110749461|ref|XP_001120267.1| PREDICTED: simila ( 660) 1159 256.2 1.6e-65 gi|47220871|emb|CAG03078.1| unnamed protein produc ( 742) 1155 255.4 3.2e-65 gi|91085665|ref|XP_971529.1| PREDICTED: similar to ( 660) 1152 254.7 4.5e-65 gi|114676516|ref|XP_001152357.1| PREDICTED: rhophi ( 685) 1146 253.4 1.1e-64 gi|114676514|ref|XP_001152684.1| PREDICTED: rhophi ( 686) 1146 253.4 1.1e-64 gi|193783689|dbj|BAG53600.1| unnamed protein produ ( 686) 1144 253.0 1.5e-64 gi|62288909|sp|Q6TNR1.1|RHPN2_DANRE RecName: Full= ( 683) 1143 252.8 1.8e-64 gi|22209019|gb|AAH36447.1| Rhophilin, Rho GTPase b ( 686) 1142 252.6 2e-64 gi|62288912|sp|Q8IUC4.1|RHPN2_HUMAN RecName: Full= ( 686) 1142 252.6 2e-64 gi|189054743|dbj|BAG37565.1| unnamed protein produ ( 686) 1142 252.6 2e-64 gi|190360199|sp|A4FUC9.1|RHPN2_BOVIN RecName: Full ( 686) 1135 251.1 5.7e-64 gi|62288910|sp|Q8BWR8.2|RHPN2_MOUSE RecName: Full= ( 686) 1134 250.9 6.6e-64 gi|72679850|gb|AAI00315.1| Rhpn2 protein [Mus musc ( 686) 1134 250.9 6.6e-64 gi|148671074|gb|EDL03021.1| rhophilin, Rho GTPase ( 692) 1134 250.9 6.7e-64 gi|62288911|sp|Q8HXG3.1|RHPN2_CANFA RecName: Full= ( 686) 1132 250.4 8.9e-64 gi|149056195|gb|EDM07626.1| rhophilin, Rho GTPase ( 686) 1130 250.0 1.2e-63 gi|26340930|dbj|BAC34127.1| unnamed protein produc ( 686) 1129 249.8 1.4e-63 gi|210130213|gb|EEA77885.1| hypothetical protein B ( 530) 1120 247.8 4.3e-63 gi|149721942|ref|XP_001490099.1| PREDICTED: simila ( 670) 1121 248.1 4.4e-63 gi|21732479|emb|CAD38597.1| hypothetical protein [ ( 657) 1113 246.4 1.4e-62 gi|14279409|gb|AAK58588.1|AF268032_1 rhophilin-lik ( 685) 1104 244.5 5.6e-62 gi|82200408|sp|Q6DJJ6.1|RHN2A_XENLA RecName: Full= ( 683) 1100 243.6 1e-61 gi|82197991|sp|Q63ZR5.1|RHN2B_XENLA RecName: Full= ( 683) 1092 241.9 3.3e-61 gi|198435173|ref|XP_002122928.1| PREDICTED: simila ( 710) 1091 241.7 3.9e-61 gi|171846788|gb|AAI61451.1| LOC100145690 protein [ ( 682) 1090 241.5 4.4e-61 >>gi|119602662|gb|EAW82256.1| rhophilin, Rho GTPase bind (413 aa) initn: 2738 init1: 2738 opt: 2738 Z-score: 3153.0 bits: 592.4 E(): 6.4e-167 Smith-Waterman score: 2738; 100.000% identity (100.000% similar) in 410 aa overlap (1-410:4-413) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA 310 320 330 340 350 360 360 370 380 390 400 410 KIAA19 MALCDGSRECPPHLPMVLPRPPRAGLTASLSPSSDRGRAPHARAGLPAAPHLL ::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 MALCDGSRECPPHLPMVLPRPPRAGLTASLSPSSDRGRAPHARAGLPAAPHLL 370 380 390 400 410 >>gi|30173334|sp|Q8TCX5.1|RHPN1_HUMAN RecName: Full=Rhop (695 aa) initn: 2553 init1: 2553 opt: 2569 Z-score: 2955.3 bits: 556.5 E(): 6.6e-156 Smith-Waterman score: 2569; 96.977% identity (97.985% similar) in 397 aa overlap (1-397:4-400) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|301 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|301 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|301 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|301 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|301 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|301 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA 310 320 330 340 350 360 360 370 380 390 400 410 KIAA19 MALCDGSRECPPHLPMVLPRPPRAGLTASLSPSSDRGRAPHARAGLPAAPHLL ::::::::::::::::::::::::: :.. .:. : gi|301 MALCDGSRECPPHLPMVLPRPPRAGSQPLCPPAATEGELPTHEQVFLQPPTSSKPRGPVL 370 380 390 400 410 420 gi|301 PQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELD 430 440 450 460 470 480 >>gi|119602657|gb|EAW82251.1| rhophilin, Rho GTPase bind (440 aa) initn: 2415 init1: 2415 opt: 2426 Z-score: 2793.5 bits: 525.9 E(): 6.8e-147 Smith-Waterman score: 2436; 89.252% identity (90.421% similar) in 428 aa overlap (1-408:4-431) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA 310 320 330 340 350 360 360 370 380 390 KIAA19 MALCDGSR----ECPPHLPMVLPRP----PRAG-LTASLSPSSDRGRAP----------H ::::::: : : : . : : ::. : : . :.:: : gi|119 MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAPMGGVPWGSDGH 370 380 390 400 410 420 400 410 KIAA19 AR-AGLPAAPHLL : :.: :: gi|119 QRWQGVPHHPHAVCHLLSPC 430 440 >>gi|19343951|gb|AAH25767.1| Rhophilin, Rho GTPase bindi (670 aa) initn: 2415 init1: 2415 opt: 2422 Z-score: 2786.3 bits: 525.2 E(): 1.7e-146 Smith-Waterman score: 2425; 91.748% identity (92.718% similar) in 412 aa overlap (1-403:4-415) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA 310 320 330 340 350 360 360 370 380 390 400 KIAA19 MALCDGSR----ECPPHLPMVLPRP----PRAG-LTASLSPSSDRGRAPHARAGLPAAPH ::::::: : : : . : : ::. : : . :.: :: : gi|193 MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA 370 380 390 400 410 420 410 KIAA19 LL gi|193 LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR 430 440 450 460 470 480 >>gi|119602661|gb|EAW82255.1| rhophilin, Rho GTPase bind (400 aa) initn: 2110 init1: 2058 opt: 2061 Z-score: 2373.9 bits: 448.2 E(): 1.6e-123 Smith-Waterman score: 2061; 98.433% identity (99.373% similar) in 319 aa overlap (1-319:4-322) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA ::::::::::::::::.. :. gi|119 QDCLAQLRLAQEAAQVSSGTRVRMQGVGPSWGQSPGPGMRELSHLLPCVSAPSQLLSCSL 310 320 330 340 350 360 >>gi|194672727|ref|XP_875821.2| PREDICTED: similar to rh (652 aa) initn: 1926 init1: 1876 opt: 1892 Z-score: 2176.4 bits: 412.3 E(): 1.6e-112 Smith-Waterman score: 1892; 74.627% identity (85.323% similar) in 402 aa overlap (1-402:4-403) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA :.: :: :::::: :::::: :. :.::::::.::::::.::.::::::::::: gi|194 MVPEDRSDGPGAGEESARLQGCDLSTDSLHGRLQSRRARIHQQIDRELRMRTGAENLYRA 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL ::: ::::::::::: :::.:::::::: :... : :. ::.::.::::::::::: : gi|194 TSNARVRETVALELSDVNSSLQLLKEELAGLDSSGDTGQPESEGVTAPMIPLGLKETKPL 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA ::. :::::: ::::::::::::::::: :::: :::::...:::::::::::::::.: gi|194 DWAPPLKELICRHFGEDGASYEAEIRELEDLRQATRTPSRSKAGLELLTAYYNQLCFLEA 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR ::.::::::::.:::::::::.:::::::::::::::::::::::::::::.::: :: gi|194 RFVTPARSLGLLFHWYDSLTGLPAQQRALAFEKGSVLFNIGALHTQIGARQNRSCPEGIG 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP ::.:::::::::::::::::::::::::: .:: ::::: ::::::::::: : : gi|194 RAVEAFQRAAGAFSLLRENFSHAPSPDMSPTSLSMLEQLMRAQAQECVFEGLLLQAPRAA 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA .:::::::::::::::::::::::::::::::. ::: : .:::::::.:..:::::.: gi|194 HDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVRGYVPFPWITLVHVKAEHFHALAHYHAA 310 320 330 340 350 360 360 370 380 390 400 410 KIAA19 MALCDGSRECPPHLPMVLPRPPRAGLTASLSPSSDRGRAPHARAGLPAAPHLL ..::::. .:: :: . :. : .:. . : ... : gi|194 LGLCDGASVAESELP-VLEKVFLASAEAR-GPALPQEREERSKLGKAHLRRALLGQEAAL 370 380 390 400 410 gi|194 QLHAVCRALRREDLLQAVLARALQRSLAKYSELDLEDDFHEATEAPDIQPKTQQRPEGRT 420 430 440 450 460 470 >>gi|119602658|gb|EAW82252.1| rhophilin, Rho GTPase bind (338 aa) initn: 1866 init1: 1843 opt: 1844 Z-score: 2125.1 bits: 401.9 E(): 1.1e-109 Smith-Waterman score: 1844; 98.947% identity (99.649% similar) in 285 aa overlap (1-284:4-288) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQE-CVFEGLSPPASMA :::::::::::::::::::::::::::::::::::::::::::.:. : gi|119 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQGQDPCTPQPWLQLAAST 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 PQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHV gi|119 EHALPTQRTSGQCLSRLMLEAASGTCLPIKDWSDLSEP 310 320 330 >>gi|6093970|sp|Q61085.1|RHPN1_MOUSE RecName: Full=Rhoph (643 aa) initn: 1838 init1: 1735 opt: 1827 Z-score: 2101.6 bits: 398.5 E(): 2.3e-108 Smith-Waterman score: 1827; 70.433% identity (83.894% similar) in 416 aa overlap (1-406:4-418) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQ-------GCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTG :::::: :.:::: : : : :..: : :::::.::..::::.:::.:::: gi|609 MILEERPDGQGTGEESSRPQDDGSIRKGYGSFVQNQPGQLQSHRARLHQQISKELRMRTG 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 AENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLG ::::::::::. ::::::::::::::::::::::: ::: .:: . .:..:.:::::: gi|609 AENLYRATSNTWVRETVALELSYVNSNLQLLKEELAELSTSVDVDQPEGEGITIPMIPLG 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 LKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYN :::::::::.:::::::: ::::::.:.:.::.::: :::: :::::.:.::.::.:::. gi|609 LKETKELDWATPLKELISEHFGEDGTSFETEIQELEDLRQATRTPSRDEAGLDLLAAYYS 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 QLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDR :::::::::..:.:: ::.:::::::::::::::::::::::::::::::::::::::: gi|609 QLCFLDARFFSPSRSPGLLFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDC 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 SCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLS :::::. .: :::::::::: ::::::::::::::::::: :::::.::::::.:.:: gi|609 SCTEGTNHAAEAFQRAAGAFRLLRENFSHAPSPDMSAASLSMLEQLMIAQAQECIFKGLL 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 PPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRS ::: .:. : ::.:::::::::.:: ::::.::::::.::.:.::: :.:::::.: . gi|609 LPASATPDICPDQLQLAQEAAQVATEYGLVHRAMAQPPVRDYLPASWTNLAHVKAEHFCA 310 320 330 340 350 360 360 370 380 390 400 KIAA19 LAHYHVAMALCDG---SRECPPHLPMVLPRPPRAGLTASLSPSSDRGRAPHARAGLPAAP :::::.:::::.. . : . . : :. : .: :. . : :.: : : gi|609 LAHYHAAMALCESHPAKGELARQEHVFQPSTPHEPLGPTL-PQHPEDRRKLAKAHLKRAI 370 380 390 400 410 410 KIAA19 HLL gi|609 LGQEEALRLHTLCRVLRKVDLLQVVVTQALRRSLAKYSQLEREDDFFEATEAPDIQPKTH 420 430 440 450 460 470 >>gi|30354357|gb|AAH52010.1| Rhpn1 protein [Mus musculus (451 aa) initn: 1826 init1: 1754 opt: 1825 Z-score: 2101.5 bits: 397.9 E(): 2.4e-108 Smith-Waterman score: 1825; 70.000% identity (83.810% similar) in 420 aa overlap (1-410:4-420) 10 20 30 40 50 KIAA19 EERPDGAGAGEESPRLQ-------GCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTG :::::: :.:::: : : : :..: : :::::.::..::::.:::.:::: gi|303 MILEERPDGQGTGEESSRPQDDGSIRKGYGSFVQNQPGQLQSHRARLHQQISKELRMRTG 10 20 30 40 50 60 60 70 80 90 100 110 KIAA19 AENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLG ::::::::::. ::::::::::::::::::::::: ::: .:: . .:..:.:::::: gi|303 AENLYRATSNTWVRETVALELSYVNSNLQLLKEELAELSTSVDVDQPEGEGITIPMIPLG 70 80 90 100 110 120 120 130 140 150 160 170 KIAA19 LKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYN :::::::::.:::::::: ::::::.:.:.::.::: :::: :::::.:.::.::.:::. gi|303 LKETKELDWATPLKELISEHFGEDGTSFETEIQELEDLRQATRTPSRDEAGLDLLAAYYS 130 140 150 160 170 180 180 190 200 210 220 230 KIAA19 QLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDR :::::::::..:.:: ::.:::::::::::::::::::::::::::::::::::::::: gi|303 QLCFLDARFFSPSRSPGLLFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDC 190 200 210 220 230 240 240 250 260 270 280 290 KIAA19 SCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLS :::::. .: :::::::::: ::::::::::::::::::: :::::.::::::.:.:: gi|303 SCTEGTNHAAEAFQRAAGAFRLLRENFSHAPSPDMSAASLSMLEQLMIAQAQECIFKGLL 250 260 270 280 290 300 300 310 320 330 340 350 KIAA19 PPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRS ::: .:. : ::.:::::::::.:: ::::.::::::.::.:.::: :.:::::.: . gi|303 LPASATPDICPDQLQLAQEAAQVATEYGLVHRAMAQPPVRDYLPASWTNLAHVKAEHFCA 310 320 330 340 350 360 360 370 380 390 400 KIAA19 LAHYHVAMALCDG---SRECPPHLPMVLPRPPRAGLTASLSPSSDRGRAPHARAGLPAAP :::::.:::::.. . : . . : :. : .: :. . : . .: :: gi|303 LAHYHAAMALCESHPAKGELARQEHVFQPSTPHEPLGPTL-PQHPEDR--RKLGGGAAAS 370 380 390 400 410 410 KIAA19 HLL ::. gi|303 HLVQSPAQGGPAAGCGDSGTAALPGQVLTARARG 420 430 440 450 >>gi|148697538|gb|EDL29485.1| rhophilin, Rho GTPase bind (472 aa) initn: 1826 init1: 1754 opt: 1825 Z-score: 2101.2 bits: 397.9 E(): 2.4e-108 Smith-Waterman score: 1825; 70.000% identity (83.810% similar) in 420 aa overlap (1-410:25-441) 10 20 KIAA19 EERPDGAGAGEESPRLQ-------GCDSLTQIQCGQ :::::: :.:::: : : : :..: : :: gi|148 SLEREGPAARSLSESASERAAMILEERPDGQGTGEESSRPQDDGSIRKGYGSFVQNQPGQ 10 20 30 40 50 60 30 40 50 60 70 80 KIAA19 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS :::.::..::::.:::.::::::::::::::. ::::::::::::::::::::::: ::: gi|148 LQSHRARLHQQISKELRMRTGAENLYRATSNTWVRETVALELSYVNSNLQLLKEELAELS 70 80 90 100 110 120 90 100 110 120 130 140 KIAA19 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR .:: . .:..:.:::::::::::::::.:::::::: ::::::.:.:.::.::: :: gi|148 TSVDVDQPEGEGITIPMIPLGLKETKELDWATPLKELISEHFGEDGTSFETEIQELEDLR 130 140 150 160 170 180 150 160 170 180 190 200 KIAA19 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFE :: :::::.:.::.::.:::.:::::::::..:.:: ::.:::::::::::::::::::: gi|148 QATRTPSRDEAGLDLLAAYYSQLCFLDARFFSPSRSPGLLFHWYDSLTGVPAQQRALAFE 190 200 210 220 230 240 210 220 230 240 250 260 KIAA19 KGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAAS :::::::::::::::::::: :::::. .: :::::::::: :::::::::::::::::: gi|148 KGSVLFNIGALHTQIGARQDCSCTEGTNHAAEAFQRAAGAFRLLRENFSHAPSPDMSAAS 250 260 270 280 290 300 270 280 290 300 310 320 KIAA19 LCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPV : :::::.::::::.:.:: ::: .:. : ::.:::::::::.:: ::::.:::::: gi|148 LSMLEQLMIAQAQECIFKGLLLPASATPDICPDQLQLAQEAAQVATEYGLVHRAMAQPPV 310 320 330 340 350 360 330 340 350 360 370 380 KIAA19 HDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDG---SRECPPHLPMVLPRPPRAGLTAS .::.:.::: :.:::::.: .:::::.:::::.. . : . . : :. : . gi|148 RDYLPASWTNLAHVKAEHFCALAHYHAAMALCESHPAKGELARQEHVFQPSTPHEPLGPT 370 380 390 400 410 420 390 400 410 KIAA19 LSPSSDRGRAPHARAGLPAAPHLL : :. . : . .: :: ::. gi|148 L-PQHPEDR--RKLGGGAAASHLVQSPAQGGPAAGCGDSGTAALPGQVLTARARG 430 440 450 460 470 410 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Fri Mar 6 03:58:55 2009 done: Fri Mar 6 04:03:48 2009 Total Scan time: 1515.070 Total Display time: 0.140 Function used was FASTA [version 34.26.5 April 26, 2007]