染色体工学研究室


論 文 リ ス ト

2019
De novo formation and epigenetic maintenance of centromere chromatin.
Ohzeki J, Larionov V, Earnshaw WC, Masumoto H.
Curr Opin Cell Biol. 58: 15-25. (2019)
Identification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata: a step toward discovering preponderant α‐amyrin‐producing activity.
Srisawat P, Fukushima EO, Yasumoto S, Robertlee J, Suzuki H, Seki H, Muranaka T.
New Phytol. 224(1): 352-366. (2019)
A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission.
Liskovykh M, Goncharov NV, Petrov N, Aksenova V, Pegoraro G, Ozbun LL, Reinhold WC, Varma S, Dasso M, Kumeiko V, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.
Genome Res. 29(10): 1719-1732. (2019)
2018
Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart.
Ito T, Okazaki K, Nakajima D, Shibata D, Murakami S, Schaffer S.
Amino Acids 50(1): 117-124. (2018)
The conserved histone variant H2A.Z illuminates meiotic recombination initiation.
Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T.
Current Genetics 64(5): 1015-1019. (2018)
Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies.
Pesenti E, Kouprina N, Liskovykh M, Aurich-Costa J, Larionov V, Masumoto H, Earnshaw WC, Molina O.
ACS Synthetic Biology 7(4): 1116-1130. (2018)
Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies.
Kouprina N, Petrov N, Molina O, Liskovykh M, Pesenti E, Ohzeki J, Masumoto H, Earnshaw WC, Larionov V.
ACS Synthetic Biology 7(9): 1974–1989. (2018)
Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy.
Lee HS, Carmena M, Liskovykh M, Peat E, Kim JH, Oshimura M, Masumoto H, Teulade-Fichou MP, Pommier Y, Earnshaw WC, Larionov V, Kouprina N.
Cancer Research 78(21): 6282-6296. (2018)
2017
The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast.
Yamada, S., Kugou, K., Ding, D. Q., Fujita, Y., Hiraoka, Y., Murakami, H., Ohta, K. and Yamada, T. 2017
Nucleic Acids Res., doi: 10.1093/nar/gkx1110.
Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis.
Tashiro, S., Nishihara, Y., Kugou, K., Ohta, K. and Kanoh, J. 2017
Nucleic Acids Res., 45, 10333-10349.
Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart.
Ito, T., Okazaki, K., Nakajima, D., Shibata, D., Murakami, S. and Schaffer, S. 2017
Amino Acids, doi: 10.1007/s00726-017-2498-y.
Method to assemble genomic DNA fragments or genes on human artificial chromosome with regulated kinetochore using a multi-integrase system.
Lee, N. C. O., Kim, J. H., Petrov, N. S., Lee, H. S., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2017
ACS Synth Biol., doi: 10.1021/acssynbio.7b00209.
Using human artificial chromosomes to study centromere assembly and function.
Molina, O., Kouprina, N., Masumoto, H., Larionov, V. and Earnshaw, W. C. 2017
Chromosoma., 126, 559-575.
CENP-Bによるセントロメアのエピジェネティクス制御への関わり CENP-B and centromere chromatin.
久郷和人、大竹興一郎、舛本 寛 2017
Medical Science Digest, Vol. 43. ニューサイエンス社, pp. 629-632.
人工染色体を用いたセントロメア機能獲得のエピゲノム制御解析 Analyses for epigenetic controls of functional centromere acquisition using human artificial chromosomes.
大関淳一郎、舛本 寛 2017
バイオサイエンスとインダストリー (B&I), Vol. 75. バイオインダストリー協会, pp. 304-309.
2016
Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
Tashiro, S., Handa, T., Matsuda, A., Ban, T., Takigawa, T., Miyasato, K., Ishii, K., Kugou, K., Ohta, K., Hiraoka, Y., Masukata, H. and Kanoh, J. 2016
Nat Commun., 7, 10393.
Analysis of novel Sir3 binding regions in Saccharomyces cerevisiae.
Mitsumori, R., Ohashi, T., Kugou, K., Ichino, A., Taniguchi, K., Ohta, K., Uchida, H. and Oki, M. 2016
J Biochem., 160, 11-17.
Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells.
Kim, J. H., Lee, H. S., Lee, N. C., Goncharov, N. V., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Kouprina, N. and Larionov, V. 2016
Oncotarget., 7, 14841-14856.
CENP-B box, a nucleotide motif involved in centromere formation, occurs in a New World monkey.
Suntronpong, A., Kugou, K., Masumoto, H., Srikulnath, K., Ohshima, K., Hirai, H. and Koga, A. 2016
Biol. Lett., 12, 20150817.
KAT7/HBO1/MYST2 regulates CENP-A chromatin assembly by antagonizing Suv39h1-mediated centromere inactivation.
Ohzeki, J., Shono, N., Otake, K., Martins, N. M. C., Kugou, K., Kimura, H., Nagase, T., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2016
Dev Cell., 37, 413-427.
Formation of functional CENP-B boxes at diverse locations in repeat units of centromeric DNA in New World monkeys.
Kugou, K., Hirai, H., Masumoto, H. and Koga, A. 2016
Sci Rep., 6, 27833.
3D-CLEM reveals that a major portion of mitotic chromosomes is not chromatin.
Booth, D. G., Beckett, A. J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I. A. and Earnshaw, W. C. 2016
Mol Cell, 64, 790-802.
Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance.
Molina, O., Vargiu, G., Abad, M. A., Zhiteneva, A., Jeyaprakash, A. A., Masumoto, H., Kouprina, N., Larionov, V. and Earnshaw, W. C. 2016
Nat Commun., 7, 13334.
2015
CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
Shono, N., Ohzeki, J., Otake, K., Martins, N. M. C., Nagase, T., Kimura, H., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2015
J. Cell Science, 128, 4572-4587.
Stable complex formation of CENP-B with the CENP-A nucleosome.
Fujita, R., Otake, K., Arimura, Y., Horikoshi, N., Miya, Y., Shiga, T., Osakabe, A., Tachiwana, H., Ohzeki, J., Larionov, V., Masumoto, H. and Kurumizaka, H. 2015
Nucleic Acids Res., 43, 4909-4922.
Genetic and epigenetic regulation of centromeres: A look at HAC formation.
Ohzeki, J., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2015
Chromosome Res., 23, 87-103.
Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.
Kononenko, A. V., Lee, N. C., Liskovykh, M., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2015
Nucleic Acids Res., 43, e57.
Generating a transgenic mouse line stably expressing human MHC surface antigen from a HAC carrying multiple genomic BACs.
Hasegawa, Y., Ishikura, T., Hasegawa, T., Watanabe, T., Suzuki, J., Nakayama, M., Okamura, Y., Okazaki, T., Koseki, H., Ohara, O., Ikeno, M. and Masumoto, H. 2015
Chromosoma, 124, 107-118.
Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome.
Erliandri, I., Fu, H., Nakano, M., Kim, J. H., Miga, K. H., Liskovykh, M., Earnshaw, W. C., Masumoto, H., Kouprina, N., Aladjem, M. I. and Larionov, V. 2015
Nucleic Acids Res., 42, 11502-11516.
2014 以前
A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.
Kononenko, A. V., Bansal, R., Lee, N. C., Grimes, B. R., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2014
Nucleic Acids Res., 42, e164.
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
Obata, Y., Furusawa, Y., Endo, T. A., Sharif, J., Takahashi, D., Atarashi, K., Nakayama, M., Onawa, S., Fujimura, Y., Takahashi, M., Ikawa, T., Otsubo, T., Kawamura, Y. I., Dohi, T., Tajima, S., Masumoto, H., Ohara, O., Honda, K., Hori, S., Ohno, H., Koseki, H. and Hase, K. 2014
Nat Immunol., 15, 571-579.
Human artificial chromosome based gene delivery vectors for biomedicine and biotechnology.
Kouprina, N., Tomilin, A. N., Masumoto, H., Earnshaw, W. C. and Larionov, V. 2014
Expert Opin. Drug Deliv., 11, 517-35.
Identification of novel α-n-methylation of CENP-B that regulates its binding to the centromeric DNA
Dai, X., Otake, K., You, C., Cai, Q., Wang, Z., Masumoto, H. and Wang, Y. 2013
J Proteome Res., 12, 4167-4175.
A new generation of human artificial chromosomes for functional genomics and gene therapy.
Kouprina, N., Earnshaw, W. C., Masumoto, H. and Larionov, V. 2013
Cell Mol Life Sci., 70, 1135-1148.
A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells.
Lee, H. S., Lee, N. C., Grimes, B. R., Samoshkin, A., Kononenko, A. V., Bansal, R., Masumoto, H., Earnshaw, W. C., Kouprina, N. and Larionov, V. 2013
BMC Cancer, 13, 252.
Protecting a transgene expression from the HAC-based vector by different chromatin insulators.
Lee, N. C., Kononenko, A. V., Lee, H. S., Tolkunova, E. N., Liskovykh, M. A., Masumoto, H., Earnshaw, W. C., Tomilin, A. N., Larionov, V. and Kouprina, N. 2013
Cell Mol Life Sci., 70, 3723-3737.
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H., Copenhaver, G. P., Deluca, J.G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., Gorbsky, G. J., Harrison, S. C., Heun, P., Hirota, T., Jansen, L. E., Karpen, G., Kops, G. J., Lampson, M. A., Lens, S. M., Losada, A., Luger, K., Maiato, H., Maddox, P. S., Margolis, R. L., Masumoto, H., McAinsh, A. D, Mellone, B. G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R. J., Salmon, E. D., Scott, K. C., Straight, A. F., Stukenberg, P. T., Sullivan, B. A., Sullivan, K. F., Sunkel, C. E., Swedlow, J. R., Walczak, C. E., Warburton, P. E., Westermann, S., Willard, H. F., Wordeman, L., Yanagida, M., Yen, T. J., Yoda, K. and Cleveland, D. W. 2013
Chromosome Res., 21, 101-106.
Nap1 regulates proper CENP-B binding to nucleosomes.
Tachiwana, H., Miya, Y., Shono, N., Ohzeki, J., Osakabe, A., Otake, K., Larionov, V., Earnshaw, W. C., Kimura, H., Masumoto, H. and Kurumizaka, H. 2013
Nucleic Acids Res., 41, 2869-2880.
Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly.
Ohzeki, J., Bergmann, J. H., Kouprina, N., Noskov, V. N., Nakano, M., Kimura, H., Earnshaw, W. C., Larionov, V., Masumoto, H. 2012
EMBO J., 31, 2391-2402.
Inactivation of a human kinetochore by specific targeting of chromatin modifiers.
Nakano, M., Cardinale, S., Noskov, V., Gassmann, R., Vagnarelli, P., Kandels-Lewis, S., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2008
Developmental Cell, 14, 507-522.
CENP-B controls centromere formation depending on the chromatin context.
Okada, T., Ohzeki, J., Nakano, M., Yoda, K., Brinkley, W. R., Larionov, V. and Masumoto, H. 2007
Cell, 131, 1287-1300.
A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere.
Okamoto, Y., Nakano, M., Ohzeki, J., Larionov, V. and Masumoto, H. 2007
EMBO J., 26, 1279-1291.
Construction of YAC based Mammalian Artificial Chromosomes.
Ikeno, M., Grimes, B., Okazaki T., Nakano, M., Saitoh, K., Hoshino, H., McGill, N., Cooke, H. and Masumoto H.1998
Nature Biotech., 16, 431-439.

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