Although the human genome has been completely sequenced and is estimated to contain ~23,000 protein-coding genes, we are still very far from a full understanding of their biological functions. For a functional analysis of a protein-coding gene, it is preferred to clone only the ORF region into suitable vectors for protein expression. A genome-wide collection of such ORF clones, or so-called "ORFeome", is expected to be an indispensable resource for functional genomics.

From this point of view, The ORFeome Collaboration (OC) was founded in 2005 to promote the research community's collection and provision of a set of full-ORF human cDNA clones. The OC plans to collect at least one fully sequenced full-ORF clone for each of the ~18,500 currently defined human genes. A number of full-ORF mouse clones have also been provided.

As a member of OC, Kazusa DNA Research Institute started distributing the human ORF clones from the ORFeome collection, all of which were validated by our own quality check. We plan to increase the number of OC clones we distribute, while maintaining the high level of quality of the clones delivered to our customers. (July 8, 2008)

• Update History of OC Clones
  
  - 1757 clones were newly validated and added to the database. (Apr 16, 2014)
  - 618 clones were newly validated and added to the database. (Aug 22, 2012)
  - 8251 clones were newly validated and added to the database. (Aug 13, 2012)
  - 2234 clones were newly validated and added to the database. (Dec 5, 2011)
  - 334 clones were newly validated and added to the database. (Augst 4, 2010)
  - 254 clones were newly validated and added to the database. (July 23, 2010)
  - 36 clones were newly validated and added to the database. (Oct 23, 2009)
  - 310 clones were newly validated and added to the database. (Aug 20, 2009)
  - 68 clones were newly validated and added to the database. (Jul 29, 2009)
  - 208 clones were newly validated and added to the database. (Jul 7, 2009)
  - 484 clones were newly validated and added to the database. (May 8, 2009)
  - 2206 clones were newly validated and added to the database. (March 26, 2009)
  - 490 clones were newly validated and added to the database. (February 23, 2009)
  - ~2200 clones were newly validated and added to the database. (January 15, 2009)
  
• PID (Product ID) for OC clones with / without stop codon
  
  OC clones are constructed by using Gateway system. Thus there are two types of ORFs (with / without stop codon). For customers who would like to construct a fusion type ORF containing any expression tag at the C-terminus, we provide OC clones without a stop codon. For customers who would like to express the native type of ORF, we provide OC clone with a stop codon.
  
  Each OC clone containing a stop codon has a PID beginning with ORS or MRS, while one excluding a stop codon has a PID beginning with ORH or MRH.
  

• Last update : 2014/04/16
  
• Download the clone list (18,314 clones)
  
• Direct access to a table of interest
  

  Enter Product ID or IMAGE clone ID or GenBank Accession no.
  

  (eg. ORS09659; ORH04030; 100015324; BC148327; MRH00535)
  

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• How to obtain ORFeome clone(s) Japan || Other countries