発表論文

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Characterization of proteogenomic signatures of differentiation of CD4⁺ T cell subsets
Toshio Kanno, Ryo Konno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K Asou, Junichiro Ohzeki, Yusuke Kawashima, Yoshinori Hasegawa, Osamu Ohara, Yusuke Endo
DNA Res. 2023;30(1):dsac054.
doi:10.1093/dnares/dsac054

SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4⁺ T cells
Toshio Kanno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K Asou, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Front Immunol. 2022;13:904875. Published 2022 Aug 18.
doi:10.3389/fimmu.2022.904875

Fatty acid metabolism in T-cell function and differentiation
Yusuke Endo, Toshio Kanno, Takahiro Nakajima
Int Immunol. 2022;34(11):579-587.
doi:10.1093/intimm/dxac025

Lipid metabolism in Th17 cell function
Toshio Kanno, Takahiro Nakajima, Keisuke Miyako, Yusuke Endo
Pharmacol Ther. 2023;245:108411.
doi:10.1016/j.pharmthera.2023.108411

Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells
Maria Koizumi, Yuichi Kama, Ken-Ichi Hirano, Yusuke Endo, Tomoaki Tanaka, Katsuto Hozumi, Hiroyuki Hosokawa
J Biol Chem. 2022;298(11):102506.
doi:10.1016/j.jbc.2022.102506

Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake
Tadamichi Kasuya , Shigeru Tanaka , Jun Tamura, Keishi Etori, Jumpei Shoda, Koto Hattori, Yusuke Endo, Masayuki Kitajima, Takahiro Kageyama, Taro Iwamoto, Masaya Yokota, Arifumi Iwata, Akira Suto, Kotaro Suzuki, Harumi Suzuki, Steven F Ziegler, Hiroshi Nakajima
Sci Rep. 2023;13(1):1653. Published 2023 Jan 30.
doi:10.1038/s41598-023-28987-1

Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages
Yinglan Cheng, Ichiro Manabe, Sumio Hayakawa, Yusuke Endo, Yumiko Oishi
Front Immunol. 2023;14:1009973. Published 2023 Jan 27.
doi:10.3389/fimmu.2023.1009973

PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
Junichiro Takano, Shinsuke Ito, Yixing Dong, Jafar Sharif, Yaeko Nakajima-Takagi, Taichi Umeyama, Yong-Woon Han, Kyoichi Isono, Takashi Kondo, Yusuke Iizuka, Tomohiro Miyai, Yoko Koseki, Mika Ikegaya, Mizuki Sakihara, Manabu Nakayama, Osamu Ohara, Yoshinori Hasegawa, Kosuke Hashimoto, Erik Arner, Robert J Klose, Atsushi Iwama, Haruhiko Koseki, Tomokatsu Ikawa
Nat Commun. 2022;13(1):7159. Published 2022 Nov 28.
doi:10.1038/s41467-022-34856-8

Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages
Osamu Masui, Catherine Corbel, Koji Nagao, Takaho A Endo, Fuyuko Kezuka, Patricia Diabangouaya, Manabu Nakayama, Mami Kumon, Yoko Koseki, Chikashi Obuse, Haruhiko Koseki, Edith Heard
Nat Cell Biol. 2023;25(1):134-144.
doi:10.1038/s41556-022-01047-y

ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice
Takahiro Nakajima, Toshio Kanno, Satoru Yokoyama, Shigemi Sasamoto, Hikari K Asou, Damon J Tumes, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
J Exp Med. 2021;218(12):e20210639.
doi:10.1084/jem.20210639

Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue T_reg cell homeostasis
Toshio Kanno, Takahiro Nakajima, Yusuke Kawashima, Satoru Yokoyama, Hikari K Asou, Shigemi Sasamoto, Koji Hayashizaki, Yuki Kinjo, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Cell Rep. 2021;37(6):109921.
doi:10.1016/j.celrep.2021.109921

SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4⁺ T cells
Toshio Kanno, Takahiro Nakajima, Satoru Yokoyama, Hikari K Asou, Shigemi Sasamoto, Yasuhiro Kamii, Koji Hayashizaki, Yasuo Ouchi, Taishi Onodera, Yoshimasa Takahashi, Kazutaka Ikeda, Yoshinori Hasegawa, Yuki Kinjo, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Commun Biol. 2021;4(1):820. Published 2021 Jun 29.
doi:10.1038/s42003-021-02310-y

A Simple Method for In-Depth Proteome Analysis of Mammalian Cell Culture Conditioned Media Containing Fetal Bovine Serum
Ren Nakamura, Daisuke Nakajima, Hironori Sato, Yusuke Endo, Osamu Ohara, Yusuke Kawashima
Int J Mol Sci. 2021;22(5):2565. Published 2021 Mar 4.
doi:10.3390/ijms22052565

LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice
Ken-Ichi Hirano , Hiroyuki Hosokawa , Maria Koizumi, Yusuke Endo, Takashi Yahata, Kiyoshi Ando, Katsuto Hozumi
eLife. 2021;10:e68227. Published 2021 Aug 12.
doi:10.7554/eLife.68227

Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
Hiroki Sugishita, Takashi Kondo, Shinsuke Ito, Manabu Nakayama, Nayuta Yakushiji-Kaminatsui, Eiryo Kawakami, Yoko Koseki, Yasuhide Ohinata, Jafar Sharif, Mio Harachi, Neil P Blackledge, Robert J Klose, Haruhiko Koseki
Nat Commun. 2021;12(1):5341. Published 2021 Sep 9.
doi:10.1038/s41467-021-24894-z

MORC3, a novel MIWI2 association partner, as an epigenetic regulator of piRNA dependent transposon silencing in male germ cells
Kanako Kojima-Kita, Satomi Kuramochi-Miyagawa, Manabu Nakayama, Haruhiko Miyata, Steven E Jacobsen, Masahito Ikawa, Haruhiko Koseki, Toru Nakano
Sci Rep. 2021;11(1):20472. Published 2021 Oct 14.
doi:10.1038/s41598-021-98940-7

Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis
Atsushi Hata, Takahiro Nakajima, Keisuke Matsusaka, Masaki Fukuyo, Manabu Nakayama, Junichi Morimoto, Yuki Ito, Takayoshi Yamamoto, Yuichi Sakairi, Bahityar Rahmutulla, Satoshi Ota, Hironobu Wada, Hidemi Suzuki, Takekazu Iwata, Hisahiro Matsubara, Osamu Ohara, Ichiro Yoshino, Atsushi Kaneda
Int J Cancer. 2021;148(12):3008-3018.
doi:10.1002/ijc.33499

Clinical phenotypes and genetic analyses for diagnosis of systemic autoinflammatory diseases in adult patients with unexplained fever
Yukiko Hidaka, Kyoko Fujimoto, Norikazu Matsuo, Takuma Koga, Shinjiro Kaieda, Satoshi Yamasaki, Munetoshi Nakashima, Kiyoshi Migita, Manabu Nakayama, Osamu Ohara, Tomoaki Hoshino, Ryuta Nishikomori, Hiroaki Ida
Mod Rheumatol. 2021;31(3):704-709.
doi:10.1080/14397595.2020.1784542

Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis
Motoshi Sonoda, Masataka Ishimura, Katsuhide Eguchi, Akira Shiraishi, Shunsuke Kanno, Noriyuki Kaku, Hirosuke Inoue, Yoshitomo Motomura, Masayuki Ochiai, Yasunari Sakai, Manabu Nakayama, Osamu Ohara, Shouichi Ohga
Int J Hematol. 2020;111(1):131-136.
doi:10.1007/s12185-019-02738-3

Effects of BMP7 produced by group 2 innate lymphoid cells on adipogenesis.
Miyajima Y, Ealey KN, Motomura Y, Mochizuki M, Takeno N, Yanagita M, Economides AN, Nakayama M, Koseki H, Moro K.
Int Immunol. 32(6): 407-419. (2020)

Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice.
Tamaura M, Satoh-Takayama N, Tsumura M, Sasaki T, Goda S, Kageyama T, Hayakawa S, Kimura S, Asano T, Nakayama M, Koseki H, Ohara O, Okada S, Ohno H, Kobayashi M.
Int Immunol. 32(4): 259-272. (2020)

Clinical phenotypes and genetic analyses for diagnosis of systemic autoinflammatory diseases in adult patients with unexplained fever.
Hidaka Y, Fujimoto K, Matsuo N, Koga T, Kaieda S, Yamasaki S, Nakashima M, Migita K, Nakayama M, Ohara O, Hoshino T, Nishikomori R, Ida H.
Mod Rheumatol. 24 :1-6. (2020)

Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.
Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato TA, Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S.
Cancer Discov. 10(6): 836-853. (2020)

A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation.
Nakayama Y, Fujiu K, Yuki R, Oishi Y, Morioka M. S, Isagawa T, Matsuda J, Oshima T, Matsubara T, Sugita J, Kudo F, Kaneda A, Endo Y, Nakayama T, Nagai R, Komuro I and Manabe I.
Proc. Natl. Acad. Sci. USA. 117:14365-14375. (2020)

Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.
Tanaka S, Ise W, Inoue T, Ito A, Ono C, Shima Y, Sakakibara S, Nakayama M, Fujii K, Miura I, Sharif J, Koseki H, Koni PA, Raman I, Li QZ, Kubo M, Fujiki K, Nakato R, Shirahige K, Araki H, Miura F, Ito T, Kawakami E, Baba Y, Kurosaki T.
Nat Immunol. 21(8): 950-961. (2020)

免疫代謝リプログラミング 代謝で免疫を制御する-脂肪酸代謝による記憶T細胞への運命決定
遠藤裕介
医学のあゆみ 275(1): 54-60. (2020)

免疫と代謝 T細胞の活性化と脂質代謝
遠藤裕介
月刊臨床免疫・アレルギー科 73(5): 449-455. (2020)

代謝で免疫を制御する 脂肪酸代謝による免疫システムのfine-tuning
遠藤裕介
感染・炎症・免疫 50(2): 74-77. (2020)

IL-33バイオロジー アレルギー疾患におけるIL-33と病原性Th2細胞
遠藤裕介
月刊臨床免疫・アレルギー科 74(5): 462-469. (2020)

PRC1 preserves epidermal tissue integrity independently of PRC2.
Cohen I, Zhao D, Menon G, Nakayama M, Koseki H, Zheng D, Ezhkova E.
Genes Dev. 33(1-2): 55-60. (2019)

ACC1 determines memory potential of individual CD4⁺T cells by regulating de novo fatty acid biosynthesis.
Endo Y, Onodera A, Ninomiya-Obata K, Nasu R, Asou HK, Ito T, Yamamoto T, Kanno T, Nakajima T, Ishiwata K, Kanuka H, Tumes DJ, and Nakayama T.
Nat Metab. 1: 261–275. (2019)

PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes.
Akizuki S, Ishigaki K, Kochi Y, Law SM, Matsuo K, Ohmura K, Suzuki A, Nakayama M, Iizuka Y, Koseki H, Ohara O, Hirata J, Kamatani Y, Matsuda F, Sumida T, Yamamoto K, Okada Y, Mimori T, Terao C.
Ann Rheum Dis. 78(4): 509-518. (2019)

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.
Matsuda M, Ono R, Iyoda T, Endo T, Iwasaki M, Tomizawa-Murasawa M, Saito Y, Kaneko A, Shimizu K, Yamada D, Ogonuki N, Watanabe T, Nakayama M, Koseki Y, Kezuka-Shiotani F, Hasegawa T, Yabe H, Kato S, Ogura A, Shultz LD, Ohara O, Taniguchi M, Koseki H, Fujii SI, Ishikawa F.
Life Sci Alliance. 2(2). pii: e201800195. (2019)

Ezh2 controls development of natural killer T cells, which cause spontaneous asthema-like pathology.
Tumes D, Hirahara K, Papadopoulos M, Shinoda K, Onodera A, Kumagai J, Yip K. H, Pant H, Kokubo K, Kiuchi M, Aoki A, Obata-Ninomiya K, Tokoyoda K, Endo Y, Kimura M. Y and Nakayama T
J Allergy Clin Immunol. 144(2): 549-560. (2019)

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression.
Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, King HW, Koseki H, Klose RJ.
Mol Cell. 74(5): 1020-1036. (2019)

Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development.
Takahashi S, Ishida A, Kubo A, Kawasaki H, Ochiai S, Nakayama M, Koseki H, Amagai M, Okada T.
Sci Rep. 9(1): 8625. (2019)

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis.
Nishida K, Hasegawa A, Yamasaki S, Uchida R, Ohashi W, Kurashima Y, Kunisawa J, Kimura S, Iwanaga T, Watarai H, Hase K, Ogura H, Nakayama M, Kashiwakura JI, Okayama Y, Kubo M, Ohara O, Kiyono H, Koseki H, Murakami M, Hirano T.
Sci Rep. 9(1): 10842. (2019)

Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis.
Sonoda M, Ishimura M, Eguchi K, Shiraishi A, Kanno S, Kaku N, Inoue H, Motomura Y, Ochiai M, Sakai Y, Nakayama M, Ohara O, Ohga S.
Int J Hematol. 111(1): 131-136. (2019)

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.
Turberfield AH, Kondo T, Nakayama M, Koseki Y, King HW, Koseki H, Klose RJ.
Nucleic Acids Res. 47(17): 9005-9023. (2019)

Human Gain-of-Function STAT1 Mutation disturbs IL-17 Immunity in Mice.
Tamaura M, Satoh-Takayama N, Tsumura M, Sasaki T, Goda S, Kageyama T, Hayakawa S, Kimura S, Asano T, Nakayama M, Koseki H, Ohara O, Okada S, Ohno H, Kobayashi M
Int Immunol. pii: dxz079. (2019)

脂肪酸代謝によるT細胞分化のユニ－クな制御
遠藤裕介、中山俊憲
炎症と免疫　27(1):14-18 (2019)

脂肪酸を基軸とする「代謝-免疫-疾患」スパイラルの分子機構解明
遠藤裕介
医学のあゆみ　269(13):1193-1199（2019）

病原性記憶Th2細胞と慢性アレルギー疾患
遠藤裕介
第55回日本アレルギー学会専門医認定教育セミナーテキスト (2019)

Novel reporter and deleter mouse strains generated using VCre/VloxP and SCre/SloxP systems, and their system specificity in mice.
Yoshimura Y, Ida-Tanaka M, Hiramaki T, Goto M, Kamisako T, Eto T, Yagoto M, Kawai K, Takahashi T, Nakayama M, Ito M.
Transgenic Res. 2018 Apr;27(2):193-201. (2018)

A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activ10.1007/s11248-018ities.
Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP.
Mol Cell. 70(3): 408-421. (2018)

PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification.
Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E.
Cell Stem Cell. 22(5): 726-739. (2018)

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.
Dimitrova E, Kondo T, Feldmann A, Nakayama M, Koseki Y, Konietzny R, Kessler BM, Koseki H, Klose RJ.
Elife. 7: pii: e37084. (2018)

Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic inflammation.
Hirahara, K., Shinoda, K., Endo, Y., Ichikawa, T., and Nakayama, T.
Inflammation and Regenerationin 38: 10 (2018)

Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing.
Ono S, Nakayama M, Kanegane H, Hoshino A, Shimodera S, Shibata H, Fujino H, Fujino T, Yunomae Y, Okano T, Yamashita M, Yasumi T, Izawa K, Takagi M, Imai K, Zhang K, Marsh R, Picard C, Latour S, Ohara O, Morio T.
Int J Hematol. 108(3):319-328. (2018)

CXCR6⁺ST2⁺ memory Th2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth.
Obata-Ninomiya, K., Ishiwata, K., Nakano, H., Endo, Y., Ichikawa, T., Onodera, A., Hirahara, K., Okamoto, Y., Kanuka, H., and Nakayama, T.
Proc. Natl. Acad. Sci. USA 115: E9849-E9858 (2018)

Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud.
Yakushiji-Kaminatsui N, Kondo T, Hironaka KI, Sharif J, Endo TA, Nakayama M, Masui O, Koseki Y, Kondo K, Ohara O, Vidal M, Morishita Y, Koseki H.
Development. 145(19): pii: dev166348. (2018)

DUSP10 constrains innate IL-33-mediated cytokine production in ST2^hi memory-type pathogenic Th2 cells.
Yamamoto T*, Endo Y*, Onodera A, Hirahara K, Asou HK, Nakajima T, Kanno T, Ouchi Y, Uematsu S, Nishimasu H, Nureki O, Damon DJ, Shimojo N, and Nakayama T.
Nat. Commun. 9: 4231. (2018)

リポクオリティを基軸としたT細胞分化システムの新展開
遠藤裕介、中山俊憲
実験医学増刊「脂質クオリティ」

肥満症におけるT細胞免疫系の変化
遠藤裕介
メディカルプラクティス 35(2):265-267 (2018・2)

Epigenetic regulation of T helper cell differentiation, memory and plasticity in allergic asthma.
Tumes DJ, Papadopoulos M, Endo Y, Onodera A, Hirahara K, and Nakayama T.
Immunol. Rev. 278:8-19 (2017).

The obesity-related pathology and Th17 cells.
Endo Y, Yokote K, and Nakayama T.
Cell. Mol. Life Sci. 74:1231-1245 (2017).

Th2 cells in health and disease.
Nakayama T, Hirahara K, Onodera A, Endo Y, Hosokawa H, Shinoda K, Tumes DJ, Okamoto Y.
Annu Rev Immunol. 2016 Nov 28, Doi: 10.1146/annurev-immunol-051116-052350 (2017).

肥満とTh17細胞の分化
遠藤裕介、中山俊憲
臨床免疫・アレルギー科 65(2):127-132 (2017・2)

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells.
Angela M*, Endo Y*, Asou HK, Yamamoto T, Tumes DJ, Tokuyama H, Yokote K, and Nakayama T. (*these authors contributed equally to this work)
Nat. Commun. 7:13683 (2016).

Akt1-mediated Gata3 phosphorylation controls the repression of IFN in memory-type Th2 cells.
Hosokawa H, Tanaka T, Endo Y, Kato M, Shinoda K, Suzuki A, Motohashi S, Matsumoto M, Nakayama KI, and Nakayama T.Nat. Commun. 7:11289 (2016).

病原性記憶Th2細胞と慢性アレルギー疾患
遠藤裕介、中山俊憲
アレルギー　65(9):1182-1186 (2016･11)

病原性Th2細胞からみたアレルギーマーチの基盤となる分子機構
遠藤裕介、山本健、中山俊憲
アレルギーマーチを断つ〜ガイドライン準拠による拡大予防〜　51-59（2016）

病原性記憶Th2細胞と慢性アレルギー疾患
遠藤裕介、中山俊憲
臨床免疫・アレルギー科　65(6):550-556 (2016･6)

肥満病態における脂肪酸代謝酵素ACC1によるTh17細胞分化制御機構の解明
遠藤裕介、中山俊憲
医学のあゆみ　257(9):942-944 (2016･5)

肥満による自己免疫疾患発症リスクを上げる脂肪酸代謝酵素ACC1を介したTh17細胞分化制御機構の解明
遠藤裕介、中山俊憲
257(6):687-692　(2016･5)

自然免疫
山本健、遠藤裕介、中山俊憲
アレルギー 65(1):1-10 (2016･2)

Pathogenic Th2 (Tpath2) cells in airway inflammation.
Endo Y, and Nakayama T.
Oncotarget. 6:32303-32304 (2015).

Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1.
Endo Y, Asou HK, Matsugae N, Hirahara K, Shinoda K, Tumes DJ, Tokuyama T, Yokote K, and Nakayama T.
Cell Rep. 12:1042-1055 (2015).

Methylation of Gata3 at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells.
Hosokawa H, Kato M, Tohyama H, Tamaki Y, Endo Y, Kimura YM, Tumes DJ, Motohashi S, Matsumoto M, Nakayama IK, Tanaka T, and Nakayama T.
J. Biol. Chem. 290:13095-13103 (2015).

The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway.
Endo Y, Hirahara K, Iinuma T, Shinoda K, Tumes DJ, Asou HK, Matsugae N, Obata-Ninomiya K, Yamamoto H, Motohashi S, Oboki K, Nakae S, Saito H, Okamoto Y, and Nakayama T.
Immunity 42:294-308 (2015).

サイトカインIL-33による病原性記憶2型ヘルパーT (Th2) 細胞の誘導
遠藤裕介、中山俊憲
臨床免疫・アレルギー科　64(3):275-280 (2015･9)

IL-33/ST2-p38シグナル経路による病原性記憶Th2細胞の誘導
遠藤裕介、中山俊憲
臨床免疫・アレルギー科　63(6):514-519 (2015･6)

インターロイキン33-ST2-p38シグナル伝達経路による病原性メモリー2型ヘルパーT細胞への機能の転換の誘導
遠藤裕介、中山俊憲
ライフサイエンス新着論文レビュー　(2015･3)

IL-33による病原性メモリーTh2細胞の誘導
遠藤裕介、中山俊憲
医学のあゆみ　252(12):1209-1213 (2015･3)

ヒト慢性炎症組織での病原性メモリーTh2細胞の解析
遠藤裕介、中山俊憲
医学のあゆみ　252(1):75-80 (2015･1)

Pathogenic memory type Th2 cells in allergic inflammation.
Endo Y, Hirahara K, Yagi R, Tumes DJ, and Nakayama T.
Trends Immunol. 35:69-78 (2014).

The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells.
Tumes DJ, Onodera A, Suzuki A, Shinoda K, Endo Y, Iwamura C, Hosokawa H, Koseki H, Tokoyoda K, Suzuki Y, Motohashi S, and Nakayama T.
Immunity. 39 : 819-832 (2013).

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.
Hosokawa H, Tanaka T, Suzuki Y, Iwamura C, Ohkubo S, Endoh K, Kato M, Endo Y, Onodera A, Tumes DJ, Kanai A, Sugano S, and Nakayama T.
Proc. Natl. Acad. Sci. USA 110:4691-4696 (2013).

免疫記憶の制御
遠藤裕介、中山俊憲
臨床免疫・アレルギー科　60(3):309-316 (2013･9)

Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo.
Iwamura C, Shinoda K, Endo Y, Watanabe Y, Tumes DJ, Motohashi S, Kawahara K, Kinjo Y, and Nakayama T.
Proc. Natl. Acad. Sci. USA 109:16992-16997 (2012).

T細胞の免疫記憶
遠藤裕介、中山俊憲
免疫学Update – 分子病態の解明と治療への展開 – 87-97 (2012)

T細胞免疫記憶 – メモリーT細胞の多様性と病因となる細胞集団 –
遠藤裕介、中山俊憲
臨床免疫・アレルギー科　58(5):613-620 (2012･11)

記憶CD4 T細胞によるウィルス感染防御
遠藤裕介、中山俊憲
アレルギーの臨床　特集：ウイルス感染と免疫・アレルギー　436(32):23-27 (2012･11)

PathogenicメモリーTh2細胞の同定とIL-5産生分子メカニズムの解明
遠藤裕介、中山俊憲
医学のあゆみ　242(3):266-267 (2012･7)

IL-5産生pathogenicメモリーTh2細胞による慢性アレルギー炎症の制御
遠藤裕介、中山俊憲
実験医学別刷　慢性アレルギー炎症 – 免疫系の役者たちの新たな姿　30(6):899-904 (2012･4)

Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3.
Endo Y, Iwamura C, Kuwahara M, Suzuki A, Sugaya K, Tumes DJ, Tokoyoda K, Hosokawa H, Yamashita M, and Nakayama T.
Immunity. 35:733-745 (2011).

Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells.
Kitajima M, Ito T, Tumes JD, Endo Y, Onodera A, Hashimoto K, Motohashi S, Yamashita M, Nishimura T, Ziegler FS, and Nakayama T.
Cancer Res. 71:4790-4798 (2011).

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.
Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, Kanai A, Suzuki Y, and Nakayama T.
J. Exp. Med. 207:2493-2506 (2010).

Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung.
Suzuki A, Iwamura C, Shinoda K, Tumes JD, Kimura YM, Hosokawa H, Endo Y, Horiuchi S, Tokoyoda K, Koseki H, Yamashita M, and Nakayama T.
J. Immunol. 184:4510-4520 (2010).

Enhanced Th2 cell differentiation and Allergen-Induced Airway Inflammation in Zfp35-Deficient Mice.
Kitajima M, Iwamura C, Miki HT, Shinoda K, Endo Y, Watanabe Y, Shinnakasu R, Hosokawa H, Hashimoto K, Motohashi S, Koseki H, Ohara O, Yamashita M, and Nakayama T.
J.　Immunol. 183:5388-5396 (2009).

Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness.
Iwamura C, Kimura YM, Shinoda K, Endo Y, Hasegawa A, Yamashita M, and Nakayama T.
Int. Immunol. 19:755-762 (2007).

Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function.
Shinnakasu R, Yamashita M, Shinoda K, Endo Y, Hosokawa H, Hasegawa A, and Nakayama T.
J. Immunol. 177:5801-5810 (2006).
 
 

 
 

【2020】

• 遠藤裕介　T細胞の機能分化を司る脂質イムノメタボリズムの分子作用点解明、第181回東京脂質談話会、2020年1月15日、東京大学（東京）（O）
• 遠藤裕介　リポクオリティが制御する脂質リガンドに依存した RORt 機能多様性の解明、第5回リポクオリティ班会議、2020年1月24日（静岡）（O）
• 遠藤裕介　脂肪酸を起点とする「代謝-免疫-疾患」の分子メカニズム解明、第872回千葉県がんセンター研究所集談会、2020年2月21日、千葉県がんセンター（千葉）（O）
• 遠藤裕介　オミックス手法で解き明かす「代謝-転写-疾患」スパイラルの分子機構解明、東京生化学研究会、2020年3月6日（東京）（O）
• 遠藤裕介　脂肪酸代謝システムによる免疫記憶システムのコントロール、アジレント・テクノロジー細胞解析セミナー2020、2020年7月20日、オンライン（O）
• 遠藤裕介　IL-33-IL-31 シグナル軸によるアトピー性皮膚炎をおこす病原性T細胞の道程、先進医薬研究報告会 血液医学分野、2020年12月11日、オンライン（O）
• 遠藤裕介　免疫システムと病気 〜代謝からアレルギーの克服を目指す〜、千葉市科学館「大人が楽しむ科学教室2020」、2020年2月7日、千葉市科学館（千葉）（O）

【2019】

• 遠藤裕介　脂肪酸を基軸とする「代謝-免疫-疾患」スパイラルの分子機構解明、愛媛大学PROS学術シンポジウム2019、2019年2月16日、愛媛大学医学部（愛媛）（O）
• 遠藤裕介　イムノメタボリズムを基軸とした高度肥満病態を制御する機能性脂質の探索　加藤記念バイオサイエンス振興財団セミナー、2019年3月1日、如水会館（東京）（O）
• 遠藤裕介　脂質代謝による病原性Th2細胞の制御と炎症性アレルギー疾患の新たな治療戦略の創出、小野医学研究財団 第30回研究成果発表会、2019年6月1日、千里ライフサイエンスセンター（大阪）（O）
• 遠藤裕介　脂肪酸を基軸とする「代謝-免疫-疾患」スパイラルの分子機構解明、第19回日本抗加齢医学会総会、2019年6月15日、パシフィコ横浜（神奈川）（O）
• 遠藤裕介　病原性記憶Th2細胞と慢性アレルギー疾患、第55回日本アレルギー学会専門医認定教育セミナー、2019年6月16日、東京国際フォーラム（東京）
• Endo, Y　ACC1 determines memory potential of individual CD4+ T cells by regulating de novo Fatty Acid biosynthesis, 60th ICBL, 2019年6月19日、一橋講堂（東京）（O）
• Endo, Y Fatty acid metabolism directs cell fate decisionDuring the generation of memory CD4 T cells, First Chiba University-University of Toronto Workshop, 2019年9月5-6日、千葉大学医学部（千葉）（O）

【2016以前】

• 遠藤裕介　肥満環境において脂肪酸代謝酵素ACC1が制御するTh17細胞分化機構の解明　第9回Symphony、2016年9月18-19日、ホテルメトロポリタンエドモント飯田橋（東京都千代田区）(O)
• 2.遠藤裕介 病原性記憶Th2細胞と慢性気道炎症制御　協和発酵キリン株式会社サイエンティフィックセミナー、2016年6月7日、三島、静岡 (O)
• 遠藤裕介、中山俊憲　Obesity drives Th17 cell differentiation by inducing lipid metabolic kinase, ACC1.　第25回東京免疫フォ－ラム、2016年3月1日、東京大学医科学研究所附属病院（東京都港区）(O)
• 遠藤裕介　肥満環境における脂肪酸代謝酵素ACC1によるTh17細胞分化制御機構の解明　ちば内分泌・免疫疾患カンファレンス2015、2015年7月27日、千葉 (O)
• 遠藤裕介、中山俊憲　The IL-33-p38 axis confers memory Th2 cell pathogenicity in the airway.　第24回東京免疫フォ－ラム、2015年2月25日、東京大学医科学研究所附属病院（東京都港区）(O)
• 遠藤裕介、中山俊憲　Eomesodermin controls the function of IL-5-producing pathogenic memory Th2 cells.　第21回東京免疫フォ－ラム、2012年3月8日、東京大学医科学研究所附属病院（東京都港区）(O)
• Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Tumes, D. J., Tokoyoda, K., Hosokawa, H., Yamashita, M., and Nakayama, T.: Eomesodermin controls IL-5 pruduction in memory Th2 cells through the inhibition of GATA3 activity.　第40回日本免疫学会総会・学術集会　シンポジウム　2011年11月27-29日、幕張（千葉県千葉市）(O)

海外招待講演

• Endo, Y.: Elucidation of the role of fatty acid metabolism in Th cell differentiation under obese conditions. AAI Annual Meeting Immunology, May 12-16, 2017, Washington DC (USA). (O)
• Endo, Y.: Elucidation of the role of fatty acid metabolism in Th cell differentiation under obese conditions. Leibniz-AMED Workshop on Chronic Inflammation, Infection and Healthy Aging, Sep 8-11, 2017, Ettal (Germany). (O)
• Endo, Y., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. The 4th CSI/JSI/KAI Joint Symposium on Immunology, Sep 19-21, 2015, Suzhou (China) (9/20). (O)
• Endo, Y.: Pathogenic memory type Th2 cells in allergic inflammation. DRFZ Seminar, 2015 Dec 15, Berlin (Germany). (O)

国内学会講演

【2020】

• 遠藤裕介　T細胞の機能分化を司る脂質イムノメタボリズムの分子作用点、第43回日本分子生物学会年会、2020年12月3日、オンライン（O）

【2019】

• 遠藤裕介　脂肪酸を基軸とする「代謝-免疫-疾患」スパイラルの分子機構解明、第92回生化学会、2019年9月19日、パシフィコ横浜（神奈川）
• 遠藤裕介　脂肪酸代謝を基軸とする「肥満-免疫-疾患」スパイラルの分子機構解明、第40回肥満学会、2019月11月3日、東京国際フォーラム（東京）
• 遠藤裕介　不均一な脂肪酸代謝動態からとらえる記憶T前駆細胞の同定、第42回日本分子生物学会、2019年12月5日、福岡国際会議場（福岡）
• Endo, Y Fatty acid metabolism directs cell fate decision during the generation of memory CD4 T cells、第48回日本免疫学会総会、2019年12月11日、アクトシティ浜松（静岡）

【2017 以前】

• Nakayama, T., Endo, Y., Shinoda, K., and Hirahara, K.: Memory type pathogenic Th2 (Tpath2) cells in airway inflammation. 7th International Workshop of Kyoto T Cell Conference, Mar 13-17, 2017, Kyoto (Japan). (O) 3/16.
• Endo, Y., and Nakayama, T.: Elucidation of the role of fatty acid metabolism in Th17 cell differentiation under obese conditions. 7th International Workshop of Kyoto T Cell Conference, Mar 13-17, 2017, Kyoto (Japan). (P) 3/16.
• Endo, Y., Yamamoto, T., Tumes, D. J., and Nakayama, T.: Fatty acid metabolic reprogramming via mTOR-mediated induction of PPAR directs early activation of T cells.　第45回日本免疫学会総会･学術集会　2016年12月5-7日、（沖縄県宜野湾市）(O) 12/7
• 遠藤裕介、中山俊憲: Obesity drives Th17 cell differentiation by inducing the carboxylase ACC1 and fatty acid biosynthesis. 第39回日本分子生物学会学術集会、2016年11月30日-12月2日、横浜(P)
• 遠藤裕介、平原潔、飯沼智久、篠田健太、山本陛三朗、本橋新一郎、大保木啓介、中江進、斎藤博久、岡本美孝、中山俊憲　The IL-33/ST2-p38 axis confers memory Th2 cell pathogenicity in the airway.　ミニシンポジウム　第64回日本アレルギ－学会学術大会　2015年5月26-28日、東京(O)
• 遠藤裕介、中山俊憲: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. 第44回日本免疫学会学術集会、2015年11月18日、札幌(O)
• Endo, Y., and Nakayama, T.: Eomesodermin controls IL-5 pruduction in memory Th2 cells through the inhibition of GATA3 activity. 21th Kyoto T Cell Conference, June 10-11, 2011, Kyoto (Japan). (O)
• Endo, T., and Nakayama, T.: Eomesodermin controls IL-5 pruduction in memory Th2 cells through the inhibition of GATA3 activity. 第4回日本エピジェネティクス研究会年回、2010年5月28日-29日、米子（P）

国際学会講演

• Endo, Y., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Keystone symposia, Immunometabolism in immune function and inflammatory disease, 21-25 Feb, 2016, Banff, Alberta, Canada (P)
• Endo, Y., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. 3rd International Conference on Immunometabolism: Molecular and Cellular Immunology of Metabolism. September 24-29, 2015, Chania, Greece (O)
• Endo, Y, and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Cell-VIB: The Multifaceted Roles of Type 2 Immunity, December 10-12, 2014, Bruges, Belgium (P)
• Endo, Y, Iwamura, C, and Nakayama, T.: Regulation of memory CD4 T cell pool size and function by natural killer T cells in vivo. Immunometabolism: from Mechanisms to Therapy, June 9-11, 2013, Toronto, Canada (P)
• Endo, Y, and Nakayama, T.: Eomesodermin controls IL-5 pruduction in memory Th2 cells through the inhibition of GATA3 activity. 14th Internatipnal Conference on Lymphocyte activation and Immune Regulation, T cell differentiation and Plasticity, February 3-5, 2012, Newport Beach, California (P)
• Endo, Y, Onodera, A, and Nakayama, T.: Generation and maintenance of memory Th1/Th2 cell identity. ASBMB Transcriptional Regulation by Chromatin and RNA Polymerase II, September 30-October 4, 2010, Tahoe City, CA (P)
• Endo, Y, Suzuki, A, Damon, J. T, Yamashita, M, and Nakayama, T.: Generation and maintenance of memory Th1/Th2 cell identity. 14th International Congress of Immunology, August 22-27, 2010, Kobe (P)