HUGE

Gene/Protein Characteristic Table for KIAA1059

Link to : GTOP \| SWISS-PROT/TrEMBL \| GeneCards\| RefDIC
Features : DNA sequence \| Protein sequence \| Expression \| Mapping

Product ID :	ORK00727
Accession No. :	AB028982
Description :	VPS10 domain-containing receptor SorCS3 precursor.
HUGO Gene Name :	sortilin-related VPS10 domain containing receptor 3 (SORCS3)
Clone Name :	hh12158 [Vector Info]
Flexi ORF Clone :	pF1KSDA1059
Source :	Human adult brain

Features of the cloned DNA sequence	Description

Length: 5757 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis) for :
cloned DNA seq.
Warning for N-terminal truncation:
YES

Warning for coding interruption:
NO

Integrity of 3' end

Length of 3'UTR 1861 bp

Genome contig ID gi89161187f_106290849
PolyA signal sequence
(AATAAA,-22)
+----*----+----*----+----*----+----
TGAAATTGTTGAAAATAAATGTATTTTTGTACATC
Flanking genome sequence
(724136 - 724185)
----+----*----+----*----+----*----+----*----+----*
AAAGCTACATACGTGGCTGAGTTTTCTCTTTGGGGAGTTTTCTTTATCCA

Ensembl ContigView (Add our DAS server as a DAS source)

Chr f/r start end exon identity class

ContigView(URL based/DAS) 10 f 106390849 107014983 26 100.0 Internal No-hit

Features of the protein sequence	Description

Length: 1297 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
AAI17418	99.9	Sortilin-relate...	Homo sapiens
XP_508024	95.9	VPS10 domain re...	Pan troglodytes
XP_609898	93.9	similar to VPS1...	Bos taurus
Q8VI51	92.4	VPS10 domain-co...	Mus musculus
XP_001916849	95.2	similar to Sort...	Equus caballus

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of homology search against other HUGE database (FASTA output, Multiple alignment)

Entry	Exp	ID%	HUGE_ID
AB037750	1e-89	45.0	KIAA1329

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of motif / domain search (InterProScan and SOSUI)

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Result of InterProScan

Search method interpro_ID From To Entry Definition

HMMPfam IPR002860 306 317 PF02012 Glycoside hydrolase

IPR002860 354 365 PF02012 Glycoside hydrolase

IPR002860 395 406 PF02012 Glycoside hydrolase

IPR002860 590 601 PF02012 Glycoside hydrolase

IPR002860 667 678 PF02012 Glycoside hydrolase

IPR002860 709 720 PF02012 Glycoside hydrolase

IPR000601 901 985 PF00801 PKD

HMMSmart IPR006581 294 896 SM00602 VPS10

ProfileScan IPR000601 935 979 PS50093 PKD

Search method	interpro_ID	From	To	Entry	Definition
HMMPfam	IPR002860	306	317	PF02012	Glycoside hydrolase
IPR002860	354	365	PF02012	Glycoside hydrolase
IPR002860	395	406	PF02012	Glycoside hydrolase
IPR002860	590	601	PF02012	Glycoside hydrolase
IPR002860	667	678	PF02012	Glycoside hydrolase
IPR002860	709	720	PF02012	Glycoside hydrolase
IPR000601	901	985	PF00801	PKD
HMMSmart	IPR006581	294	896	SM00602	VPS10
ProfileScan	IPR000601	935	979	PS50093	PKD

Prediction of transmembrane (TM) segments

Method No. N terminal transmembrane region C terminal type length

SOSUI2 1 1172 LKPGVQVIVYVTQLTLAPLVDSS 1194 SECONDARY 23

2 1200 SAMLMLLSVVFVGLAVFLIYK 1220 PRIMARY 21

Method	No.	N terminal	transmembrane region	C terminal	type	length
SOSUI2	1	1172	LKPGVQVIVYVTQLTLAPLVDSS	1194	SECONDARY	23
2	1200	SAMLMLLSVVFVGLAVFLIYK	1220	PRIMARY	21

Expression profile	Description

: RT-PCR-ELISA Description
: Experimental conditions

Primer_f
: GTTCCCATTCTTCTTTGTGAG

Primer_r
: ATTGTCTGCCCCATTTAACCC

PCR conditions
: 95 °C30 sec55 °C30 sec72 °C60 sec30 cycles

RT-PCR-ELISA	Description

RH mapping information	Description

Chromosome No.

: 10

Experimental conditions

Panel name	: GeneBridge 4
Primer_f	: GTTCCCATTCTTCTTTGTGAG
Primer_r	: ATTGTCTGCCCCATTTAACCC
PCR product length	: 132 bp
PCR conditions	: 95 °C15 sec64 °C60 sec30 cycles

How to obtain KIAA clone(s) Back to the HUGE Protein Database homepage

	cloned DNA seq.
Warning for N-terminal truncation:	YES
Warning for coding interruption:	NO

Length of 3'UTR	1861 bp
Genome contig ID	gi89161187f_106290849
PolyA signal sequence (AATAAA,-22)	+--------+--------+----*----+---- TGAAATTGTTGAAAATAAATGTATTTTTGTACATC
Flanking genome sequence (724136 - 724185)	----+--------+--------+--------+--------+----* AAAGCTACATACGTGGCTGAGTTTTCTCTTTGGGGAGTTTTCTTTATCCA

	Chr	f/r	start	end	exon	identity	class
ContigView(URL based/DAS)	10	f	106390849	107014983	26	100.0	Internal No-hit

Gene/Protein Characteristic Table for KIAA1059

Features of the cloned DNA sequence

Features of the protein sequence

Expression profile

RH mapping information