HUGE

Gene/Protein Characteristic Table for KIAA1060

Link to : Rouge \| GTOP \| SWISS-PROT/TrEMBL \| GeneCards\| RefDIC
Features : DNA sequence \| Protein sequence \| Expression \| Mapping

Product ID :	ORK04050
Accession No. :	AB028983
Description :	Adenylate cyclase type 2.
HUGO Gene Name :	adenylate cyclase 2 (brain) (ADCY2)
Clone Name :	hh13580 [Vector Info]
Source :	Human adult brain

Features of the cloned DNA sequence	Description

Length: 5873 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis) for :
cloned DNA seq.
Warning for N-terminal truncation:
YES

Warning for coding interruption:
NO

Integrity of 3' end

Length of 3'UTR 3209 bp

Genome contig ID gi51511721f_7579322
PolyA signal sequence
(None)
+----*----+----*----+----*----+----
TCCAGCCTGGGTGACAGAGCGAGACTCTGTCTCAG
Flanking genome sequence
(303874 - 303923)
----+----*----+----*----+----*----+----*----+----*
AAAAAAAAAGAAAAAAAAGAAAAAGCAACATAATTGCCCAGTGATGAAAA

Ensembl ContigView (Add our DAS server as a DAS source)

Chr f/r start end exon identity class

ContigView(URL based/DAS) 5 f 7679322 7883194 22 99.4 Perfect prediction

Features of the protein sequence	Description

Length: 887 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
BAG64952	100.0	unnamed protein...	Homo sapiens
EAX08097	100.0	adenylate cycla...	Homo sapiens
AAI11744	100.0	Adenylate cycla...	Homo sapiens
Q08462	100.0	Adenylate cycla...	Homo sapiens
AAP97285	100.0	adenylyl cyclas...	Homo sapiens

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of homology search against other HUGE database (FASTA output, Multiple alignment)

Entry	Exp	ID%	HUGE_ID
D25538	1.8e-197	58.7	KIAA0037
AB011083	3.4e-80	37.3	KIAA0511
AB007882	9.9e-48	42.4	KIAA0422
AB011092	6.2e-30	32.1	KIAA0520

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of motif / domain search (InterProScan and SOSUI)

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Result of InterProScan

Search method interpro_ID From To Entry Definition

HMMPfam IPR001054 77 261 PF00211 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR009398 273 396 PF06327 Adenylate cyclase-like

IPR001054 674 874 PF00211 Adenylyl cyclase class-3/4/guanylyl cyclase

HMMSmart IPR001054 31 239 SM00044 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR001054 643 857 SM00044 Adenylyl cyclase class-3/4/guanylyl cyclase

ProfileScan IPR001054 86 213 PS50125 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR001054 683 828 PS50125 Adenylyl cyclase class-3/4/guanylyl cyclase

ScanRegExp IPR001054 190 213 PS00452 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR001054 805 828 PS00452 Adenylyl cyclase class-3/4/guanylyl cyclase

Search method	interpro_ID	From	To	Entry	Definition
HMMPfam	IPR001054	77	261	PF00211	Adenylyl cyclase class-3/4/guanylyl cyclase
IPR009398	273	396	PF06327	Adenylate cyclase-like
IPR001054	674	874	PF00211	Adenylyl cyclase class-3/4/guanylyl cyclase
HMMSmart	IPR001054	31	239	SM00044	Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001054	643	857	SM00044	Adenylyl cyclase class-3/4/guanylyl cyclase
ProfileScan	IPR001054	86	213	PS50125	Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001054	683	828	PS50125	Adenylyl cyclase class-3/4/guanylyl cyclase
ScanRegExp	IPR001054	190	213	PS00452	Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001054	805	828	PS00452	Adenylyl cyclase class-3/4/guanylyl cyclase

Prediction of transmembrane (TM) segments

Method No. N terminal transmembrane region C terminal type length

SOSUI2 1 399 YVTCACLIFFCIFIVQILVLPKT 421 PRIMARY 23

2 427 SFGAAFLLLAFILFVCFAGQLLQ 449 PRIMARY 23

3 475 RISLTIITTAIILMMAVFNMFFL 497 PRIMARY 23

4 531 FFLPYFIYSCILGLISCSVFLRV 553 PRIMARY 23

5 598 LKTMGSVSLSIFFITLLVLGRQ 619 SECONDARY 22

Method	No.	N terminal	transmembrane region	C terminal	type	length
SOSUI2	1	399	YVTCACLIFFCIFIVQILVLPKT	421	PRIMARY	23
2	427	SFGAAFLLLAFILFVCFAGQLLQ	449	PRIMARY	23
3	475	RISLTIITTAIILMMAVFNMFFL	497	PRIMARY	23
4	531	FFLPYFIYSCILGLISCSVFLRV	553	PRIMARY	23
5	598	LKTMGSVSLSIFFITLLVLGRQ	619	SECONDARY	22

Expression profile	Description

: RT-PCR-ELISA Description
: Experimental conditions

Primer_f
: CGCTAGTGATTAAACGAGGCA

Primer_r
: GTCATGCTCTACTCACACTTC

PCR conditions
: 95 °C30 sec55 °C30 sec72 °C60 sec30 cycles

RT-PCR-ELISA	Description

RH mapping information	Description

Chromosome No.

: 5

Experimental conditions

Panel name	: UniGene
Primer_f	: -
Primer_r	: -
PCR product length	: -
PCR conditions	: -

How to obtain KIAA clone(s) Back to the HUGE Protein Database homepage

	cloned DNA seq.
Warning for N-terminal truncation:	YES
Warning for coding interruption:	NO

Length of 3'UTR	3209 bp
Genome contig ID	gi51511721f_7579322
PolyA signal sequence (None)	+--------+--------+----*----+---- TCCAGCCTGGGTGACAGAGCGAGACTCTGTCTCAG
Flanking genome sequence (303874 - 303923)	----+--------+--------+--------+--------+----* AAAAAAAAAGAAAAAAAAGAAAAAGCAACATAATTGCCCAGTGATGAAAA

	Chr	f/r	start	end	exon	identity	class
ContigView(URL based/DAS)	5	f	7679322	7883194	22	99.4	Perfect prediction

Primer_f	: CGCTAGTGATTAAACGAGGCA
Primer_r	: GTCATGCTCTACTCACACTTC
PCR conditions	: 95 °C30 sec55 °C30 sec72 °C60 sec30 cycles

Gene/Protein Characteristic Table for KIAA1060

Features of the cloned DNA sequence

Features of the protein sequence

Expression profile

RH mapping information