FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0044, 475 aa 1>>>pF1KA0044 475 - 475 aa - 475 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3382+/-0.000888; mu= 18.9447+/- 0.054 mean_var=79.5267+/-16.054, 0's: 0 Z-trim(106.8): 17 B-trim: 15 in 2/51 Lambda= 0.143819 statistics sampled from 9192 (9207) to 9192 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.652), E-opt: 0.2 (0.283), width: 16 Scan time: 2.960 The best scores are: opt bits E(32554) CCDS9965.1 PPP2R5C gene_id:5527|Hs108|chr14 ( 485) 3183 670.1 1.4e-192 CCDS53911.1 PPP2R5C gene_id:5527|Hs108|chr14 ( 540) 3053 643.2 2e-184 CCDS45163.1 PPP2R5C gene_id:5527|Hs108|chr14 ( 449) 2891 609.5 2.3e-174 CCDS9964.1 PPP2R5C gene_id:5527|Hs108|chr14 ( 524) 2887 608.7 4.6e-174 CCDS53912.1 PPP2R5C gene_id:5527|Hs108|chr14 ( 555) 2758 582.0 5.5e-166 CCDS4878.1 PPP2R5D gene_id:5528|Hs108|chr6 ( 602) 2509 530.3 2.1e-150 CCDS55002.1 PPP2R5D gene_id:5528|Hs108|chr6 ( 570) 2494 527.2 1.7e-149 CCDS43464.1 PPP2R5D gene_id:5528|Hs108|chr6 ( 496) 2484 525.1 6.5e-149 CCDS9758.1 PPP2R5E gene_id:5529|Hs108|chr14 ( 467) 2030 430.9 1.4e-120 CCDS1503.1 PPP2R5A gene_id:5525|Hs108|chr1 ( 486) 2015 427.8 1.3e-119 CCDS55686.1 PPP2R5A gene_id:5525|Hs108|chr1 ( 429) 2003 425.2 6.5e-119 CCDS61468.1 PPP2R5E gene_id:5529|Hs108|chr14 ( 462) 1997 424.0 1.6e-118 CCDS8085.1 PPP2R5B gene_id:5526|Hs108|chr11 ( 497) 1965 417.4 1.7e-116 CCDS61467.1 PPP2R5E gene_id:5529|Hs108|chr14 ( 391) 1907 405.3 6e-113 >>CCDS9965.1 PPP2R5C gene_id:5527|Hs108|chr14 (485 aa) initn: 3183 init1: 3183 opt: 3183 Z-score: 3570.9 bits: 670.1 E(32554): 1.4e-192 Smith-Waterman score: 3183; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:11-485) 10 20 30 40 50 pF1KA0 MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA0 SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA0 EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA0 EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA0 EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 LKMKEREEAWVKIENLAKANPQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 LKMKEREEAWVKIENLAKANPQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELA 430 440 450 460 470 480 pF1KA0 SQDGR ::::: CCDS99 SQDGR >>CCDS53911.1 PPP2R5C gene_id:5527|Hs108|chr14 (540 aa) initn: 3049 init1: 3049 opt: 3053 Z-score: 3424.4 bits: 643.2 E(32554): 2e-184 Smith-Waterman score: 3053; 97.2% identity (98.5% similar) in 471 aa overlap (5-475:72-540) 10 20 30 pF1KA0 MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQ .:..: .: : ..::::::::::::: CCDS53 AVPSTVSAKIKVPVSQPIVKKDKRQNSSRFSASNNRELQK--LPSLKDVPPADQEKLFIQ 50 60 70 80 90 40 50 60 70 80 90 pF1KA0 KLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 KLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KA0 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV 160 170 180 190 200 210 160 170 180 190 200 210 pF1KA0 LQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAEL 220 230 240 250 260 270 220 230 240 250 260 270 pF1KA0 LEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEP 280 290 300 310 320 330 280 290 300 310 320 330 pF1KA0 VVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAE 340 350 360 370 380 390 340 350 360 370 380 390 pF1KA0 RALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKL 400 410 420 430 440 450 400 410 420 430 440 450 pF1KA0 FDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQAQKDPKKDRPLARRKSELPQDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 FDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQAQKDPKKDRPLARRKSELPQDP 460 470 480 490 500 510 460 470 pF1KA0 HTKKALEAHCRADELASQDGR ::::::::::::::::::::: CCDS53 HTKKALEAHCRADELASQDGR 520 530 540 >>CCDS45163.1 PPP2R5C gene_id:5527|Hs108|chr14 (449 aa) initn: 2891 init1: 2891 opt: 2891 Z-score: 3243.9 bits: 609.5 E(32554): 2.3e-174 Smith-Waterman score: 2891; 99.5% identity (99.8% similar) in 435 aa overlap (1-435:11-445) 10 20 30 40 50 pF1KA0 MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA0 SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA0 EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA0 EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA0 EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 LKMKEREEAWVKIENLAKANPQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELA ::::::::::::::::::::::. : CCDS45 LKMKEREEAWVKIENLAKANPQVLKKRIT 430 440 >>CCDS9964.1 PPP2R5C gene_id:5527|Hs108|chr14 (524 aa) initn: 2887 init1: 2887 opt: 2887 Z-score: 3238.5 bits: 608.7 E(32554): 4.6e-174 Smith-Waterman score: 3050; 92.3% identity (92.3% similar) in 507 aa overlap (1-468:11-517) 10 20 30 40 50 pF1KA0 MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA0 SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA0 EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA0 EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA0 EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK 370 380 390 400 410 420 420 430 pF1KA0 LKMKEREEAWVKIENLAKANPQ-------------------------------------- :::::::::::::::::::::: CCDS99 LKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAH 430 440 450 460 470 480 440 450 460 470 pF1KA0 -AQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR :::::::::::::::::::::::::::::::::::: CCDS99 QAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR 490 500 510 520 >>CCDS53912.1 PPP2R5C gene_id:5527|Hs108|chr14 (555 aa) initn: 2757 init1: 2757 opt: 2758 Z-score: 3093.5 bits: 582.0 E(32554): 5.5e-166 Smith-Waterman score: 2921; 89.9% identity (90.5% similar) in 503 aa overlap (11-468:46-548) 10 20 30 pF1KA0 MVVDAANSNGPFQPVVLLHI------RDVPPADQEKLFIQ :. : .:. : :::::::::::::: CCDS53 KSGKSSKEGQDTVESEGTSPEEPSSPKVPPPLLPELLVLIFGGLQGRDVPPADQEKLFIQ 20 30 40 50 60 70 40 50 60 70 80 90 pF1KA0 KLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 KLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMF 80 90 100 110 120 130 100 110 120 130 140 150 pF1KA0 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV 140 150 160 170 180 190 160 170 180 190 200 210 pF1KA0 LQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAEL 200 210 220 230 240 250 220 230 240 250 260 270 pF1KA0 LEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEP 260 270 280 290 300 310 280 290 300 310 320 330 pF1KA0 VVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAE 320 330 340 350 360 370 340 350 360 370 380 390 pF1KA0 RALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKL 380 390 400 410 420 430 400 410 420 430 pF1KA0 FDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQ---------------------- :::::::::::::::::::::::::::::::::::::: CCDS53 FDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPL 440 450 460 470 480 490 440 450 460 470 pF1KA0 -----------------AQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR :::::::::::::::::::::::::::::::::::: CCDS53 FEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR 500 510 520 530 540 550 >>CCDS4878.1 PPP2R5D gene_id:5528|Hs108|chr6 (602 aa) initn: 2631 init1: 2500 opt: 2509 Z-score: 2813.8 bits: 530.3 E(32554): 2.1e-150 Smith-Waterman score: 2553; 79.3% identity (87.7% similar) in 488 aa overlap (20-468:106-593) 10 20 30 40 pF1KA0 MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDP ..: : ..:.::::::::::::::::::: CCDS48 GGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDP 80 90 100 110 120 130 50 60 70 80 90 100 pF1KA0 LSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFD :::::.::::::.:.::::::::.:.:.:: ::::.: ::.::.:::::::::::::::: CCDS48 LSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFD 140 150 160 170 180 190 110 120 130 140 150 160 pF1KA0 PEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRER :::::::::::::::::::::::::::::::::::::::::::::: ::.:::::::::: CCDS48 PEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRER 200 210 220 230 240 250 170 180 190 200 210 220 pF1KA0 DFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPL ::::: ::::::::::::::::.:::.::::::::::::::::::::::::::::::::: CCDS48 DFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPL 260 270 280 290 300 310 230 240 250 260 270 280 pF1KA0 KEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSP :::::.::..::::::::::::::::::::::::::::.:.:::::...:::.::::::: CCDS48 KEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSP 320 330 340 350 360 370 290 300 310 320 330 340 pF1KA0 KEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLI ::::::::::::::::::::: :.:::::::::::::::::::::::::::::::::::: CCDS48 KEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLI 380 390 400 410 420 430 350 360 370 380 390 400 pF1KA0 SDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKE :::::..::::::.::::::.:::::::::::::::::::::::::::::::.:::: : CCDS48 SDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKG 440 450 460 470 480 490 410 420 430 pF1KA0 KLKMKEREEAWVKIENLAKANPQAQ----------------------------------- ...:::::: : :::.::. ::: CCDS48 RFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEA 500 510 520 530 540 550 440 450 460 470 pF1KA0 ----KDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR :: ::.. : ::::::::: .: :::::: ::.: CCDS48 VQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL 560 570 580 590 600 >>CCDS55002.1 PPP2R5D gene_id:5528|Hs108|chr6 (570 aa) initn: 2616 init1: 2485 opt: 2494 Z-score: 2797.3 bits: 527.2 E(32554): 1.7e-149 Smith-Waterman score: 2538; 77.3% identity (86.1% similar) in 502 aa overlap (6-468:60-561) 10 20 30 pF1KA0 MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQK .::. : . .. : ...::::: CCDS55 GENTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKELFIQK 30 40 50 60 70 80 40 50 60 70 80 90 pF1KA0 LRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFR :::::::::::::::::::.::::::.:.::::::::.:.:.:: ::::.: ::.::.:: CCDS55 LRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFR 90 100 110 120 130 140 100 110 120 130 140 150 pF1KA0 TLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 TLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVL 150 160 170 180 190 200 160 170 180 190 200 210 pF1KA0 QLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELL ::.::::::::::::::: ::::::::::::::::.:::.::::::::::::::::::: CCDS55 ALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELL 210 220 230 240 250 260 220 230 240 250 260 270 pF1KA0 EILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPV :::::::::::::::::::.::..::::::::::::::::::::::::::::.:.::::: CCDS55 EILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPV 270 280 290 300 310 320 280 290 300 310 320 330 pF1KA0 VMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAER ...:::.:::::::::::::::::::::::::::: :.:::::::::::::::::::::: CCDS55 IVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAER 330 340 350 360 370 380 340 350 360 370 380 390 pF1KA0 ALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLF :::::::::::::::::::..::::::.::::::.::::::::::::::::::::::::: CCDS55 ALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLF 390 400 410 420 430 440 400 410 420 430 pF1KA0 DDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQAQ--------------------- ::::::.:::: : ...:::::: : :::.::. ::: CCDS55 DDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTA 450 460 470 480 490 500 440 450 460 470 pF1KA0 ------------------KDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR :: ::.. : ::::::::: .: :::::: ::.: CCDS55 EDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEA 510 520 530 540 550 560 CCDS55 L 570 >>CCDS43464.1 PPP2R5D gene_id:5528|Hs108|chr6 (496 aa) initn: 2606 init1: 2475 opt: 2484 Z-score: 2786.9 bits: 525.1 E(32554): 6.5e-149 Smith-Waterman score: 2528; 80.0% identity (88.1% similar) in 480 aa overlap (28-468:8-487) 10 20 30 40 50 60 pF1KA0 MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKR ...::::::::::::::::::::::::.::::: CCDS43 MPYKLKKEKELFIQKLRQCCVLFDFVSDPLSDLKFKEVKR 10 20 30 40 70 80 90 100 110 120 pF1KA0 AALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAA :.:.::::::::.:.:.:: ::::.: ::.::.::::::::::::::::::::::::::: CCDS43 AGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KA0 WPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIY ::::::::::::::::::::::::::::::::::: ::.::::::::::::::: ::::: CCDS43 WPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIY 110 120 130 140 150 160 190 200 210 220 230 240 pF1KA0 GKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKV :::::::::::.:::.::::::::::::::::::::::::::::::::::::::.::..: CCDS43 GKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KA0 LLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEE :::::::::::::::::::::::::::.:.:::::...:::.:::::::::::::::::: CCDS43 LLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KA0 ILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIM :::::::::: :.:::::::::::::::::::::::::::::::::::::::::..:::: CCDS43 ILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIM 290 300 310 320 330 340 370 380 390 400 410 420 pF1KA0 FPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAW ::.::::::.:::::::::::::::::::::::::::::::.:::: : ...:::::: : CCDS43 FPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMW 350 360 370 380 390 400 430 440 pF1KA0 VKIENLAKANPQAQ---------------------------------------KDPKKDR :::.::. ::: :: ::.. CCDS43 QKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEK 410 420 430 440 450 460 450 460 470 pF1KA0 PLARRKSELPQDPHTKKALEAHCRADELASQDGR : ::::::::: .: :::::: ::.: CCDS43 VLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL 470 480 490 >>CCDS9758.1 PPP2R5E gene_id:5529|Hs108|chr14 (467 aa) initn: 2027 init1: 1710 opt: 2030 Z-score: 2278.2 bits: 430.9 E(32554): 1.4e-120 Smith-Waterman score: 2030; 71.9% identity (88.1% similar) in 420 aa overlap (8-426:38-453) 10 20 30 pF1KA0 MVVDAANSNG-PFQPVVLLHIRDVPPADQEKLFIQKL :.: :.. . : ..::: ..: .::..:: CCDS97 PPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIELTPLPLLKDVPSSEQPELFLKKL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 RQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRT .::::.:::. : ::::: :: ::..:.:.:.::: .:. .:: :::::.: . :.::: CCDS97 QQCCVIFDFM-DTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVSCNIFRT 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 LPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQ ::::.. :::::::::::::.:::::::::::.::::: .:::.::::::::::::: CCDS97 LPPSDS---NEFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQPSIAKKYIDQKFVLQ 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 LLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLE ::::::::::::::.:::.:::::::::::::.::::::::: ::.::::: ::.::::: CCDS97 LLELFDSEDPRERDYLKTVLHRIYGKFLGLRAFIRKQINNIFLRFVYETEHFNGVAELLE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 ILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVV :::::::::::::: ::: ::.:::.::: :.:::..: :::::.::::::: .:::::. CCDS97 ILGSIINGFALPLKAEHKQFLVKVLIPLHTVRSLSLFHAQLAYCIVQFLEKDPSLTEPVI 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 MALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERA .:.:.:::: : ::::::.::::::::::::.::::.::::.:.::::::::::::::: CCDS97 RGLMKFWPKTCSQKEVMFLGELEEILDVIEPSQFVKIQEPLFKQIAKCVSSPHFQVAERA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 LYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFD ::::::::::::: .:. :::::: :::: :: ::: .: .:.::.:: :::::. .:: CCDS97 LYYWNNEYIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNSTMFD 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 DCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQAQKDPKKDRPLARRKSELPQDPHT . : .:... .:: : ::::: : :.:.: CCDS97 ELTATYKSDRQREKKKEKEREELWKKLEDLELKRGLRRDGIIPT 430 440 450 460 >>CCDS1503.1 PPP2R5A gene_id:5525|Hs108|chr1 (486 aa) initn: 1987 init1: 1688 opt: 2015 Z-score: 2261.1 bits: 427.8 E(32554): 1.3e-119 Smith-Waterman score: 2015; 71.1% identity (88.5% similar) in 419 aa overlap (8-426:49-461) 10 20 30 pF1KA0 MVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLR :.. ..: : ...:. .:..:: :::. CCDS15 EKVDGFTRKSVRKAQRQKRSQGSSQFRSQGSQAELHP--LPQLKDATSNEQQELFCQKLQ 20 30 40 50 60 70 40 50 60 70 80 90 pF1KA0 QCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTL :::.::::. : .:::: ::.:::.:.:.:::.. ::.::.: : ..:.:...:.:::: CCDS15 QCCILFDFM-DSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAYSDIVKMISANIFRTL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KA0 PPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQL :::.:: .::::::::::::.:::.::::::::::::::::::.:::.::::::: :: CCDS15 PPSDNP---DFDPEEDEPTLEASWPHIQLVYEFFLRFLESPDFQPSIAKRYIDQKFVQQL 140 150 160 170 180 190 160 170 180 190 200 210 pF1KA0 LELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEI :::::::::::::::::.:::::::::::::.::::::::: :::::::: ::.:::::: CCDS15 LELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEI 200 210 220 230 240 250 220 230 240 250 260 270 pF1KA0 LGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVM ::::::::::::: ::: ::.:::.:.: .:.:...: :::::::::::::.::::::. CCDS15 LGSIINGFALPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIR 260 270 280 290 300 310 280 290 300 310 320 330 pF1KA0 ALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERAL .:::.:::: : ::::::.:.:::::::::..: :: ::::.:..::::: ::::::::: CCDS15 GLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEPLFKQISKCVSSSHFQVAERAL 320 330 340 350 360 370 340 350 360 370 380 390 pF1KA0 YYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDD :.::::::.::: .: ::::::: :::. :: ::: :: .:.::.:: .:::: ::::: CCDS15 YFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDD 380 390 400 410 420 430 400 410 420 430 440 450 pF1KA0 CTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQAQKDPKKDRPLARRKSELPQDPHTK :...:::. .:: : :::: : :.:.: CCDS15 LTSSYKAERQREKKKELEREELWKKLEELKLKKALEKQNSAYNMHSILSNTSAE 440 450 460 470 480 475 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 00:22:45 2016 done: Fri Nov 4 00:22:46 2016 Total Scan time: 2.960 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]