FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0068, 1253 aa 1>>>pF1KA0068 1253 - 1253 aa - 1253 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7388+/-0.00118; mu= 20.0664+/- 0.072 mean_var=67.0446+/-13.507, 0's: 0 Z-trim(101.1): 29 B-trim: 132 in 1/49 Lambda= 0.156636 statistics sampled from 6387 (6398) to 6387 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.541), E-opt: 0.2 (0.197), width: 16 Scan time: 4.500 The best scores are: opt bits E(32554) CCDS73696.1 CYFIP1 gene_id:23191|Hs108|chr15 (1253) 8354 1897.8 0 CCDS75364.1 CYFIP2 gene_id:26999|Hs108|chr5 (1253) 7477 1699.6 0 CCDS78078.1 CYFIP2 gene_id:26999|Hs108|chr5 (1227) 6883 1565.4 0 CCDS73695.1 CYFIP1 gene_id:23191|Hs108|chr15 ( 822) 4676 1066.6 0 CCDS78077.1 CYFIP2 gene_id:26999|Hs108|chr5 (1278) 4101 936.7 0 >>CCDS73696.1 CYFIP1 gene_id:23191|Hs108|chr15 (1253 aa) initn: 8354 init1: 8354 opt: 8354 Z-score: 10190.8 bits: 1897.8 E(32554): 0 Smith-Waterman score: 8354; 100.0% identity (100.0% similar) in 1253 aa overlap (1-1253:1-1253) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS 1210 1220 1230 1240 1250 >>CCDS75364.1 CYFIP2 gene_id:26999|Hs108|chr5 (1253 aa) initn: 7474 init1: 5150 opt: 7477 Z-score: 9119.8 bits: 1699.6 E(32554): 0 Smith-Waterman score: 7477; 87.6% identity (96.8% similar) in 1253 aa overlap (1-1253:1-1252) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :...:::::::::::::::::::::::::::::::..:: ::.::::::::::::::::: CCDS75 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: CCDS75 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::.::::::.::::::.::.:::::::::::::::::.::::::::::::::::::::: CCDS75 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD ::::::::::::::::::::::::::::::::::::::.::: :.:::::: :::::::: CCDS75 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::.:::::::.::::::::::::::::::::::::.::::::::::::::::::::.:: CCDS75 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI ::::::::::::::::::::::::::::::.::::.:. ::::::::::.:::.::.::: CCDS75 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::: ..::.: :::.::::::.::::::.::::::::::::::::: CCDS75 SELARYSNSEVVTGSG-LDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPT 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV ::. ::::: .:::::::::::::::::::.::::::::::::::::::::::.:::.:. CCDS75 DKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTI 420 430 440 450 460 470 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::.:::::::::::..:::::. :::::::::.:::: :.:: ::: :::::::: CCDS75 YAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPK 480 490 500 510 520 530 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF .:::::::::::::::::::::::::::::::::::::::::::.:: .: :: ::..:: CCDS75 GGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSF 540 550 560 570 580 590 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :.:::.:.::.:::::::::::::::::::::::::::::::::::::::::::::: :: CCDS75 FFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSM 600 610 620 630 640 650 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::: ::::::::.::::.:.::::::::::::::::::::::::::::::::.:::: CCDS75 MEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGS 660 670 680 690 700 710 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL .:::::.:.:::: :. : :::::::::::::::::::::::::::::::.:::::::: CCDS75 VLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSL 720 730 740 750 760 770 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT . ::.:::::::::::::. ::::::.::.:: ...:::.:::::::::::::::::::: CCDS75 DQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRIT 780 790 800 810 820 830 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS ::::::::.::::::::::::::::::..::.:: :::: :.:: ::.::: ::.::: CCDS75 LHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSH 840 850 860 870 880 890 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC ::.:::::::::::..:::::::::::::::::::.::::::::::::::::.::::::: CCDS75 IYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKIC 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::.::::::: ::.::::::::::::::::.:: :::: CCDS75 RLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVC 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::..::::::...:::::.:::::::::::::::::::::::::::: CCDS75 DLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDL 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI ::::::::::::::::::::::.:.::::::: :.::::::::::::::::::::::::: CCDS75 LTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCI 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP ::::.:::.::::::::.:::: ::::::::::: ..::::::::::..::::::::::: CCDS75 PVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVP 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::..::::.::::.:...::.::.:: . ... ::::::::::::::::.. CCDS75 LKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC 1200 1210 1220 1230 1240 1250 >>CCDS78078.1 CYFIP2 gene_id:26999|Hs108|chr5 (1227 aa) initn: 7286 init1: 5150 opt: 6883 Z-score: 8394.5 bits: 1565.4 E(32554): 0 Smith-Waterman score: 7241; 85.6% identity (94.7% similar) in 1253 aa overlap (1-1253:1-1226) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :...:::::::::::::::::::::::::::::::..:: ::.::::::::::::::::: CCDS78 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT ::::::::: ::::::::::::::::::::::::: CCDS78 EQATVHSSM--------------------------VKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::.::::::.::::::.::.:::::::::::::::::.::::::::::::::::::::: CCDS78 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD ::::::::::::::::::::::::::::::::::::::.::: :.:::::: :::::::: CCDS78 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD 160 170 180 190 200 210 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::.:::::::.::::::::::::::::::::::::.::::::::::::::::::::.:: CCDS78 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK 220 230 240 250 260 270 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI ::::::::::::::::::::::::::::::.::::.:. ::::::::::.:::.::.::: CCDS78 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI 280 290 300 310 320 330 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::: ..::.: :::.::::::.::::::.::::::::::::::::: CCDS78 SELARYSNSEVVTGSG-LDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPT 340 350 360 370 380 390 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV ::. ::::: .:::::::::::::::::::.::::::::::::::::::::::.:::.:. CCDS78 DKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTI 400 410 420 430 440 450 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::.:::::::::::..:::::. :::::::::.:::: :.:: ::: :::::::: CCDS78 YAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPK 460 470 480 490 500 510 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF .:::::::::::::::::::::::::::::::::::::::::::.:: .: :: ::..:: CCDS78 GGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSF 520 530 540 550 560 570 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :.:::.:.::.:::::::::::::::::::::::::::::::::::::::::::::: :: CCDS78 FFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSM 580 590 600 610 620 630 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::: ::::::::.::::.:.::::::::::::::::::::::::::::::::.:::: CCDS78 MEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGS 640 650 660 670 680 690 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL .:::::.:.:::: :. : :::::::::::::::::::::::::::::::.:::::::: CCDS78 VLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSL 700 710 720 730 740 750 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT . ::.:::::::::::::. ::::::.::.:: ...:::.:::::::::::::::::::: CCDS78 DQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRIT 760 770 780 790 800 810 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS ::::::::.::::::::::::::::::..::.:: :::: :.:: ::.::: ::.::: CCDS78 LHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSH 820 830 840 850 860 870 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC ::.:::::::::::..:::::::::::::::::::.::::::::::::::::.::::::: CCDS78 IYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKIC 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::.::::::: ::.::::::::::::::::.:: :::: CCDS78 RLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVC 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::..::::::...:::::.:::::::::::::::::::::::::::: CCDS78 DLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDL 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI ::::::::::::::::::::::.:.::::::: :.::::::::::::::::::::::::: CCDS78 LTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCI 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP ::::.:::.::::::::.:::: ::::::::::: ..::::::::::..::::::::::: CCDS78 PVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVP 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::..::::.::::.:...::.::.:: . ... ::::::::::::::::.. CCDS78 LKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC 1180 1190 1200 1210 1220 >>CCDS73695.1 CYFIP1 gene_id:23191|Hs108|chr15 (822 aa) initn: 4704 init1: 4674 opt: 4676 Z-score: 5701.9 bits: 1066.6 E(32554): 0 Smith-Waterman score: 4676; 99.6% identity (99.6% similar) in 700 aa overlap (554-1253:123-822) 530 540 550 560 570 580 pF1KA0 GHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSS : :::::::::::::::::::::::::: CCDS73 QGVAEQSFSHGLFEFGITNVPCIFSPPQMFPWIIQLYMVRTMLESLIADKSGSKKTLRSS 100 110 120 130 140 150 590 600 610 620 630 640 pF1KA0 LEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMS 160 170 180 190 200 210 650 660 670 680 690 700 pF1KA0 MPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFV 220 230 240 250 260 270 710 720 730 740 750 760 pF1KA0 YKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 YKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSID 280 290 300 310 320 330 770 780 790 800 810 820 pF1KA0 LNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDA 340 350 360 370 380 390 830 840 850 860 870 880 pF1KA0 MFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNA 400 410 420 430 440 450 890 900 910 920 930 940 pF1KA0 QPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 QPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQG 460 470 480 490 500 510 950 960 970 980 990 1000 pF1KA0 TILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 TILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNA 520 530 540 550 560 570 1010 1020 1030 1040 1050 1060 pF1KA0 ILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 ILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLI 580 590 600 610 620 630 1070 1080 1090 1100 1110 1120 pF1KA0 ERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 ERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDE 640 650 660 670 680 690 1130 1140 1150 1160 1170 1180 pF1KA0 CVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 CVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHL 700 710 720 730 740 750 1190 1200 1210 1220 1230 1240 pF1KA0 LKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQ 760 770 780 790 800 810 1250 pF1KA0 PPIHQSLASS :::::::::: CCDS73 PPIHQSLASS 820 >>CCDS78077.1 CYFIP2 gene_id:26999|Hs108|chr5 (1278 aa) initn: 7463 init1: 4101 opt: 4101 Z-score: 4996.5 bits: 936.7 E(32554): 0 Smith-Waterman score: 7417; 85.9% identity (94.9% similar) in 1278 aa overlap (1-1253:1-1277) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :...:::::::::::::::::::::::::::::::..:: ::.::::::::::::::::: CCDS78 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: CCDS78 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::.::::::.::::::.::.:::::::::::::::::.::::::::::::::::::::: CCDS78 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD ::::::::::::::::::::::::::::::::::::::.::: :.:::::: :::::::: CCDS78 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::.:::::::.::::::::::::::::::::::::.::::::::::::::::::::.:: CCDS78 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI ::::::::::::::::::::::::::::::.::::.:. ::::::::::.:::.::.::: CCDS78 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::: ..::.: :::.::::::.::::::.::::::::::::::::: CCDS78 SELARYSNSEVVTGSG-LDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPT 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV ::. ::::: .:::::::::::::::::::.::::::::::::::::::::::.:::.:. CCDS78 DKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTI 420 430 440 450 460 470 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::.:::::::::::..:::::. :::::::::.:::: :.:: ::: :::::::: CCDS78 YAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPK 480 490 500 510 520 530 550 560 570 pF1KA0 SGFDIKVPRRAVGPSSTQ-------------------------LYMVRTMLESLIADKSG .::::::::::::::::: ::::::::::::::::: CCDS78 GGFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSG 540 550 560 570 580 590 580 590 600 610 620 630 pF1KA0 SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRR :::::::::.:: .: :: ::..:::.:::.:.::.:::::::::::::::::::::::: CCDS78 SKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRR 600 610 620 630 640 650 640 650 660 670 680 690 pF1KA0 IQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEV :::::::::::::::::::::: :::::::: ::::::::.::::.:.:::::::::::: CCDS78 IQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEV 660 670 680 690 700 710 700 710 720 730 740 750 pF1KA0 NLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHV ::::::::::::::::::::.::::.:::::.:.:::: :. : ::::::::::::::: CCDS78 NLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHV 720 730 740 750 760 770 760 770 780 790 800 810 pF1KA0 QLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRY ::::::::::::::::.::::::::. ::.:::::::::::::. ::::::.::.:: .. CCDS78 QLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKH 780 790 800 810 820 830 820 830 840 850 860 870 pF1KA0 LTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEF .:::.::::::::::::::::::::::::::::.::::::::::::::::::..::.:: CCDS78 MTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEP 840 850 860 870 880 890 880 890 900 910 920 930 pF1KA0 QRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLK :::: :.:: ::.::: ::.::: ::.:::::::::::..::::::::::::::::::: CCDS78 QRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLK 900 910 920 930 940 950 940 950 960 970 980 990 pF1KA0 VVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQ .::::::::::::::::.::::::::::::::::::::::::::::::.::::::: :: CCDS78 IVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQ 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KA0 NLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYA .::::::::::::::::.:: :::::::::::::::::::..::::::...:::::.::: CCDS78 SLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYA 1020 1030 1040 1050 1060 1070 1060 1070 1080 1090 1100 1110 pF1KA0 PLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPS :::::::::::::::::::::::::::::::::::::::::::::::.:.::::::: :. CCDS78 PLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPT 1080 1090 1100 1110 1120 1130 1120 1130 1140 1150 1160 1170 pF1KA0 NGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFA :::::::::::::::::::::::::::::.:::.::::::::.:::: ::::::::::: CCDS78 NGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFD 1140 1150 1160 1170 1180 1190 1180 1190 1200 1210 1220 1230 pF1KA0 VLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTP ..::::::::::..:::::::::::::::..::::.::::.:...::.::.:: . ... CCDS78 LFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSST 1200 1210 1220 1230 1240 1250 1240 1250 pF1KA0 VEHVRCFQPPIHQSLASS ::::::::::::::::.. CCDS78 VEHVRCFQPPIHQSLATTC 1260 1270 1253 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 09:07:44 2016 done: Thu Nov 3 09:07:45 2016 Total Scan time: 4.500 Total Display time: 0.350 Function used was FASTA [36.3.4 Apr, 2011]