FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0068, 1253 aa 1>>>pF1KA0068 1253 - 1253 aa - 1253 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8488+/-0.000486; mu= 19.7367+/- 0.030 mean_var=70.0461+/-13.748, 0's: 0 Z-trim(108.2): 28 B-trim: 0 in 0/50 Lambda= 0.153244 statistics sampled from 16300 (16326) to 16300 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.528), E-opt: 0.2 (0.191), width: 16 Scan time: 13.080 The best scores are: opt bits E(85289) NP_001274739 (OMIM: 606322) cytoplasmic FMR1-inter (1253) 8354 1857.1 0 NP_001311049 (OMIM: 606322) cytoplasmic FMR1-inter (1253) 8354 1857.1 0 NP_055423 (OMIM: 606322) cytoplasmic FMR1-interact (1253) 8354 1857.1 0 NP_001311052 (OMIM: 606322) cytoplasmic FMR1-inter (1253) 8354 1857.1 0 NP_001311048 (OMIM: 606322) cytoplasmic FMR1-inter (1287) 8354 1857.2 0 XP_011542178 (OMIM: 606322) PREDICTED: cytoplasmic (1285) 8112 1803.6 0 NP_001311053 (OMIM: 606322) cytoplasmic FMR1-inter (1223) 7897 1756.1 0 NP_001311054 (OMIM: 606322) cytoplasmic FMR1-inter (1131) 7544 1678.1 0 NP_001311055 (OMIM: 606322) cytoplasmic FMR1-inter (1219) 7499 1668.1 0 NP_055191 (OMIM: 606323) cytoplasmic FMR1-interact (1253) 7477 1663.3 0 NP_001032410 (OMIM: 606323) cytoplasmic FMR1-inter (1253) 7477 1663.3 0 XP_011532818 (OMIM: 606323) PREDICTED: cytoplasmic (1253) 7477 1663.3 0 XP_016864830 (OMIM: 606323) PREDICTED: cytoplasmic (1253) 7477 1663.3 0 XP_016864831 (OMIM: 606323) PREDICTED: cytoplasmic (1182) 7044 1567.5 0 NP_001278650 (OMIM: 606323) cytoplasmic FMR1-inter (1227) 6883 1531.9 0 NP_001028200 (OMIM: 606322) cytoplasmic FMR1-inter ( 822) 4676 1043.9 0 XP_011542176 (OMIM: 606322) PREDICTED: cytoplasmic (1386) 4676 1044.0 0 XP_011542175 (OMIM: 606322) PREDICTED: cytoplasmic (1386) 4676 1044.0 0 XP_016877513 (OMIM: 606322) PREDICTED: cytoplasmic (1386) 4676 1044.0 0 XP_016877512 (OMIM: 606322) PREDICTED: cytoplasmic (1420) 4676 1044.0 0 NP_001311051 (OMIM: 606322) cytoplasmic FMR1-inter ( 693) 4654 1039.0 0 NP_001278651 (OMIM: 606323) cytoplasmic FMR1-inter (1278) 4101 916.9 0 >>NP_001274739 (OMIM: 606322) cytoplasmic FMR1-interacti (1253 aa) initn: 8354 init1: 8354 opt: 8354 Z-score: 9971.1 bits: 1857.1 E(85289): 0 Smith-Waterman score: 8354; 100.0% identity (100.0% similar) in 1253 aa overlap (1-1253:1-1253) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS 1210 1220 1230 1240 1250 >>NP_001311049 (OMIM: 606322) cytoplasmic FMR1-interacti (1253 aa) initn: 8354 init1: 8354 opt: 8354 Z-score: 9971.1 bits: 1857.1 E(85289): 0 Smith-Waterman score: 8354; 100.0% identity (100.0% similar) in 1253 aa overlap (1-1253:1-1253) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS 1210 1220 1230 1240 1250 >>NP_055423 (OMIM: 606322) cytoplasmic FMR1-interacting (1253 aa) initn: 8354 init1: 8354 opt: 8354 Z-score: 9971.1 bits: 1857.1 E(85289): 0 Smith-Waterman score: 8354; 100.0% identity (100.0% similar) in 1253 aa overlap (1-1253:1-1253) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS 1210 1220 1230 1240 1250 >>NP_001311052 (OMIM: 606322) cytoplasmic FMR1-interacti (1253 aa) initn: 8354 init1: 8354 opt: 8354 Z-score: 9971.1 bits: 1857.1 E(85289): 0 Smith-Waterman score: 8354; 100.0% identity (100.0% similar) in 1253 aa overlap (1-1253:1-1253) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS 1210 1220 1230 1240 1250 >>NP_001311048 (OMIM: 606322) cytoplasmic FMR1-interacti (1287 aa) initn: 8354 init1: 8354 opt: 8354 Z-score: 9970.9 bits: 1857.2 E(85289): 0 Smith-Waterman score: 8354; 100.0% identity (100.0% similar) in 1253 aa overlap (1-1253:35-1287) 10 20 30 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIE :::::::::::::::::::::::::::::: NP_001 GPAGGVPSGLCAPTCSWDPRLEPSRRAQPRMAAQVTLEDALSNVDLLEELPLPDQQPCIE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 PPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 RAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 DFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 SMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 LYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKS 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 RWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 FDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 LVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSV 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 LQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLI 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA0 ADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLEL 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA0 TMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDE 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA0 IEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLL 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA0 KQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA0 LLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLP 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA0 FSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVM 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA0 EELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELK 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA0 TVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRL 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KA0 ESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWR 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KA0 GPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQ 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KA0 QRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGD 1210 1220 1230 1240 1250 1260 1240 1250 pF1KA0 GEGTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::::: NP_001 GEGTPVEHVRCFQPPIHQSLASS 1270 1280 >>XP_011542178 (OMIM: 606322) PREDICTED: cytoplasmic FMR (1285 aa) initn: 8112 init1: 4385 opt: 8112 Z-score: 9681.8 bits: 1803.6 E(85289): 0 Smith-Waterman score: 8112; 97.5% identity (98.2% similar) in 1256 aa overlap (1-1253:35-1285) 10 20 30 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIE :::::::::::::::::::::::::::::: XP_011 GPAGGVPSGLCAPTCSWDPRLEPSRRAQPRMAAQVTLEDALSNVDLLEELPLPDQQPCIE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 PPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 RAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 DFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 SMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 LYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKS 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 RWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 FDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 LVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSV 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 LQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLI ::::::::::::::::::::::::::::::::::::::::::::::::::.:::: ::: XP_011 LQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYLVRTMAESL- 550 560 570 580 590 600 580 590 600 610 620 pF1KA0 ADKSGSKKTLRS--SLEGPTILD-IEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFF :: . ::. :: .: .. : :.: : :..:.:::::::::::::::::: XP_011 ----GSAELLRQLKSLGMERLLHAVNTFLRQSCTYLPLLTFGETLQQCCDLSQLWFREFF 610 620 630 640 650 630 640 650 660 670 680 pF1KA0 LELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFL 660 670 680 690 700 710 690 700 710 720 730 740 pF1KA0 YDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYE 720 730 740 750 760 770 750 760 770 780 790 800 pF1KA0 TLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRM 780 790 800 810 820 830 810 820 830 840 850 860 pF1KA0 THKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 THKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRT 840 850 860 870 880 890 870 880 890 900 910 920 pF1KA0 VLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIA 900 910 920 930 940 950 930 940 950 960 970 980 pF1KA0 VVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYA 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KA0 ELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKM 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KA0 KRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDP 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KA0 IWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVL 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KA0 LGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLK 1200 1210 1220 1230 1240 1250 1230 1240 1250 pF1KA0 SGDGEGTPVEHVRCFQPPIHQSLASS :::::::::::::::::::::::::: XP_011 SGDGEGTPVEHVRCFQPPIHQSLASS 1260 1270 1280 >>NP_001311053 (OMIM: 606322) cytoplasmic FMR1-interacti (1223 aa) initn: 8144 init1: 7897 opt: 7897 Z-score: 9425.2 bits: 1756.1 E(85289): 0 Smith-Waterman score: 8088; 97.6% identity (97.6% similar) in 1253 aa overlap (1-1253:1-1223) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI ::::::::::::::::::::::::::::::::::::::: NP_001 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQ--------------------- 10 20 30 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---------NEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 40 50 60 70 80 90 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD 160 170 180 190 200 210 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK 220 230 240 250 260 270 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI 280 290 300 310 320 330 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT 340 350 360 370 380 390 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV 400 410 420 430 440 450 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK 460 470 480 490 500 510 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF 520 530 540 550 560 570 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM 580 590 600 610 620 630 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS 640 650 660 670 680 690 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL 700 710 720 730 740 750 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT 760 770 780 790 800 810 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS 820 830 840 850 860 870 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS 1180 1190 1200 1210 1220 >>NP_001311054 (OMIM: 606322) cytoplasmic FMR1-interacti (1131 aa) initn: 7544 init1: 7544 opt: 7544 Z-score: 9004.0 bits: 1678.1 E(85289): 0 Smith-Waterman score: 7544; 100.0% identity (100.0% similar) in 1131 aa overlap (123-1253:1-1131) 100 110 120 130 140 150 pF1KA0 IPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDF :::::::::::::::::::::::::::::: NP_001 MNFMYFQRNAIERFCGEVRRLCHAERRKDF 10 20 30 160 170 180 190 200 210 pF1KA0 VSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSM 40 50 60 70 80 90 220 230 240 250 260 270 pF1KA0 FLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLY 100 110 120 130 140 150 280 290 300 310 320 330 pF1KA0 LMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRW 160 170 180 190 200 210 340 350 360 370 380 390 pF1KA0 TCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFD 220 230 240 250 260 270 400 410 420 430 440 450 pF1KA0 LALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALV 280 290 300 310 320 330 460 470 480 490 500 510 pF1KA0 EVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQ 340 350 360 370 380 390 520 530 540 550 560 570 pF1KA0 AIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIAD 400 410 420 430 440 450 580 590 600 610 620 630 pF1KA0 KSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTM 460 470 480 490 500 510 640 650 660 670 680 690 pF1KA0 GRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIE 520 530 540 550 560 570 700 710 720 730 740 750 pF1KA0 AEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQ 580 590 600 610 620 630 760 770 780 790 800 810 pF1KA0 RHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLL 640 650 660 670 680 690 820 830 840 850 860 870 pF1KA0 SRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFS 700 710 720 730 740 750 880 890 900 910 920 930 pF1KA0 QEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEE 760 770 780 790 800 810 940 950 960 970 980 990 pF1KA0 LLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTV 820 830 840 850 860 870 1000 1010 1020 1030 1040 1050 pF1KA0 CFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLES 880 890 900 910 920 930 1060 1070 1080 1090 1100 1110 pF1KA0 KYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGP 940 950 960 970 980 990 1120 1130 1140 1150 1160 1170 pF1KA0 LPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQR 1000 1010 1020 1030 1040 1050 1180 1190 1200 1210 1220 1230 pF1KA0 RFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGE 1060 1070 1080 1090 1100 1110 1240 1250 pF1KA0 GTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::: NP_001 GTPVEHVRCFQPPIHQSLASS 1120 1130 >>NP_001311055 (OMIM: 606322) cytoplasmic FMR1-interacti (1219 aa) initn: 7499 init1: 7499 opt: 7499 Z-score: 8949.7 bits: 1668.1 E(85289): 0 Smith-Waterman score: 8051; 97.3% identity (97.3% similar) in 1253 aa overlap (1-1253:1-1219) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT ::::::::::::::::::::::::::::::::::: NP_001 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQ------------------------- 70 80 90 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---------RNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS 100 110 120 130 140 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD 150 160 170 180 190 200 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK 210 220 230 240 250 260 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI 270 280 290 300 310 320 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT 330 340 350 360 370 380 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV 390 400 410 420 430 440 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK 450 460 470 480 490 500 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF 510 520 530 540 550 560 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM 570 580 590 600 610 620 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS 630 640 650 660 670 680 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL 690 700 710 720 730 740 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT 750 760 770 780 790 800 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS 810 820 830 840 850 860 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC 870 880 890 900 910 920 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC 930 940 950 960 970 980 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL 990 1000 1010 1020 1030 1040 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI 1050 1060 1070 1080 1090 1100 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP 1110 1120 1130 1140 1150 1160 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS 1170 1180 1190 1200 1210 >>NP_055191 (OMIM: 606323) cytoplasmic FMR1-interacting (1253 aa) initn: 7474 init1: 5150 opt: 7477 Z-score: 8923.2 bits: 1663.3 E(85289): 0 Smith-Waterman score: 7477; 87.6% identity (96.8% similar) in 1253 aa overlap (1-1253:1-1252) 10 20 30 40 50 60 pF1KA0 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI :...:::::::::::::::::::::::::::::::..:: ::.::::::::::::::::: NP_055 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_055 EQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS :::.::::::.::::::.::.:::::::::::::::::.::::::::::::::::::::: NP_055 KLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD ::::::::::::::::::::::::::::::::::::::.::: :.:::::: :::::::: NP_055 VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK :::.:::::::.::::::::::::::::::::::::.::::::::::::::::::::.:: NP_055 IVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI ::::::::::::::::::::::::::::::.::::.:. ::::::::::.:::.::.::: NP_055 QLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT :::::::::::::::: ..::.: :::.::::::.::::::.::::::::::::::::: NP_055 SELARYSNSEVVTGSG-LDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPT 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV ::. ::::: .:::::::::::::::::::.::::::::::::::::::::::.:::.:. NP_055 DKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTI 420 430 440 450 460 470 490 500 510 520 530 540 pF1KA0 YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK :::::::.:::::::::::..:::::. :::::::::.:::: :.:: ::: :::::::: NP_055 YAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPK 480 490 500 510 520 530 550 560 570 580 590 600 pF1KA0 SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF .:::::::::::::::::::::::::::::::::::::::::::.:: .: :: ::..:: NP_055 GGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSF 540 550 560 570 580 590 610 620 630 640 650 660 pF1KA0 FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM :.:::.:.::.:::::::::::::::::::::::::::::::::::::::::::::: :: NP_055 FFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSM 600 610 620 630 640 650 670 680 690 700 710 720 pF1KA0 MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS :::::: ::::::::.::::.:.::::::::::::::::::::::::::::::::.:::: NP_055 MEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGS 660 670 680 690 700 710 730 740 750 760 770 780 pF1KA0 LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL .:::::.:.:::: :. : :::::::::::::::::::::::::::::::.:::::::: NP_055 VLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSL 720 730 740 750 760 770 790 800 810 820 830 840 pF1KA0 ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT . ::.:::::::::::::. ::::::.::.:: ...:::.:::::::::::::::::::: NP_055 DQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRIT 780 790 800 810 820 830 850 860 870 880 890 900 pF1KA0 LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS ::::::::.::::::::::::::::::..::.:: :::: :.:: ::.::: ::.::: NP_055 LHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSH 840 850 860 870 880 890 910 920 930 940 950 960 pF1KA0 IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC ::.:::::::::::..:::::::::::::::::::.::::::::::::::::.::::::: NP_055 IYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKIC 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KA0 RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC :::::::::::::::::::::::.::::::: ::.::::::::::::::::.:: :::: NP_055 RLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVC 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KA0 DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL :::::::::::::::..::::::...:::::.:::::::::::::::::::::::::::: NP_055 DLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDL 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KA0 LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI ::::::::::::::::::::::.:.::::::: :.::::::::::::::::::::::::: NP_055 LTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCI 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KA0 PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP ::::.:::.::::::::.:::: ::::::::::: ..::::::::::..::::::::::: NP_055 PVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVP 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 pF1KA0 LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS ::::..::::.::::.:...::.::.:: . ... ::::::::::::::::.. NP_055 LKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC 1200 1210 1220 1230 1240 1250 1253 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 09:07:45 2016 done: Thu Nov 3 09:07:47 2016 Total Scan time: 13.080 Total Display time: 0.570 Function used was FASTA [36.3.4 Apr, 2011]