FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0130, 989 aa 1>>>pF1KA0130 989 - 989 aa - 989 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0543+/-0.0011; mu= 16.7033+/- 0.066 mean_var=65.1167+/-12.830, 0's: 0 Z-trim(101.6): 33 B-trim: 0 in 0/49 Lambda= 0.158938 statistics sampled from 6584 (6591) to 6584 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.565), E-opt: 0.2 (0.202), width: 16 Scan time: 2.980 The best scores are: opt bits E(32554) CCDS11359.1 MED24 gene_id:9862|Hs108|chr17 ( 989) 6481 1495.7 0 CCDS42315.1 MED24 gene_id:9862|Hs108|chr17 ( 976) 5948 1373.5 0 CCDS82117.1 MED24 gene_id:9862|Hs108|chr17 (1008) 5256 1214.8 0 >>CCDS11359.1 MED24 gene_id:9862|Hs108|chr17 (989 aa) initn: 6481 init1: 6481 opt: 6481 Z-score: 8021.5 bits: 1495.7 E(32554): 0 Smith-Waterman score: 6481; 99.8% identity (99.9% similar) in 989 aa overlap (1-989:1-989) 10 20 30 40 50 60 pF1KA0 MKVVNLKQAILQAWKERWSYYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLI ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: CCDS11 MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 CRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 CRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 AKLEEASSWTAIEHSLLKLGEILTNLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTG :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: CCDS11 AKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 FPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 FPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 EELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 EELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 NFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 NFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 LKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 ESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKIL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 NPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 NPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 SIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 ERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 KGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 LVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDI 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 EDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 EDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRV 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 LANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSA 910 920 930 940 950 960 970 980 pF1KA0 MSSPKVVLAITDLSLPLGRQVAAKAIAAL ::::::::::::::::::::::::::::: CCDS11 MSSPKVVLAITDLSLPLGRQVAAKAIAAL 970 980 >>CCDS42315.1 MED24 gene_id:9862|Hs108|chr17 (976 aa) initn: 5948 init1: 5948 opt: 5948 Z-score: 7361.1 bits: 1373.5 E(32554): 0 Smith-Waterman score: 6374; 98.5% identity (98.6% similar) in 989 aa overlap (1-989:1-976) 10 20 30 40 50 60 pF1KA0 MKVVNLKQAILQAWKERWSYYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLI ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: CCDS42 MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGL ::::::::::: :::::::::::::::::::::::::::::::::::: CCDS42 LSYLKYAISSQ-------------FDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGL 70 80 90 100 130 140 150 160 170 180 pF1KA0 CRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 CRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHI 110 120 130 140 150 160 190 200 210 220 230 240 pF1KA0 AKLEEASSWTAIEHSLLKLGEILTNLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTG :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: CCDS42 AKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTG 170 180 190 200 210 220 250 260 270 280 290 300 pF1KA0 FPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGT 230 240 250 260 270 280 310 320 330 340 350 360 pF1KA0 EELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCT 290 300 310 320 330 340 370 380 390 400 410 420 pF1KA0 NFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 NFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNI 350 360 370 380 390 400 430 440 450 460 470 480 pF1KA0 LKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KA0 ESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKIL 470 480 490 500 510 520 550 560 570 580 590 600 pF1KA0 NPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 NPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFE 530 540 550 560 570 580 610 620 630 640 650 660 pF1KA0 SIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 SIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYN 590 600 610 620 630 640 670 680 690 700 710 720 pF1KA0 ERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLE 650 660 670 680 690 700 730 740 750 760 770 780 pF1KA0 KGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVT 710 720 730 740 750 760 790 800 810 820 830 840 pF1KA0 LVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDI 770 780 790 800 810 820 850 860 870 880 890 900 pF1KA0 EDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRV 830 840 850 860 870 880 910 920 930 940 950 960 pF1KA0 LANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSA 890 900 910 920 930 940 970 980 pF1KA0 MSSPKVVLAITDLSLPLGRQVAAKAIAAL ::::::::::::::::::::::::::::: CCDS42 MSSPKVVLAITDLSLPLGRQVAAKAIAAL 950 960 970 >>CCDS82117.1 MED24 gene_id:9862|Hs108|chr17 (1008 aa) initn: 5256 init1: 5256 opt: 5256 Z-score: 6503.3 bits: 1214.8 E(32554): 0 Smith-Waterman score: 6433; 97.9% identity (98.0% similar) in 1008 aa overlap (1-989:1-1008) 10 20 30 40 50 60 pF1KA0 MKVVNLKQAILQAWKERWSYYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLI ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: CCDS82 MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 CRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 CRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHI 130 140 150 160 170 180 190 200 210 220 pF1KA0 AKLEEAS-------------------SWTAIEHSLLKLGEILTNLSNPQLRSQAEQCGTL ::::::: ::::::::::::::::.::::::::::::::::: CCDS82 AKLEEASLHTSQGLGQGGTRANQPTASWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA0 IRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 IRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLF 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA0 VLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 VLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFL 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA0 LKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA0 NIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 NIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA0 KSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 KSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA0 VPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 VPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSI 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA0 SAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQ 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA0 MIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLL 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA0 PPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHT 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA0 LRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSY 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA0 SSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSS 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA0 SLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRG 910 920 930 940 950 960 950 960 970 980 pF1KA0 SVLQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL :::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SVLQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL 970 980 990 1000 989 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:10:46 2016 done: Wed Nov 2 18:10:46 2016 Total Scan time: 2.980 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]