FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0136, 939 aa 1>>>pF1KA0136 939 - 939 aa - 939 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.6263+/-0.000568; mu= -0.3425+/- 0.035 mean_var=236.0679+/-49.582, 0's: 0 Z-trim(112.9): 59 B-trim: 874 in 2/52 Lambda= 0.083475 statistics sampled from 21929 (21965) to 21929 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.258), width: 16 Scan time: 10.370 The best scores are: opt bits E(85289) NP_056173 (OMIM: 610078) MORC family CW-type zinc ( 939) 6201 761.4 0 XP_016883800 (OMIM: 610078) PREDICTED: MORC family ( 868) 5705 701.7 4.2e-201 XP_011527820 (OMIM: 610078) PREDICTED: MORC family ( 868) 5705 701.7 4.2e-201 NP_001307374 (OMIM: 610078) MORC family CW-type zi ( 868) 5705 701.7 4.2e-201 NP_001307375 (OMIM: 610078) MORC family CW-type zi ( 868) 5705 701.7 4.2e-201 XP_016883801 (OMIM: 610078) PREDICTED: MORC family ( 555) 3655 454.7 6e-127 NP_001078823 (OMIM: 300970) MORC family CW-type zi ( 900) 1795 230.8 2.4e-59 NP_078933 (OMIM: 300970) MORC family CW-type zinc ( 937) 1795 230.8 2.5e-59 XP_016885333 (OMIM: 300970) PREDICTED: MORC family ( 808) 1527 198.5 1.1e-49 XP_005262247 (OMIM: 300970) PREDICTED: MORC family ( 845) 1527 198.5 1.2e-49 XP_011529329 (OMIM: 300970) PREDICTED: MORC family ( 760) 1148 152.8 6e-36 XP_006724754 (OMIM: 300970) PREDICTED: MORC family ( 815) 989 133.7 3.7e-30 NP_055244 (OMIM: 603205) MORC family CW-type zinc ( 984) 440 67.6 3.4e-10 XP_005247419 (OMIM: 603205) PREDICTED: MORC family (1014) 440 67.7 3.5e-10 XP_011510995 (OMIM: 603205) PREDICTED: MORC family ( 951) 437 67.3 4.3e-10 XP_016861658 (OMIM: 603205) PREDICTED: MORC family ( 981) 437 67.3 4.4e-10 XP_011510994 (OMIM: 603205) PREDICTED: MORC family ( 986) 437 67.3 4.4e-10 XP_011510993 (OMIM: 603205) PREDICTED: MORC family (1016) 437 67.3 4.5e-10 NP_001290186 (OMIM: 616661,616688) MORC family CW- (1029) 422 65.5 1.6e-09 NP_001290185 (OMIM: 616661,616688) MORC family CW- (1032) 422 65.5 1.6e-09 XP_016884156 (OMIM: 616661,616688) PREDICTED: MORC (1034) 409 63.9 4.7e-09 XP_011528306 (OMIM: 616661,616688) PREDICTED: MORC (1037) 409 63.9 4.7e-09 XP_016884157 (OMIM: 616661,616688) PREDICTED: MORC ( 970) 318 53.0 8.9e-06 NP_055756 (OMIM: 616661,616688) MORC family CW-typ ( 970) 318 53.0 8.9e-06 XP_011510996 (OMIM: 603205) PREDICTED: MORC family ( 917) 240 43.5 0.0057 >>NP_056173 (OMIM: 610078) MORC family CW-type zinc fing (939 aa) initn: 6201 init1: 6201 opt: 6201 Z-score: 4053.8 bits: 761.4 E(85289): 0 Smith-Waterman score: 6201; 100.0% identity (100.0% similar) in 939 aa overlap (1-939:1-939) 10 20 30 40 50 60 pF1KA0 MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 ICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 NGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 DQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 ITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 FDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 KLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 MIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 LKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 SHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEID 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 VRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 TDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 EMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVG 850 860 870 880 890 900 910 920 930 pF1KA0 QLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST ::::::::::::::::::::::::::::::::::::::: NP_056 QLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST 910 920 930 >>XP_016883800 (OMIM: 610078) PREDICTED: MORC family CW- (868 aa) initn: 5705 init1: 5705 opt: 5705 Z-score: 3731.5 bits: 701.7 E(85289): 4.2e-201 Smith-Waterman score: 5705; 100.0% identity (100.0% similar) in 868 aa overlap (72-939:1-868) 50 60 70 80 90 100 pF1KA0 DPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYG :::::::::::::::::::::::::::::: XP_016 MTSDKLHKMLSFGFSDKVTMNGHVPVGLYG 10 20 30 110 120 130 140 150 160 pF1KA0 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAE 40 50 60 70 80 90 170 180 190 200 210 220 pF1KA0 SKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRI 100 110 120 130 140 150 230 240 250 260 270 280 pF1KA0 PEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKS 160 170 180 190 200 210 290 300 310 320 330 340 pF1KA0 LAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGV 220 230 240 250 260 270 350 360 370 380 390 400 pF1KA0 GVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVED 280 290 300 310 320 330 410 420 430 440 450 460 pF1KA0 IQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPT 340 350 360 370 380 390 470 480 490 500 510 520 pF1KA0 YEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYA 400 410 420 430 440 450 530 540 550 560 570 580 pF1KA0 TRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILE 460 470 480 490 500 510 590 600 610 620 630 640 pF1KA0 ENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQ 520 530 540 550 560 570 650 660 670 680 690 700 pF1KA0 TEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRN 580 590 600 610 620 630 710 720 730 740 750 760 pF1KA0 QLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESING :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESING 640 650 660 670 680 690 770 780 790 800 810 820 pF1KA0 KSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFR 700 710 720 730 740 750 830 840 850 860 870 880 pF1KA0 QLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEES 760 770 780 790 800 810 890 900 910 920 930 pF1KA0 VNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST 820 830 840 850 860 >>XP_011527820 (OMIM: 610078) PREDICTED: MORC family CW- (868 aa) initn: 5705 init1: 5705 opt: 5705 Z-score: 3731.5 bits: 701.7 E(85289): 4.2e-201 Smith-Waterman score: 5705; 100.0% identity (100.0% similar) in 868 aa overlap (72-939:1-868) 50 60 70 80 90 100 pF1KA0 DPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYG :::::::::::::::::::::::::::::: XP_011 MTSDKLHKMLSFGFSDKVTMNGHVPVGLYG 10 20 30 110 120 130 140 150 160 pF1KA0 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAE 40 50 60 70 80 90 170 180 190 200 210 220 pF1KA0 SKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRI 100 110 120 130 140 150 230 240 250 260 270 280 pF1KA0 PEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKS 160 170 180 190 200 210 290 300 310 320 330 340 pF1KA0 LAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGV 220 230 240 250 260 270 350 360 370 380 390 400 pF1KA0 GVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVED 280 290 300 310 320 330 410 420 430 440 450 460 pF1KA0 IQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPT 340 350 360 370 380 390 470 480 490 500 510 520 pF1KA0 YEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYA 400 410 420 430 440 450 530 540 550 560 570 580 pF1KA0 TRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILE 460 470 480 490 500 510 590 600 610 620 630 640 pF1KA0 ENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQ 520 530 540 550 560 570 650 660 670 680 690 700 pF1KA0 TEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRN 580 590 600 610 620 630 710 720 730 740 750 760 pF1KA0 QLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESING :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESING 640 650 660 670 680 690 770 780 790 800 810 820 pF1KA0 KSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFR 700 710 720 730 740 750 830 840 850 860 870 880 pF1KA0 QLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEES 760 770 780 790 800 810 890 900 910 920 930 pF1KA0 VNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST 820 830 840 850 860 >>NP_001307374 (OMIM: 610078) MORC family CW-type zinc f (868 aa) initn: 5705 init1: 5705 opt: 5705 Z-score: 3731.5 bits: 701.7 E(85289): 4.2e-201 Smith-Waterman score: 5705; 100.0% identity (100.0% similar) in 868 aa overlap (72-939:1-868) 50 60 70 80 90 100 pF1KA0 DPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYG :::::::::::::::::::::::::::::: NP_001 MTSDKLHKMLSFGFSDKVTMNGHVPVGLYG 10 20 30 110 120 130 140 150 160 pF1KA0 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAE 40 50 60 70 80 90 170 180 190 200 210 220 pF1KA0 SKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRI 100 110 120 130 140 150 230 240 250 260 270 280 pF1KA0 PEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKS 160 170 180 190 200 210 290 300 310 320 330 340 pF1KA0 LAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGV 220 230 240 250 260 270 350 360 370 380 390 400 pF1KA0 GVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVED 280 290 300 310 320 330 410 420 430 440 450 460 pF1KA0 IQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPT 340 350 360 370 380 390 470 480 490 500 510 520 pF1KA0 YEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYA 400 410 420 430 440 450 530 540 550 560 570 580 pF1KA0 TRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILE 460 470 480 490 500 510 590 600 610 620 630 640 pF1KA0 ENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQ 520 530 540 550 560 570 650 660 670 680 690 700 pF1KA0 TEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRN 580 590 600 610 620 630 710 720 730 740 750 760 pF1KA0 QLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESING :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESING 640 650 660 670 680 690 770 780 790 800 810 820 pF1KA0 KSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFR 700 710 720 730 740 750 830 840 850 860 870 880 pF1KA0 QLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEES 760 770 780 790 800 810 890 900 910 920 930 pF1KA0 VNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST 820 830 840 850 860 >>NP_001307375 (OMIM: 610078) MORC family CW-type zinc f (868 aa) initn: 5705 init1: 5705 opt: 5705 Z-score: 3731.5 bits: 701.7 E(85289): 4.2e-201 Smith-Waterman score: 5705; 100.0% identity (100.0% similar) in 868 aa overlap (72-939:1-868) 50 60 70 80 90 100 pF1KA0 DPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYG :::::::::::::::::::::::::::::: NP_001 MTSDKLHKMLSFGFSDKVTMNGHVPVGLYG 10 20 30 110 120 130 140 150 160 pF1KA0 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAE 40 50 60 70 80 90 170 180 190 200 210 220 pF1KA0 SKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRI 100 110 120 130 140 150 230 240 250 260 270 280 pF1KA0 PEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKS 160 170 180 190 200 210 290 300 310 320 330 340 pF1KA0 LAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGV 220 230 240 250 260 270 350 360 370 380 390 400 pF1KA0 GVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVED 280 290 300 310 320 330 410 420 430 440 450 460 pF1KA0 IQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPT 340 350 360 370 380 390 470 480 490 500 510 520 pF1KA0 YEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYA 400 410 420 430 440 450 530 540 550 560 570 580 pF1KA0 TRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILE 460 470 480 490 500 510 590 600 610 620 630 640 pF1KA0 ENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQ 520 530 540 550 560 570 650 660 670 680 690 700 pF1KA0 TEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRN 580 590 600 610 620 630 710 720 730 740 750 760 pF1KA0 QLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESING :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESING 640 650 660 670 680 690 770 780 790 800 810 820 pF1KA0 KSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFR 700 710 720 730 740 750 830 840 850 860 870 880 pF1KA0 QLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEES 760 770 780 790 800 810 890 900 910 920 930 pF1KA0 VNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST 820 830 840 850 860 >>XP_016883801 (OMIM: 610078) PREDICTED: MORC family CW- (555 aa) initn: 3655 init1: 3655 opt: 3655 Z-score: 2400.1 bits: 454.7 E(85289): 6e-127 Smith-Waterman score: 3655; 100.0% identity (100.0% similar) in 555 aa overlap (385-939:1-555) 360 370 380 390 400 410 pF1KA0 THNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCD :::::::::::::::::::::::::::::: XP_016 MKVKKNTEYPLNLPVEDIQKRPDQTWVQCD 10 20 30 420 430 440 450 460 470 pF1KA0 ACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKF 40 50 60 70 80 90 480 490 500 510 520 530 pF1KA0 RIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQS 100 110 120 130 140 150 540 550 560 570 580 590 pF1KA0 EPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDI 160 170 180 190 200 210 600 610 620 630 640 650 pF1KA0 DMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEET 220 230 240 250 260 270 660 670 680 690 700 710 pF1KA0 VEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYK 280 290 300 310 320 330 720 730 740 750 760 770 pF1KA0 RQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQ 340 350 360 370 380 390 780 790 800 810 820 830 pF1KA0 QALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYK 400 410 420 430 440 450 840 850 860 870 880 890 pF1KA0 SEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRS 460 470 480 490 500 510 900 910 920 930 pF1KA0 LRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST ::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST 520 530 540 550 >>NP_001078823 (OMIM: 300970) MORC family CW-type zinc f (900 aa) initn: 1384 init1: 662 opt: 1795 Z-score: 1186.5 bits: 230.8 E(85289): 2.4e-59 Smith-Waterman score: 1815; 37.9% identity (64.7% similar) in 897 aa overlap (8-887:29-875) 10 20 30 pF1KA0 MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDN :::::.. :..:..::.::: ::::.:::.:: NP_001 MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDN 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 AYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGL : ::::.:. ..:: .... ::::::.: ::: :::.::::::.::: ... :.:. NP_001 AVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 YGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKH-RQMIN .:::::::::::::::.:::::: ...:::::::::: ..:. :.:::: ::.. ..:: NP_001 FGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMII 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 LAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNA-TEFDFEKDKY .: :: :::..:.:. :. :::..::: ::::::..:::.: ::. .:.::. :.: NP_001 TEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 DIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQL :: . :.: : .: ::..:::::.:.:::.::::.:.:: .:: ::. NP_001 DILVS-DFDTEEKMTGGVTSE-----LPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQM 250 260 270 280 290 280 290 300 310 320 330 pF1KA0 VSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRAN ..:::: .: :.:.: : .: :::::::.:.:....:::::: :::::..::::::.. . NP_001 IAKSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPT 300 310 320 330 340 350 340 350 360 370 380 390 pF1KA0 -NMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLN . ::::.:.::::::::..:::::.::.::::::.::..::: ::.: . : : . NP_001 RGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFE--TS 360 370 380 390 400 410 400 410 420 430 440 450 pF1KA0 LPVEDIQKRPDQTWVQCDACLKWRKLPDGMD--QLPEKWYCSNNPDPQFRNCEVPEEPE- .. : : ::::::::: :::::::: .: .:: .:.: : :..: : :::: : NP_001 TVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQEL 420 430 440 450 460 470 460 470 480 490 500 510 pF1KA0 -DEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRH :::: .:..:.. ... . .: : . ::.: . . .. NP_001 TDEDLC-------LSKAKKQEQTVEEKKKMPMENE---------NHQVFSNPPKILTVQE 480 490 500 510 520 530 540 550 560 570 pF1KA0 LSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDD .. : :. . . :. :. : .. .: : . . :... ..::... . :.. NP_001 MA-GLNNKTIGYEGIHS--PSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKWIL--GEE 520 530 540 550 560 570 580 590 600 610 620 630 pF1KA0 DDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRC : :. : :..:. .: . .:: . : . : :... ..:: : NP_001 PVEKRRRLQ-NEMTTPSLDY--SMPAPYRRVE---APVAY-----PEGENSHDKSSSERS 580 590 600 610 620 640 650 660 670 680 pF1KA0 DQGNTAATQTEVPSLVVKKEET---VEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSA :. . . ...:. : :. . .:: .: . ..:.. :. NP_001 TPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGS-LLPEELEDQMPRLVAEESNRGST 630 640 650 660 670 690 700 710 720 730 740 pF1KA0 DDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE . .:. . .... . :. . : .... : . . :. NP_001 T---INKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVA 680 690 700 710 720 730 750 760 770 780 790 800 pF1KA0 TDAV---FLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESK . :. . :. : :: : . . .. .:.:.::. :..: :: : . NP_001 SAAIPAAAIGEKARGYEESEGHNTPKLKNQ-RELEELKRTTEKLERVLAE-----RNLFQ 740 750 760 770 780 790 810 820 830 840 850 860 pF1KA0 SEMDEMAVQLDDVFRQLDKCSIERDQYKS-EVELLEMEKSQI---RSQCEELKTEVEQLK ....:. . . .. : . : :.. :.: : :... ... . ::.:.:. : NP_001 QKVEELEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKAELERTK 800 810 820 830 840 850 870 880 890 900 910 920 pF1KA0 STNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVV .:. .. . . : ... .: NP_001 EEKQELKEKLKETETHLEMLQKAQGFGKAYAATYPRQLSPYFCPPSLGAS 860 870 880 890 900 >>NP_078933 (OMIM: 300970) MORC family CW-type zinc fing (937 aa) initn: 1482 init1: 662 opt: 1795 Z-score: 1186.2 bits: 230.8 E(85289): 2.5e-59 Smith-Waterman score: 1910; 38.0% identity (64.8% similar) in 948 aa overlap (8-931:29-931) 10 20 30 pF1KA0 MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDN :::::.. :..:..::.::: ::::.:::.:: NP_078 MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDN 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 AYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGL : ::::.:. ..:: .... ::::::.: ::: :::.::::::.::: ... :.:. NP_078 AVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 YGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKH-RQMIN .:::::::::::::::.:::::: ...:::::::::: ..:. :.:::: ::.. ..:: NP_078 FGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMII 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 LAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNA-TEFDFEKDKY .: :: :::..:.:. :. :::..::: ::::::..:::.: ::. .:.::. :.: NP_078 TEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 DIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQL :: . :.: : .: ::..:::::.:.:::.::::.:.:: .:: ::. NP_078 DILVS-DFDTEEKMTGGVTSE-----LPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQM 250 260 270 280 290 280 290 300 310 320 330 pF1KA0 VSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRAN ..:::: .: :.:.: : .: :::::::.:.:....:::::: :::::..::::::.. . NP_078 IAKSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPT 300 310 320 330 340 350 340 350 360 370 380 390 pF1KA0 -NMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLN . ::::.:.::::::::..:::::.::.::::::.::..::: ::.: . : : . NP_078 RGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFE--TS 360 370 380 390 400 410 400 410 420 430 440 450 pF1KA0 LPVEDIQKRPDQTWVQCDACLKWRKLPDGMD--QLPEKWYCSNNPDPQFRNCEVPEEPE- .. : : ::::::::: :::::::: .: .:: .:.: : :..: : :::: : NP_078 TVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQEL 420 430 440 450 460 470 460 470 480 490 500 510 pF1KA0 -DEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRH :::: .:..:.. ... . .: : . ::.: . . .. NP_078 TDEDLC-------LSKAKKQEQTVEEKKKMPMENE---------NHQVFSNPPKILTVQE 480 490 500 510 520 530 540 550 560 570 pF1KA0 LSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDD .. : :. . . :. :. : .. .: : . . :... ..::... . :.. NP_078 MA-GLNNKTIGYEGIHS--PSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKWIL--GEE 520 530 540 550 560 570 580 590 600 610 620 630 pF1KA0 DDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRC : :. : :..:. .: . .:: . : . : :... ..:: : NP_078 PVEKRRRLQ-NEMTTPSLDY--SMPAPYRRVE---APVAY-----PEGENSHDKSSSERS 580 590 600 610 620 640 650 660 670 680 pF1KA0 DQGNTAATQTEVPSLVVKKEET---VEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSA :. . . ...:. : :. . .:: .: . ..:.. :. NP_078 TPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGS-LLPEELEDQMPRLVAEESNRGST 630 640 650 660 670 690 700 710 720 730 740 pF1KA0 DDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTE . .:. . .... . :. . : .... : . . :. NP_078 T---INKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVA 680 690 700 710 720 730 750 760 770 780 790 800 pF1KA0 TDAV---FLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECS--QCSNNE . :. . :. : :: : . . .. .:.:.::. :..: :: . : . .: NP_078 SAAIPAAAIGEKARGYEESEGHNTPKLKNQ-RELEELKRTTEKLERVLAERNLFQQKVEE 740 750 760 770 780 790 810 820 830 840 850 860 pF1KA0 SKSEMDEMAVQLDDVFRQLDKCSIERDQ--YKSEVEL--LEMEKSQIRSQCEELKTEVEQ ..: .. .. : ..: : .. . : :. .. . : . .... :. : : .. NP_078 LEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKAELERTKEEKQE 800 810 820 830 840 850 870 880 890 900 910 pF1KA0 LKSTNQQTATDVSTSSNIEESVNHMDGESL-----KLRSLRVNVGQLLAMIVPDLDLQQV :: ..: : . .. . : .:..: :: ::..:. ::. ..: :.:... NP_078 LKEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVSYLLTSVLPHLELREI 860 870 880 890 900 910 920 930 pF1KA0 NYDVDVVDEILGQVVEQMSEISST .:: . :: :: :.: NP_078 GYDSEQVDGILYTVLEANHILD 920 930 >>XP_016885333 (OMIM: 300970) PREDICTED: MORC family CW- (808 aa) initn: 1150 init1: 441 opt: 1527 Z-score: 1012.7 bits: 198.5 E(85289): 1.1e-49 Smith-Waterman score: 1545; 36.4% identity (63.0% similar) in 833 aa overlap (72-887:1-783) 50 60 70 80 90 100 pF1KA0 DPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYG :: :::.::::::.::: ... :.:..: XP_016 MTPHKLHRMLSFGFTDKVIKKSQCPIGVFG 10 20 30 110 120 130 140 150 160 pF1KA0 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKH-RQMINLA ::::::::::::::.:::::: ...:::::::::: ..:. :.:::: ::.. ..:: XP_016 NGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMIITE 40 50 60 70 80 90 170 180 190 200 210 pF1KA0 ESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNA-TEFDFEKDKYDI .: :: :::..:.:. :. :::..::: ::::::..:::.: ::. .:.::. :.::: XP_016 DSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQYDI 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA0 RIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVS . :.: : .: ::..:::::.:.:::.::::.:.:: .:: ::... XP_016 LVS-DFDTEEKMTGGVTSE-----LPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIA 160 170 180 190 200 280 290 300 310 320 330 pF1KA0 KSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRAN-N :::: .: :.:.: : .: :::::::.:.:....:::::: :::::..::::::.. . . XP_016 KSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRG 210 220 230 240 250 260 340 350 360 370 380 390 pF1KA0 MGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLP ::::.:.::::::::..:::::.::.::::::.::..::: ::.: . : : . XP_016 EGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFE--TSTV 270 280 290 300 310 320 400 410 420 430 440 450 pF1KA0 VEDIQKRPDQTWVQCDACLKWRKLPDGMD--QLPEKWYCSNNPDPQFRNCEVPEEPE--D .. : : ::::::::: :::::::: .: .:: .:.: : :..: : :::: : : XP_016 ARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTD 330 340 350 360 370 380 460 470 480 490 500 510 pF1KA0 EDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLS ::: .:..:.. ... . .: : . ::.: . . .... XP_016 EDLC-------LSKAKKQEQTVEEKKKMPMENE---------NHQVFSNPPKILTVQEMA 390 400 410 420 520 530 540 550 560 570 pF1KA0 EGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDD : :. . . :. :. : .. .: : . . :... ..::... . :.. XP_016 -GLNNKTIGYEGIHS--PSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKWIL--GEEPV 430 440 450 460 470 480 580 590 600 610 620 630 pF1KA0 EDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQ : :. : :..:.. : . .:: . : . : :... ..:: : XP_016 EKRRRLQ-NEMTTPSLDYS--MPAPYRRVE---APVAY-----PEGENSHDKSSSERSTP 490 500 510 520 530 640 650 660 670 680 690 pF1KA0 GNTAATQTEVPSLVVKKEET---VEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADD :. . . ...:. : :. . .:: .: . ..:.. :. XP_016 PYLFPEYPEASKNTGQNREVSILYPGAKDQRQGS-LLPEELEDQMPRLVAEESNRGSTT- 540 550 560 570 580 700 710 720 730 740 750 pF1KA0 AGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETD . .:. . .... . :. . : .... : . . :. . XP_016 --INKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVASA 590 600 610 620 630 640 760 770 780 790 800 pF1KA0 AV---FLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSE :. . :. : :: : . . .. .:.:.::. :..: :: : ... XP_016 AIPAAAIGEKARGYEESEGHNTPKLKNQ-RELEELKRTTEKLERVLAE-----RNLFQQK 650 660 670 680 690 700 810 820 830 840 850 860 pF1KA0 MDEMAVQLDDVFRQLDKCSIERDQYKS-EVELLEMEKSQI---RSQCEELKTEVEQLKST ..:. . . .. : . : :.. :.: : :... ... . ::.:.:. : XP_016 VEELEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKAELERTKEE 710 720 730 740 750 760 870 880 890 900 910 920 pF1KA0 NQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDE .:. .. . . : ... .: XP_016 KQELKEKLKETETHLEMLQKAQGFGKAYAATYPRQLSPYFCPPSLGAS 770 780 790 800 >>XP_005262247 (OMIM: 300970) PREDICTED: MORC family CW- (845 aa) initn: 1212 init1: 441 opt: 1527 Z-score: 1012.4 bits: 198.5 E(85289): 1.2e-49 Smith-Waterman score: 1640; 36.5% identity (63.2% similar) in 884 aa overlap (72-931:1-839) 50 60 70 80 90 100 pF1KA0 DPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYG :: :::.::::::.::: ... :.:..: XP_005 MTPHKLHRMLSFGFTDKVIKKSQCPIGVFG 10 20 30 110 120 130 140 150 160 pF1KA0 NGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKH-RQMINLA ::::::::::::::.:::::: ...:::::::::: ..:. :.:::: ::.. ..:: XP_005 NGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMIITE 40 50 60 70 80 90 170 180 190 200 210 pF1KA0 ESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNA-TEFDFEKDKYDI .: :: :::..:.:. :. :::..::: ::::::..:::.: ::. .:.::. :.::: XP_005 DSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQYDI 100 110 120 130 140 150 220 230 240 250 260 270 pF1KA0 RIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVS . :.: : .: ::..:::::.:.:::.::::.:.:: .:: ::... XP_005 LVS-DFDTEEKMTGGVTSE-----LPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIA 160 170 180 190 200 280 290 300 310 320 330 pF1KA0 KSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRAN-N :::: .: :.:.: : .: :::::::.:.:....:::::: :::::..::::::.. . . XP_005 KSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRG 210 220 230 240 250 260 340 350 360 370 380 390 pF1KA0 MGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLP ::::.:.::::::::..:::::.::.::::::.::..::: ::.: . : : . XP_005 EGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFE--TSTV 270 280 290 300 310 320 400 410 420 430 440 450 pF1KA0 VEDIQKRPDQTWVQCDACLKWRKLPDGMD--QLPEKWYCSNNPDPQFRNCEVPEEPE--D .. : : ::::::::: :::::::: .: .:: .:.: : :..: : :::: : : XP_005 ARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTD 330 340 350 360 370 380 460 470 480 490 500 510 pF1KA0 EDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLS ::: .:..:.. ... . .: : . ::.: . . .... XP_005 EDLC-------LSKAKKQEQTVEEKKKMPMENE---------NHQVFSNPPKILTVQEMA 390 400 410 420 520 530 540 550 560 570 pF1KA0 EGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDD : :. . . :. :. : .. .: : . . :... ..::... . :.. XP_005 -GLNNKTIGYEGIHS--PSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKWIL--GEEPV 430 440 450 460 470 480 580 590 600 610 620 630 pF1KA0 EDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQ : :. : :..:. .: . .:: . : . : :... ..:: : XP_005 EKRRRLQ-NEMTTPSLDY--SMPAPYRRVE---APVAY-----PEGENSHDKSSSERSTP 490 500 510 520 530 640 650 660 670 680 690 pF1KA0 GNTAATQTEVPSLVVKKEET---VEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADD :. . . ...:. : :. . .:: .: . ..:.. :. XP_005 PYLFPEYPEASKNTGQNREVSILYPGAKDQRQGS-LLPEELEDQMPRLVAEESNRGSTT- 540 550 560 570 580 700 710 720 730 740 750 pF1KA0 AGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETD . .:. . .... . :. . : .... : . . :. . XP_005 --INKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVASA 590 600 610 620 630 640 760 770 780 790 800 pF1KA0 AV---FLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECS--QCSNNESK :. . :. : :: : . . .. .:.:.::. :..: :: . : . .: . XP_005 AIPAAAIGEKARGYEESEGHNTPKLKNQ-RELEELKRTTEKLERVLAERNLFQQKVEELE 650 660 670 680 690 700 810 820 830 840 850 860 pF1KA0 SEMDEMAVQLDDVFRQLDKCSIERDQ--YKSEVEL--LEMEKSQIRSQCEELKTEVEQLK .: .. .. : ..: : .. . : :. .. . : . .... :. : : ..:: XP_005 QERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKAELERTKEEKQELK 710 720 730 740 750 760 870 880 890 900 910 pF1KA0 STNQQTATDVSTSSNIEESVNHMDGESL-----KLRSLRVNVGQLLAMIVPDLDLQQVNY ..: : . .. . : .:..: :: ::..:. ::. ..: :.:....: XP_005 EKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVSYLLTSVLPHLELREIGY 770 780 790 800 810 820 920 930 pF1KA0 DVDVVDEILGQVVEQMSEISST : . :: :: :.: XP_005 DSEQVDGILYTVLEANHILD 830 840 939 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:01:21 2016 done: Sat Nov 5 02:01:23 2016 Total Scan time: 10.370 Total Display time: 0.340 Function used was FASTA [36.3.4 Apr, 2011]