FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0148, 681 aa 1>>>pF1KA0148 681 - 681 aa - 681 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0086+/-0.00119; mu= 7.1809+/- 0.071 mean_var=183.1308+/-37.697, 0's: 0 Z-trim(108.5): 91 B-trim: 288 in 2/49 Lambda= 0.094775 statistics sampled from 10189 (10271) to 10189 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.316), width: 16 Scan time: 3.230 The best scores are: opt bits E(32554) CCDS55884.1 GIT2 gene_id:9815|Hs108|chr12 ( 681) 4522 631.5 1.2e-180 CCDS81736.1 GIT2 gene_id:9815|Hs108|chr12 ( 708) 3300 464.4 2.5e-130 CCDS44969.1 GIT2 gene_id:9815|Hs108|chr12 ( 631) 2754 389.7 6.7e-108 CCDS81737.1 GIT2 gene_id:9815|Hs108|chr12 ( 421) 2746 388.5 1.1e-107 CCDS9139.1 GIT2 gene_id:9815|Hs108|chr12 ( 471) 2744 388.3 1.4e-107 CCDS44968.1 GIT2 gene_id:9815|Hs108|chr12 ( 729) 2744 388.4 1.9e-107 CCDS9138.1 GIT2 gene_id:9815|Hs108|chr12 ( 759) 2744 388.4 2e-107 CCDS42290.1 GIT1 gene_id:28964|Hs108|chr17 ( 770) 2238 319.2 1.4e-86 CCDS11250.1 GIT1 gene_id:28964|Hs108|chr17 ( 761) 2185 312.0 2e-84 >>CCDS55884.1 GIT2 gene_id:9815|Hs108|chr12 (681 aa) initn: 4522 init1: 4522 opt: 4522 Z-score: 3356.6 bits: 631.5 E(32554): 1.2e-180 Smith-Waterman score: 4522; 100.0% identity (100.0% similar) in 681 aa overlap (1-681:1-681) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 610 620 630 640 650 660 670 680 pF1KA0 AYDIAKAAKQLVTITTKENNN ::::::::::::::::::::: CCDS55 AYDIAKAAKQLVTITTKENNN 670 680 >>CCDS81736.1 GIT2 gene_id:9815|Hs108|chr12 (708 aa) initn: 4488 init1: 1763 opt: 3300 Z-score: 2453.4 bits: 464.4 E(32554): 2.5e-130 Smith-Waterman score: 4417; 95.4% identity (95.4% similar) in 711 aa overlap (1-681:1-708) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: CCDS81 HKNGQHFIIPQMAD---SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 420 430 440 450 460 470 490 500 510 pF1KA0 GEASRPEESRMRLQPFPAH------------------------------ASRLEKQNSTP ::::::::::::::::::: ::::::::::: CCDS81 GEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTP 480 490 500 510 520 530 520 530 540 550 560 570 pF1KA0 ESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 ESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTE 540 550 560 570 580 590 580 590 600 610 620 630 pF1KA0 QITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 QITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAY 600 610 620 630 640 650 640 650 660 670 680 pF1KA0 RLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 RLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN 660 670 680 690 700 >>CCDS44969.1 GIT2 gene_id:9815|Hs108|chr12 (631 aa) initn: 2949 init1: 1764 opt: 2754 Z-score: 2050.6 bits: 389.7 E(32554): 6.7e-108 Smith-Waterman score: 3851; 89.1% identity (90.9% similar) in 681 aa overlap (1-681:1-631) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: CCDS44 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK---- 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM : .:.: .: :: :. ...: : CCDS44 -SLDSDLSDGPVT----VQ---EFMEVKNA---------------------------LVA 420 430 490 500 510 520 530 540 pF1KA0 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP .:: ..: . .::::::::::::::::::::::::::::::::::::::::: CCDS44 SEA--------KIQQL-MKASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 440 450 460 470 480 490 550 560 570 580 590 600 pF1KA0 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 500 510 520 530 540 550 610 620 630 640 650 660 pF1KA0 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 560 570 580 590 600 610 670 680 pF1KA0 AYDIAKAAKQLVTITTKENNN ::::::::::::::::::::: CCDS44 AYDIAKAAKQLVTITTKENNN 620 630 >>CCDS81737.1 GIT2 gene_id:9815|Hs108|chr12 (421 aa) initn: 1764 init1: 1764 opt: 2746 Z-score: 2047.1 bits: 388.5 E(32554): 1.1e-107 Smith-Waterman score: 2746; 99.3% identity (99.3% similar) in 417 aa overlap (1-417:1-415) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: CCDS81 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLLGK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM CCDS81 DAN 420 >>CCDS9139.1 GIT2 gene_id:9815|Hs108|chr12 (471 aa) initn: 1764 init1: 1764 opt: 2744 Z-score: 2045.0 bits: 388.3 E(32554): 1.4e-107 Smith-Waterman score: 2744; 97.7% identity (98.6% similar) in 426 aa overlap (1-426:1-422) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: CCDS91 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: .: CCDS91 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK--SL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM .:. :. CCDS91 DSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLLGKDAN 420 430 440 450 460 470 >>CCDS44968.1 GIT2 gene_id:9815|Hs108|chr12 (729 aa) initn: 3506 init1: 1764 opt: 2744 Z-score: 2042.4 bits: 388.4 E(32554): 1.9e-107 Smith-Waterman score: 4286; 92.6% identity (92.6% similar) in 715 aa overlap (1-665:1-713) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: CCDS44 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDS 360 370 380 390 400 410 420 430 pF1KA0 ----------------------------------------------LQTLQSENSNLRKQ :::::::::::::: CCDS44 DLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQ 420 430 440 450 460 470 440 450 460 470 480 490 pF1KA0 ATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESR 480 490 500 510 520 530 500 510 520 530 540 550 pF1KA0 MRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAE 540 550 560 570 580 590 560 570 580 590 600 610 pF1KA0 PHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFP 600 610 620 630 640 650 620 630 640 650 660 670 pF1KA0 KKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQ 660 670 680 690 700 710 680 pF1KA0 LVTITTKENNN CCDS44 LVTITTKENNN 720 >>CCDS9138.1 GIT2 gene_id:9815|Hs108|chr12 (759 aa) initn: 3523 init1: 1764 opt: 2744 Z-score: 2042.1 bits: 388.4 E(32554): 2e-107 Smith-Waterman score: 4007; 88.4% identity (88.4% similar) in 715 aa overlap (1-635:1-713) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: CCDS91 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDS 360 370 380 390 400 410 420 430 pF1KA0 ----------------------------------------------LQTLQSENSNLRKQ :::::::::::::: CCDS91 DLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQ 420 430 440 450 460 470 440 450 460 470 480 490 pF1KA0 ATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 ATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESR 480 490 500 510 520 530 500 510 520 pF1KA0 MRLQPFPAH------------------------------ASRLEKQNSTPESDYDNTPND ::::::::: ::::::::::::::::::::: CCDS91 MRLQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTPND 540 550 560 570 580 590 530 540 550 560 570 580 pF1KA0 MEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 MEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELL 600 610 620 630 640 650 590 600 610 620 630 640 pF1KA0 RAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 RAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTL 660 670 680 690 700 710 650 660 670 680 pF1KA0 PGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN CCDS91 PGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN 720 730 740 750 >>CCDS42290.1 GIT1 gene_id:28964|Hs108|chr17 (770 aa) initn: 2776 init1: 1468 opt: 2238 Z-score: 1668.1 bits: 319.2 E(32554): 1.4e-86 Smith-Waterman score: 2516; 59.6% identity (72.6% similar) in 731 aa overlap (1-624:1-713) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL ::.. .:::::::.:::.:::..::...:::::::::::::::: :.::.:. ::::: CCDS42 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL ::::.:: .:::::::::::::::...:::::::::::::: :.::::::::::::::.: CCDS42 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI ::::::.::::::::::::::::::::::::::::::::::::::::.::::::.:::: CCDS42 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD ::::::.:::::::. : .:.::.:::::.::::::::::: :::::::::::::::::: CCDS42 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 pF1KA0 HKNGQHFIIPQMADRR------LSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR :::: :.:::::::: ::::::::::::::::.:::.:::::::::::::::: CCDS42 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 250 260 270 280 290 300 310 320 330 340 350 pF1KA0 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD :.:::::::::::.:::: ..:::::::::::.::::::::::::::.:::::.:::::. CCDS42 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KA0 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS :::::::.:::. ::.:: :.. .:. .:: :::::::::::: : : :. CCDS42 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 360 370 380 390 400 410 420 430 440 450 pF1KA0 KTNRQKLQ----------TLQSENSNLRKQATTNVYQVQ----TGSEYTDTSN------H ..:: . . ::: : .:.: .:. .:: ..: .: : CCDS42 RSNRARSMDSSDLSDGAVTLQ-EYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIH 420 430 440 450 460 470 460 470 pF1KA0 S----SLKRR-----------PSARGSR-PM--------------SMYETGSGQKPYL-P . .:. : :: :. . :: :::: ::. ::. : CCDS42 KLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGP 480 490 500 510 520 530 480 490 pF1KA0 MGEASRPEESRMRLQPF---------------PA-------------------------- :. : ::::: :: CCDS42 PGD-----ELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCS 540 550 560 570 580 500 510 520 530 540 550 pF1KA0 -----HASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHV :.:.: ...: .:::.:: . :. .:.. . . . :. CCDS42 QEGSRHTSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDG 590 600 610 620 630 640 560 570 580 590 600 610 pF1KA0 APSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKP .: :::::::: ::::.::::::::::::: ::::..::::.::.::::::.::::.: CCDS42 DLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRP 650 660 670 680 690 700 620 630 640 650 660 670 pF1KA0 KSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVT . ::.:::: CCDS42 ALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVT 710 720 730 740 750 760 >>CCDS11250.1 GIT1 gene_id:28964|Hs108|chr17 (761 aa) initn: 2776 init1: 1468 opt: 2185 Z-score: 1629.0 bits: 312.0 E(32554): 2e-84 Smith-Waterman score: 2561; 60.2% identity (73.4% similar) in 734 aa overlap (1-633:1-713) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL ::.. .:::::::.:::.:::..::...:::::::::::::::: :.::.:. ::::: CCDS11 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL ::::.:: .:::::::::::::::...:::::::::::::: :.::::::::::::::.: CCDS11 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI ::::::.::::::::::::::::::::::::::::::::::::::::.::::::.:::: CCDS11 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD ::::::.:::::::. : .:.::.:::::.::::::::::: :::::::::::::::::: CCDS11 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::: :.::::::: ::::::::::::::::.:::.:::::::::::::::::.:::: CCDS11 HKNG-HYIIPQMAD---SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::.:::: ..:::::::::::.::::::::::::::.:::::.:::::.:::::: CCDS11 LATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNRQK :.:::. ::.:: :.. .:. .:: :::::::::::: : : :...:: . CCDS11 GKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRAR 360 370 380 390 400 420 430 440 450 pF1KA0 LQ----------TLQSENSNLRKQATTNVYQVQ----TGSEYTDTSN------HS----S . ::: : .:.: .:. .:: ..: .: :. . CCDS11 SMDSSDLSDGAVTLQ-EYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAEN 410 420 430 440 450 460 460 470 480 pF1KA0 LKRR-----------PSARGSR-PM--------------SMYETGSGQKPYL-PMGEASR :. : :: :. . :: :::: ::. ::. : :. CCDS11 LQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGD--- 470 480 490 500 510 520 490 pF1KA0 PEESRMRLQPF---------------PA-------------------------------H : ::::: :: : CCDS11 --ELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRH 530 540 550 560 570 580 500 510 520 530 540 550 pF1KA0 ASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTL .:.: ...: .:::.:: . :. .:.. . . . :. .: : CCDS11 TSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPGL 590 600 610 620 630 560 570 580 590 600 610 pF1KA0 PSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVR ::::::: ::::.::::::::::::: ::::..::::.::.::::::.::::.: . :: CCDS11 PSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVR 640 650 660 670 680 690 620 630 640 650 660 670 pF1KA0 TSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKEN .:::::..:::::: CCDS11 SSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREK 700 710 720 730 740 750 681 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:15:42 2016 done: Wed Nov 2 18:15:43 2016 Total Scan time: 3.230 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]