FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0148, 681 aa 1>>>pF1KA0148 681 - 681 aa - 681 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.0678+/-0.000513; mu= 0.9740+/- 0.032 mean_var=238.2631+/-49.927, 0's: 0 Z-trim(115.9): 173 B-trim: 352 in 2/48 Lambda= 0.083089 statistics sampled from 26509 (26724) to 26509 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.313), width: 16 Scan time: 8.930 The best scores are: opt bits E(85289) NP_001128685 (OMIM: 608564) ARF GTPase-activating ( 681) 4522 556.2 1.5e-157 NP_055591 (OMIM: 608564) ARF GTPase-activating pro ( 679) 4488 552.1 2.5e-156 XP_006719772 (OMIM: 608564) PREDICTED: ARF GTPase- ( 709) 3301 409.8 1.7e-113 NP_001317082 (OMIM: 608564) ARF GTPase-activating ( 708) 3300 409.7 1.9e-113 XP_006719775 (OMIM: 608564) PREDICTED: ARF GTPase- ( 596) 2759 344.8 5.5e-94 NP_476511 (OMIM: 608564) ARF GTPase-activating pro ( 631) 2754 344.2 8.8e-94 NP_001317083 (OMIM: 608564) ARF GTPase-activating ( 421) 2746 343.1 1.3e-93 XP_006719776 (OMIM: 608564) PREDICTED: ARF GTPase- ( 456) 2744 342.9 1.6e-93 NP_631940 (OMIM: 608564) ARF GTPase-activating pro ( 471) 2744 342.9 1.6e-93 XP_016875750 (OMIM: 608564) PREDICTED: ARF GTPase- ( 470) 2743 342.8 1.7e-93 XP_006719771 (OMIM: 608564) PREDICTED: ARF GTPase- ( 714) 2746 343.3 1.9e-93 XP_016875747 (OMIM: 608564) PREDICTED: ARF GTPase- ( 713) 2745 343.2 2e-93 XP_016875749 (OMIM: 608564) PREDICTED: ARF GTPase- ( 664) 2744 343.0 2.1e-93 XP_016875748 (OMIM: 608564) PREDICTED: ARF GTPase- ( 694) 2744 343.1 2.2e-93 NP_001128686 (OMIM: 608564) ARF GTPase-activating ( 729) 2744 343.1 2.2e-93 XP_006719770 (OMIM: 608564) PREDICTED: ARF GTPase- ( 744) 2744 343.1 2.3e-93 NP_476510 (OMIM: 608564) ARF GTPase-activating pro ( 759) 2744 343.1 2.3e-93 XP_005254054 (OMIM: 608564) PREDICTED: ARF GTPase- ( 758) 2743 343.0 2.5e-93 NP_001078923 (OMIM: 608434) ARF GTPase-activating ( 770) 2238 282.4 4.2e-75 XP_011522986 (OMIM: 608434) PREDICTED: ARF GTPase- ( 777) 2238 282.4 4.3e-75 NP_054749 (OMIM: 608434) ARF GTPase-activating pro ( 761) 2185 276.1 3.4e-73 XP_011522987 (OMIM: 608434) PREDICTED: ARF GTPase- ( 768) 2185 276.1 3.5e-73 XP_016867224 (OMIM: 616813) PREDICTED: arf-GAP wit ( 462) 333 53.9 1.6e-06 XP_016867222 (OMIM: 616813) PREDICTED: arf-GAP wit ( 527) 333 53.9 1.8e-06 XP_005250000 (OMIM: 616813) PREDICTED: arf-GAP wit ( 565) 333 54.0 1.9e-06 NP_001268229 (OMIM: 616813) arf-GAP with GTPase, A ( 580) 333 54.0 1.9e-06 XP_016867223 (OMIM: 616813) PREDICTED: arf-GAP wit ( 580) 333 54.0 1.9e-06 XP_016867221 (OMIM: 616813) PREDICTED: arf-GAP wit ( 630) 333 54.0 2e-06 XP_011514082 (OMIM: 616813) PREDICTED: arf-GAP wit ( 683) 333 54.0 2.1e-06 NP_114152 (OMIM: 616813) arf-GAP with GTPase, ANK ( 911) 333 54.1 2.7e-06 NP_055729 (OMIM: 608651) arf-GAP with GTPase, ANK ( 804) 317 52.2 9.1e-06 XP_005246116 (OMIM: 608651) PREDICTED: arf-GAP wit ( 808) 317 52.2 9.2e-06 NP_001032208 (OMIM: 608651) arf-GAP with GTPase, A ( 857) 317 52.2 9.6e-06 XP_006712298 (OMIM: 608651) PREDICTED: arf-GAP wit ( 882) 317 52.2 9.8e-06 XP_006712297 (OMIM: 608651) PREDICTED: arf-GAP wit ( 886) 317 52.2 9.8e-06 XP_011508851 (OMIM: 608651) PREDICTED: arf-GAP wit (1073) 317 52.3 1.1e-05 XP_011508850 (OMIM: 608651) PREDICTED: arf-GAP wit (1098) 317 52.3 1.2e-05 XP_016858771 (OMIM: 608651) PREDICTED: arf-GAP wit (1106) 317 52.3 1.2e-05 XP_011508849 (OMIM: 608651) PREDICTED: arf-GAP wit (1126) 317 52.3 1.2e-05 XP_006712300 (OMIM: 608651) PREDICTED: arf-GAP wit (1147) 317 52.3 1.2e-05 XP_006712302 (OMIM: 608651) PREDICTED: arf-GAP wit (1151) 317 52.3 1.2e-05 NP_055585 (OMIM: 605476) arf-GAP with GTPase, ANK ( 836) 302 50.4 3.3e-05 XP_005268683 (OMIM: 605476) PREDICTED: arf-GAP wit ( 856) 302 50.4 3.3e-05 XP_005268682 (OMIM: 605476) PREDICTED: arf-GAP wit (1172) 302 50.5 4.2e-05 XP_016874261 (OMIM: 605476) PREDICTED: arf-GAP wit (1192) 302 50.5 4.3e-05 NP_001116244 (OMIM: 605476) arf-GAP with GTPase, A (1192) 302 50.5 4.3e-05 XP_011510907 (OMIM: 607766) PREDICTED: arf-GAP wit ( 776) 265 45.9 0.00067 XP_011510908 (OMIM: 607766) PREDICTED: arf-GAP wit ( 776) 265 45.9 0.00067 XP_011510906 (OMIM: 607766) PREDICTED: arf-GAP wit ( 776) 265 45.9 0.00067 NP_036419 (OMIM: 607766) arf-GAP with coiled-coil, ( 778) 265 45.9 0.00067 >>NP_001128685 (OMIM: 608564) ARF GTPase-activating prot (681 aa) initn: 4522 init1: 4522 opt: 4522 Z-score: 2949.7 bits: 556.2 E(85289): 1.5e-157 Smith-Waterman score: 4522; 100.0% identity (100.0% similar) in 681 aa overlap (1-681:1-681) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 610 620 630 640 650 660 670 680 pF1KA0 AYDIAKAAKQLVTITTKENNN ::::::::::::::::::::: NP_001 AYDIAKAAKQLVTITTKENNN 670 680 >>NP_055591 (OMIM: 608564) ARF GTPase-activating protein (679 aa) initn: 2747 init1: 2747 opt: 4488 Z-score: 2927.6 bits: 552.1 E(85289): 2.5e-156 Smith-Waterman score: 4488; 99.6% identity (99.6% similar) in 681 aa overlap (1-681:1-679) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_055 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 420 430 440 450 460 470 490 500 510 520 530 540 pF1KA0 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 480 490 500 510 520 530 550 560 570 580 590 600 pF1KA0 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 540 550 560 570 580 590 610 620 630 640 650 660 pF1KA0 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 600 610 620 630 640 650 670 680 pF1KA0 AYDIAKAAKQLVTITTKENNN ::::::::::::::::::::: NP_055 AYDIAKAAKQLVTITTKENNN 660 670 >>XP_006719772 (OMIM: 608564) PREDICTED: ARF GTPase-acti (709 aa) initn: 4489 init1: 1764 opt: 3301 Z-score: 2158.4 bits: 409.8 E(85289): 1.7e-113 Smith-Waterman score: 4418; 95.4% identity (95.4% similar) in 711 aa overlap (1-681:1-709) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_006 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 420 430 440 450 460 470 490 500 510 pF1KA0 GEASRPEESRMRLQPFPAH------------------------------ASRLEKQNSTP ::::::::::::::::::: ::::::::::: XP_006 GEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTP 480 490 500 510 520 530 520 530 540 550 560 570 pF1KA0 ESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTE 540 550 560 570 580 590 580 590 600 610 620 630 pF1KA0 QITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAY 600 610 620 630 640 650 640 650 660 670 680 pF1KA0 RLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN 660 670 680 690 700 >>NP_001317082 (OMIM: 608564) ARF GTPase-activating prot (708 aa) initn: 4488 init1: 1763 opt: 3300 Z-score: 2157.8 bits: 409.7 E(85289): 1.9e-113 Smith-Waterman score: 4417; 95.4% identity (95.4% similar) in 711 aa overlap (1-681:1-708) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_001 HKNGQHFIIPQMAD---SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 420 430 440 450 460 470 490 500 510 pF1KA0 GEASRPEESRMRLQPFPAH------------------------------ASRLEKQNSTP ::::::::::::::::::: ::::::::::: NP_001 GEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTP 480 490 500 510 520 530 520 530 540 550 560 570 pF1KA0 ESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTE 540 550 560 570 580 590 580 590 600 610 620 630 pF1KA0 QITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAY 600 610 620 630 640 650 640 650 660 670 680 pF1KA0 RLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN 660 670 680 690 700 >>XP_006719775 (OMIM: 608564) PREDICTED: ARF GTPase-acti (596 aa) initn: 2949 init1: 1764 opt: 2759 Z-score: 1808.3 bits: 344.8 E(85289): 5.5e-94 Smith-Waterman score: 3764; 87.4% identity (87.4% similar) in 681 aa overlap (1-681:1-596) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_006 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK---- 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM XP_006 ------------------------------------------------------------ 490 500 510 520 530 540 pF1KA0 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP ::::::::::::::::::::::::::::::::::::::::: XP_006 -------------------ASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 420 430 440 450 550 560 570 580 590 600 pF1KA0 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 460 470 480 490 500 510 610 620 630 640 650 660 pF1KA0 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 520 530 540 550 560 570 670 680 pF1KA0 AYDIAKAAKQLVTITTKENNN ::::::::::::::::::::: XP_006 AYDIAKAAKQLVTITTKENNN 580 590 >>NP_476511 (OMIM: 608564) ARF GTPase-activating protein (631 aa) initn: 2949 init1: 1764 opt: 2754 Z-score: 1804.7 bits: 344.2 E(85289): 8.8e-94 Smith-Waterman score: 3851; 89.1% identity (90.9% similar) in 681 aa overlap (1-681:1-631) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_476 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK---- 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM : .:.: .: :: :. ...: : NP_476 -SLDSDLSDGPVT----VQ---EFMEVKNA---------------------------LVA 420 430 490 500 510 520 530 540 pF1KA0 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP .:: ..: . .::::::::::::::::::::::::::::::::::::::::: NP_476 SEA--------KIQQL-MKASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 440 450 460 470 480 490 550 560 570 580 590 600 pF1KA0 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 500 510 520 530 540 550 610 620 630 640 650 660 pF1KA0 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 560 570 580 590 600 610 670 680 pF1KA0 AYDIAKAAKQLVTITTKENNN ::::::::::::::::::::: NP_476 AYDIAKAAKQLVTITTKENNN 620 630 >>NP_001317083 (OMIM: 608564) ARF GTPase-activating prot (421 aa) initn: 1764 init1: 1764 opt: 2746 Z-score: 1801.9 bits: 343.1 E(85289): 1.3e-93 Smith-Waterman score: 2746; 99.3% identity (99.3% similar) in 417 aa overlap (1-417:1-415) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_001 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLLGK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM NP_001 DAN 420 >>XP_006719776 (OMIM: 608564) PREDICTED: ARF GTPase-acti (456 aa) initn: 1764 init1: 1764 opt: 2744 Z-score: 1800.1 bits: 342.9 E(85289): 1.6e-93 Smith-Waterman score: 2744; 97.7% identity (98.6% similar) in 426 aa overlap (1-426:1-422) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_006 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: .: XP_006 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK--SL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM .:. :. XP_006 DSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKLLGKDAN 420 430 440 450 >>NP_631940 (OMIM: 608564) ARF GTPase-activating protein (471 aa) initn: 1764 init1: 1764 opt: 2744 Z-score: 1799.9 bits: 342.9 E(85289): 1.6e-93 Smith-Waterman score: 2744; 97.7% identity (98.6% similar) in 426 aa overlap (1-426:1-422) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_631 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: .: NP_631 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK--SL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM .:. :. NP_631 DSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLLGKDAN 420 430 440 450 460 470 >>XP_016875750 (OMIM: 608564) PREDICTED: ARF GTPase-acti (470 aa) initn: 1760 init1: 1760 opt: 2743 Z-score: 1799.3 bits: 342.8 E(85289): 1.7e-93 Smith-Waterman score: 2743; 97.7% identity (98.6% similar) in 426 aa overlap (1-426:1-421) 10 20 30 40 50 60 pF1KA0 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_016 HKNGQHFIIPQMAD---SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: .: XP_016 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK--SL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM .:. :. XP_016 DSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLLGKDAN 420 430 440 450 460 470 681 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:15:43 2016 done: Wed Nov 2 18:15:44 2016 Total Scan time: 8.930 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]