FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0151, 716 aa 1>>>pF1KA0151 716 - 716 aa - 716 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.1536+/-0.00133; mu= 1.2777+/- 0.076 mean_var=329.5672+/-77.014, 0's: 0 Z-trim(107.7): 426 B-trim: 0 in 0/51 Lambda= 0.070648 statistics sampled from 9230 (9721) to 9230 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.299), width: 16 Scan time: 2.700 The best scores are: opt bits E(32554) CCDS30996.1 IKBKE gene_id:9641|Hs108|chr1 ( 716) 4690 493.3 5.3e-139 CCDS73019.1 IKBKE gene_id:9641|Hs108|chr1 ( 657) 4207 444.0 3.3e-124 CCDS53464.1 IKBKE gene_id:9641|Hs108|chr1 ( 631) 4154 438.6 1.4e-122 CCDS8968.1 TBK1 gene_id:29110|Hs108|chr12 ( 729) 1981 217.2 7e-56 >>CCDS30996.1 IKBKE gene_id:9641|Hs108|chr1 (716 aa) initn: 4690 init1: 4690 opt: 4690 Z-score: 2609.0 bits: 493.3 E(32554): 5.3e-139 Smith-Waterman score: 4690; 100.0% identity (100.0% similar) in 716 aa overlap (1-716:1-716) 10 20 30 40 50 60 pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG 610 620 630 640 650 660 670 680 690 700 710 pF1KA0 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV 670 680 690 700 710 >>CCDS73019.1 IKBKE gene_id:9641|Hs108|chr1 (657 aa) initn: 4207 init1: 4207 opt: 4207 Z-score: 2343.4 bits: 444.0 E(32554): 3.3e-124 Smith-Waterman score: 4207; 100.0% identity (100.0% similar) in 644 aa overlap (1-644:1-644) 10 20 30 40 50 60 pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG :::::::::::::::::::::::::::::::::::::::::::: CCDS73 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKHARALRGDEAAGI 610 620 630 640 650 670 680 690 700 710 pF1KA0 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV >>CCDS53464.1 IKBKE gene_id:9641|Hs108|chr1 (631 aa) initn: 4154 init1: 4154 opt: 4154 Z-score: 2314.4 bits: 438.6 E(32554): 1.4e-122 Smith-Waterman score: 4154; 100.0% identity (100.0% similar) in 631 aa overlap (86-716:1-631) 60 70 80 90 100 110 pF1KA0 FEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVV :::::::::::::::::::::::::::::: CCDS53 MEYCSSGSLLSVLESPENAFGLPEDEFLVV 10 20 30 120 130 140 150 160 170 pF1KA0 LRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYG 40 50 60 70 80 90 180 190 200 210 220 230 pF1KA0 TEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 TEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMY 100 110 120 130 140 150 240 250 260 270 280 290 pF1KA0 RITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGF 160 170 180 190 200 210 300 310 320 330 340 350 pF1KA0 DQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFE 220 230 240 250 260 270 360 370 380 390 400 410 pF1KA0 GHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 GHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTA 280 290 300 310 320 330 420 430 440 450 460 470 pF1KA0 KGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 KGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTE 340 350 360 370 380 390 480 490 500 510 520 530 pF1KA0 RFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVH 400 410 420 430 440 450 540 550 560 570 580 590 pF1KA0 EDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 EDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEE 460 470 480 490 500 510 600 610 620 630 640 650 pF1KA0 CVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 CVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQ 520 530 540 550 560 570 660 670 680 690 700 710 pF1KA0 DRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPD 580 590 600 610 620 630 pF1KA0 V : CCDS53 V >>CCDS8968.1 TBK1 gene_id:29110|Hs108|chr12 (729 aa) initn: 2148 init1: 1951 opt: 1981 Z-score: 1116.7 bits: 217.2 E(32554): 7e-56 Smith-Waterman score: 2222; 49.3% identity (74.9% similar) in 718 aa overlap (1-707:1-714) 10 20 30 40 50 60 pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR ::::.:.:: .:.:::::::.:...:.::.:.: :.::::. :.::: .::.::::::. CCDS89 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV ::::.:::::::.:: .:.:::.::.: ::: .::: : ::.::::.:::.::: :: CCDS89 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL .::::::::::::::::::::::..::.:::.::::::::::::.:::.:::.::::::: CCDS89 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE :::::::::::: .:: .:.::::::::::.:::::::::: :: :::::::.::.: : CCDS89 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA ::.:::.:.:. ::::..:: .:..:.:: ::: :.:.::::::..: :::::::::: CCDS89 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV ::::::.:.:.:::::.: . :.::::..:: .::.: :.:::.. .:: ..::. : CCDS89 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG :::. :::. .:: .:. . : . ... ...:: :. ::..: . ::.. : CCDS89 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 370 380 390 400 410 420 430 440 450 460 470 pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQ----ATCRRTLEVARTSLLYLSSSLGT-- . : :.: .:: :::: .:..:..:... : .. ::. : . . . : CCDS89 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 430 440 450 460 470 480 480 490 500 510 520 pF1KA0 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK :.. .. . : :: ......: :. . .. . . :: :: .. CCDS89 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH 490 500 510 520 530 530 540 550 560 570 580 pF1KA0 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL .. .::.....: :. :. :: ::::.. . :.::::::::.:: .. . : . . CCDS89 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM 540 550 560 570 580 590 590 600 610 620 630 640 pF1KA0 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL : .:::.::.: : . .: . . :..: . . . :.. :: ..: : : CCDS89 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL 600 610 620 630 640 650 650 660 670 680 690 700 pF1KA0 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNR .... ..: . . :: : : : .. : :..: : :. ....: .::.:.::. CCDS89 PQKMFTA-SSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGS 660 670 680 690 700 710 710 pF1KA0 VPAPPDV CCDS89 LTMDGGLRNVDCL 720 716 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:16:25 2016 done: Wed Nov 2 18:16:26 2016 Total Scan time: 2.700 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]