FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0179, 740 aa 1>>>pF1KA0179 740 - 740 aa - 740 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6743+/-0.000417; mu= -4.6861+/- 0.026 mean_var=300.3129+/-60.248, 0's: 0 Z-trim(120.9): 37 B-trim: 35 in 1/55 Lambda= 0.074009 statistics sampled from 36615 (36664) to 36615 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.753), E-opt: 0.2 (0.43), width: 16 Scan time: 12.220 The best scores are: opt bits E(85289) NP_055871 (OMIM: 610654) ribosomal RNA processing ( 758) 4560 501.0 7.4e-141 NP_003674 (OMIM: 610653) ribosomal RNA processing ( 461) 984 119.0 4.4e-26 XP_016883974 (OMIM: 610653) PREDICTED: ribosomal R ( 415) 963 116.7 1.9e-25 XP_016883975 (OMIM: 610653) PREDICTED: ribosomal R ( 311) 609 78.8 3.6e-14 >>NP_055871 (OMIM: 610654) ribosomal RNA processing prot (758 aa) initn: 4560 init1: 4560 opt: 4560 Z-score: 2649.8 bits: 501.0 E(85289): 7.4e-141 Smith-Waterman score: 4825; 97.5% identity (97.5% similar) in 758 aa overlap (1-740:1-758) 10 20 30 40 50 pF1KA0 MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELL-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELLKIWKGLFY 10 20 30 40 50 60 60 70 80 90 100 pF1KA0 ----------QEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYML :::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CMWVQDEPLLQEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYML 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA0 IRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKVG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA0 GKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKVG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA0 DGDLSAEEIPENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DGDLSAEEIPENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDY 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA0 KAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQILSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQILSQ 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA0 GKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPGGAA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA0 PSLEQNRGREPEASGPKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRKRPRKKSP ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_055 PSLEQNRGREPEASGLKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRKRPRKKSP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA0 RAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTP 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA0 AWPPLQQEGPPTGPAEGANSHTTLPQRRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AWPPLQQEGPPTGPAEGANSHTTLPQRRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMR 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA0 VMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQKLRAESDFVKFDTPFLPKPLFFRRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQKLRAESDFVKFDTPFLPKPLFFRRAK 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA0 SSTATHPPGPAVQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGPSRVAFDPEQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SSTATHPPGPAVQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGPSRVAFDPEQK 670 680 690 700 710 720 710 720 730 740 pF1KA0 PLHGVLKTPTSSPASSPLVAKKPLTTTPRRRPRAMDFF :::::::::::::::::::::::::::::::::::::: NP_055 PLHGVLKTPTSSPASSPLVAKKPLTTTPRRRPRAMDFF 730 740 750 >>NP_003674 (OMIM: 610653) ribosomal RNA processing prot (461 aa) initn: 986 init1: 745 opt: 984 Z-score: 589.3 bits: 119.0 E(85289): 4.4e-26 Smith-Waterman score: 1156; 43.4% identity (70.6% similar) in 472 aa overlap (7-456:8-459) 10 20 30 40 50 pF1KA0 MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELL------- : :::.:::::..:. :::::.:::.:: ..::: .:::...::: NP_003 MVSRVQLPPEIQLAQRLAGNEQVTRDRAVRKLRKYIVARTQRAAGGFTHDELLKVWKGLF 10 20 30 40 50 60 60 70 80 90 100 pF1KA0 -----------QEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYM ::::. ::.::::: ... :::::.:.::::::::: :::::::::.:: NP_003 YCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQTMNREWTGIDRLRLDKFYM 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA0 LIRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKV :.:.:: .:..::: .:::: .:. .:..:: :.: : ::.::::. :::.:.:.::.:: NP_003 LMRMVLNESLKVLKMQGWEERQIEELLELLMTEILHPSSQAPNGVKSHFIEIFLEELTKV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA0 GGKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKV :..:: ::::::::::::.:::.::: ....:.::.::.::.:.:.. :. ..: :. NP_003 GAEELTADQNLKFIDPFCRIAARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQ- 190 200 210 220 230 230 240 250 260 270 pF1KA0 GDGDLSAEEIPENEVSLR-RAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTG-PLLQ : ..... .: . : :.:.:.. : . : :... : .:.: :.:: NP_003 -DEEVASDSDESSEGGERGDALSQKRSEKPPAGSICRA-EPEAGEEQAGDDRDSGGPVLQ 240 250 260 270 280 290 280 290 300 310 320 330 pF1KA0 FDYKAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQI :::.:::.::.::.::..:: ::::: :.:.:.:::. : : :: .. . NP_003 FDYEAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGI------FPEDEIPEKACRR 300 310 320 330 340 350 340 350 360 370 380 390 pF1KA0 LSQGKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPG : .:...:: .: . :..:.:. :.. : ..:.:.... .:: . . NP_003 LLEGRRQKKTKKQKRLLRLQQERGKG-----EKEPPSPGMERKRSRRRGVGADPEARAEA 360 370 380 390 400 400 410 420 430 440 450 pF1KA0 GAAP-SLEQNRGRE-PEASGPKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRKRP : : . :. :. :.. : .. . : : ::. .. .. ..: ..:.:: NP_003 GEQPGTAERALLRDQPRGRGQRGARQRRRTP-RPLTSARAKAANVQEP-----EKKKKRR 410 420 430 440 450 460 460 470 480 490 500 510 pF1KA0 RKKSPRAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGS NP_003 E >>XP_016883974 (OMIM: 610653) PREDICTED: ribosomal RNA p (415 aa) initn: 1139 init1: 745 opt: 963 Z-score: 577.9 bits: 116.7 E(85289): 1.9e-25 Smith-Waterman score: 1100; 48.9% identity (74.7% similar) in 376 aa overlap (7-362:8-374) 10 20 30 40 50 pF1KA0 MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELL------- : :::.:::::..:. :::::.:::.:: ..::: .:::...::: XP_016 MVSRVQLPPEIQLAQRLAGNEQVTRDRAVRKLRKYIVARTQRAAGGFTHDELLKVWKGLF 10 20 30 40 50 60 60 70 80 90 100 pF1KA0 -----------QEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYM ::::. ::.::::: ... :::::.:.::::::::: :::::::::.:: XP_016 YCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQTMNREWTGIDRLRLDKFYM 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA0 LIRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKV :.:.:: .:..::: .:::: .:. .:..:: :.: : ::.::::. :::.:.:.::.:: XP_016 LMRMVLNESLKVLKMQGWEERQIEELLELLMTEILHPSSQAPNGVKSHFIEIFLEELTKV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA0 GGKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKV :..:: ::::::::::::.:::.::: ....:.::.::.::.:.:.. :. ..: :. XP_016 GAEELTADQNLKFIDPFCRIAARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQ- 190 200 210 220 230 230 240 250 260 270 pF1KA0 GDGDLSAEEIPENEVSLR-RAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTG-PLLQ : ..... .: . : :.:.:.. : . : :... : .:.: :.:: XP_016 -DEEVASDSDESSEGGERGDALSQKRSEKPPAGSICRA-EPEAGEEQAGDDRDSGGPVLQ 240 250 260 270 280 290 280 290 300 310 320 330 pF1KA0 FDYKAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQI :::.:::.::.::.::..:: ::::: :.:.:.:::. : : :: .. . XP_016 FDYEAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGI------FPEDEIPEKACRR 300 310 320 330 340 350 340 350 360 370 380 390 pF1KA0 LSQGKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPG : .:...:: .: . :..:. XP_016 LLEGRRQKKTKKQKRLLRLQQERALAEVLSRVDGAWRPHWTRDASGWLLWPCCPPRSVVL 360 370 380 390 400 410 >>XP_016883975 (OMIM: 610653) PREDICTED: ribosomal RNA p (311 aa) initn: 634 init1: 370 opt: 609 Z-score: 375.4 bits: 78.8 E(85289): 3.6e-14 Smith-Waterman score: 644; 37.8% identity (67.1% similar) in 331 aa overlap (132-456:1-309) 110 120 130 140 150 160 pF1KA0 LIRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKV : :.: : ::.::::. :::.:.:.::.:: XP_016 MTEILHPSSQAPNGVKSHFIEIFLEELTKV 10 20 30 170 180 190 200 210 220 pF1KA0 GGKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKV :..:: ::::::::::::.:::.::: ....:.::.::.::.:.:.. :. ..: :. XP_016 GAEELTADQNLKFIDPFCRIAARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQ- 40 50 60 70 80 230 240 250 260 270 pF1KA0 GDGDLSAEEIPENEVSLR-RAVSKKKTALGKNHS--RKDGLSDERGRDDCGTFEDTG-PL : ..... .: . : :.:.:.. : : . : :... : .:.: :. XP_016 -DEEVASDSDESSEGGERGDALSQKRSEKPPAGSICRAE---PEAGEEQAGDDRDSGGPV 90 100 110 120 130 140 280 290 300 310 320 330 pF1KA0 LQFDYKAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDD :::::.:::.::.::.::..:: ::::: :.:.:.:::. : : :: .. XP_016 LQFDYEAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGI------FPEDEIPEKAC 150 160 170 180 190 340 350 360 370 380 390 pF1KA0 QILSQGKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPG . : .:...:: .: . :..:.:. :.. : ..:.:.... .:: . XP_016 RRLLEGRRQKKTKKQKRLLRLQQERGKG-----EKEPPSPGMERKRSRRRGVGADPEARA 200 210 220 230 240 250 400 410 420 430 440 450 pF1KA0 PGGAAP-SLEQNRGRE-PEASGPKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRK .: : . :. :. :.. : .. . : : ::. .. .. ..: ..:.: XP_016 EAGEQPGTAERALLRDQPRGRGQRGARQRRRTP-RPLTSARAKAANVQEP-----EKKKK 260 270 280 290 300 460 470 480 490 500 510 pF1KA0 RPRKKSPRAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVN : XP_016 RRE 310 740 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 09:10:05 2016 done: Thu Nov 3 09:10:07 2016 Total Scan time: 12.220 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]