Result of FASTA (omim) for
pF1KA0182
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0182, 1144 aa
1>>>pF1KA0182 1144 - 1144 aa - 1144 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.4918+/-0.000392; mu= 3.1207+/- 0.025
mean_var=418.5234+/-85.061, 0's: 0 Z-trim(124.6): 128 B-trim: 1301 in 1/60
Lambda= 0.062692
statistics sampled from 46537 (46723) to 46537 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.548), width: 16
Scan time: 21.010
The best scores are: opt bits E(85289)
NP_001265113 (OMIM: 616886) genetic suppressor ele (1144) 7709 712.3 4.2e-204
XP_016878572 (OMIM: 616886) PREDICTED: genetic sup (1214) 7699 711.4 8.2e-204
XP_011521268 (OMIM: 616886) PREDICTED: genetic sup (1214) 7699 711.4 8.2e-204
NP_055430 (OMIM: 616886) genetic suppressor elemen (1217) 7699 711.4 8.2e-204
XP_005255921 (OMIM: 616886) PREDICTED: genetic sup (1227) 7699 711.4 8.2e-204
XP_005255920 (OMIM: 616886) PREDICTED: genetic sup (1229) 7699 711.4 8.2e-204
XP_011521267 (OMIM: 616886) PREDICTED: genetic sup (1253) 7699 711.4 8.3e-204
XP_005255922 (OMIM: 616886) PREDICTED: genetic sup (1154) 7698 711.3 8.4e-204
XP_005255916 (OMIM: 616886) PREDICTED: genetic sup (1925) 7699 711.7 1.1e-203
XP_005255918 (OMIM: 616886) PREDICTED: genetic sup (1852) 7696 711.4 1.3e-203
NP_001127945 (OMIM: 616886) genetic suppressor ele (1113) 7512 694.5 9.5e-199
XP_005255917 (OMIM: 616886) PREDICTED: genetic sup (1887) 5511 513.8 4.1e-144
>>NP_001265113 (OMIM: 616886) genetic suppressor element (1144 aa)
initn: 7709 init1: 7709 opt: 7709 Z-score: 3785.3 bits: 712.3 E(85289): 4.2e-204
Smith-Waterman score: 7709; 99.9% identity (100.0% similar) in 1144 aa overlap (1-1144:1-1144)
10 20 30 40 50 60
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTPYPFGLSPSSVVQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTPYPFGLSPSSVVQD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 SRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLGLDPATAAAYYHPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLGLDPATAAAYYHPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 YLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKEREREREKEREQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKEREREREKEREQEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 EREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGHATEERGKPSEQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGHATEERGKPSEQLT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 PTRAEKLKDASLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSSSAATALLIQRTNE
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTRAEKLKDAGLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSSSAATALLIQRTNE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEHRPESTTRPGPNRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEHRPESTTRPGPNRH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 EPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRAESHSLHSHPAAFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRAESHSLHSHPAAFE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 PSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGGSLEHQPFLPGPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGGSLEHQPFLPGPGP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 FLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAPDPAYIYDEFLQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAPDPAYIYDEFLQQR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 RRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 EFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPSPRLALSTRYSPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPSPRLALSTRYSPDE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 MNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSAAVADSLTNSPRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSAAVADSLTNSPRDS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 PAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQELSRVQELAPASGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQELSRVQELAPASGEK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 ARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVAEEFAHQFHESVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVAEEFAHQFHESVLQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 STQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHNGQQEPPTARKGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHNGQQEPPTARKGPP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 TQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQNLERQVLQTQCRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQNLERQVLQTQCRR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 LEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCLALPAMHWPRGYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCLALPAMHWPRGYLK
1090 1100 1110 1120 1130 1140
pF1KA0 GYPR
::::
NP_001 GYPR
>>XP_016878572 (OMIM: 616886) PREDICTED: genetic suppres (1214 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 3780.1 bits: 711.4 E(85289): 8.2e-204
Smith-Waterman score: 7699; 99.8% identity (100.0% similar) in 1143 aa overlap (2-1144:72-1214)
10 20 30
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVP
.:::::::::::::::::::::::::::::
XP_016 ATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVP
50 60 70 80 90 100
40 50 60 70 80 90
pF1KA0 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
110 120 130 140 150 160
100 110 120 130 140 150
pF1KA0 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
170 180 190 200 210 220
160 170 180 190 200 210
pF1KA0 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
230 240 250 260 270 280
220 230 240 250 260 270
pF1KA0 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
290 300 310 320 330 340
280 290 300 310 320 330
pF1KA0 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
350 360 370 380 390 400
340 350 360 370 380 390
pF1KA0 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHT
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_016 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHT
410 420 430 440 450 460
400 410 420 430 440 450
pF1KA0 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
470 480 490 500 510 520
460 470 480 490 500 510
pF1KA0 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
530 540 550 560 570 580
520 530 540 550 560 570
pF1KA0 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
590 600 610 620 630 640
580 590 600 610 620 630
pF1KA0 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
650 660 670 680 690 700
640 650 660 670 680 690
pF1KA0 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
710 720 730 740 750 760
700 710 720 730 740 750
pF1KA0 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
770 780 790 800 810 820
760 770 780 790 800 810
pF1KA0 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
830 840 850 860 870 880
820 830 840 850 860 870
pF1KA0 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
890 900 910 920 930 940
880 890 900 910 920 930
pF1KA0 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
950 960 970 980 990 1000
940 950 960 970 980 990
pF1KA0 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
1010 1020 1030 1040 1050 1060
1000 1010 1020 1030 1040 1050
pF1KA0 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
1070 1080 1090 1100 1110 1120
1060 1070 1080 1090 1100 1110
pF1KA0 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
1130 1140 1150 1160 1170 1180
1120 1130 1140
pF1KA0 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
:::::::::::::::::::::::::::::::::
XP_016 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
1190 1200 1210
>>XP_011521268 (OMIM: 616886) PREDICTED: genetic suppres (1214 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 3780.1 bits: 711.4 E(85289): 8.2e-204
Smith-Waterman score: 7699; 99.8% identity (100.0% similar) in 1143 aa overlap (2-1144:72-1214)
10 20 30
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVP
.:::::::::::::::::::::::::::::
XP_011 ATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVP
50 60 70 80 90 100
40 50 60 70 80 90
pF1KA0 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
110 120 130 140 150 160
100 110 120 130 140 150
pF1KA0 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
170 180 190 200 210 220
160 170 180 190 200 210
pF1KA0 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
230 240 250 260 270 280
220 230 240 250 260 270
pF1KA0 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
290 300 310 320 330 340
280 290 300 310 320 330
pF1KA0 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
350 360 370 380 390 400
340 350 360 370 380 390
pF1KA0 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHT
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_011 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHT
410 420 430 440 450 460
400 410 420 430 440 450
pF1KA0 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
470 480 490 500 510 520
460 470 480 490 500 510
pF1KA0 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
530 540 550 560 570 580
520 530 540 550 560 570
pF1KA0 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
590 600 610 620 630 640
580 590 600 610 620 630
pF1KA0 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
650 660 670 680 690 700
640 650 660 670 680 690
pF1KA0 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
710 720 730 740 750 760
700 710 720 730 740 750
pF1KA0 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
770 780 790 800 810 820
760 770 780 790 800 810
pF1KA0 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
830 840 850 860 870 880
820 830 840 850 860 870
pF1KA0 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
890 900 910 920 930 940
880 890 900 910 920 930
pF1KA0 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
950 960 970 980 990 1000
940 950 960 970 980 990
pF1KA0 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
1010 1020 1030 1040 1050 1060
1000 1010 1020 1030 1040 1050
pF1KA0 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
1070 1080 1090 1100 1110 1120
1060 1070 1080 1090 1100 1110
pF1KA0 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
1130 1140 1150 1160 1170 1180
1120 1130 1140
pF1KA0 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
:::::::::::::::::::::::::::::::::
XP_011 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
1190 1200 1210
>>NP_055430 (OMIM: 616886) genetic suppressor element 1 (1217 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 3780.1 bits: 711.4 E(85289): 8.2e-204
Smith-Waterman score: 7699; 99.8% identity (100.0% similar) in 1143 aa overlap (2-1144:75-1217)
10 20 30
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVP
.:::::::::::::::::::::::::::::
NP_055 ATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVP
50 60 70 80 90 100
40 50 60 70 80 90
pF1KA0 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
110 120 130 140 150 160
100 110 120 130 140 150
pF1KA0 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
170 180 190 200 210 220
160 170 180 190 200 210
pF1KA0 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
230 240 250 260 270 280
220 230 240 250 260 270
pF1KA0 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
290 300 310 320 330 340
280 290 300 310 320 330
pF1KA0 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
350 360 370 380 390 400
340 350 360 370 380 390
pF1KA0 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHT
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
NP_055 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHT
410 420 430 440 450 460
400 410 420 430 440 450
pF1KA0 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
470 480 490 500 510 520
460 470 480 490 500 510
pF1KA0 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
530 540 550 560 570 580
520 530 540 550 560 570
pF1KA0 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
590 600 610 620 630 640
580 590 600 610 620 630
pF1KA0 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
650 660 670 680 690 700
640 650 660 670 680 690
pF1KA0 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
710 720 730 740 750 760
700 710 720 730 740 750
pF1KA0 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
770 780 790 800 810 820
760 770 780 790 800 810
pF1KA0 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
830 840 850 860 870 880
820 830 840 850 860 870
pF1KA0 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
890 900 910 920 930 940
880 890 900 910 920 930
pF1KA0 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
950 960 970 980 990 1000
940 950 960 970 980 990
pF1KA0 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
1010 1020 1030 1040 1050 1060
1000 1010 1020 1030 1040 1050
pF1KA0 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
1070 1080 1090 1100 1110 1120
1060 1070 1080 1090 1100 1110
pF1KA0 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
1130 1140 1150 1160 1170 1180
1120 1130 1140
pF1KA0 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
:::::::::::::::::::::::::::::::::
NP_055 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
1190 1200 1210
>>XP_005255921 (OMIM: 616886) PREDICTED: genetic suppres (1227 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 3780.0 bits: 711.4 E(85289): 8.2e-204
Smith-Waterman score: 7699; 99.8% identity (100.0% similar) in 1143 aa overlap (2-1144:85-1227)
10 20 30
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVP
.:::::::::::::::::::::::::::::
XP_005 ATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVP
60 70 80 90 100 110
40 50 60 70 80 90
pF1KA0 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
120 130 140 150 160 170
100 110 120 130 140 150
pF1KA0 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
180 190 200 210 220 230
160 170 180 190 200 210
pF1KA0 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
240 250 260 270 280 290
220 230 240 250 260 270
pF1KA0 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KA0 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
360 370 380 390 400 410
340 350 360 370 380 390
pF1KA0 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHT
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_005 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHT
420 430 440 450 460 470
400 410 420 430 440 450
pF1KA0 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
480 490 500 510 520 530
460 470 480 490 500 510
pF1KA0 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
540 550 560 570 580 590
520 530 540 550 560 570
pF1KA0 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
600 610 620 630 640 650
580 590 600 610 620 630
pF1KA0 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
660 670 680 690 700 710
640 650 660 670 680 690
pF1KA0 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
720 730 740 750 760 770
700 710 720 730 740 750
pF1KA0 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
780 790 800 810 820 830
760 770 780 790 800 810
pF1KA0 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
840 850 860 870 880 890
820 830 840 850 860 870
pF1KA0 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
900 910 920 930 940 950
880 890 900 910 920 930
pF1KA0 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
960 970 980 990 1000 1010
940 950 960 970 980 990
pF1KA0 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
1020 1030 1040 1050 1060 1070
1000 1010 1020 1030 1040 1050
pF1KA0 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
1080 1090 1100 1110 1120 1130
1060 1070 1080 1090 1100 1110
pF1KA0 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
1140 1150 1160 1170 1180 1190
1120 1130 1140
pF1KA0 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
:::::::::::::::::::::::::::::::::
XP_005 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
1200 1210 1220
>>XP_005255920 (OMIM: 616886) PREDICTED: genetic suppres (1229 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 3780.0 bits: 711.4 E(85289): 8.2e-204
Smith-Waterman score: 7699; 99.8% identity (100.0% similar) in 1143 aa overlap (2-1144:87-1229)
10 20 30
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVP
.:::::::::::::::::::::::::::::
XP_005 ATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVP
60 70 80 90 100 110
40 50 60 70 80 90
pF1KA0 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
120 130 140 150 160 170
100 110 120 130 140 150
pF1KA0 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
180 190 200 210 220 230
160 170 180 190 200 210
pF1KA0 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
240 250 260 270 280 290
220 230 240 250 260 270
pF1KA0 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KA0 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
360 370 380 390 400 410
340 350 360 370 380 390
pF1KA0 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHT
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_005 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHT
420 430 440 450 460 470
400 410 420 430 440 450
pF1KA0 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
480 490 500 510 520 530
460 470 480 490 500 510
pF1KA0 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
540 550 560 570 580 590
520 530 540 550 560 570
pF1KA0 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
600 610 620 630 640 650
580 590 600 610 620 630
pF1KA0 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
660 670 680 690 700 710
640 650 660 670 680 690
pF1KA0 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
720 730 740 750 760 770
700 710 720 730 740 750
pF1KA0 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
780 790 800 810 820 830
760 770 780 790 800 810
pF1KA0 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
840 850 860 870 880 890
820 830 840 850 860 870
pF1KA0 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
900 910 920 930 940 950
880 890 900 910 920 930
pF1KA0 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
960 970 980 990 1000 1010
940 950 960 970 980 990
pF1KA0 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
1020 1030 1040 1050 1060 1070
1000 1010 1020 1030 1040 1050
pF1KA0 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
1080 1090 1100 1110 1120 1130
1060 1070 1080 1090 1100 1110
pF1KA0 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
1140 1150 1160 1170 1180 1190
1120 1130 1140
pF1KA0 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
:::::::::::::::::::::::::::::::::
XP_005 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
1200 1210 1220
>>XP_011521267 (OMIM: 616886) PREDICTED: genetic suppres (1253 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 3779.9 bits: 711.4 E(85289): 8.3e-204
Smith-Waterman score: 7699; 99.8% identity (100.0% similar) in 1143 aa overlap (2-1144:111-1253)
10 20 30
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVP
.:::::::::::::::::::::::::::::
XP_011 ATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVP
90 100 110 120 130 140
40 50 60 70 80 90
pF1KA0 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
150 160 170 180 190 200
100 110 120 130 140 150
pF1KA0 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
210 220 230 240 250 260
160 170 180 190 200 210
pF1KA0 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
270 280 290 300 310 320
220 230 240 250 260 270
pF1KA0 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
330 340 350 360 370 380
280 290 300 310 320 330
pF1KA0 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
390 400 410 420 430 440
340 350 360 370 380 390
pF1KA0 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHT
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_011 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHT
450 460 470 480 490 500
400 410 420 430 440 450
pF1KA0 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
510 520 530 540 550 560
460 470 480 490 500 510
pF1KA0 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
570 580 590 600 610 620
520 530 540 550 560 570
pF1KA0 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
630 640 650 660 670 680
580 590 600 610 620 630
pF1KA0 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
690 700 710 720 730 740
640 650 660 670 680 690
pF1KA0 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
750 760 770 780 790 800
700 710 720 730 740 750
pF1KA0 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
810 820 830 840 850 860
760 770 780 790 800 810
pF1KA0 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
870 880 890 900 910 920
820 830 840 850 860 870
pF1KA0 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
930 940 950 960 970 980
880 890 900 910 920 930
pF1KA0 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
990 1000 1010 1020 1030 1040
940 950 960 970 980 990
pF1KA0 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
1050 1060 1070 1080 1090 1100
1000 1010 1020 1030 1040 1050
pF1KA0 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
1110 1120 1130 1140 1150 1160
1060 1070 1080 1090 1100 1110
pF1KA0 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
1170 1180 1190 1200 1210 1220
1120 1130 1140
pF1KA0 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
:::::::::::::::::::::::::::::::::
XP_011 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
1230 1240 1250
>>XP_005255922 (OMIM: 616886) PREDICTED: genetic suppres (1154 aa)
initn: 7698 init1: 7698 opt: 7698 Z-score: 3779.9 bits: 711.3 E(85289): 8.4e-204
Smith-Waterman score: 7698; 99.7% identity (99.9% similar) in 1144 aa overlap (1-1144:11-1154)
10 20 30 40 50
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPV
. ::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MFGLKPPLYYLPGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA0 VTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTPYPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTPYPF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA0 GLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLGLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLGLDP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA0 ATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA0 VRYPPELSHSSLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKERER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRYPPELSHSSLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKERER
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA0 EREKEREQEKEREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGHATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EREKEREQEKEREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGHATE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA0 ERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSSSAA
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_005 ERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSSSAA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA0 TALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEHRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEHRPE
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA0 STTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRAESH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRAESH
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA0 SLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGGSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGGSLE
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA0 HQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAPDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAPDPA
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA0 YIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA0 LKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPSPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPSPRL
730 740 750 760 770 780
780 790 800 810 820 830
pF1KA0 ALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSAAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSAAVA
790 800 810 820 830 840
840 850 860 870 880 890
pF1KA0 DSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQELSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQELSRV
850 860 870 880 890 900
900 910 920 930 940 950
pF1KA0 QELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVAEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVAEEF
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KA0 AHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHNGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHNGQQ
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KA0 EPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQNLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQNLE
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KA0 RQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCLALP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCLALP
1090 1100 1110 1120 1130 1140
1140
pF1KA0 AMHWPRGYLKGYPR
::::::::::::::
XP_005 AMHWPRGYLKGYPR
1150
>>XP_005255916 (OMIM: 616886) PREDICTED: genetic suppres (1925 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 3777.7 bits: 711.7 E(85289): 1.1e-203
Smith-Waterman score: 7699; 99.8% identity (100.0% similar) in 1143 aa overlap (2-1144:783-1925)
10 20 30
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVP
.:::::::::::::::::::::::::::::
XP_005 ATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVP
760 770 780 790 800 810
40 50 60 70 80 90
pF1KA0 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQ
820 830 840 850 860 870
100 110 120 130 140 150
pF1KA0 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRP
880 890 900 910 920 930
160 170 180 190 200 210
pF1KA0 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIP
940 950 960 970 980 990
220 230 240 250 260 270
pF1KA0 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERE
1000 1010 1020 1030 1040 1050
280 290 300 310 320 330
pF1KA0 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKAL
1060 1070 1080 1090 1100 1110
340 350 360 370 380 390
pF1KA0 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHT
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_005 EPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHT
1120 1130 1140 1150 1160 1170
400 410 420 430 440 450
pF1KA0 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLE
1180 1190 1200 1210 1220 1230
460 470 480 490 500 510
pF1KA0 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL
1240 1250 1260 1270 1280 1290
520 530 540 550 560 570
pF1KA0 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPA
1300 1310 1320 1330 1340 1350
580 590 600 610 620 630
pF1KA0 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSG
1360 1370 1380 1390 1400 1410
640 650 660 670 680 690
pF1KA0 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYD
1420 1430 1440 1450 1460 1470
700 710 720 730 740 750
pF1KA0 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRE
1480 1490 1500 1510 1520 1530
760 770 780 790 800 810
pF1KA0 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKE
1540 1550 1560 1570 1580 1590
820 830 840 850 860 870
pF1KA0 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIP
1600 1610 1620 1630 1640 1650
880 890 900 910 920 930
pF1KA0 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPL
1660 1670 1680 1690 1700 1710
940 950 960 970 980 990
pF1KA0 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYN
1720 1730 1740 1750 1760 1770
1000 1010 1020 1030 1040 1050
pF1KA0 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQ
1780 1790 1800 1810 1820 1830
1060 1070 1080 1090 1100 1110
pF1KA0 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVS
1840 1850 1860 1870 1880 1890
1120 1130 1140
pF1KA0 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
:::::::::::::::::::::::::::::::::
XP_005 ERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
1900 1910 1920
>>XP_005255918 (OMIM: 616886) PREDICTED: genetic suppres (1852 aa)
initn: 7696 init1: 7696 opt: 7696 Z-score: 3776.5 bits: 711.4 E(85289): 1.3e-203
Smith-Waterman score: 7696; 99.9% identity (100.0% similar) in 1142 aa overlap (3-1144:711-1852)
10 20 30
pF1KA0 MKGSSLSSESSPVSSPATNHSSPASTPKRVPM
::::::::::::::::::::::::::::::
XP_005 PRGPRMAQELRPAQCLQSSREEDGPDLTGAGSSLSSESSPVSSPATNHSSPASTPKRVPM
690 700 710 720 730 740
40 50 60 70 80 90
pF1KA0 GPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQE
750 760 770 780 790 800
100 110 120 130 140 150
pF1KA0 KAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPY
810 820 830 840 850 860
160 170 180 190 200 210
pF1KA0 HTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPT
870 880 890 900 910 920
220 230 240 250 260 270
pF1KA0 PGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERER
930 940 950 960 970 980
280 290 300 310 320 330
pF1KA0 EREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKALE
990 1000 1010 1020 1030 1040
340 350 360 370 380 390
pF1KA0 PSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDASLQAPKPVQHPLHPVPTPHHTV
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_005 PSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHTV
1050 1060 1070 1080 1090 1100
400 410 420 430 440 450
pF1KA0 PSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQ
1110 1120 1130 1140 1150 1160
460 470 480 490 500 510
pF1KA0 HLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALW
1170 1180 1190 1200 1210 1220
520 530 540 550 560 570
pF1KA0 NPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAP
1230 1240 1250 1260 1270 1280
580 590 600 610 620 630
pF1KA0 LDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGP
1290 1300 1310 1320 1330 1340
640 650 660 670 680 690
pF1KA0 LKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDE
1350 1360 1370 1380 1390 1400
700 710 720 730 740 750
pF1KA0 SDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRER
1410 1420 1430 1440 1450 1460
760 770 780 790 800 810
pF1KA0 SPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKER
1470 1480 1490 1500 1510 1520
820 830 840 850 860 870
pF1KA0 LVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPK
1530 1540 1550 1560 1570 1580
880 890 900 910 920 930
pF1KA0 AAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLS
1590 1600 1610 1620 1630 1640
940 950 960 970 980 990
pF1KA0 HSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNI
1650 1660 1670 1680 1690 1700
1000 1010 1020 1030 1040 1050
pF1KA0 PELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQG
1710 1720 1730 1740 1750 1760
1060 1070 1080 1090 1100 1110
pF1KA0 IEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSE
1770 1780 1790 1800 1810 1820
1120 1130 1140
pF1KA0 RERLQAELDHLRKCLALPAMHWPRGYLKGYPR
::::::::::::::::::::::::::::::::
XP_005 RERLQAELDHLRKCLALPAMHWPRGYLKGYPR
1830 1840 1850
1144 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 09:11:11 2016 done: Thu Nov 3 09:11:14 2016
Total Scan time: 21.010 Total Display time: 0.430
Function used was FASTA [36.3.4 Apr, 2011]