FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0234, 1482 aa 1>>>pF1KA0234 1482 - 1482 aa - 1482 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0460+/-0.000424; mu= 15.4625+/- 0.026 mean_var=129.4125+/-25.667, 0's: 0 Z-trim(115.1): 320 B-trim: 131 in 2/53 Lambda= 0.112742 statistics sampled from 24965 (25327) to 24965 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.652), E-opt: 0.2 (0.297), width: 16 Scan time: 15.090 The best scores are: opt bits E(85289) NP_001140178 (OMIM: 415000,426000) lysine-specific (1482) 10074 1651.3 0 NP_004644 (OMIM: 415000,426000) lysine-specific de (1539) 9250 1517.3 0 XP_005262617 (OMIM: 415000,426000) PREDICTED: lysi (1494) 8934 1465.9 0 XP_011529127 (OMIM: 300534,314690) PREDICTED: lysi (1519) 7294 1199.2 0 NP_004178 (OMIM: 300534,314690) lysine-specific de (1560) 7293 1199.0 0 XP_011529132 (OMIM: 300534,314690) PREDICTED: lysi (1395) 7291 1198.6 0 XP_011529131 (OMIM: 300534,314690) PREDICTED: lysi (1395) 7291 1198.6 0 NP_001269551 (OMIM: 300534,314690) lysine-specific (1559) 7291 1198.7 0 NP_001140177 (OMIM: 415000,426000) lysine-specific (1570) 7273 1195.8 0 NP_001140174 (OMIM: 300534,314690) lysine-specific (1379) 7263 1194.1 0 XP_011529128 (OMIM: 300534,314690) PREDICTED: lysi (1516) 7241 1190.5 0 XP_005262092 (OMIM: 300534,314690) PREDICTED: lysi (1557) 7241 1190.5 0 XP_016885376 (OMIM: 300534,314690) PREDICTED: lysi (1449) 7089 1165.8 0 XP_016885377 (OMIM: 300534,314690) PREDICTED: lysi (1448) 7087 1165.5 0 XP_011529133 (OMIM: 300534,314690) PREDICTED: lysi (1232) 7074 1163.3 0 XP_011529129 (OMIM: 300534,314690) PREDICTED: lysi (1452) 7073 1163.2 0 XP_016885378 (OMIM: 300534,314690) PREDICTED: lysi (1444) 7071 1162.9 0 XP_016885375 (OMIM: 300534,314690) PREDICTED: lysi (1451) 7071 1162.9 0 XP_011529130 (OMIM: 300534,314690) PREDICTED: lysi (1447) 7055 1160.3 0 XP_011529770 (OMIM: 415000,426000) PREDICTED: lysi (1513) 6065 999.3 0 XP_011529126 (OMIM: 300534,314690) PREDICTED: lysi (1534) 4931 814.8 0 XP_005262618 (OMIM: 415000,426000) PREDICTED: lysi (1462) 4764 787.6 0 NP_001036068 (OMIM: 180202) lysine-specific demeth (1690) 3801 631.0 2.3e-179 XP_011507394 (OMIM: 605393) PREDICTED: lysine-spec (1386) 3442 572.6 7.5e-162 XP_011507392 (OMIM: 605393) PREDICTED: lysine-spec (1422) 3442 572.6 7.6e-162 XP_011507393 (OMIM: 605393) PREDICTED: lysine-spec (1422) 3442 572.6 7.6e-162 XP_011507390 (OMIM: 605393) PREDICTED: lysine-spec (1499) 3442 572.6 8e-162 NP_006609 (OMIM: 605393) lysine-specific demethyla (1544) 3442 572.6 8.2e-162 NP_001300971 (OMIM: 605393) lysine-specific demeth (1580) 3442 572.6 8.3e-162 NP_001155102 (OMIM: 616581) lysine-specific demeth ( 506) 492 92.5 9.3e-18 NP_060509 (OMIM: 609766) lysine-specific demethyla ( 523) 461 87.4 3.1e-16 XP_005271413 (OMIM: 609764) PREDICTED: lysine-spec ( 973) 453 86.3 1.3e-15 XP_016858401 (OMIM: 609764) PREDICTED: lysine-spec ( 973) 453 86.3 1.3e-15 XP_005271412 (OMIM: 609764) PREDICTED: lysine-spec (1064) 453 86.4 1.4e-15 XP_005271411 (OMIM: 609764) PREDICTED: lysine-spec (1064) 453 86.4 1.4e-15 NP_055478 (OMIM: 609764) lysine-specific demethyla (1064) 453 86.4 1.4e-15 XP_016869993 (OMIM: 605469) PREDICTED: lysine-spec ( 763) 440 84.1 4.5e-15 XP_016869992 (OMIM: 605469) PREDICTED: lysine-spec ( 793) 440 84.2 4.7e-15 XP_016869991 (OMIM: 605469) PREDICTED: lysine-spec ( 811) 440 84.2 4.8e-15 NP_001140167 (OMIM: 605469) lysine-specific demeth ( 813) 440 84.2 4.8e-15 NP_001140168 (OMIM: 605469) lysine-specific demeth ( 835) 440 84.2 4.9e-15 XP_016869988 (OMIM: 605469) PREDICTED: lysine-spec ( 949) 440 84.2 5.4e-15 XP_016869987 (OMIM: 605469) PREDICTED: lysine-spec ( 999) 440 84.2 5.6e-15 XP_011526120 (OMIM: 609765) PREDICTED: lysine-spec ( 429) 434 83.0 5.6e-15 NP_001291268 (OMIM: 605469) lysine-specific demeth (1023) 440 84.2 5.7e-15 NP_055876 (OMIM: 605469) lysine-specific demethyla (1056) 440 84.2 5.9e-15 XP_006716804 (OMIM: 605469) PREDICTED: lysine-spec (1089) 440 84.2 6e-15 XP_016881993 (OMIM: 609765) PREDICTED: lysine-spec ( 473) 434 83.0 6.1e-15 XP_011526124 (OMIM: 609765) PREDICTED: lysine-spec ( 312) 430 82.2 6.9e-15 XP_011526123 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 430 82.3 7.2e-15 >>NP_001140178 (OMIM: 415000,426000) lysine-specific dem (1482 aa) initn: 10074 init1: 10074 opt: 10074 Z-score: 8856.2 bits: 1651.3 E(85289): 0 Smith-Waterman score: 10074; 100.0% identity (100.0% similar) in 1482 aa overlap (1-1482:1-1482) 10 20 30 40 50 60 pF1KA0 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKQCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKQCN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 THPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 TTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 CPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 LVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 CHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 GYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 KEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 LVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGR 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 KRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 TELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKAR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 AELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 AWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 KKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAF 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 KEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 GQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 RLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSA 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 TACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPE 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 AIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSR 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 ALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPS 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 pF1KA0 TDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL :::::::::::::::::::::::::::::::::::::::::: NP_001 TDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL 1450 1460 1470 1480 >>NP_004644 (OMIM: 415000,426000) lysine-specific demeth (1539 aa) initn: 10060 init1: 9250 opt: 9250 Z-score: 8131.6 bits: 1517.3 E(85289): 0 Smith-Waterman score: 9745; 96.2% identity (96.2% similar) in 1514 aa overlap (26-1482:26-1539) 10 20 30 40 50 60 pF1KA0 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV ::::::::::::::::::::::::::::::::::: NP_004 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV 10 20 30 40 50 60 70 80 90 100 110 pF1KA0 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSK--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVI 70 80 90 100 110 120 120 pF1KA0 ------------------------------------------------------QCNTHP :::::: NP_004 EEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHP 130 140 150 160 170 180 130 140 150 160 170 180 pF1KA0 FDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYG 190 200 210 220 230 240 190 200 210 220 230 240 pF1KA0 PGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTM 250 260 270 280 290 300 250 260 270 280 290 300 pF1KA0 QLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPK 310 320 330 340 350 360 310 320 330 340 350 360 pF1KA0 CILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVS 370 380 390 400 410 420 370 380 390 400 410 420 pF1KA0 SIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHI 430 440 450 460 470 480 430 440 450 460 470 480 pF1KA0 NADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMK 490 500 510 520 530 540 490 500 510 520 530 540 pF1KA0 MLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYN 550 560 570 580 590 600 550 560 570 580 590 600 pF1KA0 FAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEM 610 620 630 640 650 660 610 620 630 640 650 660 pF1KA0 FIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVC 670 680 690 700 710 720 670 680 690 700 710 720 pF1KA0 LSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRS 730 740 750 760 770 780 730 740 750 760 770 780 pF1KA0 FEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTEL 790 800 810 820 830 840 790 800 810 820 830 840 pF1KA0 RVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGV 850 860 870 880 890 900 850 860 870 880 890 900 pF1KA0 EVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAEL 910 920 930 940 950 960 910 920 930 940 950 960 pF1KA0 QELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWI 970 980 990 1000 1010 1020 970 980 990 1000 1010 1020 pF1KA0 ADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKN 1030 1040 1050 1060 1070 1080 1030 1040 1050 1060 1070 1080 pF1KA0 SCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEG 1090 1100 1110 1120 1130 1140 1090 1100 1110 1120 1130 1140 pF1KA0 EQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQC 1150 1160 1170 1180 1190 1200 1150 1160 1170 1180 1190 1200 pF1KA0 VSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLP 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KA0 EGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATAC 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KA0 DPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIR 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KA0 APLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 APLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALE 1390 1400 1410 1420 1430 1440 1390 1400 1410 1420 1430 1440 pF1KA0 RRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDH 1450 1460 1470 1480 1490 1500 1450 1460 1470 1480 pF1KA0 SPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL ::::::::::::::::::::::::::::::::::::::: NP_004 SPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL 1510 1520 1530 >>XP_005262617 (OMIM: 415000,426000) PREDICTED: lysine-s (1494 aa) initn: 9744 init1: 8934 opt: 8934 Z-score: 7854.0 bits: 1465.9 E(85289): 0 Smith-Waterman score: 9720; 96.7% identity (97.6% similar) in 1494 aa overlap (1-1482:1-1494) 10 20 30 40 50 60 pF1KA0 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV 10 20 30 40 50 60 70 80 90 100 110 pF1KA0 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKQC- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVI 70 80 90 100 110 120 120 130 140 150 160 pF1KA0 NTHPFDNEVKDKEY-----KPHSIPLRQ--SVQPSKFSSYSRRAKRLQPD----PEPTEE . .. ::... . : : .. :. :.. . .: :::::: XP_005 EEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVPEPTEE 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA0 DIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA0 LKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA0 PPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA0 VPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWN 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA0 LNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWY 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA0 GVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVI 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA0 TFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFP 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA0 ETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCF 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA0 LSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWAN 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA0 KVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSG 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA0 QVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSP 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA0 GLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGA 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA0 KIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPN 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA0 IQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTA 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KA0 HSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQ 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KA0 DLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVG 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KA0 VLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETI 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 1230 1240 pF1KA0 LALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAK 1210 1220 1230 1240 1250 1260 1250 1260 1270 1280 1290 1300 pF1KA0 PRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLL 1270 1280 1290 1300 1310 1320 1310 1320 1330 1340 1350 1360 pF1KA0 PQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELE 1330 1340 1350 1360 1370 1380 1370 1380 1390 1400 1410 1420 pF1KA0 KFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQE 1390 1400 1410 1420 1430 1440 1430 1440 1450 1460 1470 1480 pF1KA0 KADRENMFLTPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KADRENMFLTPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL 1450 1460 1470 1480 1490 >>XP_011529127 (OMIM: 300534,314690) PREDICTED: lysine-s (1519 aa) initn: 5249 init1: 3556 opt: 7294 Z-score: 6412.3 bits: 1199.2 E(85289): 0 Smith-Waterman score: 8275; 81.6% identity (90.7% similar) in 1524 aa overlap (1-1482:1-1519) 10 20 30 40 50 60 pF1KA0 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV :::: :.:::::::::::::::::.::::::::::::::::::::::::::::::::::: XP_011 MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV 10 20 30 40 50 60 70 80 90 100 pF1KA0 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAK--FWEIQGSSLKIP---NV--------ER ::::::::.::::::: :. . . : : : .. :. : :. :: XP_011 DNFRFTPRIQRLNELEIV--VEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYER 70 80 90 100 110 110 120 130 140 150 160 pF1KA0 KIL--DLYSLSK---QCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPD . ..:. . ::::.::::: :::::::::::::::::::::.::.::::::::: XP_011 IVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPD 120 130 140 150 160 170 170 180 190 200 210 pF1KA0 PEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKK----VTCPPTVTVKDEQ ::::::::::.:::::::::: ::::::::::::: ::..:: :::::.::.: XP_011 PEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKD--KTLRKKDKEGPECPPTVVVKEEL 180 190 200 210 220 230 220 230 240 250 260 270 pF1KA0 SGGGNVSSTLLKQHL--------SLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDD .: .: :: : : : ::::: ::.::.:::.::::.::.:..:::::::: XP_011 GGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDD 240 250 260 270 280 290 280 290 300 310 320 330 pF1KA0 KLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSF :::.:::::::::::::::::::::.:.::::::..::::.:::::::::::.::.:::: XP_011 KLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSF 300 310 320 330 340 350 340 350 360 370 380 390 pF1KA0 GEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSN ::::::::.:::::::::::::::::::::::.::::::::::::::::::::::::::. XP_011 GEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSD 360 370 380 390 400 410 400 410 420 430 440 450 pF1KA0 SKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIED ::..:.:::.:::::::::::::::.:::::::::::::::::::::::::::::::::: XP_011 SKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIED 420 430 440 450 460 470 460 470 480 490 500 510 pF1KA0 HWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLM ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_011 HWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLM 480 490 500 510 520 530 520 530 540 550 560 570 pF1KA0 SHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLR 540 550 560 570 580 590 580 590 600 610 620 630 pF1KA0 RYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAF :::::::::::::::: :: ::::::.::::::::::::::::::::::::.:::::::: XP_011 RYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAF 600 610 620 630 640 650 640 650 660 670 680 690 pF1KA0 ELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELP 660 670 680 690 700 710 700 710 720 730 740 750 pF1KA0 TMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKN .::::::.:::::::::::::::::::::::::.::::::::::::::::::::::.::: XP_011 AMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKN 720 730 740 750 760 770 760 770 780 790 800 pF1KA0 CLSEVEACIAQVLGLVSGQVA---RMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVL ::::.:::....::::::: : :. :.::::::..:.::..:::::::::::: :: XP_011 CLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVL 780 790 800 810 820 830 810 820 830 840 850 860 pF1KA0 EQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQA :::::::::::::::.::::::::.::::::.:::::::::.:::.:::::.::::::.. XP_011 EQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRT 840 850 860 870 880 890 870 880 890 900 910 920 pF1KA0 LAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKH :::::.::.:..:.:::: ::..: ::.::::.::::::::::::::::::.:::::::: XP_011 LAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKH 900 910 920 930 940 950 930 940 950 960 970 980 pF1KA0 PPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAV :::::::::::.:::::::::::::::::.::.::::::::::::::::::::::::::: XP_011 PPATLEAIIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAV 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KA0 GRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSR 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KA0 WMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAP :::: ::::. :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAS 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KA0 SLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWE : ::: ::::::::: ::.:.::::::::::::.:::::.::.::.:. :::::::::: XP_011 SSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWE 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KA0 WDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALA :::::::::::::::::::::::::::::::::::::::::::::::::.:: :::.::: XP_011 WDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALA 1200 1210 1220 1230 1240 1250 1230 1240 1250 1260 1270 1280 pF1KA0 SEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSV :::::::: .::::::.:::.::::: : .: : ::.:::::... :::::::::::: XP_011 SEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSV 1260 1270 1280 1290 1300 1310 1290 1300 1310 1320 1330 1340 pF1KA0 TSPENMAPGKGS---DLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENH ::::..:: .:: :::::::::::::::::::::: :::::::::::::::::::::: XP_011 TSPEKVAPEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENH 1320 1330 1340 1350 1360 1370 1350 1360 1370 1380 1390 1400 pF1KA0 SIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQE ::::::::::::::.:::::::::: :..:::.:.::::::::: :::.: . .. ...: XP_011 SIWQLLQAGQPPDLERIRTLLELEKAERHGSRARGRALERRRRR-KVDRGGEGDDPAREE 1380 1390 1400 1410 1420 1430 1410 1420 1430 1440 1450 1460 pF1KA0 LQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKGNQNSLQHKD---SGS :. ::.:::: .. .:::. .:.. :. : :: . :::.:. . :: XP_011 LEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGP 1440 1450 1460 1470 1480 1490 1470 1480 pF1KA0 SAACPSLMPLLQL---SYSDEQQL :: .: : :.: . .::: XP_011 SAPFSTLTPRLHLPCPQQPPQQQL 1500 1510 >>NP_004178 (OMIM: 300534,314690) lysine-specific demeth (1560 aa) initn: 5505 init1: 3556 opt: 7293 Z-score: 6411.2 bits: 1199.0 E(85289): 0 Smith-Waterman score: 8203; 81.3% identity (89.5% similar) in 1528 aa overlap (36-1482:36-1560) 10 20 30 40 50 60 pF1KA0 DEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRF :::::::::::::::::::::::::::::: NP_004 DDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRF 10 20 30 40 50 60 70 80 90 100 110 pF1KA0 TPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSK-------- :::.::::::::::::::::::::::::::::::::::::::.::::::::: NP_004 TPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGY 70 80 90 100 110 120 120 pF1KA0 -------------------------------------------------QCNTHPFDNEV ::::.::::: NP_004 EAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEE 130 140 150 160 170 180 130 140 150 160 170 180 pF1KA0 KDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKM :::::::::::::::::::::.::.:::::::::::::::::::.:::::::::: :::: NP_004 KDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKM 190 200 210 220 230 240 190 200 210 220 230 pF1KA0 MGLGLMAKDKDKTVHKK----VTCPPTVTVKDEQSGGGNVSSTLLKQHL--------SLE :::::::::: :..:: :::::.::.: .: .: :: : : : : NP_004 MGLGLMAKDK--TLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPE 250 260 270 280 290 300 240 250 260 270 280 290 pF1KA0 PCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPR :::: ::.::.:::.::::.::.:..:::::::::::.:::::::::::::::::::::. NP_004 PCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPK 310 320 330 340 350 360 300 310 320 330 340 350 pF1KA0 GIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEK :.::::::..::::.:::::::::::.::.::::::::::::.::::::::::::::::: NP_004 GVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEK 370 380 390 400 410 420 360 370 380 390 400 410 pF1KA0 EFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLD ::::::.::::::::::::::::::::::::::.::..:.:::.:::::::::::::::. NP_004 EFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLE 430 440 450 460 470 480 420 430 440 450 460 470 pF1KA0 QSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAE 490 500 510 520 530 540 480 490 500 510 520 530 pF1KA0 HLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHS ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KA0 GFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLA :::::::::::::::::::::::::::::::::::::::::::::::::: :: :::::: NP_004 GFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLA 610 620 630 640 650 660 600 610 620 630 640 650 pF1KA0 VAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYD .::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: NP_004 AAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYD 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA0 CPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEV ::::::::::::::::::::::::::::::::::.::::::.:::::::::::::::::: NP_004 CPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEV 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA0 EDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVA---RM :::::::.::::::::::::::::::::::.:::::::.:::....::::::: : :. NP_004 EDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRV 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA0 DTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRS :.::::::..:.::..:::::::::::: :::::::::::::::::.::::::::.: NP_004 AGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQS 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA0 LLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASS :::::.:::::::::.:::.:::::.::::::..:::::.::.:..:.:::: ::..: : NP_004 LLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPS 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA0 PSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALK :.::::.::::::::::::::::::.:::::::::::::::::::.:::::::::::::: NP_004 PAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALK 970 980 990 1000 1010 1020 960 970 980 990 1000 1010 pF1KA0 EALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWRE :::.::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWRE 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 1060 1070 pF1KA0 KASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDP :::::::::::::::::::::::::::::::::::::: ::::. ::::::::::::::: NP_004 KASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDP 1090 1100 1110 1120 1130 1140 1080 1090 1100 1110 1120 1130 pF1KA0 GSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCD ::::::::::::::::::::::::::::::::: : ::: ::::::::: ::.:.:::: NP_004 GSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCD 1150 1160 1170 1180 1190 1200 1140 1150 1160 1170 1180 1190 pF1KA0 LCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLV ::::::::.:::::.::.::.:. :::::::::::::::::::::::::::::::::::: NP_004 LCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLV 1210 1220 1230 1240 1250 1260 1200 1210 1220 1230 1240 1250 pF1KA0 ALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEE :::::::::::::::::::::::.:: :::.::::::::::: .::::::.:::.::::: NP_004 ALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEE 1270 1280 1290 1300 1310 1320 1260 1270 1280 1290 1300 1310 pF1KA0 ASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGS---DLELLSSLLPQ : .: : ::.:::::... ::::::::::::::::..:: .:: ::::::::::: NP_004 PPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSLLPQ 1330 1340 1350 1360 1370 1380 1320 1330 1340 1350 1360 1370 pF1KA0 LTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKF ::::::::::: ::::::::::::::::::::::::::::::::::::.:::::::::: NP_004 LTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKA 1390 1400 1410 1420 1430 1440 1380 1390 1400 1410 1420 1430 pF1KA0 EHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKA :..:::.:.::::::::: :::.: . .. ...::. ::.:::: .. .:::. .:.. NP_004 ERHGSRARGRALERRRRR-KVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEET 1450 1460 1470 1480 1490 1500 1440 1450 1460 1470 1480 pF1KA0 DRENMFLTPSTDHSPFLKGNQNSLQHKD---SGSSAACPSLMPLLQL---SYSDEQQL :. : :: . :::.:. . :: :: .: : :.: . .::: NP_004 GGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL 1510 1520 1530 1540 1550 1560 >-- initn: 248 init1: 248 opt: 248 Z-score: 218.3 bits: 53.1 E(85289): 2e-05 Smith-Waterman score: 248; 91.4% identity (97.1% similar) in 35 aa overlap (1-35:1-35) 10 20 30 40 50 60 pF1KA0 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV :::: :.:::::::::::::::::.:::::::::: NP_004 MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKQCN NP_004 DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV 70 80 90 100 110 120 >>XP_011529132 (OMIM: 300534,314690) PREDICTED: lysine-s (1395 aa) initn: 4723 init1: 3556 opt: 7291 Z-score: 6410.2 bits: 1198.6 E(85289): 0 Smith-Waterman score: 7779; 83.7% identity (92.5% similar) in 1389 aa overlap (118-1482:10-1395) 90 100 110 120 130 140 pF1KA0 QIAKFWEIQGSSLKIPNVERKILDLYSLSKQCNTHPFDNEVKDKEYKPHSIPLRQSVQPS ::::.::::: ::::::::::::::::::: XP_011 MYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPS 10 20 30 150 160 170 180 190 200 pF1KA0 KFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKK-- ::.::.:::::::::::::::::::.:::::::::: ::::::::::::: ::..:: XP_011 KFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKD--KTLRKKDK 40 50 60 70 80 90 210 220 230 240 250 pF1KA0 --VTCPPTVTVKDEQSGGGNVSSTLLKQHL--------SLEPCTKTTMQLRKNHSSAQFI :::::.::.: .: .: :: : : : ::::: ::.::.:::.:::: XP_011 EGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFI 100 110 120 130 140 150 260 270 280 290 300 310 pF1KA0 DSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEA .::.:..:::::::::::.:::::::::::::::::::::.:.::::::..::::.:::: XP_011 ESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEA 160 170 180 190 200 210 320 330 340 350 360 370 pF1KA0 FGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGA :::::::.::.::::::::::::.:::::::::::::::::::::::.:::::::::::: XP_011 FGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGA 220 230 240 250 260 270 380 390 400 410 420 430 pF1KA0 DIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWL ::::::::::::::.::..:.:::.:::::::::::::::.::::::::::::::::::: XP_011 DIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWL 280 290 300 310 320 330 440 450 460 470 480 490 pF1KA0 YVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPD :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 YVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPD 340 350 360 370 380 390 500 510 520 530 540 550 pF1KA0 LLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADW 400 410 420 430 440 450 560 570 580 590 600 610 pF1KA0 LPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRK ::::::::::::::::::::::::::::::: :: ::::::.:::::::::::::::::: XP_011 LPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRK 460 470 480 490 500 510 620 630 640 650 660 670 pF1KA0 ALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSS 520 530 540 550 560 570 680 690 700 710 720 730 pF1KA0 SRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEAR :::::::::::::::.::::::.:::::::::::::::::::::::::.::::::::::: XP_011 SRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEAR 580 590 600 610 620 630 740 750 760 770 780 790 pF1KA0 ERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVA---RMDTPQLTLTELRVLLEQMGS :::::::::::.:::::::.:::....::::::: : :. :.::::::..:.::.. XP_011 ERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNN 640 650 660 670 680 690 800 810 820 830 840 850 pF1KA0 LPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQ :::::::::::: :::::::::::::::::.::::::::.::::::.:::::::::.::: XP_011 LPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQ 700 710 720 730 740 750 860 870 880 890 900 910 pF1KA0 QQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAER .:::::.::::::..:::::.::.:..:.:::: ::..: ::.::::.:::::::::::: XP_011 RQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAER 760 770 780 790 800 810 920 930 940 950 960 970 pF1KA0 WEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNG ::::::.:::::::::::::::::::.:::::::::::::::::.::.:::::::::::: XP_011 WEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNG 820 830 840 850 860 870 980 990 1000 1010 1020 1030 pF1KA0 DHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVL 880 890 900 910 920 930 1040 1050 1060 1070 1080 1090 pF1KA0 CPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGIL ::::::::::::::::::: ::::. :::::::::::::::::::::::::::::::::: XP_011 CPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGIL 940 950 960 970 980 990 1100 1110 1120 1130 1140 1150 pF1KA0 QLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTS :::::::::::::: : ::: ::::::::: ::.:.::::::::::::.:::::.::.: XP_011 QLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSS 1000 1010 1020 1030 1040 1050 1160 1170 1180 1190 1200 1210 pF1KA0 PKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLT :.:. ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLT 1060 1070 1080 1090 1100 1110 1220 1230 1240 1250 1260 1270 pF1KA0 ERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGN ::::.:: :::.::::::::::: .::::::.:::.::::: : .: : ::.:::::. XP_011 ERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSGK 1120 1130 1140 1150 1160 1170 1280 1290 1300 1310 1320 pF1KA0 NISKVQGLLENGDSVTSPENMAPGKGS---DLELLSSLLPQLTGPVLELPEAIRAPLEEL .. ::::::::::::::::..:: .:: :::::::::::::::::::::: ::::::: XP_011 DMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEEL 1180 1190 1200 1210 1220 1230 1330 1340 1350 1360 1370 1380 pF1KA0 MMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQ :::::::::::::::::::::::::::::.:::::::::: :..:::.:.::::::::: XP_011 MMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKAERHGSRARGRALERRRRR- 1240 1250 1260 1270 1280 1290 1390 1400 1410 1420 1430 1440 pF1KA0 KVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKG :::.: . .. ...::. ::.:::: .. .:::. .:.. :. : :: . XP_011 KVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE 1300 1310 1320 1330 1340 1350 1450 1460 1470 1480 pF1KA0 NQNSLQHKD---SGSSAACPSLMPLLQL---SYSDEQQL :::.:. . :: :: .: : :.: . .::: XP_011 NQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL 1360 1370 1380 1390 >>XP_011529131 (OMIM: 300534,314690) PREDICTED: lysine-s (1395 aa) initn: 4723 init1: 3556 opt: 7291 Z-score: 6410.2 bits: 1198.6 E(85289): 0 Smith-Waterman score: 7779; 83.7% identity (92.5% similar) in 1389 aa overlap (118-1482:10-1395) 90 100 110 120 130 140 pF1KA0 QIAKFWEIQGSSLKIPNVERKILDLYSLSKQCNTHPFDNEVKDKEYKPHSIPLRQSVQPS ::::.::::: ::::::::::::::::::: XP_011 MYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPS 10 20 30 150 160 170 180 190 200 pF1KA0 KFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKK-- ::.::.:::::::::::::::::::.:::::::::: ::::::::::::: ::..:: XP_011 KFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKD--KTLRKKDK 40 50 60 70 80 90 210 220 230 240 250 pF1KA0 --VTCPPTVTVKDEQSGGGNVSSTLLKQHL--------SLEPCTKTTMQLRKNHSSAQFI :::::.::.: .: .: :: : : : ::::: ::.::.:::.:::: XP_011 EGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFI 100 110 120 130 140 150 260 270 280 290 300 310 pF1KA0 DSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEA .::.:..:::::::::::.:::::::::::::::::::::.:.::::::..::::.:::: XP_011 ESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEA 160 170 180 190 200 210 320 330 340 350 360 370 pF1KA0 FGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGA :::::::.::.::::::::::::.:::::::::::::::::::::::.:::::::::::: XP_011 FGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGA 220 230 240 250 260 270 380 390 400 410 420 430 pF1KA0 DIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWL ::::::::::::::.::..:.:::.:::::::::::::::.::::::::::::::::::: XP_011 DIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWL 280 290 300 310 320 330 440 450 460 470 480 490 pF1KA0 YVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPD :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 YVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPD 340 350 360 370 380 390 500 510 520 530 540 550 pF1KA0 LLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADW 400 410 420 430 440 450 560 570 580 590 600 610 pF1KA0 LPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRK ::::::::::::::::::::::::::::::: :: ::::::.:::::::::::::::::: XP_011 LPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRK 460 470 480 490 500 510 620 630 640 650 660 670 pF1KA0 ALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSS ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSS 520 530 540 550 560 570 680 690 700 710 720 730 pF1KA0 SRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEAR :::::::::::::::.::::::.:::::::::::::::::::::::::.::::::::::: XP_011 SRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEAR 580 590 600 610 620 630 740 750 760 770 780 790 pF1KA0 ERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVA---RMDTPQLTLTELRVLLEQMGS :::::::::::.:::::::.:::....::::::: : :. :.::::::..:.::.. XP_011 ERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNN 640 650 660 670 680 690 800 810 820 830 840 850 pF1KA0 LPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQ :::::::::::: :::::::::::::::::.::::::::.::::::.:::::::::.::: XP_011 LPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQ 700 710 720 730 740 750 860 870 880 890 900 910 pF1KA0 QQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAER .:::::.::::::..:::::.::.:..:.:::: ::..: ::.::::.:::::::::::: XP_011 RQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAER 760 770 780 790 800 810 920 930 940 950 960 970 pF1KA0 WEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNG ::::::.:::::::::::::::::::.:::::::::::::::::.::.:::::::::::: XP_011 WEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNG 820 830 840 850 860 870 980 990 1000 1010 1020 1030 pF1KA0 DHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVL 880 890 900 910 920 930 1040 1050 1060 1070 1080 1090 pF1KA0 CPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGIL ::::::::::::::::::: ::::. :::::::::::::::::::::::::::::::::: XP_011 CPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGIL 940 950 960 970 980 990 1100 1110 1120 1130 1140 1150 pF1KA0 QLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTS :::::::::::::: : ::: ::::::::: ::.:.::::::::::::.:::::.::.: XP_011 QLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSS 1000 1010 1020 1030 1040 1050 1160 1170 1180 1190 1200 1210 pF1KA0 PKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLT :.:. ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLT 1060 1070 1080 1090 1100 1110 1220 1230 1240 1250 1260 1270 pF1KA0 ERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGN ::::.:: :::.::::::::::: .::::::.:::.::::: : .: : ::.:::::. XP_011 ERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSGK 1120 1130 1140 1150 1160 1170 1280 1290 1300 1310 1320 pF1KA0 NISKVQGLLENGDSVTSPENMAPGKGS---DLELLSSLLPQLTGPVLELPEAIRAPLEEL .. ::::::::::::::::..:: .:: :::::::::::::::::::::: ::::::: XP_011 DMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEEL 1180 1190 1200 1210 1220 1230 1330 1340 1350 1360 1370 1380 pF1KA0 MMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQ :::::::::::::::::::::::::::::.:::::::::: :..:::.:.::::::::: XP_011 MMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKAERHGSRARGRALERRRRR- 1240 1250 1260 1270 1280 1290 1390 1400 1410 1420 1430 1440 pF1KA0 KVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKG :::.: . .. ...::. ::.:::: .. .:::. .:.. :. : :: . XP_011 KVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQE 1300 1310 1320 1330 1340 1350 1450 1460 1470 1480 pF1KA0 NQNSLQHKD---SGSSAACPSLMPLLQL---SYSDEQQL :::.:. . :: :: .: : :.: . .::: XP_011 NQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL 1360 1370 1380 1390 >>NP_001269551 (OMIM: 300534,314690) lysine-specific dem (1559 aa) initn: 5498 init1: 3556 opt: 7291 Z-score: 6409.5 bits: 1198.7 E(85289): 0 Smith-Waterman score: 8202; 81.3% identity (89.5% similar) in 1528 aa overlap (35-1482:35-1559) 10 20 30 40 50 60 pF1KA0 CDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFR :::::::::::::::::::::::::::::: NP_001 SDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFR 10 20 30 40 50 60 70 80 90 100 110 pF1KA0 FTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKQ------ ::::.::::::::::::::::::::::::::::::::::::::.::::::::: NP_001 FTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGG 70 80 90 100 110 120 120 pF1KA0 --------------------------------------------------CNTHPFDNEV :::.::::: NP_001 YEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVCNTRPFDNEE 130 140 150 160 170 180 130 140 150 160 170 180 pF1KA0 KDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKM :::::::::::::::::::::.::.:::::::::::::::::::.:::::::::: :::: NP_001 KDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKM 190 200 210 220 230 240 190 200 210 220 230 pF1KA0 MGLGLMAKDKDKTVHKK----VTCPPTVTVKDEQSGGGNVSSTLLKQHL--------SLE :::::::::: :..:: :::::.::.: .: .: :: : : : : NP_001 MGLGLMAKDK--TLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPE 250 260 270 280 290 300 240 250 260 270 280 290 pF1KA0 PCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPR :::: ::.::.:::.::::.::.:..:::::::::::.:::::::::::::::::::::. NP_001 PCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPK 310 320 330 340 350 360 300 310 320 330 340 350 pF1KA0 GIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEK :.::::::..::::.:::::::::::.::.::::::::::::.::::::::::::::::: NP_001 GVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEK 370 380 390 400 410 420 360 370 380 390 400 410 pF1KA0 EFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLD ::::::.::::::::::::::::::::::::::.::..:.:::.:::::::::::::::. NP_001 EFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLE 430 440 450 460 470 480 420 430 440 450 460 470 pF1KA0 QSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAE 490 500 510 520 530 540 480 490 500 510 520 530 pF1KA0 HLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHS ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHS 550 560 570 580 590 600 540 550 560 570 580 590 pF1KA0 GFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLA :::::::::::::::::::::::::::::::::::::::::::::::::: :: :::::: NP_001 GFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLA 610 620 630 640 650 660 600 610 620 630 640 650 pF1KA0 VAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYD .::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: NP_001 AAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYD 670 680 690 700 710 720 660 670 680 690 700 710 pF1KA0 CPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEV ::::::::::::::::::::::::::::::::::.::::::.:::::::::::::::::: NP_001 CPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEV 730 740 750 760 770 780 720 730 740 750 760 770 pF1KA0 EDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVA---RM :::::::.::::::::::::::::::::::.:::::::.:::....::::::: : :. NP_001 EDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRV 790 800 810 820 830 840 780 790 800 810 820 830 pF1KA0 DTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRS :.::::::..:.::..:::::::::::: :::::::::::::::::.::::::::.: NP_001 AGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQS 850 860 870 880 890 900 840 850 860 870 880 890 pF1KA0 LLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASS :::::.:::::::::.:::.:::::.::::::..:::::.::.:..:.:::: ::..: : NP_001 LLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPS 910 920 930 940 950 960 900 910 920 930 940 950 pF1KA0 PSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALK :.::::.::::::::::::::::::.:::::::::::::::::::.:::::::::::::: NP_001 PAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALK 970 980 990 1000 1010 1020 960 970 980 990 1000 1010 pF1KA0 EALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWRE :::.::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWRE 1030 1040 1050 1060 1070 1080 1020 1030 1040 1050 1060 1070 pF1KA0 KASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDP :::::::::::::::::::::::::::::::::::::: ::::. ::::::::::::::: NP_001 KASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDP 1090 1100 1110 1120 1130 1140 1080 1090 1100 1110 1120 1130 pF1KA0 GSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCD ::::::::::::::::::::::::::::::::: : ::: ::::::::: ::.:.:::: NP_001 GSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCD 1150 1160 1170 1180 1190 1200 1140 1150 1160 1170 1180 1190 pF1KA0 LCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLV ::::::::.:::::.::.::.:. :::::::::::::::::::::::::::::::::::: NP_001 LCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLV 1210 1220 1230 1240 1250 1260 1200 1210 1220 1230 1240 1250 pF1KA0 ALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEE :::::::::::::::::::::::.:: :::.::::::::::: .::::::.:::.::::: NP_001 ALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEE 1270 1280 1290 1300 1310 1320 1260 1270 1280 1290 1300 1310 pF1KA0 ASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGS---DLELLSSLLPQ : .: : ::.:::::... ::::::::::::::::..:: .:: ::::::::::: NP_001 PPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSLLPQ 1330 1340 1350 1360 1370 1380 1320 1330 1340 1350 1360 1370 pF1KA0 LTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKF ::::::::::: ::::::::::::::::::::::::::::::::::::.:::::::::: NP_001 LTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKA 1390 1400 1410 1420 1430 1440 1380 1390 1400 1410 1420 1430 pF1KA0 EHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKA :..:::.:.::::::::: :::.: . .. ...::. ::.:::: .. .:::. .:.. NP_001 ERHGSRARGRALERRRRR-KVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEET 1450 1460 1470 1480 1490 1500 1440 1450 1460 1470 1480 pF1KA0 DRENMFLTPSTDHSPFLKGNQNSLQHKD---SGSSAACPSLMPLLQL---SYSDEQQL :. : :: . :::.:. . :: :: .: : :.: . .::: NP_001 GGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL 1510 1520 1530 1540 1550 >-- initn: 241 init1: 241 opt: 241 Z-score: 212.2 bits: 52.0 E(85289): 4.4e-05 Smith-Waterman score: 241; 91.2% identity (97.1% similar) in 34 aa overlap (1-34:1-34) 10 20 30 40 50 60 pF1KA0 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV :::: :.:::::::::::::::::.::::::::: NP_001 MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKQCN NP_001 DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV 70 80 90 100 110 120 >>NP_001140177 (OMIM: 415000,426000) lysine-specific dem (1570 aa) initn: 8083 init1: 7273 opt: 7273 Z-score: 6393.6 bits: 1195.8 E(85289): 0 Smith-Waterman score: 9442; 94.2% identity (94.2% similar) in 1514 aa overlap (57-1482:57-1570) 30 40 50 60 70 80 pF1KA0 PLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYL :::::::::::::::::::::::::::::: NP_001 PLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYL 30 40 50 60 70 80 90 100 110 pF1KA0 DQIAKFWEIQGSSLKIPNVERKILDLYSLSK----------------------------- ::::::::::::::::::::::::::::::: NP_001 DQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPG 90 100 110 120 130 140 120 130 140 pF1KA0 ----------------------------QCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKF :::::::::::::::::::::::::::::::: NP_001 KNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKF 150 160 170 180 190 200 150 160 170 180 190 200 pF1KA0 SSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCP 210 220 230 240 250 260 210 220 230 240 250 260 pF1KA0 PTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDED 270 280 290 300 310 320 270 280 290 300 310 320 pF1KA0 DKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQS 330 340 350 360 370 380 330 340 350 360 370 380 pF1KA0 FGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVS 390 400 410 420 430 440 390 400 410 pF1KA0 NSKQNLSPEEK-------------------------------EYATSGWNLNVMPVLDQS ::::::::::: :::::::::::::::::: NP_001 NSKQNLSPEEKRQSLTVLTRLISSFWAQAVLPPWPPKVLGLQEYATSGWNLNVMPVLDQS 450 460 470 480 490 500 420 430 440 450 460 470 pF1KA0 VLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHL 510 520 530 540 550 560 480 490 500 510 520 530 pF1KA0 EEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGF 570 580 590 600 610 620 540 550 560 570 580 590 pF1KA0 NQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVA 630 640 650 660 670 680 600 610 620 630 640 650 pF1KA0 VHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCP 690 700 710 720 730 740 660 670 680 690 700 710 pF1KA0 DGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVED 750 760 770 780 790 800 720 730 740 750 760 770 pF1KA0 GRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQL 810 820 830 840 850 860 780 790 800 810 820 830 pF1KA0 TLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERG 870 880 890 900 910 920 840 850 860 870 880 890 pF1KA0 QQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDK 930 940 950 960 970 980 900 910 920 930 940 950 pF1KA0 ARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTK 990 1000 1010 1020 1030 1040 960 970 980 990 1000 1010 pF1KA0 AQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKT 1050 1060 1070 1080 1090 1100 1020 1030 1040 1050 1060 1070 pF1KA0 FLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIV 1110 1120 1130 1140 1150 1160 1080 1090 1100 1110 1120 1130 pF1KA0 AFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDW 1170 1180 1190 1200 1210 1220 1140 1150 1160 1170 1180 1190 pF1KA0 FHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRL 1230 1240 1250 1260 1270 1280 1200 1210 1220 1230 1240 1250 pF1KA0 PVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYT 1290 1300 1310 1320 1330 1340 1260 1270 1280 1290 1300 1310 pF1KA0 SATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLEL 1350 1360 1370 1380 1390 1400 1320 1330 1340 1350 1360 1370 pF1KA0 PEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTR 1410 1420 1430 1440 1450 1460 1380 1390 1400 1410 1420 1430 pF1KA0 SRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLT 1470 1480 1490 1500 1510 1520 1440 1450 1460 1470 1480 pF1KA0 PSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL :::::::::::::::::::::::::::::::::::::::::::: NP_001 PSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL 1530 1540 1550 1560 1570 >-- initn: 436 init1: 436 opt: 436 Z-score: 383.6 bits: 83.7 E(85289): 1.3e-14 Smith-Waterman score: 436; 100.0% identity (100.0% similar) in 56 aa overlap (1-56:1-56) 10 20 30 40 50 60 pF1KA0 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKQCN NP_001 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVI 70 80 90 100 110 120 >>NP_001140174 (OMIM: 300534,314690) lysine-specific dem (1379 aa) initn: 3683 init1: 3683 opt: 7263 Z-score: 6385.6 bits: 1194.1 E(85289): 0 Smith-Waterman score: 7734; 84.3% identity (92.6% similar) in 1366 aa overlap (1-1346:1-1349) 10 20 30 40 50 60 pF1KA0 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV :::: :.:::::::::::::::::.::::::::::::::::::::::::: ..:: NP_001 MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPA-----IVVEE 10 20 30 40 50 70 80 90 100 110 pF1KA0 DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKIL--DLYSLSK- ... . .: .. :: .::: . :: :. . :: . ..:. . NP_001 GGYEAICKDRRWARV-AQ---RLNYPPG-----KNIGSLLR-SHYERIVYPYEMYQSGAN 60 70 80 90 100 120 130 140 150 160 170 pF1KA0 --QCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPE ::::.::::: :::::::::::::::::::::.::.:::::::::::::::::::.:: NP_001 LVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KA0 LKKLQIYGPGPKMMGLGLMAKDKDKTVHKK----VTCPPTVTVKDEQSGGGNVSSTLLKQ :::::::: ::::::::::::: ::..:: :::::.::.: .: .: :: : NP_001 LKKLQIYGAGPKMMGLGLMAKD--KTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKT 170 180 190 200 210 220 240 250 260 270 280 pF1KA0 HL--------SLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYH : : ::::: ::.::.:::.::::.::.:..:::::::::::.::::::::: NP_001 FLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYH 230 240 250 260 270 280 290 300 310 320 330 340 pF1KA0 IFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFN ::::::::::::.:.::::::..::::.:::::::::::.::.::::::::::::.:::: NP_001 IFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFN 290 300 310 320 330 340 350 360 370 380 390 400 pF1KA0 MPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYA :::::::::::::::::::.::::::::::::::::::::::::::.::..:.:::.::: NP_001 MPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYA 350 360 370 380 390 400 410 420 430 440 450 460 pF1KA0 TSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGE ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGE 410 420 430 440 450 460 470 480 490 500 510 520 pF1KA0 PKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCA :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_001 PKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCA 470 480 490 500 510 520 530 540 550 560 570 580 pF1KA0 GEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICK 530 540 550 560 570 580 590 600 610 620 630 640 pF1KA0 MAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKC ::: :: ::::::.::::::::::::::::::::::::.::::::::::::::::::::: NP_001 MAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKC 590 600 610 620 630 640 650 660 670 680 690 700 pF1KA0 KTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESF :::::::::::::::::::::::::::::::::::::::::::::::.::::::.::::: NP_001 KTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESF 650 660 670 680 690 700 710 720 730 740 750 760 pF1KA0 DTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVL ::::::::::::::::::::.::::::::::::::::::::::.:::::::.:::....: NP_001 DTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRAL 710 720 730 740 750 760 770 780 790 800 810 820 pF1KA0 GLVSGQVA---RMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREA :::::: : :. :.::::::..:.::..:::::::::::: ::::::::::::::: NP_001 GLVSGQEAGPHRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREA 770 780 790 800 810 820 830 840 850 860 870 880 pF1KA0 LATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIM ::.::::::::.::::::.:::::::::.:::.:::::.::::::..:::::.::.:..: NP_001 LASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVM 830 840 850 860 870 880 890 900 910 920 930 940 pF1KA0 QGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETE .:::: ::..: ::.::::.::::::::::::::::::.:::::::::::::::::::.: NP_001 RGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAE 890 900 910 920 930 940 950 960 970 980 990 1000 pF1KA0 NIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQ ::::::::::::::::.::.:::::::::::::::::::::::::::::::::::::::: NP_001 NIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQ 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 pF1KA0 LELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDT ::::::::::::::::::::::::::::::::::::::::::::::::::: ::::. :: NP_001 LELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDT 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KA0 ELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVC :::::::::::::::::::::::::::::::::::::::::::::: : ::: :::::: NP_001 ELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVC 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 pF1KA0 GQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRS ::: ::.:.::::::::::::.:::::.::.::.:. ::::::::::::::::::::::: NP_001 GQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRS 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KA0 RRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAE ::::::::::::::::::::::::::::::::::::.:: :::.::::::::::: .::: NP_001 RRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAE 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 pF1KA0 LRQQLQAKPRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSD :::.:::.::::: : .: : ::.:::::... ::::::::::::::::..:: .::: NP_001 LRQRLQAEPRPEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSD 1250 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 pF1KA0 LELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDR ::::::::::::::::::::: :::::::::::::::::::::::: NP_001 LELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIPESLDFCILTPRYC 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KA0 IRTLLELEKFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVG NP_001 SDLSSWGPAPGVFPPW 1370 1482 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:24:59 2016 done: Wed Nov 2 18:25:02 2016 Total Scan time: 15.090 Total Display time: 0.940 Function used was FASTA [36.3.4 Apr, 2011]