FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0288, 1084 aa 1>>>pF1KA0288 1084 - 1084 aa - 1084 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6445+/-0.000461; mu= -7.8346+/- 0.028 mean_var=337.7576+/-71.901, 0's: 0 Z-trim(120.2): 146 B-trim: 1480 in 2/57 Lambda= 0.069787 statistics sampled from 35098 (35248) to 35098 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.413), width: 16 Scan time: 17.320 The best scores are: opt bits E(85289) NP_006028 (OMIM: 605314) histone deacetylase 4 [Ho (1084) 7222 742.0 4.4e-213 XP_011510525 (OMIM: 605314) PREDICTED: histone dea (1089) 7202 740.0 1.8e-212 XP_006712941 (OMIM: 605314) PREDICTED: histone dea (1089) 7202 740.0 1.8e-212 XP_011510523 (OMIM: 605314) PREDICTED: histone dea (1089) 7202 740.0 1.8e-212 XP_011510524 (OMIM: 605314) PREDICTED: histone dea (1089) 7202 740.0 1.8e-212 XP_011510527 (OMIM: 605314) PREDICTED: histone dea (1079) 7173 737.0 1.3e-211 XP_006712940 (OMIM: 605314) PREDICTED: histone dea (1108) 7173 737.1 1.4e-211 XP_011510526 (OMIM: 605314) PREDICTED: histone dea (1084) 7153 735.0 5.4e-211 XP_011510522 (OMIM: 605314) PREDICTED: histone dea (1090) 7153 735.0 5.4e-211 XP_011510519 (OMIM: 605314) PREDICTED: histone dea (1113) 7153 735.0 5.5e-211 XP_011510521 (OMIM: 605314) PREDICTED: histone dea (1103) 7123 732.0 4.4e-210 XP_011510520 (OMIM: 605314) PREDICTED: histone dea (1108) 7103 730.0 1.8e-209 XP_006712942 (OMIM: 605314) PREDICTED: histone dea (1062) 7015 721.1 8.1e-207 XP_006712943 (OMIM: 605314) PREDICTED: histone dea (1062) 7015 721.1 8.1e-207 XP_011510528 (OMIM: 605314) PREDICTED: histone dea (1065) 6988 718.4 5.3e-206 XP_011510529 (OMIM: 605314) PREDICTED: histone dea (1041) 6883 707.8 8e-203 XP_016860884 (OMIM: 605314) PREDICTED: histone dea ( 917) 6083 627.3 1.3e-178 XP_016860883 (OMIM: 605314) PREDICTED: histone dea (1069) 5381 556.6 2.7e-157 XP_011510532 (OMIM: 605314) PREDICTED: histone dea ( 673) 4469 464.7 8.1e-130 XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 3947 412.3 8e-114 XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 3906 408.1 1.4e-112 NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 3906 408.1 1.4e-112 XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 3906 408.1 1.4e-112 XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 3878 405.3 9.7e-112 NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 3878 405.3 9.7e-112 XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 3834 400.9 2e-110 XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 3834 400.9 2e-110 XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 3806 398.0 1.4e-109 NP_478056 (OMIM: 606543) histone deacetylase 9 iso (1011) 3744 391.8 1.1e-107 XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 3496 366.8 3.7e-100 XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 3496 366.8 3.7e-100 XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 3480 365.2 1.1e-99 XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 3480 365.2 1.1e-99 XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 3480 365.2 1.1e-99 XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 3480 365.2 1.1e-99 XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 3480 365.2 1.1e-99 XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 3480 365.2 1.1e-99 XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096) 3480 365.2 1.1e-99 XP_016879481 (OMIM: 605315) PREDICTED: histone dea (1156) 2978 314.7 2e-84 XP_016879484 (OMIM: 605315) PREDICTED: histone dea (1113) 2961 313.0 6.2e-84 XP_011522451 (OMIM: 605315) PREDICTED: histone dea (1114) 2961 313.0 6.2e-84 XP_016879482 (OMIM: 605315) PREDICTED: histone dea (1152) 2961 313.0 6.4e-84 XP_005256962 (OMIM: 605315) PREDICTED: histone dea (1122) 2952 312.1 1.2e-83 XP_016879480 (OMIM: 605315) PREDICTED: histone dea (1160) 2952 312.1 1.2e-83 XP_016879485 (OMIM: 605315) PREDICTED: histone dea (1081) 2946 311.5 1.7e-83 XP_011522452 (OMIM: 605315) PREDICTED: histone dea (1113) 2946 311.5 1.8e-83 NP_005465 (OMIM: 605315) histone deacetylase 5 iso (1122) 2946 311.5 1.8e-83 XP_005256963 (OMIM: 605315) PREDICTED: histone dea (1122) 2946 311.5 1.8e-83 NP_001015053 (OMIM: 605315) histone deacetylase 5 (1123) 2946 311.5 1.8e-83 XP_016879479 (OMIM: 605315) PREDICTED: histone dea (1160) 2946 311.5 1.8e-83 >>NP_006028 (OMIM: 605314) histone deacetylase 4 [Homo s (1084 aa) initn: 7222 init1: 7222 opt: 7222 Z-score: 3946.5 bits: 742.0 E(85289): 4.4e-213 Smith-Waterman score: 7222; 100.0% identity (100.0% similar) in 1084 aa overlap (1-1084:1-1084) 10 20 30 40 50 60 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE 1030 1040 1050 1060 1070 1080 pF1KA0 EPPL :::: NP_006 EPPL >>XP_011510525 (OMIM: 605314) PREDICTED: histone deacety (1089 aa) initn: 4395 init1: 4395 opt: 7202 Z-score: 3935.6 bits: 740.0 E(85289): 1.8e-212 Smith-Waterman score: 7202; 99.5% identity (99.5% similar) in 1089 aa overlap (1-1084:1-1089) 10 20 30 40 50 60 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 370 380 390 400 410 420 430 440 450 460 470 pF1KA0 EQPPAQAPLVT-----GLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ ::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_011 EQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE 1030 1040 1050 1060 1070 1080 1080 pF1KA0 EPMEEEPPL ::::::::: XP_011 EPMEEEPPL >>XP_006712941 (OMIM: 605314) PREDICTED: histone deacety (1089 aa) initn: 4395 init1: 4395 opt: 7202 Z-score: 3935.6 bits: 740.0 E(85289): 1.8e-212 Smith-Waterman score: 7202; 99.5% identity (99.5% similar) in 1089 aa overlap (1-1084:1-1089) 10 20 30 40 50 60 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 370 380 390 400 410 420 430 440 450 460 470 pF1KA0 EQPPAQAPLVT-----GLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ ::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_006 EQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE 1030 1040 1050 1060 1070 1080 1080 pF1KA0 EPMEEEPPL ::::::::: XP_006 EPMEEEPPL >>XP_011510523 (OMIM: 605314) PREDICTED: histone deacety (1089 aa) initn: 4395 init1: 4395 opt: 7202 Z-score: 3935.6 bits: 740.0 E(85289): 1.8e-212 Smith-Waterman score: 7202; 99.5% identity (99.5% similar) in 1089 aa overlap (1-1084:1-1089) 10 20 30 40 50 60 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 370 380 390 400 410 420 430 440 450 460 470 pF1KA0 EQPPAQAPLVT-----GLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ ::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_011 EQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE 1030 1040 1050 1060 1070 1080 1080 pF1KA0 EPMEEEPPL ::::::::: XP_011 EPMEEEPPL >>XP_011510524 (OMIM: 605314) PREDICTED: histone deacety (1089 aa) initn: 4395 init1: 4395 opt: 7202 Z-score: 3935.6 bits: 740.0 E(85289): 1.8e-212 Smith-Waterman score: 7202; 99.5% identity (99.5% similar) in 1089 aa overlap (1-1084:1-1089) 10 20 30 40 50 60 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 370 380 390 400 410 420 430 440 450 460 470 pF1KA0 EQPPAQAPLVT-----GLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ ::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_011 EQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE 1030 1040 1050 1060 1070 1080 1080 pF1KA0 EPMEEEPPL ::::::::: XP_011 EPMEEEPPL >>XP_011510527 (OMIM: 605314) PREDICTED: histone deacety (1079 aa) initn: 7173 init1: 7173 opt: 7173 Z-score: 3919.9 bits: 737.0 E(85289): 1.3e-211 Smith-Waterman score: 7173; 100.0% identity (100.0% similar) in 1077 aa overlap (8-1084:3-1079) 10 20 30 40 50 60 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 10 20 30 40 50 70 80 90 100 110 120 pF1KA0 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KA0 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KA0 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 180 190 200 210 220 230 250 260 270 280 290 300 pF1KA0 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KA0 EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL 420 430 440 450 460 470 490 500 510 520 530 540 pF1KA0 VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY 480 490 500 510 520 530 550 560 570 580 590 600 pF1KA0 LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ 540 550 560 570 580 590 610 620 630 640 650 660 pF1KA0 RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT 600 610 620 630 640 650 670 680 690 700 710 720 pF1KA0 LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT 660 670 680 690 700 710 730 740 750 760 770 780 pF1KA0 LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE 720 730 740 750 760 770 790 800 810 820 830 840 pF1KA0 LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD 780 790 800 810 820 830 850 860 870 880 890 900 pF1KA0 VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP 840 850 860 870 880 890 910 920 930 940 950 960 pF1KA0 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KA0 MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KA0 MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE 1020 1030 1040 1050 1060 1070 pF1KA0 EPPL :::: XP_011 EPPL >>XP_006712940 (OMIM: 605314) PREDICTED: histone deacety (1108 aa) initn: 7173 init1: 7173 opt: 7173 Z-score: 3919.7 bits: 737.1 E(85289): 1.4e-211 Smith-Waterman score: 7173; 100.0% identity (100.0% similar) in 1077 aa overlap (8-1084:32-1108) 10 20 30 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATA :::::::::::::::::::::::::::::: XP_006 NIDLCAFEIQKTSSPGYEVWFRKQYLAVDGDGLSGRDQPVELLNPARVNHMPSTVDVATA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 LPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 EQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 KEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 QSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 TALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVARE 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 GSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 STSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 STSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLR 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 QHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQ 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 PESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVE 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA0 PGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASA 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA0 TFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGK 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA0 CECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVD 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA0 SDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNS 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA0 VAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAP 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA0 DEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVE 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA0 GHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNEL 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA0 DPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 1030 1040 1050 1060 1070 1080 1060 1070 1080 pF1KA0 AMASLSVGVKPAEKRPDEEPMEEEPPL ::::::::::::::::::::::::::: XP_006 AMASLSVGVKPAEKRPDEEPMEEEPPL 1090 1100 >>XP_011510526 (OMIM: 605314) PREDICTED: histone deacety (1084 aa) initn: 4395 init1: 4395 opt: 7153 Z-score: 3909.0 bits: 735.0 E(85289): 5.4e-211 Smith-Waterman score: 7153; 99.5% identity (99.5% similar) in 1082 aa overlap (8-1084:3-1084) 10 20 30 40 50 60 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP 10 20 30 40 50 70 80 90 100 110 120 pF1KA0 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KA0 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KA0 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP 180 190 200 210 220 230 250 260 270 280 290 300 pF1KA0 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KA0 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KA0 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL 360 370 380 390 400 410 430 440 450 460 470 pF1KA0 EQPPAQAPLVT-----GLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ ::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_011 EQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQ 420 430 440 450 460 470 480 490 500 510 520 530 pF1KA0 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQAL 480 490 500 510 520 530 540 550 560 570 580 590 pF1KA0 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL 540 550 560 570 580 590 600 610 620 630 640 650 pF1KA0 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTG 600 610 620 630 640 650 660 670 680 690 700 710 pF1KA0 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVH 660 670 680 690 700 710 720 730 740 750 760 770 pF1KA0 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAV 720 730 740 750 760 770 780 790 800 810 820 830 pF1KA0 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 780 790 800 810 820 830 840 850 860 870 880 890 pF1KA0 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 840 850 860 870 880 890 900 910 920 930 940 950 pF1KA0 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KA0 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KA0 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDE 1020 1030 1040 1050 1060 1070 1080 pF1KA0 EPMEEEPPL ::::::::: XP_011 EPMEEEPPL 1080 >>XP_011510522 (OMIM: 605314) PREDICTED: histone deacety (1090 aa) initn: 4395 init1: 4395 opt: 7153 Z-score: 3909.0 bits: 735.0 E(85289): 5.4e-211 Smith-Waterman score: 7153; 99.5% identity (99.5% similar) in 1082 aa overlap (8-1084:9-1090) 10 20 30 40 50 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSL :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRKLGPREDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA0 PVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEML 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA0 AMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 LNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA0 PLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA0 PSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLP 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 ATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 LEQPPAQAPLVT-----GLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNA :::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_011 LEQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNA 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 QALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 LLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTT 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 GLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTV 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 HSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLA 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 VGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 LIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAF 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 TGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 YLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAV 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 RSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPD 1030 1040 1050 1060 1070 1080 1080 pF1KA0 EEPMEEEPPL :::::::::: XP_011 EEPMEEEPPL 1090 >>XP_011510519 (OMIM: 605314) PREDICTED: histone deacety (1113 aa) initn: 4395 init1: 4395 opt: 7153 Z-score: 3908.8 bits: 735.0 E(85289): 5.5e-211 Smith-Waterman score: 7153; 99.5% identity (99.5% similar) in 1082 aa overlap (8-1084:32-1113) 10 20 30 pF1KA0 MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATA :::::::::::::::::::::::::::::: XP_011 NIDLCAFEIQKTSSPGYEVWFRKQYLAVDGDGLSGRDQPVELLNPARVNHMPSTVDVATA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 LPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 EQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 KEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 QSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 TALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVARE 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 GSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 STSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVT-----GLGALPLHAQSLVGADRVSPS :::::::::::::::::::::::::::::::::: ::::::::::::::::::::: XP_011 STSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPS 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 IHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPS 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 EPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA0 PREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQS 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA0 SPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQET 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA0 GLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCG 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA0 GVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGF 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA0 CYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA0 GSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSG 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA0 FDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSAL 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA0 LGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEE 1030 1040 1050 1060 1070 1080 1060 1070 1080 pF1KA0 AETVTAMASLSVGVKPAEKRPDEEPMEEEPPL :::::::::::::::::::::::::::::::: XP_011 AETVTAMASLSVGVKPAEKRPDEEPMEEEPPL 1090 1100 1110 1084 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:38:08 2016 done: Thu Nov 3 19:38:10 2016 Total Scan time: 17.320 Total Display time: 0.500 Function used was FASTA [36.3.4 Apr, 2011]