FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0322, 1606 aa 1>>>pF1KA0322 1606 - 1606 aa - 1606 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5911+/-0.000437; mu= 9.7275+/- 0.028 mean_var=207.0146+/-41.358, 0's: 0 Z-trim(117.7): 273 B-trim: 210 in 2/52 Lambda= 0.089140 statistics sampled from 29619 (29925) to 29619 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.351), width: 16 Scan time: 18.550 The best scores are: opt bits E(85289) NP_055867 (OMIM: 610384) E3 ubiquitin-protein liga (1606) 10761 1398.1 0 XP_016867375 (OMIM: 610384) PREDICTED: E3 ubiquiti (1606) 10761 1398.1 0 XP_011513522 (OMIM: 610384) PREDICTED: E3 ubiquiti (1607) 10749 1396.6 0 XP_016867374 (OMIM: 610384) PREDICTED: E3 ubiquiti (1607) 10749 1396.6 0 XP_005249722 (OMIM: 610384) PREDICTED: E3 ubiquiti (1607) 10749 1396.6 0 XP_006715734 (OMIM: 610384) PREDICTED: E3 ubiquiti (1607) 10707 1391.2 0 XP_016867373 (OMIM: 610384) PREDICTED: E3 ubiquiti (1638) 10704 1390.8 0 XP_006715733 (OMIM: 610384) PREDICTED: E3 ubiquiti (1608) 10695 1389.6 0 XP_016867372 (OMIM: 610384) PREDICTED: E3 ubiquiti (1639) 10692 1389.3 0 XP_016867371 (OMIM: 610384) PREDICTED: E3 ubiquiti (1639) 10692 1389.3 0 XP_011513524 (OMIM: 610384) PREDICTED: E3 ubiquiti (1586) 10611 1378.8 0 XP_011513526 (OMIM: 610384) PREDICTED: E3 ubiquiti (1586) 10611 1378.8 0 XP_011513525 (OMIM: 610384) PREDICTED: E3 ubiquiti (1586) 10611 1378.8 0 XP_011513527 (OMIM: 610384) PREDICTED: E3 ubiquiti (1480) 9705 1262.3 0 XP_011513528 (OMIM: 610384) PREDICTED: E3 ubiquiti (1437) 9498 1235.7 0 XP_016867379 (OMIM: 610384) PREDICTED: E3 ubiquiti (1356) 8971 1167.9 0 XP_016867378 (OMIM: 610384) PREDICTED: E3 ubiquiti (1572) 5332 699.9 4.3e-200 NP_001273988 (OMIM: 610384) E3 ubiquitin-protein l (1572) 5332 699.9 4.3e-200 XP_006715736 (OMIM: 610384) PREDICTED: E3 ubiquiti (1573) 5278 693.0 5.3e-198 XP_016867376 (OMIM: 610384) PREDICTED: E3 ubiquiti (1605) 5278 693.0 5.4e-198 XP_016867377 (OMIM: 610384) PREDICTED: E3 ubiquiti (1604) 5275 692.6 7e-198 XP_016881168 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 854) 1473 203.5 6.6e-51 NP_001138438 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1473 203.5 6.6e-51 NP_001138437 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1473 203.5 6.6e-51 NP_001138436 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1473 203.5 6.6e-51 XP_005266717 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 942) 1473 203.5 7.2e-51 NP_001138440 (OMIM: 606384) E3 ubiquitin-protein l ( 967) 1473 203.5 7.3e-51 NP_001138439 (OMIM: 606384) E3 ubiquitin-protein l ( 975) 1473 203.5 7.4e-51 XP_006722484 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 940) 1370 190.2 6.9e-47 XP_016881167 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 973) 1368 190.0 8.5e-47 NP_001138442 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1363 189.3 1.2e-46 NP_001138443 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1363 189.3 1.2e-46 XP_005266720 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 922) 1363 189.3 1.3e-46 NP_001138441 (OMIM: 606384) E3 ubiquitin-protein l ( 947) 1363 189.3 1.3e-46 NP_056092 (OMIM: 606384) E3 ubiquitin-protein liga ( 955) 1363 189.3 1.3e-46 NP_001316141 (OMIM: 602278) E3 ubiquitin-protein l ( 753) 1350 187.6 3.5e-46 XP_011519929 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 827) 1350 187.6 3.7e-46 XP_011519927 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 1350 187.6 3.8e-46 XP_011519928 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 1350 187.6 3.8e-46 XP_011519926 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 875) 1350 187.6 3.9e-46 NP_006145 (OMIM: 602278) E3 ubiquitin-protein liga ( 900) 1350 187.7 4e-46 NP_940682 (OMIM: 602278) E3 ubiquitin-protein liga (1247) 1350 187.8 5.1e-46 NP_001271269 (OMIM: 602278) E3 ubiquitin-protein l (1302) 1350 187.8 5.3e-46 NP_001271268 (OMIM: 602278) E3 ubiquitin-protein l (1303) 1350 187.8 5.3e-46 NP_001271267 (OMIM: 602278) E3 ubiquitin-protein l (1319) 1350 187.8 5.4e-46 XP_016881170 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 684) 1282 178.8 1.4e-43 XP_016881169 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 750) 1282 178.8 1.5e-43 XP_006722488 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 772) 1282 178.9 1.5e-43 XP_016881166 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 838) 1282 178.9 1.6e-43 XP_006722487 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 790) 1281 178.7 1.7e-43 >>NP_055867 (OMIM: 610384) E3 ubiquitin-protein ligase H (1606 aa) initn: 10761 init1: 10761 opt: 10761 Z-score: 7486.5 bits: 1398.1 E(85289): 0 Smith-Waterman score: 10761; 99.9% identity (99.9% similar) in 1606 aa overlap (1-1606:1-1606) 10 20 30 40 50 60 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDRPGNQSIELSRPAEEAA ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_055 SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA0 ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA0 YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 pF1KA0 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE :::::::::::::::::::::::::::::::::::::::::::::: NP_055 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1570 1580 1590 1600 >>XP_016867375 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1606 aa) initn: 10761 init1: 10761 opt: 10761 Z-score: 7486.5 bits: 1398.1 E(85289): 0 Smith-Waterman score: 10761; 99.9% identity (99.9% similar) in 1606 aa overlap (1-1606:1-1606) 10 20 30 40 50 60 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDRPGNQSIELSRPAEEAA ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_016 SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA0 ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA0 YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 pF1KA0 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE :::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1570 1580 1590 1600 >>XP_011513522 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1607 aa) initn: 8427 init1: 8427 opt: 10749 Z-score: 7478.1 bits: 1396.6 E(85289): 0 Smith-Waterman score: 10749; 99.9% identity (99.9% similar) in 1607 aa overlap (1-1606:1-1607) 10 20 30 40 50 60 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK 250 260 270 280 290 300 310 320 330 340 350 pF1KA0 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHP-DDEEISLSTEP :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPADDEEISLSTEP 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 ESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDRPGNQSIELSRPAEEA :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_011 ESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 AVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 ASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 SELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 SSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRF 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 SSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGH 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 VERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 DSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 DSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFIT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA0 SEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSL 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA0 ARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPR 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA0 CSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHL 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA0 LEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSA 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA0 NDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSD 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KA0 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEY 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KA0 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNT 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KA0 EYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 pF1KA0 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1570 1580 1590 1600 >>XP_016867374 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1607 aa) initn: 8427 init1: 8427 opt: 10749 Z-score: 7478.1 bits: 1396.6 E(85289): 0 Smith-Waterman score: 10749; 99.9% identity (99.9% similar) in 1607 aa overlap (1-1606:1-1607) 10 20 30 40 50 60 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK 250 260 270 280 290 300 310 320 330 340 350 pF1KA0 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHP-DDEEISLSTEP :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_016 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPADDEEISLSTEP 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 ESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDRPGNQSIELSRPAEEA :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_016 ESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 AVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 ASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 SELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 SSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRF 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 SSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGH 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 VERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 DSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 DSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFIT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA0 SEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSL 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA0 ARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPR 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA0 CSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHL 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA0 LEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSA 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA0 NDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSD 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KA0 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEY 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KA0 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNT 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KA0 EYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 pF1KA0 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1570 1580 1590 1600 >>XP_005249722 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1607 aa) initn: 8427 init1: 8427 opt: 10749 Z-score: 7478.1 bits: 1396.6 E(85289): 0 Smith-Waterman score: 10749; 99.9% identity (99.9% similar) in 1607 aa overlap (1-1606:1-1607) 10 20 30 40 50 60 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK 250 260 270 280 290 300 310 320 330 340 350 pF1KA0 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHP-DDEEISLSTEP :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_005 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPADDEEISLSTEP 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 ESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDRPGNQSIELSRPAEEA :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_005 ESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 AVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 ASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 SELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 SSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRF 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 SSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGH 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 VERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 DSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 DSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFIT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA0 SEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSL 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA0 ARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPR 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA0 CSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHL 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA0 LEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSA 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA0 NDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSD 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KA0 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEY 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KA0 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNT 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KA0 EYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 pF1KA0 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1570 1580 1590 1600 >>XP_006715734 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1607 aa) initn: 10707 init1: 10707 opt: 10707 Z-score: 7448.9 bits: 1391.2 E(85289): 0 Smith-Waterman score: 10707; 99.8% identity (99.9% similar) in 1600 aa overlap (7-1606:8-1607) 10 20 30 40 50 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHD ..::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MICAQARAAKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA0 GVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA0 VLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 KNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA0 IFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA0 KLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEP 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 ESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDRPGNQSIELSRPAEEA :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_006 ESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 AVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 ASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 SELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 LSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 SSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRF 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 SSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGH 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 VERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 DSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 DSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFIT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA0 SEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSL 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA0 ARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPR 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA0 CSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHL 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA0 LEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSA 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA0 NDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSD 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KA0 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEY 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KA0 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNT 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KA0 EYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 pF1KA0 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1570 1580 1590 1600 >>XP_016867373 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1638 aa) initn: 10704 init1: 10704 opt: 10704 Z-score: 7446.7 bits: 1390.8 E(85289): 0 Smith-Waterman score: 10704; 99.8% identity (99.9% similar) in 1600 aa overlap (7-1606:39-1638) 10 20 30 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCK .. ::::::::::::::::::::::::::: XP_016 VKDPGSVVVQGVSKQVARSAFLISRLTPAVAITNLYQNRFLGLAAMASPSRNSQSRRRCK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 EPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 VIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPET 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 KICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 LKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 DVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 QFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 GEGSVPDRPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAE ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAE 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 ELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLE 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 QGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGG 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA0 SAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGH 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA0 FPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSS 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA0 CYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSP 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA0 ELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPS 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA0 LRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQ 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA0 QMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREG 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA0 SLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARN 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA0 FERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KA0 RLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYN 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KA0 DKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLF 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KA0 EEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYR 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KA0 KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPS 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KA0 REFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQY 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KA0 LLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQ 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KA0 VTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFD 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KA0 ARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTG 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 1580 1590 pF1KA0 TSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTA 1570 1580 1590 1600 1610 1620 1600 pF1KA0 VEETSTFGLE :::::::::: XP_016 VEETSTFGLE 1630 >>XP_006715733 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1608 aa) initn: 8427 init1: 8427 opt: 10695 Z-score: 7440.6 bits: 1389.6 E(85289): 0 Smith-Waterman score: 10695; 99.8% identity (99.9% similar) in 1601 aa overlap (7-1606:8-1608) 10 20 30 40 50 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHD ..::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MICAQARAAKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA0 GVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA0 VLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA0 KNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA0 IFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA0 KLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHP-DDEEISLSTE ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: XP_006 KLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPADDEEISLSTE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA0 PESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDRPGNQSIELSRPAEE ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: XP_006 PESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA0 AAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEA 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA0 PASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA0 VSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKD 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA0 GLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSES 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA0 DSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTR 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA0 FSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSG 730 740 750 760 770 780 780 790 800 810 820 830 pF1KA0 HVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEAR 790 800 810 820 830 840 840 850 860 870 880 890 pF1KA0 IDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KA0 EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFI 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KA0 TNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KA0 ELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGE 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA0 ASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPS 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA0 LARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSP 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA0 RCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDH 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KA0 LLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYS 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KA0 ANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLS 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KA0 DLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKE 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KA0 YIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNN 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KA0 TEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFC 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 pF1KA0 IEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE :::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1570 1580 1590 1600 >>XP_016867372 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1639 aa) initn: 8427 init1: 8427 opt: 10692 Z-score: 7438.4 bits: 1389.3 E(85289): 0 Smith-Waterman score: 10692; 99.7% identity (99.8% similar) in 1601 aa overlap (7-1606:39-1639) 10 20 30 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCK .. ::::::::::::::::::::::::::: XP_016 VKDPGSVVVQGVSKQVARSAFLISRLTPAVAITNLYQNRFLGLAAMASPSRNSQSRRRCK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 EPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 VIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPET 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 KICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 LKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 DVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 QFRFEITSSIHP-DDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQ :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QFRFEITSSIHPADDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQ 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 LGEGSVPDRPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSA :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 EELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTL 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 EQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQG 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA0 GSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGG 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA0 HFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSS 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA0 SCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQS 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA0 PELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLP 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA0 SLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSI 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA0 QQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRRE 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA0 GSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDAR 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA0 NFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQN 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KA0 GRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAY 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KA0 NDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSL 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KA0 FEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFY 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KA0 RKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGP 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KA0 SREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQ 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KA0 YLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFG 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KA0 QVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVF 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KA0 DARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVT 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 1580 1590 pF1KA0 GTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLT 1570 1580 1590 1600 1610 1620 1600 pF1KA0 AVEETSTFGLE ::::::::::: XP_016 AVEETSTFGLE 1630 >>XP_016867371 (OMIM: 610384) PREDICTED: E3 ubiquitin-pr (1639 aa) initn: 8427 init1: 8427 opt: 10692 Z-score: 7438.4 bits: 1389.3 E(85289): 0 Smith-Waterman score: 10692; 99.7% identity (99.8% similar) in 1601 aa overlap (7-1606:39-1639) 10 20 30 pF1KA0 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCK .. ::::::::::::::::::::::::::: XP_016 VKDPGSVVVQGVSKQVARSAFLISRLTPAVAITNLYQNRFLGLAAMASPSRNSQSRRRCK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA0 EPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA0 VIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPET 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA0 KICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA0 LKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA0 DVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA0 QFRFEITSSIHP-DDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQ :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QFRFEITSSIHPADDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQ 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA0 LGEGSVPDRPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSA :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA0 EELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTL 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA0 EQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQG 550 560 570 580 590 600 580 590 600 610 620 630 pF1KA0 GSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGG 610 620 630 640 650 660 640 650 660 670 680 690 pF1KA0 HFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSS 670 680 690 700 710 720 700 710 720 730 740 750 pF1KA0 SCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQS 730 740 750 760 770 780 760 770 780 790 800 810 pF1KA0 PELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLP 790 800 810 820 830 840 820 830 840 850 860 870 pF1KA0 SLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSI 850 860 870 880 890 900 880 890 900 910 920 930 pF1KA0 QQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRRE 910 920 930 940 950 960 940 950 960 970 980 990 pF1KA0 GSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDAR 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KA0 NFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQN 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KA0 GRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAY 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KA0 NDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSL 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KA0 FEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFY 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KA0 RKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGP 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KA0 SREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQ 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KA0 YLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFG 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KA0 QVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVF 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KA0 DARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVT 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 1580 1590 pF1KA0 GTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLT 1570 1580 1590 1600 1610 1620 1600 pF1KA0 AVEETSTFGLE ::::::::::: XP_016 AVEETSTFGLE 1630 1606 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 09:18:47 2016 done: Thu Nov 3 09:18:50 2016 Total Scan time: 18.550 Total Display time: 0.830 Function used was FASTA [36.3.4 Apr, 2011]