FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0348, 1496 aa 1>>>pF1KA0348 1496 - 1496 aa - 1496 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.8219+/-0.000502; mu= -16.0731+/- 0.031 mean_var=525.4700+/-108.225, 0's: 0 Z-trim(120.6): 137 B-trim: 0 in 0/62 Lambda= 0.055950 statistics sampled from 35946 (36084) to 35946 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.72), E-opt: 0.2 (0.423), width: 16 Scan time: 13.950 The best scores are: opt bits E(85289) NP_003889 (OMIM: 609410) synaptojanin-2 isoform 1 (1496) 10062 828.5 0 NP_001171559 (OMIM: 609410) synaptojanin-2 isoform (1259) 8472 700.1 2.8e-200 XP_011534527 (OMIM: 609410) PREDICTED: synaptojani (1259) 8472 700.1 2.8e-200 XP_006715655 (OMIM: 609410) PREDICTED: synaptojani (1288) 8350 690.3 2.7e-197 XP_005267255 (OMIM: 609410) PREDICTED: synaptojani (1165) 7825 647.9 1.4e-184 XP_011534528 (OMIM: 609410) PREDICTED: synaptojani (1165) 7825 647.9 1.4e-184 XP_011534529 (OMIM: 609410) PREDICTED: synaptojani (1158) 7718 639.2 5.6e-182 XP_016866895 (OMIM: 609410) PREDICTED: synaptojani (1113) 7468 619.0 6.4e-176 XP_011534530 (OMIM: 609410) PREDICTED: synaptojani (1113) 7468 619.0 6.4e-176 XP_005267256 (OMIM: 609410) PREDICTED: synaptojani (1113) 7468 619.0 6.4e-176 XP_011534526 (OMIM: 609410) PREDICTED: synaptojani (1451) 7252 601.7 1.4e-170 XP_011534532 (OMIM: 609410) PREDICTED: synaptojani (1243) 7165 594.6 1.6e-168 XP_005267257 (OMIM: 609410) PREDICTED: synaptojani ( 909) 6155 513.0 4.4e-144 NP_001153778 (OMIM: 604297,615530) synaptojanin-1 (1526) 4066 344.5 3.8e-93 XP_016883988 (OMIM: 604297,615530) PREDICTED: syna (1565) 4066 344.5 3.9e-93 XP_016883984 (OMIM: 604297,615530) PREDICTED: syna (1607) 4053 343.5 8.2e-93 XP_016883994 (OMIM: 604297,615530) PREDICTED: syna (1303) 4042 342.5 1.3e-92 XP_016883989 (OMIM: 604297,615530) PREDICTED: syna (1311) 3837 326.0 1.2e-87 NP_982271 (OMIM: 604297,615530) synaptojanin-1 iso (1350) 3837 326.0 1.3e-87 XP_016883987 (OMIM: 604297,615530) PREDICTED: syna (1531) 3836 326.0 1.5e-87 XP_016883990 (OMIM: 604297,615530) PREDICTED: syna (1310) 3825 325.0 2.4e-87 NP_003886 (OMIM: 604297,615530) synaptojanin-1 iso (1612) 3823 324.9 3.2e-87 XP_016883993 (OMIM: 604297,615530) PREDICTED: syna (1269) 3812 324.0 4.9e-87 XP_016883983 (OMIM: 604297,615530) PREDICTED: syna (1557) 3812 324.0 5.7e-87 XP_016883986 (OMIM: 604297,615530) PREDICTED: syna (1596) 3812 324.0 5.8e-87 XP_016883985 (OMIM: 604297,615530) PREDICTED: syna (1544) 3809 323.8 6.7e-87 XP_016883992 (OMIM: 604297,615530) PREDICTED: syna (1282) 3803 323.2 8.2e-87 XP_016883991 (OMIM: 604297,615530) PREDICTED: syna (1294) 3780 321.4 3e-86 NP_001153774 (OMIM: 604297,615530) synaptojanin-1 (1295) 3777 321.1 3.5e-86 XP_005262479 (OMIM: 300535,300555,309000) PREDICTE ( 744) 663 69.6 1.1e-10 XP_016885043 (OMIM: 300535,300555,309000) PREDICTE ( 831) 663 69.6 1.2e-10 XP_011529647 (OMIM: 300535,300555,309000) PREDICTE ( 853) 663 69.6 1.2e-10 XP_011529646 (OMIM: 300535,300555,309000) PREDICTE ( 853) 663 69.6 1.2e-10 NP_001578 (OMIM: 300535,300555,309000) inositol po ( 893) 663 69.7 1.2e-10 NP_000267 (OMIM: 300535,300555,309000) inositol po ( 901) 663 69.7 1.2e-10 NP_001305713 (OMIM: 300535,300555,309000) inositol ( 902) 663 69.7 1.2e-10 XP_016856698 (OMIM: 147264) PREDICTED: type II ino ( 693) 656 69.0 1.5e-10 XP_016856697 (OMIM: 147264) PREDICTED: type II ino ( 693) 656 69.0 1.5e-10 XP_011539695 (OMIM: 147264) PREDICTED: type II ino ( 720) 656 69.0 1.5e-10 XP_011539694 (OMIM: 147264) PREDICTED: type II ino ( 720) 656 69.0 1.5e-10 NP_001284363 (OMIM: 147264) type II inositol 1,4,5 ( 749) 656 69.0 1.6e-10 XP_016856696 (OMIM: 147264) PREDICTED: type II ino ( 794) 656 69.1 1.7e-10 XP_016856695 (OMIM: 147264) PREDICTED: type II ino ( 823) 656 69.1 1.7e-10 XP_006710684 (OMIM: 147264) PREDICTED: type II ino ( 848) 656 69.1 1.7e-10 NP_005531 (OMIM: 147264) type II inositol 1,4,5-tr ( 913) 656 69.1 1.8e-10 NP_001271218 (OMIM: 606481) phosphatidylinositol 4 ( 639) 628 66.7 6.7e-10 NP_001271217 (OMIM: 606481) phosphatidylinositol 4 ( 639) 628 66.7 6.7e-10 XP_016884262 (OMIM: 606481) PREDICTED: phosphatidy ( 702) 628 66.8 7.2e-10 XP_016884261 (OMIM: 606481) PREDICTED: phosphatidy ( 702) 628 66.8 7.2e-10 XP_011528445 (OMIM: 606481) PREDICTED: phosphatidy ( 702) 628 66.8 7.2e-10 >>NP_003889 (OMIM: 609410) synaptojanin-2 isoform 1 [Hom (1496 aa) initn: 10062 init1: 10062 opt: 10062 Z-score: 4409.1 bits: 828.5 E(85289): 0 Smith-Waterman score: 10062; 100.0% identity (100.0% similar) in 1496 aa overlap (1-1496:1-1496) 10 20 30 40 50 60 pF1KA0 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KA0 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1450 1460 1470 1480 1490 >>NP_001171559 (OMIM: 609410) synaptojanin-2 isoform 2 [ (1259 aa) initn: 8472 init1: 8472 opt: 8472 Z-score: 3716.5 bits: 700.1 E(85289): 2.8e-200 Smith-Waterman score: 8472; 100.0% identity (100.0% similar) in 1259 aa overlap (238-1496:1-1259) 210 220 230 240 250 260 pF1KA0 RVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWEQPGLQVG :::::::::::::::::::::::::::::: NP_001 MIYMDDGVSSFVQIRGSVPLFWEQPGLQVG 10 20 30 270 280 290 300 310 320 pF1KA0 SHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHA 40 50 60 70 80 90 330 340 350 360 370 380 pF1KA0 GDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCL 100 110 120 130 140 150 390 400 410 420 430 440 pF1KA0 DCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRA 160 170 180 190 200 210 450 460 470 480 490 500 pF1KA0 LEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTAL 220 230 240 250 260 270 510 520 530 540 550 560 pF1KA0 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 280 290 300 310 320 330 570 580 590 600 610 620 pF1KA0 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 340 350 360 370 380 390 630 640 650 660 670 680 pF1KA0 QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLT 400 410 420 430 440 450 690 700 710 720 730 740 pF1KA0 AGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDW 460 470 480 490 500 510 750 760 770 780 790 800 pF1KA0 KKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWW 520 530 540 550 560 570 810 820 830 840 850 860 pF1KA0 RKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQ 580 590 600 610 620 630 870 880 890 900 910 920 pF1KA0 EVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVL 640 650 660 670 680 690 930 940 950 960 970 980 pF1KA0 VRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAP 700 710 720 730 740 750 990 1000 1010 1020 1030 1040 pF1KA0 VSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGP 760 770 780 790 800 810 1050 1060 1070 1080 1090 1100 pF1KA0 TALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQP 820 830 840 850 860 870 1110 1120 1130 1140 1150 1160 pF1KA0 PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQ 880 890 900 910 920 930 1170 1180 1190 1200 1210 1220 pF1KA0 IKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLL 940 950 960 970 980 990 1230 1240 1250 1260 1270 1280 pF1KA0 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP 1000 1010 1020 1030 1040 1050 1290 1300 1310 1320 1330 1340 pF1KA0 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQ 1060 1070 1080 1090 1100 1110 1350 1360 1370 1380 1390 1400 pF1KA0 VLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPL 1120 1130 1140 1150 1160 1170 1410 1420 1430 1440 1450 1460 pF1KA0 LGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDH 1180 1190 1200 1210 1220 1230 1470 1480 1490 pF1KA0 EHKTLGHWVTISDQEKRTALQVFDPLAKT ::::::::::::::::::::::::::::: NP_001 EHKTLGHWVTISDQEKRTALQVFDPLAKT 1240 1250 >>XP_011534527 (OMIM: 609410) PREDICTED: synaptojanin-2 (1259 aa) initn: 8472 init1: 8472 opt: 8472 Z-score: 3716.5 bits: 700.1 E(85289): 2.8e-200 Smith-Waterman score: 8472; 100.0% identity (100.0% similar) in 1259 aa overlap (238-1496:1-1259) 210 220 230 240 250 260 pF1KA0 RVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWEQPGLQVG :::::::::::::::::::::::::::::: XP_011 MIYMDDGVSSFVQIRGSVPLFWEQPGLQVG 10 20 30 270 280 290 300 310 320 pF1KA0 SHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHA 40 50 60 70 80 90 330 340 350 360 370 380 pF1KA0 GDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCL 100 110 120 130 140 150 390 400 410 420 430 440 pF1KA0 DCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRA 160 170 180 190 200 210 450 460 470 480 490 500 pF1KA0 LEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTAL 220 230 240 250 260 270 510 520 530 540 550 560 pF1KA0 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 280 290 300 310 320 330 570 580 590 600 610 620 pF1KA0 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 340 350 360 370 380 390 630 640 650 660 670 680 pF1KA0 QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLT 400 410 420 430 440 450 690 700 710 720 730 740 pF1KA0 AGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDW 460 470 480 490 500 510 750 760 770 780 790 800 pF1KA0 KKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWW 520 530 540 550 560 570 810 820 830 840 850 860 pF1KA0 RKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQ 580 590 600 610 620 630 870 880 890 900 910 920 pF1KA0 EVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVL 640 650 660 670 680 690 930 940 950 960 970 980 pF1KA0 VRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAP 700 710 720 730 740 750 990 1000 1010 1020 1030 1040 pF1KA0 VSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGP 760 770 780 790 800 810 1050 1060 1070 1080 1090 1100 pF1KA0 TALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQP 820 830 840 850 860 870 1110 1120 1130 1140 1150 1160 pF1KA0 PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQ 880 890 900 910 920 930 1170 1180 1190 1200 1210 1220 pF1KA0 IKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLL 940 950 960 970 980 990 1230 1240 1250 1260 1270 1280 pF1KA0 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP 1000 1010 1020 1030 1040 1050 1290 1300 1310 1320 1330 1340 pF1KA0 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQ 1060 1070 1080 1090 1100 1110 1350 1360 1370 1380 1390 1400 pF1KA0 VLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPL 1120 1130 1140 1150 1160 1170 1410 1420 1430 1440 1450 1460 pF1KA0 LGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDH 1180 1190 1200 1210 1220 1230 1470 1480 1490 pF1KA0 EHKTLGHWVTISDQEKRTALQVFDPLAKT ::::::::::::::::::::::::::::: XP_011 EHKTLGHWVTISDQEKRTALQVFDPLAKT 1240 1250 >>XP_006715655 (OMIM: 609410) PREDICTED: synaptojanin-2 (1288 aa) initn: 8350 init1: 8350 opt: 8350 Z-score: 3663.1 bits: 690.3 E(85289): 2.7e-197 Smith-Waterman score: 8350; 100.0% identity (100.0% similar) in 1248 aa overlap (1-1248:1-1248) 10 20 30 40 50 60 pF1KA0 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT :::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKIVFCSRSQASQP 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP XP_006 CLLLQRHEFVRTVAAQRLASVDTSGSSV 1270 1280 >>XP_005267255 (OMIM: 609410) PREDICTED: synaptojanin-2 (1165 aa) initn: 7825 init1: 7825 opt: 7825 Z-score: 3434.7 bits: 647.9 E(85289): 1.4e-184 Smith-Waterman score: 7825; 100.0% identity (100.0% similar) in 1165 aa overlap (332-1496:1-1165) 310 320 330 340 350 360 pF1KA0 NLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHW :::::::::::::::::::::::::::::: XP_005 MINFDFHQFAKGGKLEKLETLLRPQLKLHW 10 20 30 370 380 390 400 410 420 pF1KA0 EDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVD 40 50 60 70 80 90 430 440 450 460 470 480 pF1KA0 RFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI 100 110 120 130 140 150 490 500 510 520 530 540 pF1KA0 KLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNG 160 170 180 190 200 210 550 560 570 580 590 600 pF1KA0 GKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAST 220 230 240 250 260 270 610 620 630 640 650 660 pF1KA0 TNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGK 280 290 300 310 320 330 670 680 690 700 710 720 pF1KA0 AGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYV 340 350 360 370 380 390 730 740 750 760 770 780 pF1KA0 FWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYK 400 410 420 430 440 450 790 800 810 820 830 840 pF1KA0 YDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGA 460 470 480 490 500 510 850 860 870 880 890 900 pF1KA0 LQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTL 520 530 540 550 560 570 910 920 930 940 950 960 pF1KA0 EEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAV 580 590 600 610 620 630 970 980 990 1000 1010 1020 pF1KA0 KIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDY 640 650 660 670 680 690 1030 1040 1050 1060 1070 1080 pF1KA0 LVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKREL 700 710 720 730 740 750 1090 1100 1110 1120 1130 1140 pF1KA0 EAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQT 760 770 780 790 800 810 1150 1160 1170 1180 1190 1200 pF1KA0 ARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPR 820 830 840 850 860 870 1210 1220 1230 1240 1250 1260 pF1KA0 DLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 880 890 900 910 920 930 1270 1280 1290 1300 1310 1320 pF1KA0 HFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPP 940 950 960 970 980 990 1330 1340 1350 1360 1370 1380 pF1KA0 PLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQG 1000 1010 1020 1030 1040 1050 1390 1400 1410 1420 1430 1440 pF1KA0 DFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGT 1060 1070 1080 1090 1100 1110 1450 1460 1470 1480 1490 pF1KA0 RSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1120 1130 1140 1150 1160 >>XP_011534528 (OMIM: 609410) PREDICTED: synaptojanin-2 (1165 aa) initn: 7825 init1: 7825 opt: 7825 Z-score: 3434.7 bits: 647.9 E(85289): 1.4e-184 Smith-Waterman score: 7825; 100.0% identity (100.0% similar) in 1165 aa overlap (332-1496:1-1165) 310 320 330 340 350 360 pF1KA0 NLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHW :::::::::::::::::::::::::::::: XP_011 MINFDFHQFAKGGKLEKLETLLRPQLKLHW 10 20 30 370 380 390 400 410 420 pF1KA0 EDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVD 40 50 60 70 80 90 430 440 450 460 470 480 pF1KA0 RFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI 100 110 120 130 140 150 490 500 510 520 530 540 pF1KA0 KLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNG 160 170 180 190 200 210 550 560 570 580 590 600 pF1KA0 GKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAST 220 230 240 250 260 270 610 620 630 640 650 660 pF1KA0 TNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGK 280 290 300 310 320 330 670 680 690 700 710 720 pF1KA0 AGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYV 340 350 360 370 380 390 730 740 750 760 770 780 pF1KA0 FWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYK 400 410 420 430 440 450 790 800 810 820 830 840 pF1KA0 YDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGA 460 470 480 490 500 510 850 860 870 880 890 900 pF1KA0 LQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTL 520 530 540 550 560 570 910 920 930 940 950 960 pF1KA0 EEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAV 580 590 600 610 620 630 970 980 990 1000 1010 1020 pF1KA0 KIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDY 640 650 660 670 680 690 1030 1040 1050 1060 1070 1080 pF1KA0 LVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKREL 700 710 720 730 740 750 1090 1100 1110 1120 1130 1140 pF1KA0 EAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQT 760 770 780 790 800 810 1150 1160 1170 1180 1190 1200 pF1KA0 ARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPR 820 830 840 850 860 870 1210 1220 1230 1240 1250 1260 pF1KA0 DLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 880 890 900 910 920 930 1270 1280 1290 1300 1310 1320 pF1KA0 HFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPP 940 950 960 970 980 990 1330 1340 1350 1360 1370 1380 pF1KA0 PLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQG 1000 1010 1020 1030 1040 1050 1390 1400 1410 1420 1430 1440 pF1KA0 DFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGT 1060 1070 1080 1090 1100 1110 1450 1460 1470 1480 1490 pF1KA0 RSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT 1120 1130 1140 1150 1160 >>XP_011534529 (OMIM: 609410) PREDICTED: synaptojanin-2 (1158 aa) initn: 7716 init1: 7716 opt: 7718 Z-score: 3388.1 bits: 639.2 E(85289): 5.6e-182 Smith-Waterman score: 7718; 99.8% identity (99.8% similar) in 1156 aa overlap (1-1154:1-1156) 10 20 30 40 50 60 pF1KA0 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KA0 TARLLPGAPQQP--PKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAV :::::::::::: :: XP_011 TARLLPGAPQQPVPPKKP 1150 >>XP_016866895 (OMIM: 609410) PREDICTED: synaptojanin-2 (1113 aa) initn: 7468 init1: 7468 opt: 7468 Z-score: 3279.3 bits: 619.0 E(85289): 6.4e-176 Smith-Waterman score: 7468; 100.0% identity (100.0% similar) in 1113 aa overlap (384-1496:1-1113) 360 370 380 390 400 410 pF1KA0 RPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLG :::::::::::::::::::::::::::::: XP_016 MNCLDCLDRTNTVQSFIALEVLHLQLKTLG 10 20 30 420 430 440 450 460 470 pF1KA0 LSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFF 40 50 60 70 80 90 480 490 500 510 520 530 pF1KA0 DGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIA 100 110 120 130 140 150 540 550 560 570 580 590 pF1KA0 MGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSA 160 170 180 190 200 210 600 610 620 630 640 650 pF1KA0 GNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDT 220 230 240 250 260 270 660 670 680 690 700 710 pF1KA0 VKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGR 280 290 300 310 320 330 720 730 740 750 760 770 pF1KA0 NVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGA 340 350 360 370 380 390 780 790 800 810 820 830 pF1KA0 INFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKV 400 410 420 430 440 450 840 850 860 870 880 890 pF1KA0 RHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVV 460 470 480 490 500 510 900 910 920 930 940 950 pF1KA0 VNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDG 520 530 540 550 560 570 960 970 980 990 1000 1010 pF1KA0 MKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGD 580 590 600 610 620 630 1020 1030 1040 1050 1060 1070 pF1KA0 ILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDAD 640 650 660 670 680 690 1080 1090 1100 1110 1120 1130 pF1KA0 LVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTH 700 710 720 730 740 750 1140 1150 1160 1170 1180 1190 pF1KA0 GQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE 760 770 780 790 800 810 1200 1210 1220 1230 1240 1250 pF1KA0 ALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPE 820 830 840 850 860 870 1260 1270 1280 1290 1300 1310 pF1KA0 EQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP 880 890 900 910 920 930 1320 1330 1340 1350 1360 1370 pF1KA0 GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPA 940 950 960 970 980 990 1380 1390 1400 1410 1420 1430 pF1KA0 AGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKS 1000 1010 1020 1030 1040 1050 1440 1450 1460 1470 1480 1490 pF1KA0 SDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPL 1060 1070 1080 1090 1100 1110 pF1KA0 AKT ::: XP_016 AKT >>XP_011534530 (OMIM: 609410) PREDICTED: synaptojanin-2 (1113 aa) initn: 7468 init1: 7468 opt: 7468 Z-score: 3279.3 bits: 619.0 E(85289): 6.4e-176 Smith-Waterman score: 7468; 100.0% identity (100.0% similar) in 1113 aa overlap (384-1496:1-1113) 360 370 380 390 400 410 pF1KA0 RPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLG :::::::::::::::::::::::::::::: XP_011 MNCLDCLDRTNTVQSFIALEVLHLQLKTLG 10 20 30 420 430 440 450 460 470 pF1KA0 LSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFF 40 50 60 70 80 90 480 490 500 510 520 530 pF1KA0 DGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIA 100 110 120 130 140 150 540 550 560 570 580 590 pF1KA0 MGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSA 160 170 180 190 200 210 600 610 620 630 640 650 pF1KA0 GNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDT 220 230 240 250 260 270 660 670 680 690 700 710 pF1KA0 VKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGR 280 290 300 310 320 330 720 730 740 750 760 770 pF1KA0 NVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGA 340 350 360 370 380 390 780 790 800 810 820 830 pF1KA0 INFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKV 400 410 420 430 440 450 840 850 860 870 880 890 pF1KA0 RHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVV 460 470 480 490 500 510 900 910 920 930 940 950 pF1KA0 VNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDG 520 530 540 550 560 570 960 970 980 990 1000 1010 pF1KA0 MKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGD 580 590 600 610 620 630 1020 1030 1040 1050 1060 1070 pF1KA0 ILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDAD 640 650 660 670 680 690 1080 1090 1100 1110 1120 1130 pF1KA0 LVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTH 700 710 720 730 740 750 1140 1150 1160 1170 1180 1190 pF1KA0 GQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE 760 770 780 790 800 810 1200 1210 1220 1230 1240 1250 pF1KA0 ALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPE 820 830 840 850 860 870 1260 1270 1280 1290 1300 1310 pF1KA0 EQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP 880 890 900 910 920 930 1320 1330 1340 1350 1360 1370 pF1KA0 GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPA 940 950 960 970 980 990 1380 1390 1400 1410 1420 1430 pF1KA0 AGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKS 1000 1010 1020 1030 1040 1050 1440 1450 1460 1470 1480 1490 pF1KA0 SDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPL 1060 1070 1080 1090 1100 1110 pF1KA0 AKT ::: XP_011 AKT >>XP_005267256 (OMIM: 609410) PREDICTED: synaptojanin-2 (1113 aa) initn: 7468 init1: 7468 opt: 7468 Z-score: 3279.3 bits: 619.0 E(85289): 6.4e-176 Smith-Waterman score: 7468; 100.0% identity (100.0% similar) in 1113 aa overlap (384-1496:1-1113) 360 370 380 390 400 410 pF1KA0 RPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLG :::::::::::::::::::::::::::::: XP_005 MNCLDCLDRTNTVQSFIALEVLHLQLKTLG 10 20 30 420 430 440 450 460 470 pF1KA0 LSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFF 40 50 60 70 80 90 480 490 500 510 520 530 pF1KA0 DGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIA 100 110 120 130 140 150 540 550 560 570 580 590 pF1KA0 MGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSA 160 170 180 190 200 210 600 610 620 630 640 650 pF1KA0 GNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDT 220 230 240 250 260 270 660 670 680 690 700 710 pF1KA0 VKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGR 280 290 300 310 320 330 720 730 740 750 760 770 pF1KA0 NVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGA 340 350 360 370 380 390 780 790 800 810 820 830 pF1KA0 INFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKV 400 410 420 430 440 450 840 850 860 870 880 890 pF1KA0 RHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVV 460 470 480 490 500 510 900 910 920 930 940 950 pF1KA0 VNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDG 520 530 540 550 560 570 960 970 980 990 1000 1010 pF1KA0 MKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGD 580 590 600 610 620 630 1020 1030 1040 1050 1060 1070 pF1KA0 ILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDAD 640 650 660 670 680 690 1080 1090 1100 1110 1120 1130 pF1KA0 LVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTH 700 710 720 730 740 750 1140 1150 1160 1170 1180 1190 pF1KA0 GQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEE 760 770 780 790 800 810 1200 1210 1220 1230 1240 1250 pF1KA0 ALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPE 820 830 840 850 860 870 1260 1270 1280 1290 1300 1310 pF1KA0 EQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPP 880 890 900 910 920 930 1320 1330 1340 1350 1360 1370 pF1KA0 GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPA 940 950 960 970 980 990 1380 1390 1400 1410 1420 1430 pF1KA0 AGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKS 1000 1010 1020 1030 1040 1050 1440 1450 1460 1470 1480 1490 pF1KA0 SDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPL 1060 1070 1080 1090 1100 1110 pF1KA0 AKT ::: XP_005 AKT 1496 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:39:41 2016 done: Wed Nov 2 18:39:43 2016 Total Scan time: 13.950 Total Display time: 0.520 Function used was FASTA [36.3.4 Apr, 2011]