FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0358, 1581 aa 1>>>pF1KA0358 1581 - 1581 aa - 1581 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7724+/-0.00101; mu= 12.2113+/- 0.061 mean_var=121.2912+/-24.932, 0's: 0 Z-trim(108.2): 47 B-trim: 170 in 2/50 Lambda= 0.116455 statistics sampled from 9992 (10035) to 9992 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.308), width: 16 Scan time: 4.580 The best scores are: opt bits E(32554) CCDS41642.1 MADD gene_id:8567|Hs108|chr11 (1581) 10463 1770.0 0 CCDS7930.1 MADD gene_id:8567|Hs108|chr11 (1647) 10416 1762.1 0 CCDS7932.1 MADD gene_id:8567|Hs108|chr11 (1608) 7447 1263.3 0 CCDS44586.1 MADD gene_id:8567|Hs108|chr11 (1587) 5885 1000.9 0 CCDS7931.1 MADD gene_id:8567|Hs108|chr11 (1588) 5885 1000.9 0 CCDS44590.1 MADD gene_id:8567|Hs108|chr11 (1479) 5079 865.4 0 CCDS44589.1 MADD gene_id:8567|Hs108|chr11 (1541) 5079 865.4 0 CCDS44588.1 MADD gene_id:8567|Hs108|chr11 (1545) 5079 865.4 0 CCDS44587.1 MADD gene_id:8567|Hs108|chr11 (1565) 5079 865.4 0 >>CCDS41642.1 MADD gene_id:8567|Hs108|chr11 (1581 aa) initn: 10463 init1: 10463 opt: 10463 Z-score: 9496.5 bits: 1770.0 E(32554): 0 Smith-Waterman score: 10463; 100.0% identity (100.0% similar) in 1581 aa overlap (1-1581:1-1581) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1510 1520 1530 1540 1550 1560 1570 1580 pF1KA0 VTLEGINLKFMHNQFLKLKKW ::::::::::::::::::::: CCDS41 VTLEGINLKFMHNQFLKLKKW 1570 1580 >>CCDS7930.1 MADD gene_id:8567|Hs108|chr11 (1647 aa) initn: 10412 init1: 10412 opt: 10416 Z-score: 9453.5 bits: 1762.1 E(32554): 0 Smith-Waterman score: 10416; 99.8% identity (99.9% similar) in 1579 aa overlap (1-1578:1-1579) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1510 1520 1530 1540 1550 1560 1570 1580 pF1KA0 VTLEGINLKFMHNQ-FLKLKKW :::::::::::::: :..: CCDS79 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1570 1580 1590 1600 1610 1620 >>CCDS7932.1 MADD gene_id:8567|Hs108|chr11 (1608 aa) initn: 9202 init1: 7420 opt: 7447 Z-score: 6757.9 bits: 1263.3 E(32554): 0 Smith-Waterman score: 10046; 97.3% identity (97.4% similar) in 1579 aa overlap (1-1578:1-1540) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::: : CCDS79 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1190 1200 1210 1220 1230 1240 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::: ::::::::: CCDS79 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1250 1260 1270 1280 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1290 1300 1310 1320 1330 1340 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1350 1360 1370 1380 1390 1400 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1410 1420 1430 1440 1450 1460 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1470 1480 1490 1500 1510 1520 1570 1580 pF1KA0 VTLEGINLKFMHNQ-FLKLKKW :::::::::::::: :..: CCDS79 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1530 1540 1550 1560 1570 1580 >>CCDS44586.1 MADD gene_id:8567|Hs108|chr11 (1587 aa) initn: 8027 init1: 5885 opt: 5885 Z-score: 5339.7 bits: 1000.9 E(32554): 0 Smith-Waterman score: 9852; 95.9% identity (96.1% similar) in 1579 aa overlap (1-1578:1-1519) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::: CCDS44 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 850 860 870 880 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::: : CCDS44 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1070 1080 1090 1100 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1110 1120 1130 1140 1150 1160 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 -SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1170 1180 1190 1200 1210 1220 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::: ::::::::: CCDS44 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1230 1240 1250 1260 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1270 1280 1290 1300 1310 1320 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1330 1340 1350 1360 1370 1380 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1390 1400 1410 1420 1430 1440 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1450 1460 1470 1480 1490 1500 1570 1580 pF1KA0 VTLEGINLKFMHNQ-FLKLKKW :::::::::::::: :..: CCDS44 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1510 1520 1530 1540 1550 1560 >>CCDS7931.1 MADD gene_id:8567|Hs108|chr11 (1588 aa) initn: 7667 init1: 5885 opt: 5885 Z-score: 5339.6 bits: 1000.9 E(32554): 0 Smith-Waterman score: 9869; 96.0% identity (96.1% similar) in 1579 aa overlap (1-1578:1-1520) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::: CCDS79 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 850 860 870 880 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::: : CCDS79 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1070 1080 1090 1100 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1110 1120 1130 1140 1150 1160 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1170 1180 1190 1200 1210 1220 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::: ::::::::: CCDS79 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1230 1240 1250 1260 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1270 1280 1290 1300 1310 1320 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1330 1340 1350 1360 1370 1380 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1390 1400 1410 1420 1430 1440 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1450 1460 1470 1480 1490 1500 1570 1580 pF1KA0 VTLEGINLKFMHNQ-FLKLKKW :::::::::::::: :..: CCDS79 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1510 1520 1530 1540 1550 1560 >>CCDS44590.1 MADD gene_id:8567|Hs108|chr11 (1479 aa) initn: 8308 init1: 5079 opt: 5079 Z-score: 4608.3 bits: 865.4 E(32554): 0 Smith-Waterman score: 9510; 93.5% identity (93.5% similar) in 1581 aa overlap (1-1581:1-1479) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP ::::::::::::::::::::::::::::::::::::::::: CCDS44 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 730 740 750 760 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::: CCDS44 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 770 780 790 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::: CCDS44 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 800 810 820 830 840 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 850 860 870 880 890 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 900 910 920 930 940 950 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 960 970 980 990 1000 1010 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::: : CCDS44 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1020 1030 1040 1050 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1060 1070 1080 1090 1100 1110 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1120 1130 1140 1150 1160 1170 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::: ::::::::: CCDS44 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1180 1190 1200 1210 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1220 1230 1240 1250 1260 1270 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1280 1290 1300 1310 1320 1330 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1340 1350 1360 1370 1380 1390 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1400 1410 1420 1430 1440 1450 1570 1580 pF1KA0 VTLEGINLKFMHNQFLKLKKW ::::::::::::::::::::: CCDS44 VTLEGINLKFMHNQFLKLKKW 1460 1470 >>CCDS44589.1 MADD gene_id:8567|Hs108|chr11 (1541 aa) initn: 8602 init1: 5079 opt: 5079 Z-score: 4608.0 bits: 865.4 E(32554): 0 Smith-Waterman score: 9425; 93.0% identity (93.2% similar) in 1579 aa overlap (1-1578:1-1473) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP ::::::::::::::::::::::::::::::::::::::::: CCDS44 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 730 740 750 760 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::: CCDS44 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 770 780 790 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::: CCDS44 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 800 810 820 830 840 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 850 860 870 880 890 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 900 910 920 930 940 950 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 960 970 980 990 1000 1010 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::: : CCDS44 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1020 1030 1040 1050 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVS-- 1060 1070 1080 1090 1100 1110 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 --NSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1120 1130 1140 1150 1160 1170 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::: ::::::::: CCDS44 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1180 1190 1200 1210 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1220 1230 1240 1250 1260 1270 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1280 1290 1300 1310 1320 1330 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1340 1350 1360 1370 1380 1390 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1400 1410 1420 1430 1440 1450 1570 1580 pF1KA0 VTLEGINLKFMHNQ-FLKLKKW :::::::::::::: :..: CCDS44 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1460 1470 1480 1490 1500 1510 >>CCDS44588.1 MADD gene_id:8567|Hs108|chr11 (1545 aa) initn: 8257 init1: 5079 opt: 5079 Z-score: 4608.0 bits: 865.4 E(32554): 0 Smith-Waterman score: 9463; 93.3% identity (93.4% similar) in 1579 aa overlap (1-1578:1-1477) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP ::::::::::::::::::::::::::::::::::::::::: CCDS44 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 730 740 750 760 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::: CCDS44 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 770 780 790 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::: CCDS44 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 800 810 820 830 840 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 850 860 870 880 890 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 900 910 920 930 940 950 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 960 970 980 990 1000 1010 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::: : CCDS44 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1020 1030 1040 1050 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1060 1070 1080 1090 1100 1110 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1120 1130 1140 1150 1160 1170 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::: ::::::::: CCDS44 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1180 1190 1200 1210 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1220 1230 1240 1250 1260 1270 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1280 1290 1300 1310 1320 1330 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1340 1350 1360 1370 1380 1390 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1400 1410 1420 1430 1440 1450 1570 1580 pF1KA0 VTLEGINLKFMHNQ-FLKLKKW :::::::::::::: :..: CCDS44 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1460 1470 1480 1490 1500 1510 >>CCDS44587.1 MADD gene_id:8567|Hs108|chr11 (1565 aa) initn: 6861 init1: 5079 opt: 5079 Z-score: 4607.9 bits: 865.4 E(32554): 0 Smith-Waterman score: 9640; 94.6% identity (94.7% similar) in 1579 aa overlap (1-1578:1-1497) 10 20 30 40 50 60 pF1KA0 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP ::::::::::::::::::::::::::::::::::::::::: CCDS44 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 730 740 750 760 790 800 810 820 830 840 pF1KA0 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST :::::::::::::::::::::::::::::::::::: CCDS44 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 770 780 790 850 860 870 880 890 900 pF1KA0 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 800 810 820 830 840 850 910 920 930 940 950 960 pF1KA0 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 860 870 880 890 900 910 970 980 990 1000 1010 1020 pF1KA0 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 920 930 940 950 960 970 1030 1040 1050 1060 1070 1080 pF1KA0 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 980 990 1000 1010 1020 1030 1090 1100 1110 1120 1130 1140 pF1KA0 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP :::::::::::::::::::::::::::::::::::::::: : CCDS44 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1040 1050 1060 1070 1150 1160 1170 1180 1190 1200 pF1KA0 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1080 1090 1100 1110 1120 1130 1210 1220 1230 1240 1250 1260 pF1KA0 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1140 1150 1160 1170 1180 1190 1270 1280 1290 1300 1310 1320 pF1KA0 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ :::::::::::::::::::::::::::::: ::::::::: CCDS44 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1200 1210 1220 1230 1330 1340 1350 1360 1370 1380 pF1KA0 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1240 1250 1260 1270 1280 1290 1390 1400 1410 1420 1430 1440 pF1KA0 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1300 1310 1320 1330 1340 1350 1450 1460 1470 1480 1490 1500 pF1KA0 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1360 1370 1380 1390 1400 1410 1510 1520 1530 1540 1550 1560 pF1KA0 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1420 1430 1440 1450 1460 1470 1570 1580 pF1KA0 VTLEGINLKFMHNQ-FLKLKKW :::::::::::::: :..: CCDS44 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1480 1490 1500 1510 1520 1530 1581 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:42:33 2016 done: Wed Nov 2 18:42:33 2016 Total Scan time: 4.580 Total Display time: 0.750 Function used was FASTA [36.3.4 Apr, 2011]