Result of FASTA (omim) for
pF1KA0371
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0371, 1198 aa
1>>>pF1KA0371 1198 - 1198 aa - 1198 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4866+/-0.000385; mu= 12.9540+/- 0.024
mean_var=137.5837+/-27.371, 0's: 0 Z-trim(117.5): 267 B-trim: 385 in 1/54
Lambda= 0.109343
statistics sampled from 29256 (29537) to 29256 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.346), width: 16
Scan time: 16.090
The best scores are: opt bits E(85289)
NP_066576 (OMIM: 603558) myotubularin-related prot (1198) 8237 1311.8 0
XP_016884518 (OMIM: 603558) PREDICTED: myotubulari (1244) 8233 1311.2 0
XP_005261863 (OMIM: 603558) PREDICTED: myotubulari (1207) 7845 1249.9 0
XP_016884517 (OMIM: 603558) PREDICTED: myotubulari (1253) 7841 1249.3 0
XP_005261862 (OMIM: 603558) PREDICTED: myotubulari (1211) 7783 1240.2 0
XP_005261860 (OMIM: 603558) PREDICTED: myotubulari (1220) 7391 1178.3 0
XP_005261861 (OMIM: 603558) PREDICTED: myotubulari (1220) 7391 1178.3 0
NP_694690 (OMIM: 603558) myotubularin-related prot (1170) 7370 1175.0 0
XP_016884519 (OMIM: 603558) PREDICTED: myotubulari (1216) 7366 1174.4 0
XP_016884521 (OMIM: 603558) PREDICTED: myotubulari (1161) 7362 1173.7 0
NP_694691 (OMIM: 603558) myotubularin-related prot (1161) 7362 1173.7 0
XP_016884520 (OMIM: 603558) PREDICTED: myotubulari (1207) 7358 1173.1 0
XP_005261865 (OMIM: 603558) PREDICTED: myotubulari (1174) 6908 1102.1 0
XP_016884522 (OMIM: 603558) PREDICTED: myotubulari (1069) 6788 1083.2 0
XP_016884523 (OMIM: 603558) PREDICTED: myotubulari ( 638) 3901 627.6 7.7e-179
NP_004678 (OMIM: 603559) myotubularin-related prot (1195) 3770 607.1 2.1e-172
XP_006722231 (OMIM: 603559) PREDICTED: myotubulari (1195) 3770 607.1 2.1e-172
XP_005257843 (OMIM: 603559) PREDICTED: myotubulari (1195) 3770 607.1 2.1e-172
XP_011523762 (OMIM: 603559) PREDICTED: myotubulari (1199) 3770 607.1 2.1e-172
XP_005257842 (OMIM: 603559) PREDICTED: myotubulari (1199) 3770 607.1 2.1e-172
XP_005257841 (OMIM: 603559) PREDICTED: myotubulari (1209) 3764 606.2 4.1e-172
XP_005274431 (OMIM: 601382,603557) PREDICTED: myot ( 571) 966 164.6 1.7e-39
XP_006718997 (OMIM: 601382,603557) PREDICTED: myot ( 571) 966 164.6 1.7e-39
XP_005274432 (OMIM: 601382,603557) PREDICTED: myot ( 571) 966 164.6 1.7e-39
NP_958435 (OMIM: 601382,603557) myotubularin-relat ( 571) 966 164.6 1.7e-39
XP_006718998 (OMIM: 601382,603557) PREDICTED: myot ( 571) 966 164.6 1.7e-39
XP_016874007 (OMIM: 601382,603557) PREDICTED: myot ( 571) 966 164.6 1.7e-39
XP_006718999 (OMIM: 601382,603557) PREDICTED: myot ( 571) 966 164.6 1.7e-39
NP_001230500 (OMIM: 601382,603557) myotubularin-re ( 571) 966 164.6 1.7e-39
XP_016874006 (OMIM: 601382,603557) PREDICTED: myot ( 571) 966 164.6 1.7e-39
NP_958438 (OMIM: 601382,603557) myotubularin-relat ( 571) 966 164.6 1.7e-39
XP_011541360 (OMIM: 601382,603557) PREDICTED: myot ( 596) 966 164.6 1.7e-39
XP_011541361 (OMIM: 601382,603557) PREDICTED: myot ( 596) 966 164.6 1.7e-39
NP_057240 (OMIM: 601382,603557) myotubularin-relat ( 643) 966 164.6 1.8e-39
XP_011533608 (OMIM: 603561) PREDICTED: myotubulari ( 659) 954 162.7 6.9e-39
XP_011533609 (OMIM: 603561) PREDICTED: myotubulari ( 573) 938 160.2 3.5e-38
XP_016885040 (OMIM: 300415,310400) PREDICTED: myot ( 355) 910 155.6 5.1e-37
XP_016885039 (OMIM: 300415,310400) PREDICTED: myot ( 566) 910 155.8 7.5e-37
XP_016885038 (OMIM: 300415,310400) PREDICTED: myot ( 602) 910 155.8 7.9e-37
XP_011529475 (OMIM: 300415,310400) PREDICTED: myot ( 603) 910 155.8 7.9e-37
NP_000243 (OMIM: 300415,310400) myotubularin [Homo ( 603) 910 155.8 7.9e-37
XP_005274744 (OMIM: 300415,310400) PREDICTED: myot ( 603) 910 155.8 7.9e-37
XP_016885036 (OMIM: 300415,310400) PREDICTED: myot ( 617) 910 155.8 8e-37
XP_011529473 (OMIM: 300415,310400) PREDICTED: myot ( 618) 910 155.8 8.1e-37
XP_011529474 (OMIM: 300415,310400) PREDICTED: myot ( 618) 910 155.8 8.1e-37
XP_016885037 (OMIM: 300415,310400) PREDICTED: myot ( 618) 910 155.8 8.1e-37
XP_016885412 (OMIM: 300171) PREDICTED: myotubulari ( 552) 885 151.8 1.1e-35
XP_016885411 (OMIM: 300171) PREDICTED: myotubulari ( 571) 885 151.8 1.2e-35
XP_016885410 (OMIM: 300171) PREDICTED: myotubulari ( 571) 885 151.8 1.2e-35
XP_011529511 (OMIM: 300171) PREDICTED: myotubulari ( 571) 885 151.8 1.2e-35
>>NP_066576 (OMIM: 603558) myotubularin-related protein (1198 aa)
initn: 8237 init1: 8237 opt: 8237 Z-score: 7024.4 bits: 1311.8 E(85289): 0
Smith-Waterman score: 8237; 100.0% identity (100.0% similar) in 1198 aa overlap (1-1198:1-1198)
10 20 30 40 50 60
pF1KA0 MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 SESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KA0 CRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 CRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
1150 1160 1170 1180 1190
>>XP_016884518 (OMIM: 603558) PREDICTED: myotubularin-re (1244 aa)
initn: 8233 init1: 8233 opt: 8233 Z-score: 7020.7 bits: 1311.2 E(85289): 0
Smith-Waterman score: 8233; 99.9% identity (100.0% similar) in 1198 aa overlap (1-1198:47-1244)
10 20 30
pF1KA0 MDEETRHSLECIQANQIFPRKQLIREDENL
.:::::::::::::::::::::::::::::
XP_016 RISHLTLEWQLCKDFLVKPPSRKSSWDKLHLDEETRHSLECIQANQIFPRKQLIREDENL
20 30 40 50 60 70
40 50 60 70 80 90
pF1KA0 QVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KA0 CKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDL
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 CRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVS
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 SFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGS
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 KLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKG
320 330 340 350 360 370
340 350 360 370 380 390
pF1KA0 GGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSV
380 390 400 410 420 430
400 410 420 430 440 450
pF1KA0 LLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWL
440 450 460 470 480 490
460 470 480 490 500 510
pF1KA0 DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYS
500 510 520 530 540 550
520 530 540 550 560 570
pF1KA0 CLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLM
560 570 580 590 600 610
580 590 600 610 620 630
pF1KA0 LWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASR
620 630 640 650 660 670
640 650 660 670 680 690
pF1KA0 RCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQME
680 690 700 710 720 730
700 710 720 730 740 750
pF1KA0 NILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAAL
740 750 760 770 780 790
760 770 780 790 800 810
pF1KA0 RSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVL
800 810 820 830 840 850
820 830 840 850 860 870
pF1KA0 PIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVN
860 870 880 890 900 910
880 890 900 910 920 930
pF1KA0 SGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNG
920 930 940 950 960 970
940 950 960 970 980 990
pF1KA0 APETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLH
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KA0 HKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQ
1040 1050 1060 1070 1080 1090
1060 1070 1080 1090 1100 1110
pF1KA0 ELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQD
1100 1110 1120 1130 1140 1150
1120 1130 1140 1150 1160 1170
pF1KA0 TEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRV
1160 1170 1180 1190 1200 1210
1180 1190
pF1KA0 CKSCYSSLHPTSSSIDLELDKPIAATSN
::::::::::::::::::::::::::::
XP_016 CKSCYSSLHPTSSSIDLELDKPIAATSN
1220 1230 1240
>>XP_005261863 (OMIM: 603558) PREDICTED: myotubularin-re (1207 aa)
initn: 8260 init1: 7844 opt: 7845 Z-score: 6690.1 bits: 1249.9 E(85289): 0
Smith-Waterman score: 8209; 99.3% identity (99.3% similar) in 1207 aa overlap (1-1198:1-1207)
10 20 30 40 50 60
pF1KA0 MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 SESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KA0 CR---------NCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDK
:: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDK
1150 1160 1170 1180 1190 1200
pF1KA0 PIAATSN
:::::::
XP_005 PIAATSN
>>XP_016884517 (OMIM: 603558) PREDICTED: myotubularin-re (1253 aa)
initn: 8253 init1: 7837 opt: 7841 Z-score: 6686.5 bits: 1249.3 E(85289): 0
Smith-Waterman score: 8205; 99.2% identity (99.3% similar) in 1207 aa overlap (1-1198:47-1253)
10 20 30
pF1KA0 MDEETRHSLECIQANQIFPRKQLIREDENL
.:::::::::::::::::::::::::::::
XP_016 RISHLTLEWQLCKDFLVKPPSRKSSWDKLHLDEETRHSLECIQANQIFPRKQLIREDENL
20 30 40 50 60 70
40 50 60 70 80 90
pF1KA0 QVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KA0 CKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDL
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 CRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVS
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 SFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGS
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 KLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKG
320 330 340 350 360 370
340 350 360 370 380 390
pF1KA0 GGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSV
380 390 400 410 420 430
400 410 420 430 440 450
pF1KA0 LLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWL
440 450 460 470 480 490
460 470 480 490 500 510
pF1KA0 DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYS
500 510 520 530 540 550
520 530 540 550 560 570
pF1KA0 CLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLM
560 570 580 590 600 610
580 590 600 610 620 630
pF1KA0 LWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASR
620 630 640 650 660 670
640 650 660 670 680 690
pF1KA0 RCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQME
680 690 700 710 720 730
700 710 720 730 740 750
pF1KA0 NILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAAL
740 750 760 770 780 790
760 770 780 790 800 810
pF1KA0 RSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVL
800 810 820 830 840 850
820 830 840 850 860 870
pF1KA0 PIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVN
860 870 880 890 900 910
880 890 900 910 920 930
pF1KA0 SGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNG
920 930 940 950 960 970
940 950 960 970 980 990
pF1KA0 APETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLH
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KA0 HKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQ
1040 1050 1060 1070 1080 1090
1060 1070 1080 1090 1100 1110
pF1KA0 ELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQD
1100 1110 1120 1130 1140 1150
1120 1130 1140 1150 1160
pF1KA0 TEMTRWLPDHLAAHCYACDSAFWLASRKHHCR---------NCGNVFCSSCCNQKVPVPS
:::::::::::::::::::::::::::::::: :::::::::::::::::::
XP_016 TEMTRWLPDHLAAHCYACDSAFWLASRKHHCRDTDRVDQTWNCGNVFCSSCCNQKVPVPS
1160 1170 1180 1190 1200 1210
1170 1180 1190
pF1KA0 QQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
:::::::::::::::::::::::::::::::::::::
XP_016 QQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
1220 1230 1240 1250
>>XP_005261862 (OMIM: 603558) PREDICTED: myotubularin-re (1211 aa)
initn: 7783 init1: 7783 opt: 7783 Z-score: 6637.3 bits: 1240.2 E(85289): 0
Smith-Waterman score: 7783; 100.0% identity (100.0% similar) in 1128 aa overlap (71-1198:84-1211)
50 60 70 80 90 100
pF1KA0 STEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQ
::::::::::::::::::::::::::::::
XP_005 CISCSFSQHLGVKDVNKNRRPKAPFVLRTQVPLQLIESVECRDIFQLHLTCKDCKVIRCQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KA0 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
120 130 140 150 160 170
170 180 190 200 210 220
pF1KA0 FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KA0 VIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRD
240 250 260 270 280 290
290 300 310 320 330 340
pF1KA0 FPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYP
300 310 320 330 340 350
350 360 370 380 390 400
pF1KA0 NCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KA0 AVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRC
420 430 440 450 460 470
470 480 490 500 510 520
pF1KA0 GHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN
480 490 500 510 520 530
530 540 550 560 570 580
pF1KA0 AKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCP
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 SPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEK
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 WQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEE
660 670 680 690 700 710
710 720 730 740 750 760
pF1KA0 SGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPL
720 730 740 750 760 770
770 780 790 800 810 820
pF1KA0 FSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGY
780 790 800 810 820 830
830 840 850 860 870 880
pF1KA0 GTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTM
840 850 860 870 880 890
890 900 910 920 930 940
pF1KA0 EPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASE
900 910 920 930 940 950
950 960 970 980 990 1000
pF1KA0 QPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGR
960 970 980 990 1000 1010
1010 1020 1030 1040 1050 1060
pF1KA0 PSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQY
1020 1030 1040 1050 1060 1070
1070 1080 1090 1100 1110 1120
pF1KA0 LTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDH
1080 1090 1100 1110 1120 1130
1130 1140 1150 1160 1170 1180
pF1KA0 LAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHP
1140 1150 1160 1170 1180 1190
1190
pF1KA0 TSSSIDLELDKPIAATSN
::::::::::::::::::
XP_005 TSSSIDLELDKPIAATSN
1200 1210
>>XP_005261860 (OMIM: 603558) PREDICTED: myotubularin-re (1220 aa)
initn: 7806 init1: 7390 opt: 7391 Z-score: 6303.0 bits: 1178.3 E(85289): 0
Smith-Waterman score: 7755; 99.2% identity (99.2% similar) in 1137 aa overlap (71-1198:84-1220)
50 60 70 80 90 100
pF1KA0 STEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQ
::::::::::::::::::::::::::::::
XP_005 CISCSFSQHLGVKDVNKNRRPKAPFVLRTQVPLQLIESVECRDIFQLHLTCKDCKVIRCQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KA0 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
120 130 140 150 160 170
170 180 190 200 210 220
pF1KA0 FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KA0 VIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRD
240 250 260 270 280 290
290 300 310 320 330 340
pF1KA0 FPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYP
300 310 320 330 340 350
350 360 370 380 390 400
pF1KA0 NCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KA0 AVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRC
420 430 440 450 460 470
470 480 490 500 510 520
pF1KA0 GHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN
480 490 500 510 520 530
530 540 550 560 570 580
pF1KA0 AKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCP
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 SPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEK
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 WQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEE
660 670 680 690 700 710
710 720 730 740 750 760
pF1KA0 SGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPL
720 730 740 750 760 770
770 780 790 800 810 820
pF1KA0 FSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGY
780 790 800 810 820 830
830 840 850 860 870 880
pF1KA0 GTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTM
840 850 860 870 880 890
890 900 910 920 930 940
pF1KA0 EPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASE
900 910 920 930 940 950
950 960 970 980 990 1000
pF1KA0 QPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGR
960 970 980 990 1000 1010
1010 1020 1030 1040 1050 1060
pF1KA0 PSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQY
1020 1030 1040 1050 1060 1070
1070 1080 1090 1100 1110 1120
pF1KA0 LTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDH
1080 1090 1100 1110 1120 1130
1130 1140 1150 1160 1170
pF1KA0 LAAHCYACDSAFWLASRKHHCR---------NCGNVFCSSCCNQKVPVPSQQLFEPSRVC
:::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_005 LAAHCYACDSAFWLASRKHHCRDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVC
1140 1150 1160 1170 1180 1190
1180 1190
pF1KA0 KSCYSSLHPTSSSIDLELDKPIAATSN
:::::::::::::::::::::::::::
XP_005 KSCYSSLHPTSSSIDLELDKPIAATSN
1200 1210 1220
>>XP_005261861 (OMIM: 603558) PREDICTED: myotubularin-re (1220 aa)
initn: 7806 init1: 7390 opt: 7391 Z-score: 6303.0 bits: 1178.3 E(85289): 0
Smith-Waterman score: 7755; 99.2% identity (99.2% similar) in 1137 aa overlap (71-1198:84-1220)
50 60 70 80 90 100
pF1KA0 STEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQ
::::::::::::::::::::::::::::::
XP_005 CISCSFSQHLGVKDVNKNRRPKAPFVLRTQVPLQLIESVECRDIFQLHLTCKDCKVIRCQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KA0 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
120 130 140 150 160 170
170 180 190 200 210 220
pF1KA0 FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KA0 VIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRD
240 250 260 270 280 290
290 300 310 320 330 340
pF1KA0 FPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYP
300 310 320 330 340 350
350 360 370 380 390 400
pF1KA0 NCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KA0 AVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRC
420 430 440 450 460 470
470 480 490 500 510 520
pF1KA0 GHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN
480 490 500 510 520 530
530 540 550 560 570 580
pF1KA0 AKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCP
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 SPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEK
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 WQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEE
660 670 680 690 700 710
710 720 730 740 750 760
pF1KA0 SGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPL
720 730 740 750 760 770
770 780 790 800 810 820
pF1KA0 FSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGY
780 790 800 810 820 830
830 840 850 860 870 880
pF1KA0 GTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTM
840 850 860 870 880 890
890 900 910 920 930 940
pF1KA0 EPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASE
900 910 920 930 940 950
950 960 970 980 990 1000
pF1KA0 QPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGR
960 970 980 990 1000 1010
1010 1020 1030 1040 1050 1060
pF1KA0 PSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQY
1020 1030 1040 1050 1060 1070
1070 1080 1090 1100 1110 1120
pF1KA0 LTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDH
1080 1090 1100 1110 1120 1130
1130 1140 1150 1160 1170
pF1KA0 LAAHCYACDSAFWLASRKHHCR---------NCGNVFCSSCCNQKVPVPSQQLFEPSRVC
:::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_005 LAAHCYACDSAFWLASRKHHCRDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVC
1140 1150 1160 1170 1180 1190
1180 1190
pF1KA0 KSCYSSLHPTSSSIDLELDKPIAATSN
:::::::::::::::::::::::::::
XP_005 KSCYSSLHPTSSSIDLELDKPIAATSN
1200 1210 1220
>>NP_694690 (OMIM: 603558) myotubularin-related protein (1170 aa)
initn: 7973 init1: 7352 opt: 7370 Z-score: 6285.4 bits: 1175.0 E(85289): 0
Smith-Waterman score: 7876; 96.2% identity (96.2% similar) in 1207 aa overlap (1-1198:1-1170)
10 20 30 40 50 60
pF1KA0 MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEV-----
1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 SESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHH
::::::::::::::::::::::::::::
NP_694 --------------------------------MTRWLPDHLAAHCYACDSAFWLASRKHH
1080 1090 1100
1150 1160 1170 1180 1190
pF1KA0 CR---------NCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDK
:: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 CRDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDK
1110 1120 1130 1140 1150 1160
pF1KA0 PIAATSN
:::::::
NP_694 PIAATSN
1170
>>XP_016884519 (OMIM: 603558) PREDICTED: myotubularin-re (1216 aa)
initn: 7966 init1: 7345 opt: 7366 Z-score: 6281.7 bits: 1174.4 E(85289): 0
Smith-Waterman score: 7872; 96.1% identity (96.2% similar) in 1207 aa overlap (1-1198:47-1216)
10 20 30
pF1KA0 MDEETRHSLECIQANQIFPRKQLIREDENL
.:::::::::::::::::::::::::::::
XP_016 RISHLTLEWQLCKDFLVKPPSRKSSWDKLHLDEETRHSLECIQANQIFPRKQLIREDENL
20 30 40 50 60 70
40 50 60 70 80 90
pF1KA0 QVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KA0 CKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDL
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 CRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVS
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 SFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGS
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 KLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKG
320 330 340 350 360 370
340 350 360 370 380 390
pF1KA0 GGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSV
380 390 400 410 420 430
400 410 420 430 440 450
pF1KA0 LLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWL
440 450 460 470 480 490
460 470 480 490 500 510
pF1KA0 DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYS
500 510 520 530 540 550
520 530 540 550 560 570
pF1KA0 CLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLM
560 570 580 590 600 610
580 590 600 610 620 630
pF1KA0 LWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASR
620 630 640 650 660 670
640 650 660 670 680 690
pF1KA0 RCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQME
680 690 700 710 720 730
700 710 720 730 740 750
pF1KA0 NILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAAL
740 750 760 770 780 790
760 770 780 790 800 810
pF1KA0 RSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVL
800 810 820 830 840 850
820 830 840 850 860 870
pF1KA0 PIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVN
860 870 880 890 900 910
880 890 900 910 920 930
pF1KA0 SGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNG
920 930 940 950 960 970
940 950 960 970 980 990
pF1KA0 APETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLH
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KA0 HKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQ
1040 1050 1060 1070 1080 1090
1060 1070 1080 1090 1100 1110
pF1KA0 ELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQD
:::::::::::::::::::::::::
XP_016 ELKSRLESQYLTSSLHFNGDFGDEV-----------------------------------
1100 1110 1120
1120 1130 1140 1150 1160
pF1KA0 TEMTRWLPDHLAAHCYACDSAFWLASRKHHCR---------NCGNVFCSSCCNQKVPVPS
:::::::::::::::::::::::::::::: :::::::::::::::::::
XP_016 --MTRWLPDHLAAHCYACDSAFWLASRKHHCRDTDRVDQTWNCGNVFCSSCCNQKVPVPS
1130 1140 1150 1160 1170
1170 1180 1190
pF1KA0 QQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
:::::::::::::::::::::::::::::::::::::
XP_016 QQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
1180 1190 1200 1210
>>XP_016884521 (OMIM: 603558) PREDICTED: myotubularin-re (1161 aa)
initn: 7352 init1: 7352 opt: 7362 Z-score: 6278.6 bits: 1173.7 E(85289): 0
Smith-Waterman score: 7904; 96.9% identity (96.9% similar) in 1198 aa overlap (1-1198:1-1161)
10 20 30 40 50 60
pF1KA0 MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEV-----
1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 SESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHH
::::::::::::::::::::::::::::
XP_016 --------------------------------MTRWLPDHLAAHCYACDSAFWLASRKHH
1080 1090 1100
1150 1160 1170 1180 1190
pF1KA0 CRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
1110 1120 1130 1140 1150 1160
1198 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 09:30:25 2016 done: Thu Nov 3 09:30:28 2016
Total Scan time: 16.090 Total Display time: 0.560
Function used was FASTA [36.3.4 Apr, 2011]