FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0389, 1285 aa 1>>>pF1KA0389 1285 - 1285 aa - 1285 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.4505+/-0.000737; mu= -20.3592+/- 0.046 mean_var=689.2640+/-139.815, 0's: 0 Z-trim(115.8): 252 B-trim: 0 in 0/56 Lambda= 0.048852 statistics sampled from 26266 (26516) to 26266 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.311), width: 16 Scan time: 11.480 The best scores are: opt bits E(85289) NP_004990 (OMIM: 600970,606346,607821) unconventio (1285) 8521 617.9 1.4e-175 XP_005248778 (OMIM: 600970,606346,607821) PREDICTE (1281) 8343 605.3 8.5e-172 XP_005248777 (OMIM: 600970,606346,607821) PREDICTE (1285) 7733 562.3 7.4e-159 XP_005248779 (OMIM: 600970,606346,607821) PREDICTE (1276) 7485 544.8 1.4e-153 XP_016866388 (OMIM: 600970,606346,607821) PREDICTE (1263) 6883 502.4 7.9e-141 XP_005248781 (OMIM: 600970,606346,607821) PREDICTE (1272) 6883 502.4 8e-141 XP_005248783 (OMIM: 600970,606346,607821) PREDICTE (1253) 6810 497.3 2.8e-139 NP_001287828 (OMIM: 600970,606346,607821) unconven (1262) 6810 497.3 2.8e-139 XP_005248776 (OMIM: 600970,606346,607821) PREDICTE (1294) 6807 497.1 3.3e-139 NP_005954 (OMIM: 160730) myosin-1 [Homo sapiens] (1939) 980 86.6 1.9e-15 XP_016880164 (OMIM: 160730) PREDICTED: myosin-1 is (1939) 980 86.6 1.9e-15 XP_016880165 (OMIM: 160742) PREDICTED: myosin-4 is (1939) 979 86.5 2e-15 NP_060003 (OMIM: 160742) myosin-4 [Homo sapiens] (1939) 979 86.5 2e-15 NP_002462 (OMIM: 160710,192600,613251,613252,61408 (1939) 969 85.8 3.2e-15 NP_001073936 (OMIM: 251850,606540) unconventional (1848) 930 83.0 2.1e-14 XP_016877898 (OMIM: 610022) PREDICTED: unconventio (1455) 890 80.1 1.2e-13 NP_203693 (OMIM: 606538) unconventional myosin-Ic (1028) 874 78.8 2.1e-13 NP_001074419 (OMIM: 606538) unconventional myosin- (1044) 874 78.8 2.1e-13 NP_001074248 (OMIM: 606538) unconventional myosin- (1063) 874 78.8 2.2e-13 XP_016861411 (OMIM: 609929) PREDICTED: myosin-15 i (1599) 877 79.2 2.5e-13 NP_001094891 (OMIM: 614636) unconventional myosin- (1022) 812 74.4 4.3e-12 XP_016874696 (OMIM: 614636) PREDICTED: unconventio (1027) 812 74.5 4.4e-12 NP_008832 (OMIM: 604875) unconventional myosin-IXa (2548) 784 72.9 3.3e-11 XP_016877718 (OMIM: 604875) PREDICTED: unconventio (2566) 784 72.9 3.3e-11 XP_011519924 (OMIM: 604875) PREDICTED: unconventio (2566) 784 72.9 3.3e-11 XP_011519923 (OMIM: 604875) PREDICTED: unconventio (2598) 784 72.9 3.3e-11 XP_006720602 (OMIM: 604875) PREDICTED: unconventio (2619) 784 72.9 3.3e-11 XP_011519920 (OMIM: 604875) PREDICTED: unconventio (2620) 784 72.9 3.3e-11 XP_011519919 (OMIM: 604875) PREDICTED: unconventio (2637) 784 72.9 3.3e-11 XP_011519916 (OMIM: 604875) PREDICTED: unconventio (2638) 784 72.9 3.3e-11 XP_011519915 (OMIM: 604875) PREDICTED: unconventio (2638) 784 72.9 3.3e-11 XP_011519917 (OMIM: 604875) PREDICTED: unconventio (2638) 784 72.9 3.3e-11 XP_011519918 (OMIM: 604875) PREDICTED: unconventio (2638) 784 72.9 3.3e-11 XP_016880174 (OMIM: 606539) PREDICTED: unconventio ( 955) 760 70.8 5.3e-11 NP_001290208 (OMIM: 606539) unconventional myosin- ( 961) 760 70.8 5.3e-11 NP_056009 (OMIM: 606539) unconventional myosin-Id (1006) 760 70.8 5.4e-11 XP_011536525 (OMIM: 614636) PREDICTED: unconventio (1044) 756 70.5 6.8e-11 XP_016867993 (OMIM: 600642) PREDICTED: unconventio ( 780) 749 69.9 7.8e-11 XP_016867992 (OMIM: 600642) PREDICTED: unconventio ( 903) 749 70.0 8.6e-11 NP_149043 (OMIM: 600642) unconventional myosin-Ig (1018) 749 70.0 9.4e-11 NP_001073996 (OMIM: 606541) unconventional myosin- (2116) 759 71.0 9.7e-11 XP_006712602 (OMIM: 606541) PREDICTED: unconventio (2142) 759 71.0 9.8e-11 XP_011509520 (OMIM: 606541) PREDICTED: unconventio (2145) 759 71.0 9.8e-11 XP_016859658 (OMIM: 606541) PREDICTED: unconventio (2164) 759 71.0 9.8e-11 NP_001120651 (OMIM: 276900,276903,600060,601317) u (1178) 744 69.7 1.3e-10 XP_016873276 (OMIM: 276900,276903,600060,601317) P (1451) 744 69.8 1.5e-10 XP_016873275 (OMIM: 276900,276903,600060,601317) P (2154) 744 70.0 2e-10 NP_001120652 (OMIM: 276900,276903,600060,601317) u (2175) 744 70.0 2.1e-10 XP_016873273 (OMIM: 276900,276903,600060,601317) P (2206) 744 70.0 2.1e-10 XP_016873277 (OMIM: 276900,276903,600060,601317) P (2207) 744 70.0 2.1e-10 >>NP_004990 (OMIM: 600970,606346,607821) unconventional (1285 aa) initn: 8521 init1: 8521 opt: 8521 Z-score: 3273.1 bits: 617.9 E(85289): 1.4e-175 Smith-Waterman score: 8521; 100.0% identity (100.0% similar) in 1285 aa overlap (1-1285:1-1285) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 AELISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AELISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKW 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ 1210 1220 1230 1240 1250 1260 1270 1280 pF1KA0 YLQNAIESRQARPTYATAMLQSLLK ::::::::::::::::::::::::: NP_004 YLQNAIESRQARPTYATAMLQSLLK 1270 1280 >>XP_005248778 (OMIM: 600970,606346,607821) PREDICTED: u (1281 aa) initn: 8349 init1: 6803 opt: 8343 Z-score: 3205.3 bits: 605.3 E(85289): 8.5e-172 Smith-Waterman score: 8373; 98.2% identity (98.3% similar) in 1294 aa overlap (1-1285:1-1281) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KA0 AELISDEAQADLALR---------RNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAG ::::::::::::::: .:::::::::: :::::::::::: XP_005 AELISDEAQADLALRSLDSYPVTSKNDGTRPKMTP-------------GPAVLATKAAAG 1030 1040 1050 1060 1080 1090 1100 1110 1120 1130 pF1KA0 TKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAP 1070 1080 1090 1100 1110 1120 1140 1150 1160 1170 1180 1190 pF1KA0 KSVTDYDFAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSVTDYDFAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKG 1130 1140 1150 1160 1170 1180 1200 1210 1220 1230 1240 1250 pF1KA0 WWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEE 1190 1200 1210 1220 1230 1240 1260 1270 1280 pF1KA0 IWERCGGIQYLQNAIESRQARPTYATAMLQSLLK :::::::::::::::::::::::::::::::::: XP_005 IWERCGGIQYLQNAIESRQARPTYATAMLQSLLK 1250 1260 1270 1280 >>XP_005248777 (OMIM: 600970,606346,607821) PREDICTED: u (1285 aa) initn: 7656 init1: 7656 opt: 7733 Z-score: 2972.9 bits: 562.3 E(85289): 7.4e-159 Smith-Waterman score: 8387; 98.5% identity (98.5% similar) in 1294 aa overlap (1-1285:1-1285) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KA0 AELISDEAQADLALR---------RNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAG ::::::::::::::: .::::::::::::::::::::::::::::::::::: XP_005 AELISDEAQADLALRSLDSYPVTSKNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAG 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA0 TKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAP 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA0 KSVTDYDFAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKG :::::: :::::::::::::::::::::::::::::::::::::::::::: XP_005 KSVTDY---------AQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKG 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KA0 WWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEE 1200 1210 1220 1230 1240 1250 1260 1270 1280 pF1KA0 IWERCGGIQYLQNAIESRQARPTYATAMLQSLLK :::::::::::::::::::::::::::::::::: XP_005 IWERCGGIQYLQNAIESRQARPTYATAMLQSLLK 1260 1270 1280 >>XP_005248779 (OMIM: 600970,606346,607821) PREDICTED: u (1276 aa) initn: 7480 init1: 7480 opt: 7485 Z-score: 2878.5 bits: 544.8 E(85289): 1.4e-153 Smith-Waterman score: 8419; 99.2% identity (99.2% similar) in 1285 aa overlap (1-1285:1-1276) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 AELISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AELISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKW 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDY--- 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KA0 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ------AQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KA0 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ 1200 1210 1220 1230 1240 1250 1270 1280 pF1KA0 YLQNAIESRQARPTYATAMLQSLLK ::::::::::::::::::::::::: XP_005 YLQNAIESRQARPTYATAMLQSLLK 1260 1270 >>XP_016866388 (OMIM: 600970,606346,607821) PREDICTED: u (1263 aa) initn: 7838 init1: 6883 opt: 6883 Z-score: 2649.3 bits: 502.4 E(85289): 7.9e-141 Smith-Waterman score: 8303; 98.2% identity (98.2% similar) in 1285 aa overlap (1-1285:1-1263) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 AELISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKW :::::::::::::::::::::::::: ::::::::::::::::::::: XP_016 AELISDEAQADLALRRNDGTRPKMTP-------------GPAVLATKAAAGTKKYDLSKW 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KA0 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDY--- 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KA0 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ------AQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 pF1KA0 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ 1180 1190 1200 1210 1220 1230 1270 1280 pF1KA0 YLQNAIESRQARPTYATAMLQSLLK ::::::::::::::::::::::::: XP_016 YLQNAIESRQARPTYATAMLQSLLK 1240 1250 1260 >>XP_005248781 (OMIM: 600970,606346,607821) PREDICTED: u (1272 aa) initn: 6883 init1: 6883 opt: 6883 Z-score: 2649.2 bits: 502.4 E(85289): 8e-141 Smith-Waterman score: 8405; 99.0% identity (99.0% similar) in 1285 aa overlap (1-1285:1-1272) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 AELISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKW :::::::::::::::::::::::::: ::::::::::::::::::::: XP_005 AELISDEAQADLALRRNDGTRPKMTP-------------GPAVLATKAAAGTKKYDLSKW 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KA0 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KA0 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 pF1KA0 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ 1190 1200 1210 1220 1230 1240 1270 1280 pF1KA0 YLQNAIESRQARPTYATAMLQSLLK ::::::::::::::::::::::::: XP_005 YLQNAIESRQARPTYATAMLQSLLK 1250 1260 1270 >>XP_005248783 (OMIM: 600970,606346,607821) PREDICTED: u (1253 aa) initn: 7765 init1: 6810 opt: 6810 Z-score: 2621.5 bits: 497.3 E(85289): 2.8e-139 Smith-Waterman score: 8210; 97.4% identity (97.4% similar) in 1285 aa overlap (1-1285:1-1253) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 AELISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKW :::::::::::::::: ::::::::::::::::::::: XP_005 AELISDEAQADLALRR-----------------------GPAVLATKAAAGTKKYDLSKW 1030 1040 1050 1090 1100 1110 1120 1130 1140 pF1KA0 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDY--- 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 pF1KA0 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ------AQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP 1120 1130 1140 1150 1160 1210 1220 1230 1240 1250 1260 pF1KA0 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ 1170 1180 1190 1200 1210 1220 1270 1280 pF1KA0 YLQNAIESRQARPTYATAMLQSLLK ::::::::::::::::::::::::: XP_005 YLQNAIESRQARPTYATAMLQSLLK 1230 1240 1250 >>NP_001287828 (OMIM: 600970,606346,607821) unconvention (1262 aa) initn: 6810 init1: 6810 opt: 6810 Z-score: 2621.5 bits: 497.3 E(85289): 2.8e-139 Smith-Waterman score: 8312; 98.2% identity (98.2% similar) in 1285 aa overlap (1-1285:1-1262) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 AELISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKW :::::::::::::::: ::::::::::::::::::::: NP_001 AELISDEAQADLALRR-----------------------GPAVLATKAAAGTKKYDLSKW 1030 1040 1050 1090 1100 1110 1120 1130 1140 pF1KA0 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFA 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 pF1KA0 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGP 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 pF1KA0 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQ 1180 1190 1200 1210 1220 1230 1270 1280 pF1KA0 YLQNAIESRQARPTYATAMLQSLLK ::::::::::::::::::::::::: NP_001 YLQNAIESRQARPTYATAMLQSLLK 1240 1250 1260 >>XP_005248776 (OMIM: 600970,606346,607821) PREDICTED: u (1294 aa) initn: 6806 init1: 6806 opt: 6807 Z-score: 2620.2 bits: 497.1 E(85289): 3.3e-139 Smith-Waterman score: 8489; 99.2% identity (99.3% similar) in 1294 aa overlap (1-1285:1-1294) 10 20 30 40 50 60 pF1KA0 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KA0 AELISDEAQADLALR---------RNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAG ::::::::::::::: .::::::::::::::::::::::::::::::::::: XP_005 AELISDEAQADLALRSLDSYPVTSKNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAG 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KA0 TKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAP 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KA0 KSVTDYDFAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSVTDYDFAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKG 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KA0 WWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEE 1210 1220 1230 1240 1250 1260 1260 1270 1280 pF1KA0 IWERCGGIQYLQNAIESRQARPTYATAMLQSLLK :::::::::::::::::::::::::::::::::: XP_005 IWERCGGIQYLQNAIESRQARPTYATAMLQSLLK 1270 1280 1290 >>NP_005954 (OMIM: 160730) myosin-1 [Homo sapiens] (1939 aa) initn: 1216 init1: 400 opt: 980 Z-score: 398.5 bits: 86.6 E(85289): 1.9e-15 Smith-Waterman score: 1556; 30.2% identity (60.9% similar) in 1193 aa overlap (36-1169:65-1180) 10 20 30 40 50 60 pF1KA0 PVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSL . : : . .:::: . . .:: . NP_005 KTSVFVVDPKESFVKATVQSREGGKVTAKTEAGATVTVKDDQVFPMNPPKYDKIEDMAMM 40 50 60 70 80 90 70 80 90 100 110 120 pF1KA0 MYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPP .:.: ..:.:.: ::. :::: . . ..:::: .: .:..:.. .:.::. :: NP_005 THLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVTAYRGKKRQEAPP 100 110 120 130 140 150 130 140 150 160 170 pF1KA0 HVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQD-------- :.:.:.:.:.. : . . .:::...:::::::: ::: :..:.. ::. NP_005 HIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEVTSG 160 170 180 190 200 210 180 190 200 210 220 230 pF1KA0 -----IDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEK ..:.:. ::::::::::::::::.::::::::..:::. ...... . ::::: NP_005 KMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEK 220 230 240 250 260 270 240 250 260 270 280 290 pF1KA0 SRICVQGKEERNYHIFYRLCAGASEDIREKLHLSS-PDNFRYLNRGCTRYFANKETDKQI ::. : : ::.:::::.. .. . :. : : ... : .. ....: NP_005 SRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQG-------------- 280 290 300 310 300 310 320 330 340 350 pF1KA0 LQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNID . : .::. ... .:.. .:. ..:..........:.: ::. NP_005 -------------EITVPSIDDQEELMATDSAIEILGFTSDERVSIYKLTGAVMHYGNMK 320 330 340 350 360 360 370 380 390 400 pF1KA0 FE----EAGSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSLT-TRVMLTTAGGTKGTV :. : . : .. .:.: : .:.. :: .: :: . . ::: . NP_005 FKQKQREEQAEPDGTEVADKAAY-------LQNLNSADLLKALCYPRVKVGNEYVTKGQT 370 380 390 400 410 410 420 430 440 450 460 pF1KA0 IKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPF-ETSSYFIGVLDIAGFEYFEH :.:. :: ::::.::...: .:.:.:: . . .:::::::::::: :. NP_005 ------VQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDF 420 430 440 450 460 470 470 480 490 500 510 520 pF1KA0 NSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHY-VDNQDCIDLIEAKLVG ::.::.:::. :::::::::.... ::: :.:::. . . . .: ::.::: : .: NP_005 NSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KPMG 480 490 500 510 520 530 530 540 550 560 570 580 pF1KA0 ILDILDEENRLPQPSDQHFTSAVHQKH---KDHFRLTIPRKSKLAVHRNIRDDEGFIIRH :..::.:: .:. .: : . ....: ...:. : :.: .: : . : NP_005 IFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAH--------FSLIH 540 550 560 570 580 590 600 610 620 630 pF1KA0 FAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTK--QKAGKL- .::.: :. . ...::.: :. .. .: .: : . :: ..:. . .. .:.:: NP_005 YAGTVDYNIAGWLDKNKDPLNETVVGLYQKSAMKTLALLFVGATGAEAEAGGGKKGGKKK 590 600 610 620 630 640 640 650 660 670 680 690 pF1KA0 --SFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVS :: .:. :. .:: :. .:::: :.::: :: : .: .: ::.:.:.. NP_005 GSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLE 650 660 670 680 690 700 700 710 720 730 740 750 pF1KA0 VLDLMQGGYPSR---ASFHELYNMYKKYMPDKLARLDPRLFCKALFKALGLNENDYKFGL . . . :.::: :.:.. :.. . . .: . . :. .. .....:::: NP_005 GIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGH 710 720 730 740 750 760 760 770 780 790 800 810 pF1KA0 TKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYR :::::. : .. ... :... .::.:. :.. : . :. .. .. .. : NP_005 TKVFFKAGLLGLLEE-MRDE--KLAQLITRTQA--MCRGF-------LARVEYQKMVERR 770 780 790 800 810 820 830 840 850 860 pF1KA0 AEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEVVSV---LKDGKPEMNK- :. . .: ..: .. . .: : . :. : : . .:.... .. : :. : NP_005 -ESIFCIQYNVRAFM-NVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKT 820 830 840 850 860 870 870 880 890 900 910 920 pF1KA0 --QIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQE------- . :.:: .. ::: . :. . : :.: : :.:. . :. . .. : : : NP_005 EAKRKELEEKMVTLMQE-KNDL--QLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVT 880 890 900 910 920 930 940 950 960 970 980 pF1KA0 EEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKR :.:: ..:. :. .... :.. .. .:. .. .. : :.:. :.. : .: NP_005 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 930 940 950 960 970 980 990 1000 1010 1020 1030 pF1KA0 IQAEVEAQLARQKE--EESQQQAVLE-QERRDRELALRIAQSEAELISDEAQADLALR-- :. :.:...:. .:..::.. . : ..:. .: :. . : :. ...: . NP_005 GLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK 990 1000 1010 1020 1030 1040 1040 1050 1060 1070 1080 pF1KA0 -RNDGTRPKMTPE---QMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKWKYAELRDT--- : : : : : ..:.: . . : : :....: . ....: NP_005 IRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLK--KKEFEMSGLQ-SKIEDEQAL 1050 1060 1070 1080 1090 1100 1090 1100 1110 1120 1130 1140 pF1KA0 -INTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFAPFLNNSP .. . :. : : ::....... .: ..: .: ::. : ... :... NP_005 GMQLQKKIKELQARIEELEEEIEAERASRAKAEK------QRSDLSRELEEISERLEEAG 1110 1120 1130 1140 1150 1150 1160 1170 1180 1190 1200 pF1KA0 QQNPAAQIPA-RQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGPWIARQM . .::: ..:: :.....: NP_005 GAT-SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1160 1170 1180 1190 1200 1210 1285 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 09:32:41 2016 done: Thu Nov 3 09:32:42 2016 Total Scan time: 11.480 Total Display time: 0.500 Function used was FASTA [36.3.4 Apr, 2011]