FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0443, 1395 aa 1>>>pF1KA0443 1395 - 1395 aa - 1395 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8260+/-0.000461; mu= 15.5740+/- 0.029 mean_var=102.2565+/-19.967, 0's: 0 Z-trim(111.2): 68 B-trim: 66 in 1/58 Lambda= 0.126832 statistics sampled from 19726 (19793) to 19726 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.232), width: 16 Scan time: 13.130 The best scores are: opt bits E(85289) NP_055525 (OMIM: 300417) G-protein coupled recepto (1395) 9424 1736.3 0 XP_016885470 (OMIM: 300417) PREDICTED: G-protein c (1395) 9424 1736.3 0 NP_001092881 (OMIM: 300417) G-protein coupled rece (1395) 9424 1736.3 0 XP_016885471 (OMIM: 300417) PREDICTED: G-protein c (1395) 9424 1736.3 0 NP_001171656 (OMIM: 300417) G-protein coupled rece (1395) 9424 1736.3 0 NP_001092880 (OMIM: 300417) G-protein coupled rece (1395) 9424 1736.3 0 NP_001004051 (OMIM: 300969) G-protein coupled rece ( 838) 2043 385.7 8e-106 NP_001171803 (OMIM: 300969) G-protein coupled rece ( 838) 2043 385.7 8e-106 NP_001171805 (OMIM: 300969) G-protein coupled rece ( 838) 2043 385.7 8e-106 NP_001171804 (OMIM: 300969) G-protein coupled rece ( 838) 2043 385.7 8e-106 NP_612446 (OMIM: 300969) G-protein coupled recepto ( 838) 2043 385.7 8e-106 NP_001135998 (OMIM: 300921) protein BHLHb9 [Homo s ( 547) 799 158.0 1.8e-37 NP_001135996 (OMIM: 300921) protein BHLHb9 [Homo s ( 547) 799 158.0 1.8e-37 NP_085142 (OMIM: 300921) protein BHLHb9 [Homo sapi ( 547) 799 158.0 1.8e-37 NP_001136001 (OMIM: 300921) protein BHLHb9 [Homo s ( 547) 799 158.0 1.8e-37 NP_001135999 (OMIM: 300921) protein BHLHb9 [Homo s ( 547) 799 158.0 1.8e-37 NP_001136002 (OMIM: 300921) protein BHLHb9 [Homo s ( 547) 799 158.0 1.8e-37 NP_001136000 (OMIM: 300921) protein BHLHb9 [Homo s ( 547) 799 158.0 1.8e-37 NP_001135997 (OMIM: 300921) protein BHLHb9 [Homo s ( 547) 799 158.0 1.8e-37 NP_808817 (OMIM: 300364) armadillo repeat-containi ( 379) 440 92.2 7.9e-18 NP_057691 (OMIM: 300364) armadillo repeat-containi ( 379) 440 92.2 7.9e-18 XP_005262198 (OMIM: 300364) PREDICTED: armadillo r ( 379) 440 92.2 7.9e-18 NP_808816 (OMIM: 300364) armadillo repeat-containi ( 379) 440 92.2 7.9e-18 NP_057692 (OMIM: 300362) armadillo repeat-containi ( 453) 437 91.7 1.4e-17 XP_016868176 (OMIM: 611864) PREDICTED: armadillo r ( 273) 388 82.6 4.4e-15 XP_011514904 (OMIM: 611864) PREDICTED: armadillo r ( 280) 388 82.6 4.5e-15 NP_001154481 (OMIM: 611864) armadillo repeat-conta ( 308) 388 82.6 4.9e-15 XP_011514903 (OMIM: 611864) PREDICTED: armadillo r ( 316) 388 82.6 5e-15 NP_114111 (OMIM: 611864) armadillo repeat-containi ( 343) 388 82.7 5.3e-15 XP_016868173 (OMIM: 611864) PREDICTED: armadillo r ( 352) 388 82.7 5.4e-15 XP_011529373 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_016885480 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_016885481 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_005278167 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 NP_055597 (OMIM: 300363) armadillo repeat-containi ( 632) 362 78.0 2.4e-13 XP_016885477 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_005278170 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_011529374 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_005278173 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_005278166 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_005278174 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_016885478 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_016885482 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_016885483 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 NP_001269160 (OMIM: 300363) armadillo repeat-conta ( 632) 362 78.0 2.4e-13 XP_016885486 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_005278168 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 XP_016885476 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 NP_808818 (OMIM: 300363) armadillo repeat-containi ( 632) 362 78.0 2.4e-13 XP_016885484 (OMIM: 300363) PREDICTED: armadillo r ( 632) 362 78.0 2.4e-13 >>NP_055525 (OMIM: 300417) G-protein coupled receptor-as (1395 aa) initn: 9424 init1: 9424 opt: 9424 Z-score: 9316.5 bits: 1736.3 E(85289): 0 Smith-Waterman score: 9424; 99.9% identity (100.0% similar) in 1395 aa overlap (1-1395:1-1395) 10 20 30 40 50 60 pF1KA0 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 HEDHLESWFGAGKEGKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_055 HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1330 1340 1350 1360 1370 1380 1390 pF1KA0 GKTDNQNDPEGDQEN ::::::::::::::: NP_055 GKTDNQNDPEGDQEN 1390 >>XP_016885470 (OMIM: 300417) PREDICTED: G-protein coupl (1395 aa) initn: 9424 init1: 9424 opt: 9424 Z-score: 9316.5 bits: 1736.3 E(85289): 0 Smith-Waterman score: 9424; 99.9% identity (100.0% similar) in 1395 aa overlap (1-1395:1-1395) 10 20 30 40 50 60 pF1KA0 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 HEDHLESWFGAGKEGKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1330 1340 1350 1360 1370 1380 1390 pF1KA0 GKTDNQNDPEGDQEN ::::::::::::::: XP_016 GKTDNQNDPEGDQEN 1390 >>NP_001092881 (OMIM: 300417) G-protein coupled receptor (1395 aa) initn: 9424 init1: 9424 opt: 9424 Z-score: 9316.5 bits: 1736.3 E(85289): 0 Smith-Waterman score: 9424; 99.9% identity (100.0% similar) in 1395 aa overlap (1-1395:1-1395) 10 20 30 40 50 60 pF1KA0 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 HEDHLESWFGAGKEGKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_001 HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1330 1340 1350 1360 1370 1380 1390 pF1KA0 GKTDNQNDPEGDQEN ::::::::::::::: NP_001 GKTDNQNDPEGDQEN 1390 >>XP_016885471 (OMIM: 300417) PREDICTED: G-protein coupl (1395 aa) initn: 9424 init1: 9424 opt: 9424 Z-score: 9316.5 bits: 1736.3 E(85289): 0 Smith-Waterman score: 9424; 99.9% identity (100.0% similar) in 1395 aa overlap (1-1395:1-1395) 10 20 30 40 50 60 pF1KA0 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 HEDHLESWFGAGKEGKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1330 1340 1350 1360 1370 1380 1390 pF1KA0 GKTDNQNDPEGDQEN ::::::::::::::: XP_016 GKTDNQNDPEGDQEN 1390 >>NP_001171656 (OMIM: 300417) G-protein coupled receptor (1395 aa) initn: 9424 init1: 9424 opt: 9424 Z-score: 9316.5 bits: 1736.3 E(85289): 0 Smith-Waterman score: 9424; 99.9% identity (100.0% similar) in 1395 aa overlap (1-1395:1-1395) 10 20 30 40 50 60 pF1KA0 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 HEDHLESWFGAGKEGKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_001 HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1330 1340 1350 1360 1370 1380 1390 pF1KA0 GKTDNQNDPEGDQEN ::::::::::::::: NP_001 GKTDNQNDPEGDQEN 1390 >>NP_001092880 (OMIM: 300417) G-protein coupled receptor (1395 aa) initn: 9424 init1: 9424 opt: 9424 Z-score: 9316.5 bits: 1736.3 E(85289): 0 Smith-Waterman score: 9424; 99.9% identity (100.0% similar) in 1395 aa overlap (1-1395:1-1395) 10 20 30 40 50 60 pF1KA0 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 HEDHLESWFGAGKEGKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_001 HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1330 1340 1350 1360 1370 1380 1390 pF1KA0 GKTDNQNDPEGDQEN ::::::::::::::: NP_001 GKTDNQNDPEGDQEN 1390 >>NP_001004051 (OMIM: 300969) G-protein coupled receptor (838 aa) initn: 2260 init1: 1468 opt: 2043 Z-score: 2020.9 bits: 385.7 E(85289): 8e-106 Smith-Waterman score: 2128; 47.2% identity (68.9% similar) in 852 aa overlap (559-1395:39-838) 530 540 550 560 570 580 pF1KA0 SVESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAEN .: .: : ::: .: ... .. .: NP_001 SAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTG--ARPKTETKSVPAARPKTEA 10 20 30 40 50 60 590 600 610 620 630 640 pF1KA0 QTYMDCRAETSCDTMQGAE---EEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPC :.. : .: ..: ::. : . : :. ...: . : . ::.. . : : NP_001 QAMSGARPKTEVQVMGGARPKTEAQGITGAR--PKTDARAVGGARSKTDAKAIPGAR-PK 70 80 90 100 110 120 650 660 670 680 690 700 pF1KA0 FGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRP-EEEEDIV :. .. . :: . . :. .:: . : : .:. ::. ....: NP_001 DEAQAWAQSEFGTEAVSQ-AEGVSQTNAVA--W----PLATAESGSVTKSKGLSMDRELV 130 140 150 160 170 710 720 730 740 750 760 pF1KA0 NSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEAT : . :. . : :. ::.:. :. .. ..::. .: ::. :: : NP_001 NVDAETFPGTQGQKGIQPWFGPGEETNM-GSWCYSRPRAREEASNESGFWSADE-----T 180 190 200 210 220 230 770 780 790 800 810 820 pF1KA0 DREESRPEAEEGDIIGSWFWAGEED----RLEPAAETREEDRLAAEKEGIVGSWFGAREE . : .:: .. . : ::. : . .: ..: ...:. : :: :...: NP_001 STASSFWTGEETSVRS---WPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDE 240 250 260 270 280 830 840 850 860 870 pF1KA0 T---IRREAGSCSKS--SPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITV . . .: ... :...:: : .. ..: :::. :.:. NP_001 ASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDC--------FESE---SEDEFYK 290 300 310 320 330 880 890 900 910 920 930 pF1KA0 GSWFWPEEEASIQAGSQAVEEMESETEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEM :: : :::. . . :. .. . . .. :. .:..: :. .::. NP_001 QSWVLPGEEANSRFRHRDKEDPNTALK---LRAQKDVDSDRVKQE--------PRFEEEV 340 350 360 370 380 940 950 960 970 980 990 pF1KA0 IVESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLA :. ::::.. .: : :. : :::.: .::::: :: . ::. ... :. .. NP_001 IIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEE----KSSLGAVAREEAKP 390 400 410 420 430 440 1000 1010 1020 1030 1040 1050 pF1KA0 D-EDEAIVGSWFWAGDEAHFESNPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP . :.::: ::::: ::: :. :: ::... : ..: : . : :::.:.::::.::: NP_001 ESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAE-ELNASSRPQTWDEVTVEFKP 450 460 470 480 490 500 1060 1070 1080 1090 1100 1110 pF1KA0 GPWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQ : . ::: : ::: .:.::. ::. .::.:. ::::::.:::::::::::::: :: NP_001 GLFHGVGFRSTSPFGIPEEAS----EMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQ 510 520 530 540 550 1120 1130 1140 1150 1160 1170 pF1KA0 YDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEI ::::::::.::::::::.::.: :: ::.:::::::::::::::.::::.:::::::::: NP_001 YDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEI 560 570 580 590 600 610 1180 1190 1200 1210 1220 1230 pF1KA0 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQ :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::.:. NP_001 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIE 620 630 640 650 660 670 1240 1250 1260 1270 1280 1290 pF1KA0 TYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRF :.::.:::::::.:::: :::.::::.:::: : :::::.:::::::::::.:.::.:.: NP_001 TFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKF 680 690 700 710 720 730 1300 1310 1320 1330 1340 1350 pF1KA0 HVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIKK-ET :::::::::::: ..:.:.::.:.: :.:::: ::::::::::. .:.::.: ::. . NP_001 HVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKM 740 750 760 770 780 790 1360 1370 1380 1390 pF1KA0 VFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPEGDQEN . ::::..:::::::.. :..::.::.. ::::::: :.. NP_001 SLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS 800 810 820 830 >>NP_001171803 (OMIM: 300969) G-protein coupled receptor (838 aa) initn: 2260 init1: 1468 opt: 2043 Z-score: 2020.9 bits: 385.7 E(85289): 8e-106 Smith-Waterman score: 2128; 47.2% identity (68.9% similar) in 852 aa overlap (559-1395:39-838) 530 540 550 560 570 580 pF1KA0 SVESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAEN .: .: : ::: .: ... .. .: NP_001 SAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTG--ARPKTETKSVPAARPKTEA 10 20 30 40 50 60 590 600 610 620 630 640 pF1KA0 QTYMDCRAETSCDTMQGAE---EEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPC :.. : .: ..: ::. : . : :. ...: . : . ::.. . : : NP_001 QAMSGARPKTEVQVMGGARPKTEAQGITGAR--PKTDARAVGGARSKTDAKAIPGAR-PK 70 80 90 100 110 120 650 660 670 680 690 700 pF1KA0 FGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRP-EEEEDIV :. .. . :: . . :. .:: . : : .:. ::. ....: NP_001 DEAQAWAQSEFGTEAVSQ-AEGVSQTNAVA--W----PLATAESGSVTKSKGLSMDRELV 130 140 150 160 170 710 720 730 740 750 760 pF1KA0 NSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEAT : . :. . : :. ::.:. :. .. ..::. .: ::. :: : NP_001 NVDAETFPGTQGQKGIQPWFGPGEETNM-GSWCYSRPRAREEASNESGFWSADE-----T 180 190 200 210 220 230 770 780 790 800 810 820 pF1KA0 DREESRPEAEEGDIIGSWFWAGEED----RLEPAAETREEDRLAAEKEGIVGSWFGAREE . : .:: .. . : ::. : . .: ..: ...:. : :: :...: NP_001 STASSFWTGEETSVRS---WPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDE 240 250 260 270 280 830 840 850 860 870 pF1KA0 T---IRREAGSCSKS--SPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITV . . .: ... :...:: : .. ..: :::. :.:. NP_001 ASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDC--------FESE---SEDEFYK 290 300 310 320 330 880 890 900 910 920 930 pF1KA0 GSWFWPEEEASIQAGSQAVEEMESETEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEM :: : :::. . . :. .. . . .. :. .:..: :. .::. NP_001 QSWVLPGEEANSRFRHRDKEDPNTALK---LRAQKDVDSDRVKQE--------PRFEEEV 340 350 360 370 380 940 950 960 970 980 990 pF1KA0 IVESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLA :. ::::.. .: : :. : :::.: .::::: :: . ::. ... :. .. NP_001 IIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEE----KSSLGAVAREEAKP 390 400 410 420 430 440 1000 1010 1020 1030 1040 1050 pF1KA0 D-EDEAIVGSWFWAGDEAHFESNPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP . :.::: ::::: ::: :. :: ::... : ..: : . : :::.:.::::.::: NP_001 ESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAE-ELNASSRPQTWDEVTVEFKP 450 460 470 480 490 500 1060 1070 1080 1090 1100 1110 pF1KA0 GPWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQ : . ::: : ::: .:.::. ::. .::.:. ::::::.:::::::::::::: :: NP_001 GLFHGVGFRSTSPFGIPEEAS----EMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQ 510 520 530 540 550 1120 1130 1140 1150 1160 1170 pF1KA0 YDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEI ::::::::.::::::::.::.: :: ::.:::::::::::::::.::::.:::::::::: NP_001 YDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEI 560 570 580 590 600 610 1180 1190 1200 1210 1220 1230 pF1KA0 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQ :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::.:. NP_001 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIE 620 630 640 650 660 670 1240 1250 1260 1270 1280 1290 pF1KA0 TYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRF :.::.:::::::.:::: :::.::::.:::: : :::::.:::::::::::.:.::.:.: NP_001 TFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKF 680 690 700 710 720 730 1300 1310 1320 1330 1340 1350 pF1KA0 HVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIKK-ET :::::::::::: ..:.:.::.:.: :.:::: ::::::::::. .:.::.: ::. . NP_001 HVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKM 740 750 760 770 780 790 1360 1370 1380 1390 pF1KA0 VFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPEGDQEN . ::::..:::::::.. :..::.::.. ::::::: :.. NP_001 SLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS 800 810 820 830 >>NP_001171805 (OMIM: 300969) G-protein coupled receptor (838 aa) initn: 2260 init1: 1468 opt: 2043 Z-score: 2020.9 bits: 385.7 E(85289): 8e-106 Smith-Waterman score: 2128; 47.2% identity (68.9% similar) in 852 aa overlap (559-1395:39-838) 530 540 550 560 570 580 pF1KA0 SVESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAEN .: .: : ::: .: ... .. .: NP_001 SAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTG--ARPKTETKSVPAARPKTEA 10 20 30 40 50 60 590 600 610 620 630 640 pF1KA0 QTYMDCRAETSCDTMQGAE---EEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPC :.. : .: ..: ::. : . : :. ...: . : . ::.. . : : NP_001 QAMSGARPKTEVQVMGGARPKTEAQGITGAR--PKTDARAVGGARSKTDAKAIPGAR-PK 70 80 90 100 110 120 650 660 670 680 690 700 pF1KA0 FGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRP-EEEEDIV :. .. . :: . . :. .:: . : : .:. ::. ....: NP_001 DEAQAWAQSEFGTEAVSQ-AEGVSQTNAVA--W----PLATAESGSVTKSKGLSMDRELV 130 140 150 160 170 710 720 730 740 750 760 pF1KA0 NSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEAT : . :. . : :. ::.:. :. .. ..::. .: ::. :: : NP_001 NVDAETFPGTQGQKGIQPWFGPGEETNM-GSWCYSRPRAREEASNESGFWSADE-----T 180 190 200 210 220 230 770 780 790 800 810 820 pF1KA0 DREESRPEAEEGDIIGSWFWAGEED----RLEPAAETREEDRLAAEKEGIVGSWFGAREE . : .:: .. . : ::. : . .: ..: ...:. : :: :...: NP_001 STASSFWTGEETSVRS---WPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDE 240 250 260 270 280 830 840 850 860 870 pF1KA0 T---IRREAGSCSKS--SPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITV . . .: ... :...:: : .. ..: :::. :.:. NP_001 ASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDC--------FESE---SEDEFYK 290 300 310 320 330 880 890 900 910 920 930 pF1KA0 GSWFWPEEEASIQAGSQAVEEMESETEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEM :: : :::. . . :. .. . . .. :. .:..: :. .::. NP_001 QSWVLPGEEANSRFRHRDKEDPNTALK---LRAQKDVDSDRVKQE--------PRFEEEV 340 350 360 370 380 940 950 960 970 980 990 pF1KA0 IVESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLA :. ::::.. .: : :. : :::.: .::::: :: . ::. ... :. .. NP_001 IIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEE----KSSLGAVAREEAKP 390 400 410 420 430 440 1000 1010 1020 1030 1040 1050 pF1KA0 D-EDEAIVGSWFWAGDEAHFESNPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP . :.::: ::::: ::: :. :: ::... : ..: : . : :::.:.::::.::: NP_001 ESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAE-ELNASSRPQTWDEVTVEFKP 450 460 470 480 490 500 1060 1070 1080 1090 1100 1110 pF1KA0 GPWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQ : . ::: : ::: .:.::. ::. .::.:. ::::::.:::::::::::::: :: NP_001 GLFHGVGFRSTSPFGIPEEAS----EMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQ 510 520 530 540 550 1120 1130 1140 1150 1160 1170 pF1KA0 YDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEI ::::::::.::::::::.::.: :: ::.:::::::::::::::.::::.:::::::::: NP_001 YDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEI 560 570 580 590 600 610 1180 1190 1200 1210 1220 1230 pF1KA0 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQ :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::.:. NP_001 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIE 620 630 640 650 660 670 1240 1250 1260 1270 1280 1290 pF1KA0 TYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRF :.::.:::::::.:::: :::.::::.:::: : :::::.:::::::::::.:.::.:.: NP_001 TFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKF 680 690 700 710 720 730 1300 1310 1320 1330 1340 1350 pF1KA0 HVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIKK-ET :::::::::::: ..:.:.::.:.: :.:::: ::::::::::. .:.::.: ::. . NP_001 HVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKM 740 750 760 770 780 790 1360 1370 1380 1390 pF1KA0 VFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPEGDQEN . ::::..:::::::.. :..::.::.. ::::::: :.. NP_001 SLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS 800 810 820 830 >>NP_001171804 (OMIM: 300969) G-protein coupled receptor (838 aa) initn: 2260 init1: 1468 opt: 2043 Z-score: 2020.9 bits: 385.7 E(85289): 8e-106 Smith-Waterman score: 2128; 47.2% identity (68.9% similar) in 852 aa overlap (559-1395:39-838) 530 540 550 560 570 580 pF1KA0 SVESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAEN .: .: : ::: .: ... .. .: NP_001 SAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTG--ARPKTETKSVPAARPKTEA 10 20 30 40 50 60 590 600 610 620 630 640 pF1KA0 QTYMDCRAETSCDTMQGAE---EEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPC :.. : .: ..: ::. : . : :. ...: . : . ::.. . : : NP_001 QAMSGARPKTEVQVMGGARPKTEAQGITGAR--PKTDARAVGGARSKTDAKAIPGAR-PK 70 80 90 100 110 120 650 660 670 680 690 700 pF1KA0 FGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRP-EEEEDIV :. .. . :: . . :. .:: . : : .:. ::. ....: NP_001 DEAQAWAQSEFGTEAVSQ-AEGVSQTNAVA--W----PLATAESGSVTKSKGLSMDRELV 130 140 150 160 170 710 720 730 740 750 760 pF1KA0 NSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEAT : . :. . : :. ::.:. :. .. ..::. .: ::. :: : NP_001 NVDAETFPGTQGQKGIQPWFGPGEETNM-GSWCYSRPRAREEASNESGFWSADE-----T 180 190 200 210 220 230 770 780 790 800 810 820 pF1KA0 DREESRPEAEEGDIIGSWFWAGEED----RLEPAAETREEDRLAAEKEGIVGSWFGAREE . : .:: .. . : ::. : . .: ..: ...:. : :: :...: NP_001 STASSFWTGEETSVRS---WPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDE 240 250 260 270 280 830 840 850 860 870 pF1KA0 T---IRREAGSCSKS--SPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITV . . .: ... :...:: : .. ..: :::. :.:. NP_001 ASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDC--------FESE---SEDEFYK 290 300 310 320 330 880 890 900 910 920 930 pF1KA0 GSWFWPEEEASIQAGSQAVEEMESETEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEM :: : :::. . . :. .. . . .. :. .:..: :. .::. NP_001 QSWVLPGEEANSRFRHRDKEDPNTALK---LRAQKDVDSDRVKQE--------PRFEEEV 340 350 360 370 380 940 950 960 970 980 990 pF1KA0 IVESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLA :. ::::.. .: : :. : :::.: .::::: :: . ::. ... :. .. NP_001 IIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEE----KSSLGAVAREEAKP 390 400 410 420 430 440 1000 1010 1020 1030 1040 1050 pF1KA0 D-EDEAIVGSWFWAGDEAHFESNPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP . :.::: ::::: ::: :. :: ::... : ..: : . : :::.:.::::.::: NP_001 ESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAE-ELNASSRPQTWDEVTVEFKP 450 460 470 480 490 500 1060 1070 1080 1090 1100 1110 pF1KA0 GPWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQ : . ::: : ::: .:.::. ::. .::.:. ::::::.:::::::::::::: :: NP_001 GLFHGVGFRSTSPFGIPEEAS----EMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQ 510 520 530 540 550 1120 1130 1140 1150 1160 1170 pF1KA0 YDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEI ::::::::.::::::::.::.: :: ::.:::::::::::::::.::::.:::::::::: NP_001 YDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEI 560 570 580 590 600 610 1180 1190 1200 1210 1220 1230 pF1KA0 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQ :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::.:. NP_001 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIE 620 630 640 650 660 670 1240 1250 1260 1270 1280 1290 pF1KA0 TYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRF :.::.:::::::.:::: :::.::::.:::: : :::::.:::::::::::.:.::.:.: NP_001 TFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKF 680 690 700 710 720 730 1300 1310 1320 1330 1340 1350 pF1KA0 HVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIKK-ET :::::::::::: ..:.:.::.:.: :.:::: ::::::::::. .:.::.: ::. . NP_001 HVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKM 740 750 760 770 780 790 1360 1370 1380 1390 pF1KA0 VFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPEGDQEN . ::::..:::::::.. :..::.::.. ::::::: :.. NP_001 SLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS 800 810 820 830 1395 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:57:15 2016 done: Wed Nov 2 18:57:17 2016 Total Scan time: 13.130 Total Display time: 0.570 Function used was FASTA [36.3.4 Apr, 2011]