FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0474, 681 aa 1>>>pF1KA0474 681 - 681 aa - 681 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0569+/-0.000375; mu= 12.2749+/- 0.023 mean_var=131.0612+/-25.975, 0's: 0 Z-trim(116.9): 122 B-trim: 104 in 1/58 Lambda= 0.112031 statistics sampled from 28398 (28522) to 28398 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.334), width: 16 Scan time: 11.720 The best scores are: opt bits E(85289) XP_016857473 (OMIM: 600278) PREDICTED: rap1 GTPase ( 681) 4537 745.1 2e-214 XP_005246012 (OMIM: 600278) PREDICTED: rap1 GTPase ( 681) 4537 745.1 2e-214 XP_016857459 (OMIM: 600278) PREDICTED: rap1 GTPase ( 681) 4537 745.1 2e-214 NP_001139129 (OMIM: 600278) rap1 GTPase-activating ( 681) 4537 745.1 2e-214 XP_016857458 (OMIM: 600278) PREDICTED: rap1 GTPase ( 689) 4511 740.9 3.7e-213 XP_016857457 (OMIM: 600278) PREDICTED: rap1 GTPase ( 689) 4511 740.9 3.7e-213 XP_016857470 (OMIM: 600278) PREDICTED: rap1 GTPase ( 689) 4511 740.9 3.7e-213 XP_016857472 (OMIM: 600278) PREDICTED: rap1 GTPase ( 689) 4511 740.9 3.7e-213 XP_016857471 (OMIM: 600278) PREDICTED: rap1 GTPase ( 689) 4511 740.9 3.7e-213 XP_016857463 (OMIM: 600278) PREDICTED: rap1 GTPase ( 651) 3619 596.7 8.8e-170 XP_016857456 (OMIM: 600278) PREDICTED: rap1 GTPase ( 710) 3380 558.1 4e-158 XP_016857455 (OMIM: 600278) PREDICTED: rap1 GTPase ( 740) 3380 558.1 4.2e-158 XP_016857468 (OMIM: 600278) PREDICTED: rap1 GTPase ( 740) 3380 558.1 4.2e-158 XP_006710868 (OMIM: 600278) PREDICTED: rap1 GTPase ( 740) 3380 558.1 4.2e-158 XP_016857454 (OMIM: 600278) PREDICTED: rap1 GTPase ( 748) 3380 558.1 4.2e-158 XP_006710867 (OMIM: 600278) PREDICTED: rap1 GTPase ( 748) 3380 558.1 4.2e-158 NP_001317312 (OMIM: 600278) rap1 GTPase-activating ( 748) 3380 558.1 4.2e-158 XP_016857460 (OMIM: 600278) PREDICTED: rap1 GTPase ( 804) 3380 558.2 4.4e-158 XP_016857477 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663) 3336 551.0 5.3e-156 XP_016857462 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663) 3336 551.0 5.3e-156 NP_002876 (OMIM: 600278) rap1 GTPase-activating pr ( 663) 3336 551.0 5.3e-156 XP_016857476 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663) 3336 551.0 5.3e-156 XP_016857475 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663) 3336 551.0 5.3e-156 NP_001139130 (OMIM: 600278) rap1 GTPase-activating ( 727) 3336 551.0 5.7e-156 XP_016857464 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655) 3325 549.2 1.8e-155 XP_016857478 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655) 3325 549.2 1.8e-155 XP_016857479 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655) 3325 549.2 1.8e-155 XP_016857461 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655) 3325 549.2 1.8e-155 XP_016857469 (OMIM: 600278) PREDICTED: rap1 GTPase ( 719) 3325 549.2 1.9e-155 XP_016857480 (OMIM: 600278) PREDICTED: rap1 GTPase ( 625) 3315 547.6 5.3e-155 XP_016857465 (OMIM: 600278) PREDICTED: rap1 GTPase ( 625) 3315 547.6 5.3e-155 XP_016857466 (OMIM: 600278) PREDICTED: rap1 GTPase ( 617) 3312 547.1 7.3e-155 XP_016857474 (OMIM: 600278) PREDICTED: rap1 GTPase ( 681) 3312 547.1 7.9e-155 XP_016857387 (OMIM: 611609) PREDICTED: signal-indu (1704) 676 121.3 2.9e-26 XP_016857386 (OMIM: 611609) PREDICTED: signal-indu (1704) 676 121.3 2.9e-26 NP_065859 (OMIM: 611609) signal-induced proliferat (1722) 676 121.4 2.9e-26 XP_005273270 (OMIM: 611609) PREDICTED: signal-indu (1722) 676 121.4 2.9e-26 XP_016857385 (OMIM: 611609) PREDICTED: signal-indu (1722) 676 121.4 2.9e-26 XP_005273269 (OMIM: 611609) PREDICTED: signal-indu (1722) 676 121.4 2.9e-26 XP_005273268 (OMIM: 611609) PREDICTED: signal-indu (1722) 676 121.4 2.9e-26 XP_011542545 (OMIM: 611609) PREDICTED: signal-indu (1722) 676 121.4 2.9e-26 XP_016882007 (OMIM: 616655,616851) PREDICTED: sign (1780) 672 120.7 4.7e-26 XP_011524959 (OMIM: 616655,616851) PREDICTED: sign (1781) 672 120.7 4.7e-26 XP_005258728 (OMIM: 616655,616851) PREDICTED: sign (1781) 672 120.7 4.7e-26 NP_055888 (OMIM: 616655,616851) signal-induced pro (1781) 672 120.7 4.7e-26 XP_016882006 (OMIM: 616655,616851) PREDICTED: sign (1781) 672 120.7 4.7e-26 XP_011543516 (OMIM: 602180) PREDICTED: signal-indu (1042) 636 114.7 1.8e-24 XP_005274246 (OMIM: 602180) PREDICTED: signal-indu (1042) 636 114.7 1.8e-24 NP_006738 (OMIM: 602180) signal-induced proliferat (1042) 636 114.7 1.8e-24 NP_694985 (OMIM: 602180) signal-induced proliferat (1042) 636 114.7 1.8e-24 >>XP_016857473 (OMIM: 600278) PREDICTED: rap1 GTPase-act (681 aa) initn: 4537 init1: 4537 opt: 4537 Z-score: 3970.7 bits: 745.1 E(85289): 2e-214 Smith-Waterman score: 4537; 100.0% identity (100.0% similar) in 681 aa overlap (1-681:1-681) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPDAGKLGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPDAGKLGDP 610 620 630 640 650 660 670 680 pF1KA0 ACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::: XP_016 ACPEIKIQLEASEQHMPQLGC 670 680 >>XP_005246012 (OMIM: 600278) PREDICTED: rap1 GTPase-act (681 aa) initn: 4537 init1: 4537 opt: 4537 Z-score: 3970.7 bits: 745.1 E(85289): 2e-214 Smith-Waterman score: 4537; 100.0% identity (100.0% similar) in 681 aa overlap (1-681:1-681) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPDAGKLGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPDAGKLGDP 610 620 630 640 650 660 670 680 pF1KA0 ACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::: XP_005 ACPEIKIQLEASEQHMPQLGC 670 680 >>XP_016857459 (OMIM: 600278) PREDICTED: rap1 GTPase-act (681 aa) initn: 4537 init1: 4537 opt: 4537 Z-score: 3970.7 bits: 745.1 E(85289): 2e-214 Smith-Waterman score: 4537; 100.0% identity (100.0% similar) in 681 aa overlap (1-681:1-681) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPDAGKLGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPDAGKLGDP 610 620 630 640 650 660 670 680 pF1KA0 ACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::: XP_016 ACPEIKIQLEASEQHMPQLGC 670 680 >>NP_001139129 (OMIM: 600278) rap1 GTPase-activating pro (681 aa) initn: 4537 init1: 4537 opt: 4537 Z-score: 3970.7 bits: 745.1 E(85289): 2e-214 Smith-Waterman score: 4537; 100.0% identity (100.0% similar) in 681 aa overlap (1-681:1-681) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPDAGKLGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPDAGKLGDP 610 620 630 640 650 660 670 680 pF1KA0 ACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::: NP_001 ACPEIKIQLEASEQHMPQLGC 670 680 >>XP_016857458 (OMIM: 600278) PREDICTED: rap1 GTPase-act (689 aa) initn: 4370 init1: 4329 opt: 4511 Z-score: 3947.9 bits: 740.9 E(85289): 3.7e-213 Smith-Waterman score: 4511; 98.8% identity (98.8% similar) in 689 aa overlap (1-681:1-689) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSP-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHP 610 620 630 640 650 660 660 670 680 pF1KA0 DAGKLGDPACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::::::::::: XP_016 DAGKLGDPACPEIKIQLEASEQHMPQLGC 670 680 >>XP_016857457 (OMIM: 600278) PREDICTED: rap1 GTPase-act (689 aa) initn: 4370 init1: 4329 opt: 4511 Z-score: 3947.9 bits: 740.9 E(85289): 3.7e-213 Smith-Waterman score: 4511; 98.8% identity (98.8% similar) in 689 aa overlap (1-681:1-689) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSP-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHP 610 620 630 640 650 660 660 670 680 pF1KA0 DAGKLGDPACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::::::::::: XP_016 DAGKLGDPACPEIKIQLEASEQHMPQLGC 670 680 >>XP_016857470 (OMIM: 600278) PREDICTED: rap1 GTPase-act (689 aa) initn: 4370 init1: 4329 opt: 4511 Z-score: 3947.9 bits: 740.9 E(85289): 3.7e-213 Smith-Waterman score: 4511; 98.8% identity (98.8% similar) in 689 aa overlap (1-681:1-689) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSP-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHP 610 620 630 640 650 660 660 670 680 pF1KA0 DAGKLGDPACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::::::::::: XP_016 DAGKLGDPACPEIKIQLEASEQHMPQLGC 670 680 >>XP_016857472 (OMIM: 600278) PREDICTED: rap1 GTPase-act (689 aa) initn: 4370 init1: 4329 opt: 4511 Z-score: 3947.9 bits: 740.9 E(85289): 3.7e-213 Smith-Waterman score: 4511; 98.8% identity (98.8% similar) in 689 aa overlap (1-681:1-689) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSP-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHP 610 620 630 640 650 660 660 670 680 pF1KA0 DAGKLGDPACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::::::::::: XP_016 DAGKLGDPACPEIKIQLEASEQHMPQLGC 670 680 >>XP_016857471 (OMIM: 600278) PREDICTED: rap1 GTPase-act (689 aa) initn: 4370 init1: 4329 opt: 4511 Z-score: 3947.9 bits: 740.9 E(85289): 3.7e-213 Smith-Waterman score: 4511; 98.8% identity (98.8% similar) in 689 aa overlap (1-681:1-689) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS 550 560 570 580 590 600 610 620 630 640 650 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSP-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHP 610 620 630 640 650 660 660 670 680 pF1KA0 DAGKLGDPACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::::::::::: XP_016 DAGKLGDPACPEIKIQLEASEQHMPQLGC 670 680 >>XP_016857463 (OMIM: 600278) PREDICTED: rap1 GTPase-act (651 aa) initn: 4068 init1: 3611 opt: 3619 Z-score: 3169.1 bits: 596.7 E(85289): 8.8e-170 Smith-Waterman score: 4170; 93.3% identity (93.3% similar) in 689 aa overlap (1-681:1-651) 10 20 30 40 50 60 pF1KA0 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKSASRFGRRGSAIGIGTVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKR- 490 500 510 520 530 550 560 570 580 590 600 pF1KA0 SPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASS ::::::::::::::::::::::: XP_016 -------------------------------------AETAAQRAEALKDFSRSSSSASS 540 550 560 610 620 630 640 650 pF1KA0 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSP-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHP 570 580 590 600 610 620 660 670 680 pF1KA0 DAGKLGDPACPEIKIQLEASEQHMPQLGC ::::::::::::::::::::::::::::: XP_016 DAGKLGDPACPEIKIQLEASEQHMPQLGC 630 640 650 681 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 19:06:44 2016 done: Wed Nov 2 19:06:46 2016 Total Scan time: 11.720 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]