Result of FASTA (omim) for
pF1KA0520
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0520, 1353 aa
1>>>pF1KA0520 1353 - 1353 aa - 1353 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4653+/-0.00042; mu= 22.8217+/- 0.026
mean_var=85.2683+/-17.238, 0's: 0 Z-trim(113.3): 115 B-trim: 703 in 2/51
Lambda= 0.138893
statistics sampled from 22446 (22568) to 22446 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.265), width: 16
Scan time: 13.410
The best scores are: opt bits E(85289)
NP_001107 (OMIM: 603302) adenylate cyclase type 9 (1353) 9030 1820.5 0
XP_005255136 (OMIM: 603302) PREDICTED: adenylate c (1372) 4556 924.0 0
XP_011520655 (OMIM: 603302) PREDICTED: adenylate c (1001) 4485 909.7 0
XP_016858680 (OMIM: 600291) PREDICTED: adenylate c ( 974) 706 152.4 1.5e-35
XP_011530791 (OMIM: 600291) PREDICTED: adenylate c (1186) 707 152.7 1.5e-35
XP_011530798 (OMIM: 600291) PREDICTED: adenylate c ( 945) 702 151.6 2.5e-35
XP_011530792 (OMIM: 600291) PREDICTED: adenylate c (1185) 699 151.1 4.5e-35
XP_016874232 (OMIM: 600294,616287) PREDICTED: aden (1067) 682 147.7 4.4e-34
NP_056085 (OMIM: 600294,616287) adenylate cyclase (1168) 682 147.7 4.7e-34
XP_006719273 (OMIM: 600294,616287) PREDICTED: aden (1168) 682 147.7 4.7e-34
XP_016868496 (OMIM: 103070) PREDICTED: adenylate c ( 646) 670 145.1 1.6e-33
XP_016868495 (OMIM: 103070) PREDICTED: adenylate c (1155) 670 145.3 2.5e-33
XP_006716564 (OMIM: 103070) PREDICTED: adenylate c (1185) 670 145.3 2.5e-33
XP_005250826 (OMIM: 103070) PREDICTED: adenylate c (1221) 670 145.3 2.6e-33
NP_001106 (OMIM: 103070) adenylate cyclase type 8 (1251) 670 145.3 2.6e-33
NP_001268697 (OMIM: 103072,610154,610154) adenylat ( 338) 661 143.1 3.4e-33
XP_011510661 (OMIM: 600293,606703) PREDICTED: aden ( 953) 666 144.4 3.7e-33
XP_005249642 (OMIM: 103072,610154,610154) PREDICTE ( 563) 662 143.4 4.3e-33
NP_899200 (OMIM: 600293,606703) adenylate cyclase (1261) 666 144.5 4.6e-33
XP_005247134 (OMIM: 600293,606703) PREDICTED: aden (1286) 666 144.5 4.6e-33
XP_006713546 (OMIM: 600293,606703) PREDICTED: aden ( 919) 663 143.8 5.5e-33
XP_016861127 (OMIM: 600293,606703) PREDICTED: aden ( 920) 663 143.8 5.5e-33
NP_001186571 (OMIM: 600293,606703) adenylate cycla ( 911) 662 143.6 6.2e-33
XP_016861128 (OMIM: 600293,606703) PREDICTED: aden ( 920) 662 143.6 6.3e-33
XP_011510662 (OMIM: 600293,606703) PREDICTED: aden ( 923) 662 143.6 6.3e-33
XP_005247135 (OMIM: 600293,606703) PREDICTED: aden ( 936) 662 143.6 6.3e-33
XP_005249641 (OMIM: 103072,610154,610154) PREDICTE ( 979) 662 143.6 6.6e-33
NP_066939 (OMIM: 103072,610154,610154) adenylate c (1119) 662 143.7 7.3e-33
XP_006713547 (OMIM: 600293,606703) PREDICTED: aden ( 845) 659 143.0 8.9e-33
XP_016861129 (OMIM: 600293,606703) PREDICTED: aden ( 845) 659 143.0 8.9e-33
XP_011510663 (OMIM: 600293,606703) PREDICTED: aden ( 845) 659 143.0 8.9e-33
XP_016858679 (OMIM: 600291) PREDICTED: adenylate c (1098) 639 139.1 1.7e-31
NP_004027 (OMIM: 600291) adenylate cyclase type 3 (1144) 639 139.1 1.8e-31
NP_001307542 (OMIM: 600291) adenylate cyclase type (1145) 639 139.1 1.8e-31
XP_016858676 (OMIM: 600291) PREDICTED: adenylate c (1163) 639 139.1 1.8e-31
XP_011530793 (OMIM: 600291) PREDICTED: adenylate c (1164) 639 139.1 1.8e-31
XP_016858682 (OMIM: 600291) PREDICTED: adenylate c ( 903) 634 138.0 3e-31
XP_016858681 (OMIM: 600291) PREDICTED: adenylate c ( 904) 634 138.0 3e-31
XP_016878388 (OMIM: 600385) PREDICTED: adenylate c ( 723) 624 135.9 1e-30
NP_001272986 (OMIM: 600385) adenylate cyclase type ( 734) 624 135.9 1e-30
XP_016878387 (OMIM: 600385) PREDICTED: adenylate c ( 734) 624 135.9 1e-30
XP_016878385 (OMIM: 600385) PREDICTED: adenylate c ( 886) 624 136.0 1.2e-30
XP_016878386 (OMIM: 600385) PREDICTED: adenylate c ( 886) 624 136.0 1.2e-30
NP_001105 (OMIM: 600385) adenylate cyclase type 7 (1080) 624 136.0 1.4e-30
XP_016878384 (OMIM: 600385) PREDICTED: adenylate c (1080) 624 136.0 1.4e-30
XP_011521144 (OMIM: 600385) PREDICTED: adenylate c (1086) 624 136.0 1.4e-30
XP_011521141 (OMIM: 600385) PREDICTED: adenylate c (1086) 624 136.0 1.4e-30
XP_011521142 (OMIM: 600385) PREDICTED: adenylate c (1086) 624 136.0 1.4e-30
XP_011521138 (OMIM: 600385) PREDICTED: adenylate c (1086) 624 136.0 1.4e-30
XP_011521140 (OMIM: 600385) PREDICTED: adenylate c (1086) 624 136.0 1.4e-30
>>NP_001107 (OMIM: 603302) adenylate cyclase type 9 [Hom (1353 aa)
initn: 9030 init1: 9030 opt: 9030 Z-score: 9772.0 bits: 1820.5 E(85289): 0
Smith-Waterman score: 9030; 99.9% identity (100.0% similar) in 1353 aa overlap (1-1353:1-1353)
10 20 30 40 50 60
pF1KA0 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 STKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 ASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 AALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 IQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 FAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTT
:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTT
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 GVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEE
1270 1280 1290 1300 1310 1320
1330 1340 1350
pF1KA0 RGRFGKAIEKDDCDETGIEEANELTKLNVSKSV
:::::::::::::::::::::::::::::::::
NP_001 RGRFGKAIEKDDCDETGIEEANELTKLNVSKSV
1330 1340 1350
>>XP_005255136 (OMIM: 603302) PREDICTED: adenylate cycla (1372 aa)
initn: 4556 init1: 4556 opt: 4556 Z-score: 4926.8 bits: 924.0 E(85289): 0
Smith-Waterman score: 8982; 98.5% identity (98.6% similar) in 1372 aa overlap (1-1353:1-1372)
10 20 30 40 50 60
pF1KA0 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
610 620 630 640 650 660
670 680 690 700
pF1KA0 STK-------------------ASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGR
::: ::::::::::::::::::::::::::::::::::::::
XP_005 STKVTSSWLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGR
670 680 690 700 710 720
710 720 730 740 750 760
pF1KA0 WAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELER
730 740 750 760 770 780
770 780 790 800 810 820
pF1KA0 SYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAAL
790 800 810 820 830 840
830 840 850 860 870 880
pF1KA0 AVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVY
850 860 870 880 890 900
890 900 910 920 930 940
pF1KA0 SHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KA0 DSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFE
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KA0 VSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIF
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KA0 ASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLN
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KA0 TAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTK
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_005 TAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTK
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KA0 LLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYL
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KA0 YPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQA
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350
pF1KA0 KDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCDETGIEEANELTKLNVSKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCDETGIEEANELTKLNVSKSV
1330 1340 1350 1360 1370
>>XP_011520655 (OMIM: 603302) PREDICTED: adenylate cycla (1001 aa)
initn: 4482 init1: 4482 opt: 4485 Z-score: 4851.8 bits: 909.7 E(85289): 0
Smith-Waterman score: 6362; 97.7% identity (97.9% similar) in 982 aa overlap (1-963:1-981)
10 20 30 40 50 60
pF1KA0 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
610 620 630 640 650 660
670 680 690 700
pF1KA0 STK-------------------ASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGR
::: ::::::::::::::::::::::::::::::::::::::
XP_011 STKVTSSWLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGR
670 680 690 700 710 720
710 720 730 740 750 760
pF1KA0 WAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELER
730 740 750 760 770 780
770 780 790 800 810 820
pF1KA0 SYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAAL
790 800 810 820 830 840
830 840 850 860 870 880
pF1KA0 AVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVY
850 860 870 880 890 900
890 900 910 920 930 940
pF1KA0 SHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KA0 DSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFE
::::::::::::::: .:.::
XP_011 DSSVLTSPLDAVQNFR-RREPCGEGDSKFPFSSQEESCRAGA
970 980 990 1000
>>XP_016858680 (OMIM: 600291) PREDICTED: adenylate cycla (974 aa)
initn: 1084 init1: 552 opt: 706 Z-score: 759.5 bits: 152.4 E(85289): 1.5e-35
Smith-Waterman score: 1282; 31.2% identity (57.9% similar) in 1010 aa overlap (280-1241:13-948)
250 260 270 280 290 300
pF1KA0 VAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRST
:.:. .:. : :.:. . :.. . :..
XP_016 MLSCPECWPHREEILANVFLYLCAIAVGIMSYYMADRKHRKA
10 20 30 40
310 320 330 340 350 360
pF1KA0 FLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNR
::.. ::. .:: .. .: .. :..:. .::...:.
XP_016 FLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD--------------------
50 60 70 80
370 380 390 400 410 420
pF1KA0 KKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRL
::. :: : . : . :.::::::::::::..:. ::. :: :::.::.:::.:
XP_016 MKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKL
90 100 110 120 130 140
430 440 450 460 470 480
pF1KA0 CEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVG
. . .:. :::::::. : :. : ::: : : :::.:..:: .. : :.::::
XP_016 AAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVG
150 160 170 180 190 200
490 500 510 520 530 540
pF1KA0 VHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISE-----ATAKYLDDRYE
::::::: :.::..:...::::.::..:: :: :. : .: : ..: : :.:
XP_016 VHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWE
210 220 230 240 250 260
550 560 570 580 590 600
pF1KA0 MEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPR
.: ...::.. : ::: . . :. . :::. : .:.:. ..: :.
XP_016 ----RV--HISQSTM-DCLKG-EFDVEPGDGG--SRCDYLEE--KGIETY--LIIASKPE
270 280 290 300
610 620 630 640 650 660
pF1KA0 GQGTASSGNVSDLAQTVKTFDNLKTC-PSCGITFAPKSEAGAEGGAPQNGC-QDEHKNST
. ::...... : . . :. :. : :.. : . :.. .. :: . :
XP_016 VKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQLFPT
310 320 330 340 350 360
670 680 690 700 710 720
pF1KA0 KASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIRE
: :. . : : .. .. : . : .. . : . .: :. : : . . :
XP_016 TLSHLPHSRCLPG--SQADNPSFPNPRRRL-RLQDLADRVVDASEDEHELNQLLNEALLE
370 380 390 400 410 420
730 740 750 760 770
pF1KA0 KTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEE-----------V
. .:. :.:. .. :. .:. :.: :.: : . ... .
XP_016 RESAQ---VVKK----RNTFL------LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVL
430 440 450 460 470
780 790 800 810 820 830
pF1KA0 IKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPP-PAALAVFSAALLL
. .. :. . .: . . .:. ..: . : : : :: : : :..::. .
XP_016 LCTALVEILIDPWLMTNYVTFMVGEILLLILTICSL---AAIFPRAFPKKLVAFSTWIDR
480 490 500 510 520
840 850 860 870 880 890
pF1KA0 EVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYET
. . ...:. ::: . .: :. . : :..:. .::
XP_016 TRWARNTWAMLAIFIL-VMANVVDMLS---------CLQ--YYTGP-----SNATAGMET
530 540 550 560 570
900 910 920 930 940
pF1KA0 N---IHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVV-GAGPLLLLY----VSLCPD
. .. : . . .:..... . :.: .. .: .: :: . :: : :
XP_016 EGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYD
580 590 600 610 620 630
950 960 970 980 990
pF1KA0 SSVLTS---PLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNRE
. . :. :...... :.. : : : .... ::..: ....:.
XP_016 HKRFREHDLPMVALEQMQGFNPGLNGT---DSRLPLVPSKYSMTVMVFLMMLSFYYFSRH
640 650 660 670 680
1000 1010 1020 1030 1040 1050
pF1KA0 FEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQT-----YSKNH
: : . .:. .. .. :: . :. :..: :::... :. ::...
XP_016 VEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTY
690 700 710 720 730 740
1060 1070 1080 1090 1100 1110
pF1KA0 DSGGVIFASIVNFSEFYEENY--EGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGA
: ::.:::. ::..:: :. .:: :: : :::.:.::: ::..: . : ::::::.
XP_016 DEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGS
750 760 770 780 790 800
1120 1130 1140 1150 1160
pF1KA0 TYMAASGLN---------TAQAQDGSHPQ--EHLQILFEFAKEMMRVVDDFNSNMLWFNF
:::::::.. ... .: :. . .:: : .:: : .. ..: :. . ::
XP_016 TYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNIN-NQSFNNF
810 820 830 840 850 860
1170 1180 1190 1200 1210 1220
pF1KA0 KLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGY
::.:.:.: . :::::. : :::::.:::.::::..::: ::: ::. .: ..:.
XP_016 MLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGF
870 880 890 900 910 920
1230 1240 1250 1260 1270 1280
pF1KA0 DFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANL
: :: . :::::.. :..
XP_016 RFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS
930 940 950 960 970
>>XP_011530791 (OMIM: 600291) PREDICTED: adenylate cycla (1186 aa)
initn: 1084 init1: 552 opt: 707 Z-score: 759.4 bits: 152.7 E(85289): 1.5e-35
Smith-Waterman score: 1317; 29.7% identity (56.4% similar) in 1206 aa overlap (97-1241:39-1160)
70 80 90 100 110 120
pF1KA0 VGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFA
:: .:: :.: :: :
XP_011 EPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCL--CLP----RFMRLTFVPESL
10 20 30 40 50 60
130 140 150 160 170 180
pF1KA0 CLLWSIYFAVHMRSRLIVMVAPAL---CFLLV-CVGFFLFTFTKLYARHYAWTSLALTLL
:.. :: . . :.:.:. : :...: :. .:. :: . : .:.: ..
XP_011 ENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCA--VVFSSDKLASLAVAGIGLVLDII
70 80 90 100 110 120
190 200 210 220 230
pF1KA0 VFALTLAAQF------QVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYT
.:.: . . .:: : .... . . ....: .. .:.:..
XP_011 LFVLCKKGLLPDRVTRRVLPYVLWLLITAQIF-SYLGLNFARAHAASDTVGWQVFFVFSF
130 140 150 160 170
240 250 260 270 280 290
pF1KA0 VMHLPLYLS--LCLGVAYSVLFE-TFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHA
. ::: :: . ..:. :. ..: .. : :. :.:. .:. : :
XP_011 FITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLR-EILANVFLYLCAIA
180 190 200 210 220 230
300 310 320 330 340 350
pF1KA0 IGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEE
.:. . :.. . :..::.. ::. .:: .. .: .. :..:. .::...:.
XP_011 VGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD----
240 250 260 270 280 290
360 370 380 390 400 410
pF1KA0 SENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAH
::. :: : . : . :.::::::::::::..:. ::.
XP_011 ----------------MKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQ
300 310 320 330
420 430 440 450 460 470
pF1KA0 ALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAI
:: :::.::.:::.: . . .:. :::::::. : :. : ::: : : :::.:..::
XP_011 ELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAI
340 350 360 370 380 390
480 490 500 510 520 530
pF1KA0 EQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISE
.. : :.::::::::::: :.::..:...::::.::..:: :: :. : .: :
XP_011 SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEE
400 410 420 430 440 450
540 550 560 570 580
pF1KA0 -----ATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALL
..: : :.: .: ...::.. : ::: . . :. . :::. :
XP_011 RLYSCVVAPTLRLRWE----RV--HISQSTM-DCLKG-EFDVEPGDGG--SRCDYLEE--
460 470 480 490 500
590 600 610 620 630 640
pF1KA0 SGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC-PSCGITFAPKSEAGAEG
.:.:. ..: :. . ::...... : . . :. :. : :.. : . :
XP_011 KGIETY--LIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSG
510 520 530 540 550 560
650 660 670 680 690 700
pF1KA0 GAPQNGC-QDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVS
.. .. :: . : : :. . : : .. .. : . : .. . : . .:
XP_011 STSEKPEEQDAQLFPTTLSHLPHSRCLPG--SQADNPSFPNPRRRL-RLQDLADRVVDAS
570 580 590 600 610 620
710 720 730 740 750 760
pF1KA0 LDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTS
:. : : . . :. .:. :.:. .. :. .:. :.: :.: : .
XP_011 EDEHELNQLLNEALLERESAQ---VVKK----RNTFL------LSMRFMDPEMETRYSVE
630 640 650 660
770 780 790 800 810
pF1KA0 YQEE-----------VIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVP
... .. .. :. . .: . . .:. ..: . : : : :: :
XP_011 KEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSL---AAIFP
670 680 690 700 710 720
820 830 840 850 860 870
pF1KA0 PP-PAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVS
: :..::. . . . ...:. ::: . .: :. .
XP_011 RAFPKKLVAFSTWIDRTRWARNTWAMLAIFIL-VMANVVDMLS---------CLQ--YYT
730 740 750 760 770
880 890 900 910 920 930
pF1KA0 LPALAVYSHVTSEYETN---IHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVV-GAG
: :..:. .::. .. : . . .:..... . :.: .. .: .: ::
XP_011 GP-----SNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAV
780 790 800 810 820
940 950 960 970 980
pF1KA0 PLLLLY----VSLCPDSSVLTS---PLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVV
. :: : : . . :. :...... :.. : : : ..
XP_011 ATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGT---DSRLPLVPSKYSMT
830 840 850 860 870 880
990 1000 1010 1020 1030 1040
pF1KA0 LVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQ
.. ::..: ....:. : : . .:. .. .. :: . :. :..: :::..
XP_011 VMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARH
890 900 910 920 930 940
1050 1060 1070 1080 1090
pF1KA0 LKVSQT-----YSKNHDSGGVIFASIVNFSEFYEENY--EGGKECYRVLNELIGDFDELL
. :. ::...: ::.:::. ::..:: :. .:: :: : :::.:.::: ::
XP_011 FLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLL
950 960 970 980 990 1000
1100 1110 1120 1130 1140
pF1KA0 SKPDYSSIEKIKTIGATYMAASGLN---------TAQAQDGSHPQ--EHLQILFEFAKEM
..: . : ::::::.:::::::.. ... .: :. . .:: : .:: :
XP_011 DNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAM
1010 1020 1030 1040 1050 1060
1150 1160 1170 1180 1190 1200
pF1KA0 MRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECR
.. ..: :. . :: ::.:.:.: . :::::. : :::::.:::.::::..:::
XP_011 KDTLTNIN-NQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGN
1070 1080 1090 1100 1110 1120
1210 1220 1230 1240 1250 1260
pF1KA0 IQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQ
::: ::. .: ..:. : :: . :::::.. :..
XP_011 IQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVD
1130 1140 1150 1160 1170 1180
1270 1280 1290 1300 1310 1320
pF1KA0 VDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFG
XP_011 NS
>>XP_011530798 (OMIM: 600291) PREDICTED: adenylate cycla (945 aa)
initn: 1084 init1: 552 opt: 702 Z-score: 755.3 bits: 151.6 E(85289): 2.5e-35
Smith-Waterman score: 1244; 31.2% identity (57.8% similar) in 991 aa overlap (299-1241:3-919)
270 280 290 300 310 320
pF1KA0 FPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKA
. :.. . :..::.. ::. .:: ..
XP_011 MSYYMADRKHRKAFLEARQSLEVKMNLEEQSQ
10 20 30
330 340 350 360 370 380
pF1KA0 LKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQ
.: .. :..:. .::...:. ::. :: : . :
XP_011 QQENLMLSILPKHVADEMLKD--------------------MKKDESQKDQQQFNTMYMY
40 50 60 70
390 400 410 420 430 440
pF1KA0 QIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCV
. :.::::::::::::..:. ::. :: :::.::.:::.: . . .:. :::::::.
XP_011 RHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCI
80 90 100 110 120 130
450 460 470 480 490 500
pF1KA0 AGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFD
: :. : ::: : : :::.:..:: .. : :.::::::::::: :.::..:...:
XP_011 CGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYD
140 150 160 170 180 190
510 520 530 540 550 560
pF1KA0 VWSNDVNLANLMEQLGVAGKVHISE-----ATAKYLDDRYEMEDGKVIERLGQSVVADQL
:::.::..:: :: :. : .: : ..: : :.: .: ...::.. : :
XP_011 VWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWE----RV--HISQSTM-DCL
200 210 220 230 240
570 580 590 600 610 620
pF1KA0 KGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKT
:: . . :. . :::. : .:.:. ..: :. . ::...... : .
XP_011 KG-EFDVEPGDGG--SRCDYLEE--KGIETY--LIIASKPEVKKTATQNGLNGSALPNGA
250 260 270 280 290
630 640 650 660 670 680
pF1KA0 FDNLKTC-PSCGITFAPKSEAGAEGGAPQNGC-QDEHKNSTKASGGPNPKTQNGLLSPPQ
. :. :. : :.. : . :.. .. :: . : : :. . : : .
XP_011 PASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQLFPTTLSHLPHSRCLPG--SQAD
300 310 320 330 340 350
690 700 710 720 730 740
pF1KA0 EEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDY
. .. : . : .. . : . .: :. : : . . :. .:. :.:. ..
XP_011 NPSFPNPRRRL-RLQDLADRVVDASEDEHELNQLLNEALLERESAQ---VVKK----RNT
360 370 380 390 400
750 760 770 780 790
pF1KA0 FFKPPINQFSLNFLDQELERSYRTSYQEE-----------VIKNSPVKTFASPTFSSLLD
:. .:. :.: :.: : . ... .. .. :. . .: . .
XP_011 FL------LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYV
410 420 430 440 450 460
800 810 820 830 840
pF1KA0 VFLSTTVFLTLSTTCFLKYEAATVPPP-PAALAVFSAALLLEVLSLAVSIRMVFFLEDVM
.:. ..: . : : : :: : : :..::. . . . ...:. ::
XP_011 TFMVGEILLLILTICSL---AAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFIL-VM
470 480 490 500 510
850 860 870 880 890 900
pF1KA0 ACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETN---IHFPVFTGSAALIAV
: . .: :. . : :..:. .::. .. : . . .:....
XP_011 ANVVDMLS---------CLQ--YYTGP-----SNATAGMETEGSCLENPKYYNYVAVLSL
520 530 540 550 560
910 920 930 940 950
pF1KA0 VHYCNFCQLSSWMRSSLATVV-GAGPLLLLY----VSLCPDSSVLTS---PLDAVQNFSS
. . :.: .. .: .: :: . :: : : . . :. :......
XP_011 IATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQG
570 580 590 600 610 620
960 970 980 990 1000 1010
pF1KA0 ERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHR
:.. : : : .... ::..: ....:. : : . .:. ..
XP_011 FNPGLNGT---DSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQK
630 640 650 660 670
1020 1030 1040 1050 1060 1070
pF1KA0 TKIQSMRDQADWLLRNIIPYHVAEQLKVSQT-----YSKNHDSGGVIFASIVNFSEFYEE
.. :: . :. :..: :::... :. ::...: ::.:::. ::..:: :
XP_011 ERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTE
680 690 700 710 720 730
1080 1090 1100 1110 1120
pF1KA0 NY--EGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLN---------T
. .:: :: : :::.:.::: ::..: . : ::::::.:::::::.. .
XP_011 ESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFAS
740 750 760 770 780 790
1130 1140 1150 1160 1170 1180
pF1KA0 AQAQDGSHPQ--EHLQILFEFAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTT
.. .: :. . .:: : .:: : .. ..: :. . :: ::.:.:.: . :::::.
XP_011 SNKEDKSERERWQHLADLADFALAMKDTLTNIN-NQSFNNFMLRIGMNKGGVLAGVIGAR
800 810 820 830 840 850
1190 1200 1210 1220 1230 1240
pF1KA0 KLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY
: :::::.:::.::::..::: ::: ::. .: ..:. : :: . :::::.. :.
XP_011 KPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTF
860 870 880 890 900 910
1250 1260 1270 1280 1290 1300
pF1KA0 LYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQ
.
XP_011 FLKGRDKLATFPNGPSVTLPHQVVDNS
920 930 940
>>XP_011530792 (OMIM: 600291) PREDICTED: adenylate cycla (1185 aa)
initn: 1084 init1: 552 opt: 699 Z-score: 750.7 bits: 151.1 E(85289): 4.5e-35
Smith-Waterman score: 1311; 29.7% identity (56.6% similar) in 1206 aa overlap (97-1241:39-1159)
70 80 90 100 110 120
pF1KA0 VGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFA
:: .:: :.: :: :
XP_011 EPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCL--CLP----RFMRLTFVPESL
10 20 30 40 50 60
130 140 150 160 170 180
pF1KA0 CLLWSIYFAVHMRSRLIVMVAPAL---CFLLV-CVGFFLFTFTKLYARHYAWTSLALTLL
:.. :: . . :.:.:. : :...: :. .:. :: . : .:.: ..
XP_011 ENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCA--VVFSSDKLASLAVAGIGLVLDII
70 80 90 100 110 120
190 200 210 220 230
pF1KA0 VFALTLAAQF------QVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYT
.:.: . . .:: : .... . . ....: .. .:.:..
XP_011 LFVLCKKGLLPDRVTRRVLPYVLWLLITAQIF-SYLGLNFARAHAASDTVGWQVFFVFSF
130 140 150 160 170
240 250 260 270 280 290
pF1KA0 VMHLPLYLS--LCLGVAYSVLFE-TFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHA
. ::: :: . ..:. :. ..: .. : :. :.:. .:. : :
XP_011 FITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLR-EILANVFLYLCAIA
180 190 200 210 220 230
300 310 320 330 340 350
pF1KA0 IGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEE
.:. . :.. . :..::.. ::. .:: .. .: .. :..:. .::...:.
XP_011 VGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD----
240 250 260 270 280 290
360 370 380 390 400 410
pF1KA0 SENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAH
::. :: : . : . :.::::::::::::..:. ::.
XP_011 ----------------MKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQ
300 310 320 330
420 430 440 450 460 470
pF1KA0 ALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAI
:: :::.::.:::.: . . .:. :::::::. : :. : ::: : : :::.:..::
XP_011 ELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAI
340 350 360 370 380 390
480 490 500 510 520 530
pF1KA0 EQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISE
.. : :.::::::::::: :.::..:...::::.::..:: :: :. : .: :
XP_011 SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEE
400 410 420 430 440 450
540 550 560 570 580
pF1KA0 -----ATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALL
..: : :.: .: ...::.. : ::: . . :. . :::. :
XP_011 RLYSCVVAPTLRLRWE----RV--HISQSTM-DCLKG-EFDVEPGDGG--SRCDYLEE--
460 470 480 490 500
590 600 610 620 630 640
pF1KA0 SGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC-PSCGITFAPKSEAGAEG
.:.:. ..: :. . ::...... : . . :. :. : :.. : . :
XP_011 KGIETY--LIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSG
510 520 530 540 550 560
650 660 670 680 690 700
pF1KA0 GAPQNGC-QDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVS
.. .. :: . : : :. . : : .. .. : . : .. . : . .:
XP_011 STSEKPEEQDAQLFPTTLSHLPHSRCLPG--SQADNPSFPNPRRRL-RLQDLADRVVDAS
570 580 590 600 610 620
710 720 730 740 750 760
pF1KA0 LDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTS
:. : : . . :. .:. :.:. .. :. .:. :.: :.: : .
XP_011 EDEHELNQLLNEALLERESAQ---VVKK----RNTFL------LSMRFMDPEMETRYSVE
630 640 650 660
770 780 790 800 810
pF1KA0 YQEE-----------VIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVP
... .. .. :. . .: . . .:. ..: . : : : :: :
XP_011 KEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSL---AAIFP
670 680 690 700 710 720
820 830 840 850 860 870
pF1KA0 PP-PAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVS
: :..::. . . . ...:. ::: . .: :. .
XP_011 RAFPKKLVAFSTWIDRTRWARNTWAMLAIFIL-VMANVVDMLS---------CLQ--YYT
730 740 750 760 770
880 890 900 910 920 930
pF1KA0 LPALAVYSHVTSEYETN---IHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVV-GAG
: :..:. .::. .. : . . .:..... . :.: .. .: .: ::
XP_011 GP-----SNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAV
780 790 800 810 820
940 950 960 970 980
pF1KA0 PLLLLY----VSLCPDSSVLTS---PLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVV
. :: : : . . :. :...... :: ... : :.. ..
XP_011 ATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGF-NPGLNGTDRLPLVPSKY---SMT
830 840 850 860 870 880
990 1000 1010 1020 1030 1040
pF1KA0 LVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQ
.. ::..: ....:. : : . .:. .. .. :: . :. :..: :::..
XP_011 VMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARH
890 900 910 920 930 940
1050 1060 1070 1080 1090
pF1KA0 LKVSQT-----YSKNHDSGGVIFASIVNFSEFYEENY--EGGKECYRVLNELIGDFDELL
. :. ::...: ::.:::. ::..:: :. .:: :: : :::.:.::: ::
XP_011 FLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLL
950 960 970 980 990 1000
1100 1110 1120 1130 1140
pF1KA0 SKPDYSSIEKIKTIGATYMAASGLN---------TAQAQDGSHPQ--EHLQILFEFAKEM
..: . : ::::::.:::::::.. ... .: :. . .:: : .:: :
XP_011 DNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAM
1010 1020 1030 1040 1050 1060
1150 1160 1170 1180 1190 1200
pF1KA0 MRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECR
.. ..: :. . :: ::.:.:.: . :::::. : :::::.:::.::::..:::
XP_011 KDTLTNIN-NQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGN
1070 1080 1090 1100 1110 1120
1210 1220 1230 1240 1250 1260
pF1KA0 IQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQ
::: ::. .: ..:. : :: . :::::.. :..
XP_011 IQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVD
1130 1140 1150 1160 1170 1180
1270 1280 1290 1300 1310 1320
pF1KA0 VDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFG
XP_011 NS
>>XP_016874232 (OMIM: 600294,616287) PREDICTED: adenylat (1067 aa)
initn: 1217 init1: 667 opt: 682 Z-score: 733.0 bits: 147.7 E(85289): 4.4e-34
Smith-Waterman score: 1230; 28.6% identity (53.6% similar) in 1203 aa overlap (53-1241:97-1060)
30 40 50 60 70 80
pF1KA0 GDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQL
. ...: . .: : .:: ..: :.
XP_016 DDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGR-SCWRRLVQV
70 80 90 100 110 120
90 100 110 120 130 140
pF1KA0 FERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRL
:. . .: :..::. . : ..: . . .. :: .. .: :
XP_016 FQ-------SKQFRSAKLERLYQRYFFQMNQSSLT---LLMAVLVLLTAVLLAFHAAP--
130 140 150 160 170
150 160 170 180 190 200
pF1KA0 IVMVAPALCFLLVCVGFFLFTFTKLYARH-YAWTSL-ALTLLVFALTLAAQFQVLTPVSG
. :: ::.:.. .. . . :: . :. ... .:... :.: :.:
XP_016 -ARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQ------VGG
180 190 200 210 220
210 220 230 240 250
pF1KA0 RGDSSNLTATARPTDTCLSQVGSFSMC-IEVLFLLYTVMHLPLYLSLCLGVAYSVLFETF
:.: : .. : : . ... ::.. . . .. :.. :.: .
XP_016 -----ALAADPRSPSAGL-------WCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLIL
230 240 250 260 270
260 270 280 290 300 310
pF1KA0 GYHFRDEACFPSPGAGALHWELLSRG-LLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIM
.... . :. :. :. . :: : ..::. ..: .:..: .. :.
XP_016 AWQLNR--------GDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQ
280 290 300 310 320
320 330 340 350 360 370
pF1KA0 HGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKA
:. :. .::.. ::.:. .: .. :. . .:
XP_016 ARLHLQHENRQQERLLLSVLPQHVAMEM-----------------------KEDINTKKE
330 340 350 360
380 390 400 410 420 430
pF1KA0 PIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKI
. :. . .:. ..:::::::: :::..... .:. :: ::.::.:::.: :..: .:
XP_016 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
370 380 390 400 410 420
440 450 460 470 480 490
pF1KA0 STLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCG
. ::::::::.: :: :::::.::.:::. ::.:: . ::::::.:.: : ::
XP_016 KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
430 440 450 460 470 480
500 510 520 530 540 550
pF1KA0 ILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSV
.::.:...::::::::.::: :: : ::..::..:: .::. ::.: :. :: ..
XP_016 VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGER--NAY
490 500 510 520 530 540
560 570 580 590 600 610
pF1KA0 VADQLKGLKTYLISG--QRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSD
. .: ..:.:: : :. :: . :. . . ..: . :: : :
XP_016 LKEQ--HIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLM----PRW--------VPD
550 560 570 580
620 630 640 650 660 670
pF1KA0 LAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGL
..:. : . : : : .: :. : ::..:
XP_016 -----RAFSRTKDSKA----FR------------QMGIDDSSKD--------NRGTQDAL
590 600 610
680 690 700 710 720 730
pF1KA0 LSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDS
:..: .:. : . . ::. .: ...:
XP_016 --NPEDE-----------------------VDE-------F--LSRAIDARSIDQLRKDH
620 630 640
740 750 760 770 780 790
pF1KA0 LMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTT
. .: :.: ..::... .. .:... :. .:..
XP_016 ----------VRRFLLTFQREDLEKKFTCNH-------TPIRSCAA----RMLNL-----
650 660 670
800 810 820 830 840 850
pF1KA0 VFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLL
:: .. : :. :. .... . . .:.
XP_016 --------------------TPADIT----ACHLQQLNYSLGLDAPLCEGTMPTCS----
680 690 700 710
860 870 880 890 900 910
pF1KA0 EWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLS
.:.. :: .:.:: : .:. :..: :. :.: :. . :
XP_016 ------FPEYFIGNMLLSLLASSVFLHISS-----------IGKLAMIFVLGLIYLVLL-
720 730 740 750
920 930 940 950 960 970
pF1KA0 SWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPAS
. . ::. ::: .: .. ..:.. : . : :.
XP_016 --LLGPPATIFDNYDLLLGVHGLASSN----------ETFDGLDCPAAGRVALKYMTPV-
760 770 780 790
980 990 1000 1010 1020 1030
pF1KA0 LIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNII
..::: : : : .. : . :: . ..: .. ... .. ::.::.
XP_016 -----ILLVFALALYL---HAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNIL
800 810 820 830 840 850
1040 1050 1060 1070 1080
pF1KA0 PYHVAEQL-----KVSQTYSKNHDSGGVIFASIVNFSEFY---EENYEGGKECYRVLNEL
: :: .. . .. : .. . .:.::::.:::::: : : :: :: :.:::.
XP_016 PKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEG-VECLRLLNEI
860 870 880 890 900 910
1090 1100 1110 1120 1130 1140
pF1KA0 IGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRV
:.::::..:. . ..:::::::.::::::::: :.. : . :. : ..: ..:.
XP_016 IADFDEIISEERFRQLEKIKTIGSTYMAASGLN-ASTYDQVG-RSHITALADYAMRLMEQ
920 930 940 950 960
1150 1160 1170 1180 1190 1200
pF1KA0 VDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQV
. .: . . ::....:.: ::..:::::. : :::::.:::..::::.::: ::::
XP_016 MKHINEHSFN-NFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQV
970 980 990 1000 1010 1020
1210 1220 1230 1240 1250 1260
pF1KA0 SEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDG
. . :.::. ::... ::.:.:::::.: ::.
XP_016 TTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
1030 1040 1050 1060
1270 1280 1290 1300 1310 1320
pF1KA0 SIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAI
>>NP_056085 (OMIM: 600294,616287) adenylate cyclase type (1168 aa)
initn: 1217 init1: 667 opt: 682 Z-score: 732.4 bits: 147.7 E(85289): 4.7e-34
Smith-Waterman score: 1313; 29.2% identity (55.5% similar) in 1224 aa overlap (53-1241:97-1161)
30 40 50 60 70 80
pF1KA0 GDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQL
. ...: . .: : .:: ..: :.
NP_056 DDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGR-SCWRRLVQV
70 80 90 100 110 120
90 100 110 120 130 140
pF1KA0 FERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRL
:. . .: :..::. . : ..: . . .. :: .. .: :
NP_056 FQ-------SKQFRSAKLERLYQRYFFQMNQSSLT---LLMAVLVLLTAVLLAFHAAP--
130 140 150 160 170
150 160 170 180 190 200
pF1KA0 IVMVAPALCFLLVCVGFFLFTFTKLYARH-YAWTSL-ALTLLVFALTLAAQFQVLTPVSG
. :: ::.:.. .. . . :: . :. ... .:... :.: :.:
NP_056 -ARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQ------VGG
180 190 200 210 220
210 220 230 240 250
pF1KA0 RGDSSNLTATARPTDTCLSQVGSFSMC-IEVLFLLYTVMHLPLYLSLCLGVAYSVLFETF
:.: : .. : : . ... ::.. . . .. :.. :.: .
NP_056 -----ALAADPRSPSAGL-------WCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLIL
230 240 250 260 270
260 270 280 290 300 310
pF1KA0 GYHFRDEACFPSPGAGALHWELLSRG-LLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIM
.... . :. :. :. . :: : ..::. ..: .:..: .. :.
NP_056 AWQLNR--------GDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQ
280 290 300 310 320
320 330 340 350 360 370
pF1KA0 HGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKA
:. :. .::.. ::.:. .: .. :. . .:
NP_056 ARLHLQHENRQQERLLLSVLPQHVAMEM-----------------------KEDINTKKE
330 340 350 360
380 390 400 410 420 430
pF1KA0 PIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKI
. :. . .:. ..:::::::: :::..... .:. :: ::.::.:::.: :..: .:
NP_056 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
370 380 390 400 410 420
440 450 460 470 480 490
pF1KA0 STLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCG
. ::::::::.: :: :::::.::.:::. ::.:: . ::::::.:.: : ::
NP_056 KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
430 440 450 460 470 480
500 510 520 530 540 550
pF1KA0 ILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSV
.::.:...::::::::.::: :: : ::..::..:: .::. ::.: :. :: ..
NP_056 VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGER--NAY
490 500 510 520 530 540
560 570 580 590 600 610
pF1KA0 VADQLKGLKTYLISG--QRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSD
. .: ..:.:: : :. :: . :. . . ..: . :: : :
NP_056 LKEQ--HIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLM----PRW--------VPD
550 560 570 580
620 630 640 650 660 670
pF1KA0 LAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGL
..:. : . : : : .: :. : ::..:
NP_056 -----RAFSRTKDSKA----FR------------QMGIDDSSKD--------NRGTQDAL
590 600 610
680 690 700 710 720 730
pF1KA0 LSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDS
:..: . :.:.. ..: .. :: ..:. :. ......
NP_056 --NPEDE--------VDEFLSR-------AIDARSIDQLRKDHVRR-----FLLTFQRED
620 630 640 650
740 750 760 770 780 790
pF1KA0 LMKDYFFK-PPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLST
: : : : : .:. : . : .. : .:. ..:.. ..:
NP_056 LEKKYSRKVDP--RFGAYVACALLVFCFICFIQLLIF---PHSTLMLGIYASIF-LLLLI
660 670 680 690 700 710
800 810 820 830 840
pF1KA0 TVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLL-EVLSLAV---SIRMVFF--LEDVM
::.. .: . : :: .: ... .. : :: :. .:: . ...
NP_056 TVLICAVYSCGSLF--------PKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMF
720 730 740 750 760
850 860 870 880 890 900
pF1KA0 ACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTS-EYETNIHFPVFTGSAALIAVVH
.:.. . : : . .: :: . :. . .: .. :. :. . .
NP_056 TCNHTPI--------RSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPE
770 780 790 800 810
910 920 930 940 950
pF1KA0 YCNFCQLSSWMRSS----------LATVVGAGPLLLLYVSLCPDSSVLTSP--LDAVQNF
: .: : . :: :: . : . :. . : : .... . : .:...
NP_056 YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGL
820 830 840 850 860 870
960 970 980 990 1000 1010
pF1KA0 SSERNPCNS-SVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEAD
.: . .. . : : . . ..::: : : : .. : . :: . ..:
NP_056 ASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYL---HAQQVESTARLDFLWKLQAT
880 890 900 910 920 930
1020 1030 1040 1050 1060 1070
pF1KA0 LHRTKIQSMRDQADWLLRNIIPYHVAEQL-----KVSQTYSKNHDSGGVIFASIVNFSEF
.. ... .. ::.::.: :: .. . .. : .. . .:.::::.:::::
NP_056 GEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF
940 950 960 970 980 990
1080 1090 1100 1110 1120
pF1KA0 Y---EENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQD
: : : :: :: :.:::.:.::::..:. . ..:::::::.::::::::: :.. :
NP_056 YVELEANNEG-VECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN-ASTYD
1000 1010 1020 1030 1040
1130 1140 1150 1160 1170 1180
pF1KA0 GSHPQEHLQILFEFAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIW
. :. : ..: ..:. . .: . . ::....:.: ::..:::::. : ::::
NP_056 QVG-RSHITALADYAMRLMEQMKHINEHSFN-NFQMKIGLNMGPVVAGVIGARKPQYDIW
1050 1060 1070 1080 1090 1100
1190 1200 1210 1220 1230 1240
pF1KA0 GDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTD
:.:::..::::.::: ::::. . :.::. ::... ::.:.:::::.: ::.
NP_056 GNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPS
1110 1120 1130 1140 1150 1160
1250 1260 1270 1280 1290 1300
pF1KA0 HRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLS
NP_056 S
>>XP_006719273 (OMIM: 600294,616287) PREDICTED: adenylat (1168 aa)
initn: 1217 init1: 667 opt: 682 Z-score: 732.4 bits: 147.7 E(85289): 4.7e-34
Smith-Waterman score: 1313; 29.2% identity (55.5% similar) in 1224 aa overlap (53-1241:97-1161)
30 40 50 60 70 80
pF1KA0 GDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQL
. ...: . .: : .:: ..: :.
XP_006 DDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGR-SCWRRLVQV
70 80 90 100 110 120
90 100 110 120 130 140
pF1KA0 FERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRL
:. . .: :..::. . : ..: . . .. :: .. .: :
XP_006 FQ-------SKQFRSAKLERLYQRYFFQMNQSSLT---LLMAVLVLLTAVLLAFHAAP--
130 140 150 160 170
150 160 170 180 190 200
pF1KA0 IVMVAPALCFLLVCVGFFLFTFTKLYARH-YAWTSL-ALTLLVFALTLAAQFQVLTPVSG
. :: ::.:.. .. . . :: . :. ... .:... :.: :.:
XP_006 -ARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQ------VGG
180 190 200 210 220
210 220 230 240 250
pF1KA0 RGDSSNLTATARPTDTCLSQVGSFSMC-IEVLFLLYTVMHLPLYLSLCLGVAYSVLFETF
:.: : .. : : . ... ::.. . . .. :.. :.: .
XP_006 -----ALAADPRSPSAGL-------WCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLIL
230 240 250 260 270
260 270 280 290 300 310
pF1KA0 GYHFRDEACFPSPGAGALHWELLSRG-LLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIM
.... . :. :. :. . :: : ..::. ..: .:..: .. :.
XP_006 AWQLNR--------GDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQ
280 290 300 310 320
320 330 340 350 360 370
pF1KA0 HGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKA
:. :. .::.. ::.:. .: .. :. . .:
XP_006 ARLHLQHENRQQERLLLSVLPQHVAMEM-----------------------KEDINTKKE
330 340 350 360
380 390 400 410 420 430
pF1KA0 PIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKI
. :. . .:. ..:::::::: :::..... .:. :: ::.::.:::.: :..: .:
XP_006 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
370 380 390 400 410 420
440 450 460 470 480 490
pF1KA0 STLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCG
. ::::::::.: :: :::::.::.:::. ::.:: . ::::::.:.: : ::
XP_006 KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
430 440 450 460 470 480
500 510 520 530 540 550
pF1KA0 ILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSV
.::.:...::::::::.::: :: : ::..::..:: .::. ::.: :. :: ..
XP_006 VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGER--NAY
490 500 510 520 530 540
560 570 580 590 600 610
pF1KA0 VADQLKGLKTYLISG--QRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSD
. .: ..:.:: : :. :: . :. . . ..: . :: : :
XP_006 LKEQ--HIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLM----PRW--------VPD
550 560 570 580
620 630 640 650 660 670
pF1KA0 LAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGL
..:. : . : : : .: :. : ::..:
XP_006 -----RAFSRTKDSKA----FR------------QMGIDDSSKD--------NRGTQDAL
590 600 610
680 690 700 710 720 730
pF1KA0 LSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDS
:..: . :.:.. ..: .. :: ..:. :. ......
XP_006 --NPEDE--------VDEFLSR-------AIDARSIDQLRKDHVRR-----FLLTFQRED
620 630 640 650
740 750 760 770 780 790
pF1KA0 LMKDYFFK-PPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLST
: : : : : .:. : . : .. : .:. ..:.. ..:
XP_006 LEKKYSRKVDP--RFGAYVACALLVFCFICFIQLLIF---PHSTLMLGIYASIF-LLLLI
660 670 680 690 700 710
800 810 820 830 840
pF1KA0 TVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLL-EVLSLAV---SIRMVFF--LEDVM
::.. .: . : :: .: ... .. : :: :. .:: . ...
XP_006 TVLICAVYSCGSLF--------PKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMF
720 730 740 750 760
850 860 870 880 890 900
pF1KA0 ACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTS-EYETNIHFPVFTGSAALIAVVH
.:.. . : : . .: :: . :. . .: .. :. :. . .
XP_006 TCNHTPI--------RSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPE
770 780 790 800 810
910 920 930 940 950
pF1KA0 YCNFCQLSSWMRSS----------LATVVGAGPLLLLYVSLCPDSSVLTSP--LDAVQNF
: .: : . :: :: . : . :. . : : .... . : .:...
XP_006 YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGL
820 830 840 850 860 870
960 970 980 990 1000 1010
pF1KA0 SSERNPCNS-SVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEAD
.: . .. . : : . . ..::: : : : .. : . :: . ..:
XP_006 ASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYL---HAQQVESTARLDFLWKLQAT
880 890 900 910 920 930
1020 1030 1040 1050 1060 1070
pF1KA0 LHRTKIQSMRDQADWLLRNIIPYHVAEQL-----KVSQTYSKNHDSGGVIFASIVNFSEF
.. ... .. ::.::.: :: .. . .. : .. . .:.::::.:::::
XP_006 GEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF
940 950 960 970 980 990
1080 1090 1100 1110 1120
pF1KA0 Y---EENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQD
: : : :: :: :.:::.:.::::..:. . ..:::::::.::::::::: :.. :
XP_006 YVELEANNEG-VECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN-ASTYD
1000 1010 1020 1030 1040
1130 1140 1150 1160 1170 1180
pF1KA0 GSHPQEHLQILFEFAKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIW
. :. : ..: ..:. . .: . . ::....:.: ::..:::::. : ::::
XP_006 QVG-RSHITALADYAMRLMEQMKHINEHSFN-NFQMKIGLNMGPVVAGVIGARKPQYDIW
1050 1060 1070 1080 1090 1100
1190 1200 1210 1220 1230 1240
pF1KA0 GDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTD
:.:::..::::.::: ::::. . :.::. ::... ::.:.:::::.: ::.
XP_006 GNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPS
1110 1120 1130 1140 1150 1160
1250 1260 1270 1280 1290 1300
pF1KA0 HRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLS
XP_006 S
1353 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:44:14 2016 done: Thu Nov 3 19:44:16 2016
Total Scan time: 13.410 Total Display time: 0.530
Function used was FASTA [36.3.4 Apr, 2011]