Result of FASTA (omim) for
pF1KA0522
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0522, 1488 aa
1>>>pF1KA0522 1488 - 1488 aa - 1488 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 17.2425+/-0.000483; mu= -32.4204+/- 0.030
mean_var=765.0109+/-160.676, 0's: 0 Z-trim(125.1): 160 B-trim: 926 in 1/61
Lambda= 0.046370
statistics sampled from 47953 (48146) to 47953 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.8), E-opt: 0.2 (0.565), width: 16
Scan time: 18.940
The best scores are: opt bits E(85289)
NP_001104595 (OMIM: 300522,300551,309530) IQ motif (1488) 10335 707.9 1.5e-202
XP_016884848 (OMIM: 300522,300551,309530) PREDICTE (1478) 8794 604.8 1.6e-171
XP_006724642 (OMIM: 300522,300551,309530) PREDICTE (1520) 8787 604.3 2.3e-171
XP_011529075 (OMIM: 300522,300551,309530) PREDICTE (1251) 8684 597.4 2.4e-169
XP_006724643 (OMIM: 300522,300551,309530) PREDICTE (1283) 8683 597.3 2.5e-169
XP_016884849 (OMIM: 300522,300551,309530) PREDICTE (1322) 8679 597.1 3.1e-169
XP_011529076 (OMIM: 300522,300551,309530) PREDICTE (1222) 6351 441.3 2.2e-122
XP_006724645 (OMIM: 300522,300551,309530) PREDICTE (1212) 6339 440.5 3.9e-122
XP_006724644 (OMIM: 300522,300551,309530) PREDICTE (1244) 6323 439.4 8.3e-122
XP_006724646 (OMIM: 300522,300551,309530) PREDICTE (1200) 6234 433.5 5e-120
XP_006724647 (OMIM: 300522,300551,309530) PREDICTE (1186) 6223 432.7 8.2e-120
NP_055890 (OMIM: 300522,300551,309530) IQ motif an ( 949) 6119 425.7 8.6e-118
XP_011529079 (OMIM: 300522,300551,309530) PREDICTE (1126) 5849 407.7 2.7e-112
XP_011529078 (OMIM: 300522,300551,309530) PREDICTE (1130) 5844 407.4 3.4e-112
XP_016863070 (OMIM: 610166) PREDICTED: IQ motif an (1212) 2955 214.1 5.4e-54
XP_016863071 (OMIM: 610166) PREDICTED: IQ motif an (1207) 2011 151.0 5.6e-35
XP_011532606 (OMIM: 610166) PREDICTED: IQ motif an (1222) 1960 147.5 6e-34
XP_011532608 (OMIM: 610166) PREDICTED: IQ motif an (1129) 1955 147.2 7.1e-34
XP_011532609 (OMIM: 610166) PREDICTED: IQ motif an (1129) 1942 146.3 1.3e-33
XP_011532607 (OMIM: 610166) PREDICTED: IQ motif an (1132) 1942 146.3 1.3e-33
NP_001127854 (OMIM: 610166) IQ motif and SEC7 doma (1114) 1939 146.1 1.5e-33
XP_011532610 (OMIM: 610166) PREDICTED: IQ motif an (1128) 1937 146.0 1.6e-33
XP_011532614 (OMIM: 610166) PREDICTED: IQ motif an (1006) 1883 142.3 1.8e-32
XP_011532613 (OMIM: 610166) PREDICTED: IQ motif an (1006) 1883 142.3 1.8e-32
XP_011532616 (OMIM: 610166) PREDICTED: IQ motif an (1006) 1883 142.3 1.8e-32
XP_011532615 (OMIM: 610166) PREDICTED: IQ motif an (1006) 1883 142.3 1.8e-32
XP_011532612 (OMIM: 610166) PREDICTED: IQ motif an (1030) 1767 134.6 4e-30
XP_011519263 (OMIM: 612118) PREDICTED: IQ motif an ( 879) 1754 133.7 6.5e-30
NP_001164209 (OMIM: 612118) IQ motif and SEC7 doma (1182) 1754 133.8 8.2e-30
NP_055684 (OMIM: 610166) IQ motif and SEC7 domain- ( 963) 1745 133.1 1.1e-29
NP_056047 (OMIM: 612118) IQ motif and SEC7 domain- ( 759) 1708 130.5 4.8e-29
XP_011519260 (OMIM: 612118) PREDICTED: IQ motif an (1063) 1710 130.8 5.8e-29
XP_016874799 (OMIM: 612118) PREDICTED: IQ motif an (1041) 1708 130.6 6.2e-29
XP_016874800 (OMIM: 612118) PREDICTED: IQ motif an (1041) 1708 130.6 6.2e-29
XP_011519262 (OMIM: 612118) PREDICTED: IQ motif an (1062) 1708 130.6 6.3e-29
XP_011519261 (OMIM: 612118) PREDICTED: IQ motif an (1062) 1708 130.6 6.3e-29
XP_011532617 (OMIM: 610166) PREDICTED: IQ motif an ( 814) 1690 129.4 1.2e-28
NP_001317548 (OMIM: 610166) IQ motif and SEC7 doma ( 814) 1690 129.4 1.2e-28
XP_006723536 (OMIM: 602488) PREDICTED: cytohesin-2 ( 394) 517 50.7 2.8e-05
NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Ho ( 399) 517 50.7 2.8e-05
NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Ho ( 400) 517 50.7 2.8e-05
XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 ( 421) 517 50.7 2.9e-05
XP_011515744 (OMIM: 604141) PREDICTED: brefeldin A (1649) 537 52.4 3.4e-05
XP_005251193 (OMIM: 604141) PREDICTED: brefeldin A (1800) 537 52.5 3.7e-05
XP_005251192 (OMIM: 604141) PREDICTED: brefeldin A (1843) 537 52.5 3.8e-05
NP_006412 (OMIM: 604141) brefeldin A-inhibited gua (1849) 537 52.5 3.8e-05
XP_005251191 (OMIM: 604141) PREDICTED: brefeldin A (1849) 537 52.5 3.8e-05
XP_011523777 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 496 49.2 6.2e-05
XP_011523778 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 496 49.2 6.2e-05
XP_016880827 (OMIM: 182115) PREDICTED: cytohesin-1 ( 338) 496 49.2 6.5e-05
>>NP_001104595 (OMIM: 300522,300551,309530) IQ motif and (1488 aa)
initn: 10335 init1: 10335 opt: 10335 Z-score: 3757.2 bits: 707.9 E(85289): 1.5e-202
Smith-Waterman score: 10335; 100.0% identity (100.0% similar) in 1488 aa overlap (1-1488:1-1488)
10 20 30 40 50 60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480
pF1KA0 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
1450 1460 1470 1480
>>XP_016884848 (OMIM: 300522,300551,309530) PREDICTED: I (1478 aa)
initn: 8673 init1: 8673 opt: 8794 Z-score: 3200.1 bits: 604.8 E(85289): 1.6e-171
Smith-Waterman score: 10239; 99.3% identity (99.3% similar) in 1488 aa overlap (1-1488:1-1478)
10 20 30 40 50 60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQR-----
190 200 210 220 230
250 260 270 280 290 300
pF1KA0 NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -----NVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KA0 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
300 310 320 330 340 350
370 380 390 400 410 420
pF1KA0 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
360 370 380 390 400 410
430 440 450 460 470 480
pF1KA0 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
420 430 440 450 460 470
490 500 510 520 530 540
pF1KA0 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
480 490 500 510 520 530
550 560 570 580 590 600
pF1KA0 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
540 550 560 570 580 590
610 620 630 640 650 660
pF1KA0 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
600 610 620 630 640 650
670 680 690 700 710 720
pF1KA0 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
660 670 680 690 700 710
730 740 750 760 770 780
pF1KA0 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
720 730 740 750 760 770
790 800 810 820 830 840
pF1KA0 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
780 790 800 810 820 830
850 860 870 880 890 900
pF1KA0 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
840 850 860 870 880 890
910 920 930 940 950 960
pF1KA0 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KA0 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KA0 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KA0 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KA0 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KA0 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KA0 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480
pF1KA0 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
1440 1450 1460 1470
>>XP_006724642 (OMIM: 300522,300551,309530) PREDICTED: I (1520 aa)
initn: 10321 init1: 8677 opt: 8787 Z-score: 3197.4 bits: 604.3 E(85289): 2.3e-171
Smith-Waterman score: 10261; 97.9% identity (97.9% similar) in 1520 aa overlap (1-1488:1-1520)
10 20 30 40 50 60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
190 200 210 220 230 240
250 260
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
::::: :::::::::::::::::::::::
XP_006 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
250 260 270 280 290 300
270 280 290 300 310 320
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
310 320 330 340 350 360
330 340 350 360 370 380
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
370 380 390 400 410 420
390 400 410 420 430 440
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
430 440 450 460 470 480
450 460 470 480 490 500
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
490 500 510 520 530 540
510 520 530 540 550 560
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
730 740 750 760 770 780
750 760 770 780 790 800
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
790 800 810 820 830 840
810 820 830 840 850 860
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
850 860 870 880 890 900
870 880 890 900 910 920
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
910 920 930 940 950 960
930 940 950 960 970 980
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KA0 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270 1280
pF1KA0 SASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQP
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330 1340
pF1KA0 SLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAG
1330 1340 1350 1360 1370 1380
1350 1360 1370 1380 1390 1400
pF1KA0 GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGS
1390 1400 1410 1420 1430 1440
1410 1420 1430 1440 1450 1460
pF1KA0 RPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPG
1450 1460 1470 1480 1490 1500
1470 1480
pF1KA0 TANPPSANPKAKPSRISTVV
::::::::::::::::::::
XP_006 TANPPSANPKAKPSRISTVV
1510 1520
>>XP_011529075 (OMIM: 300522,300551,309530) PREDICTED: I (1251 aa)
initn: 8684 init1: 8684 opt: 8684 Z-score: 3161.4 bits: 597.4 E(85289): 2.4e-169
Smith-Waterman score: 8684; 99.8% identity (99.9% similar) in 1246 aa overlap (243-1488:6-1251)
220 230 240 250 260 270
pF1KA0 SSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLS
:. :::::::::::::::::::::::::::
XP_011 MEPPGRSSSVEGDAPGSDLSTAVDSPGSQPPYRLS
10 20 30
280 290 300 310 320 330
pF1KA0 QLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDK
40 50 60 70 80 90
340 350 360 370 380 390
pF1KA0 KVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQF
100 110 120 130 140 150
400 410 420 430 440 450
pF1KA0 SFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGE
160 170 180 190 200 210
460 470 480 490 500 510
pF1KA0 FSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATS
220 230 240 250 260 270
520 530 540 550 560 570
pF1KA0 FSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGT
280 290 300 310 320 330
580 590 600 610 620 630
pF1KA0 RRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTL
340 350 360 370 380 390
640 650 660 670 680 690
pF1KA0 KHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSD
400 410 420 430 440 450
700 710 720 730 740 750
pF1KA0 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV
460 470 480 490 500 510
760 770 780 790 800 810
pF1KA0 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK
520 530 540 550 560 570
820 830 840 850 860 870
pF1KA0 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV
580 590 600 610 620 630
880 890 900 910 920 930
pF1KA0 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI
640 650 660 670 680 690
940 950 960 970 980 990
pF1KA0 YQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGL
700 710 720 730 740 750
1000 1010 1020 1030 1040 1050
pF1KA0 HQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPG
760 770 780 790 800 810
1060 1070 1080 1090 1100 1110
pF1KA0 GERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGA
820 830 840 850 860 870
1120 1130 1140 1150 1160 1170
pF1KA0 KDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVIS
880 890 900 910 920 930
1180 1190 1200 1210 1220 1230
pF1KA0 SPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASS
940 950 960 970 980 990
1240 1250 1260 1270 1280 1290
pF1KA0 SSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPP
1000 1010 1020 1030 1040 1050
1300 1310 1320 1330 1340 1350
pF1KA0 PPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQ
1060 1070 1080 1090 1100 1110
1360 1370 1380 1390 1400 1410
pF1KA0 FAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPG
1120 1130 1140 1150 1160 1170
1420 1430 1440 1450 1460 1470
pF1KA0 GSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANP
1180 1190 1200 1210 1220 1230
1480
pF1KA0 PSANPKAKPSRISTVV
::::::::::::::::
XP_011 PSANPKAKPSRISTVV
1240 1250
>>XP_006724643 (OMIM: 300522,300551,309530) PREDICTED: I (1283 aa)
initn: 8677 init1: 8677 opt: 8683 Z-score: 3160.9 bits: 597.3 E(85289): 2.5e-169
Smith-Waterman score: 8683; 97.7% identity (98.4% similar) in 1280 aa overlap (211-1488:6-1283)
190 200 210 220 230 240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
::: : .:. :. .:. .
XP_006 MEPPGRSSRSTA--SHTLHQYCCPTQVLDSMKLTP
10 20 30
250 260 270 280 290
pF1KA0 NSRTV--SVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARL
..: . :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGRLAESSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARL
40 50 60 70 80 90
300 310 320 330 340 350
pF1KA0 QPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAF
100 110 120 130 140 150
360 370 380 390 400 410
pF1KA0 RQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAM
160 170 180 190 200 210
420 430 440 450 460 470
pF1KA0 AGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEA
220 230 240 250 260 270
480 490 500 510 520 530
pF1KA0 LNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPP
280 290 300 310 320 330
540 550 560 570 580 590
pF1KA0 PQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEP
340 350 360 370 380 390
600 610 620 630 640 650
pF1KA0 PSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAP
400 410 420 430 440 450
660 670 680 690 700 710
pF1KA0 PGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSR
460 470 480 490 500 510
720 730 740 750 760 770
pF1KA0 DSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIER
520 530 540 550 560 570
780 790 800 810 820 830
pF1KA0 GFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALR
580 590 600 610 620 630
840 850 860 870 880 890
pF1KA0 KFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSP
640 650 660 670 680 690
900 910 920 930 940 950
pF1KA0 SVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMI
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KA0 VGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVT
760 770 780 790 800 810
1020 1030 1040 1050 1060 1070
pF1KA0 YSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRE
820 830 840 850 860 870
1080 1090 1100 1110 1120 1130
pF1KA0 SIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRG
880 890 900 910 920 930
1140 1150 1160 1170 1180 1190
pF1KA0 ALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPV
940 950 960 970 980 990
1200 1210 1220 1230 1240 1250
pF1KA0 SNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLP
1000 1010 1020 1030 1040 1050
1260 1270 1280 1290 1300 1310
pF1KA0 DGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGP
1060 1070 1080 1090 1100 1110
1320 1330 1340 1350 1360 1370
pF1KA0 HRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHP
1120 1130 1140 1150 1160 1170
1380 1390 1400 1410 1420 1430
pF1KA0 PAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYP
1180 1190 1200 1210 1220 1230
1440 1450 1460 1470 1480
pF1KA0 PLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
1240 1250 1260 1270 1280
>>XP_016884849 (OMIM: 300522,300551,309530) PREDICTED: I (1322 aa)
initn: 8677 init1: 8677 opt: 8679 Z-score: 3159.3 bits: 597.1 E(85289): 3.1e-169
Smith-Waterman score: 8679; 98.2% identity (98.8% similar) in 1270 aa overlap (221-1488:53-1322)
200 210 220 230 240
pF1KA0 AVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTV--SVE
:. :. .:. . ..: . :::
XP_016 PPSPTLPLPSLPVSLSVSLCLLLSLRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVE
30 40 50 60 70 80
250 260 270 280 290 300
pF1KA0 GDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQ
90 100 110 120 130 140
310 320 330 340 350 360
pF1KA0 EEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFE
150 160 170 180 190 200
370 380 390 400 410 420
pF1KA0 RLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLER
210 220 230 240 250 260
430 440 450 460 470 480
pF1KA0 GLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMS
270 280 290 300 310 320
490 500 510 520 530 540
pF1KA0 EEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAP
330 340 350 360 370 380
550 560 570 580 590 600
pF1KA0 APLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSD
390 400 410 420 430 440
610 620 630 640 650 660
pF1KA0 RSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNS
450 460 470 480 490 500
670 680 690 700 710 720
pF1KA0 GTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATG
510 520 530 540 550 560
730 740 750 760 770 780
pF1KA0 LCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGV
570 580 590 600 610 620
790 800 810 820 830 840
pF1KA0 AHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQG
630 640 650 660 670 680
850 860 870 880 890 900
pF1KA0 EAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKL
690 700 710 720 730 740
910 920 930 940 950 960
pF1KA0 DDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLP
750 760 770 780 790 800
970 980 990 1000 1010 1020
pF1KA0 HRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLV
810 820 830 840 850 860
1030 1040 1050 1060 1070 1080
pF1KA0 EMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEK
870 880 890 900 910 920
1090 1100 1110 1120 1130 1140
pF1KA0 YRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLS
930 940 950 960 970 980
1150 1160 1170 1180 1190 1200
pF1KA0 DAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSL
990 1000 1010 1020 1030 1040
1210 1220 1230 1240 1250 1260
pF1KA0 FGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH
1050 1060 1070 1080 1090 1100
1270 1280 1290 1300 1310 1320
pF1KA0 AQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV
1110 1120 1130 1140 1150 1160
1330 1340 1350 1360 1370 1380
pF1KA0 PGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHF
1170 1180 1190 1200 1210 1220
1390 1400 1410 1420 1430 1440
pF1KA0 IFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTP
1230 1240 1250 1260 1270 1280
1450 1460 1470 1480
pF1KA0 HSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
::::::::::::::::::::::::::::::::::::::::
XP_016 HSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
1290 1300 1310 1320
>>XP_011529076 (OMIM: 300522,300551,309530) PREDICTED: I (1222 aa)
initn: 7864 init1: 6220 opt: 6351 Z-score: 2318.1 bits: 441.3 E(85289): 2.2e-122
Smith-Waterman score: 7825; 96.1% identity (96.6% similar) in 1220 aa overlap (1-1185:1-1220)
10 20 30 40 50 60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
190 200 210 220 230 240
250 260
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
::::: :::::::::::::::::::::::
XP_011 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
250 260 270 280 290 300
270 280 290 300 310 320
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
310 320 330 340 350 360
330 340 350 360 370 380
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
370 380 390 400 410 420
390 400 410 420 430 440
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
430 440 450 460 470 480
450 460 470 480 490 500
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
490 500 510 520 530 540
510 520 530 540 550 560
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
730 740 750 760 770 780
750 760 770 780 790 800
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
790 800 810 820 830 840
810 820 830 840 850 860
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
850 860 870 880 890 900
870 880 890 900 910 920
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
910 920 930 940 950 960
930 940 950 960 970 980
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KA0 SV-ISSPRP--HQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPT
.. : :... :: :
XP_011 RRRVGMPLELGHEKLLPPSPAL
1210 1220
>>XP_006724645 (OMIM: 300522,300551,309530) PREDICTED: I (1212 aa)
initn: 7923 init1: 6214 opt: 6339 Z-score: 2313.8 bits: 440.5 E(85289): 3.9e-122
Smith-Waterman score: 7813; 96.5% identity (96.9% similar) in 1212 aa overlap (1-1180:1-1212)
10 20 30 40 50 60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
190 200 210 220 230 240
250 260
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
::::: :::::::::::::::::::::::
XP_006 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
250 260 270 280 290 300
270 280 290 300 310 320
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
310 320 330 340 350 360
330 340 350 360 370 380
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
370 380 390 400 410 420
390 400 410 420 430 440
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
430 440 450 460 470 480
450 460 470 480 490 500
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
490 500 510 520 530 540
510 520 530 540 550 560
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
730 740 750 760 770 780
750 760 770 780 790 800
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
790 800 810 820 830 840
810 820 830 840 850 860
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
850 860 870 880 890 900
870 880 890 900 910 920
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
910 920 930 940 950 960
930 940 950 960 970 980
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIED
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KA0 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
. . . :..:.
XP_006 GCVWAKGPQRRL
1210
>>XP_006724644 (OMIM: 300522,300551,309530) PREDICTED: I (1244 aa)
initn: 7922 init1: 6213 opt: 6323 Z-score: 2307.8 bits: 439.4 E(85289): 8.3e-122
Smith-Waterman score: 7797; 97.3% identity (97.3% similar) in 1201 aa overlap (1-1169:1-1201)
10 20 30 40 50 60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
190 200 210 220 230 240
250 260
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
::::: :::::::::::::::::::::::
XP_006 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
250 260 270 280 290 300
270 280 290 300 310 320
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
310 320 330 340 350 360
330 340 350 360 370 380
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
370 380 390 400 410 420
390 400 410 420 430 440
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
430 440 450 460 470 480
450 460 470 480 490 500
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
490 500 510 520 530 540
510 520 530 540 550 560
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
730 740 750 760 770 780
750 760 770 780 790 800
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
790 800 810 820 830 840
810 820 830 840 850 860
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
850 860 870 880 890 900
870 880 890 900 910 920
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
910 920 930 940 950 960
930 940 950 960 970 980
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEV
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KA0 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
:
XP_006 SQGRQLAKAAAGATYAFDAASWTRLEGLKSLDPQGPESSPINIF
1210 1220 1230 1240
>>XP_006724646 (OMIM: 300522,300551,309530) PREDICTED: I (1200 aa)
initn: 7757 init1: 6113 opt: 6234 Z-score: 2275.9 bits: 433.5 E(85289): 5e-120
Smith-Waterman score: 7708; 96.7% identity (97.0% similar) in 1193 aa overlap (1-1161:1-1193)
10 20 30 40 50 60
pF1KA0 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
190 200 210 220 230 240
250 260
pF1KA0 NSRTV--------------------------------SVEGDAPGSDLSTAVDSPGSQPP
::::: :::::::::::::::::::::::
XP_006 NSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGSQPP
250 260 270 280 290 300
270 280 290 300 310 320
pF1KA0 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTD
310 320 330 340 350 360
330 340 350 360 370 380
pF1KA0 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNM
370 380 390 400 410 420
390 400 410 420 430 440
pF1KA0 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVT
430 440 450 460 470 480
450 460 470 480 490 500
pF1KA0 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
490 500 510 520 530 540
510 520 530 540 550 560
pF1KA0 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSR
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA0 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KA0 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KA0 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN
730 740 750 760 770 780
750 760 770 780 790 800
pF1KA0 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG
790 800 810 820 830 840
810 820 830 840 850 860
pF1KA0 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN
850 860 870 880 890 900
870 880 890 900 910 920
pF1KA0 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL
910 920 930 940 950 960
930 940 950 960 970 980
pF1KA0 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQ
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KA0 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLS
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KA0 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQ
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KA0 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEG
::::::::::::::::::::::::::::::::::::::::::: :. .: .:
XP_006 PGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGVPGKTTSKSSSWGHLRI
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KA0 SVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQA
1488 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 01:24:04 2016 done: Sat Nov 5 01:24:07 2016
Total Scan time: 18.940 Total Display time: 0.750
Function used was FASTA [36.3.4 Apr, 2011]