FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0560, 1485 aa 1>>>pF1KA0560 1485 - 1485 aa - 1485 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8429+/-0.00122; mu= 15.5644+/- 0.073 mean_var=90.9695+/-17.758, 0's: 0 Z-trim(102.9): 41 B-trim: 0 in 0/51 Lambda= 0.134470 statistics sampled from 7136 (7146) to 7136 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.559), E-opt: 0.2 (0.22), width: 16 Scan time: 2.860 The best scores are: opt bits E(32554) CCDS42013.1 AQR gene_id:9716|Hs108|chr15 (1485) 9917 1935.3 0 CCDS12386.1 UPF1 gene_id:5976|Hs108|chr19 (1118) 324 74.2 2.5e-12 CCDS74315.1 UPF1 gene_id:5976|Hs108|chr19 (1129) 324 74.2 2.5e-12 >>CCDS42013.1 AQR gene_id:9716|Hs108|chr15 (1485 aa) initn: 9917 init1: 9917 opt: 9917 Z-score: 10390.7 bits: 1935.3 E(32554): 0 Smith-Waterman score: 9917; 100.0% identity (100.0% similar) in 1485 aa overlap (1-1485:1-1485) 10 20 30 40 50 60 pF1KA0 MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIKVIEDIYEKEIVKSRFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIKVIEDIYEKEIVKSRFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 IRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWEIFKKKPDHFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWEIFKKKPDHFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 FFFKHILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FFFKHILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 ARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQERRFLSQLIQKFISVLKSVPLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQERRFLSQLIQKFISVLKSVPLSE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 PVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDDSHLLVHCYLSNLVRREEDGHLFSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDDSHLLVHCYLSNLVRREEDGHLFSQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 LLDMLKFYTGFEINDQTGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LLDMLKFYTGFEINDQTGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 TRESLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTTFDKEFLLELLVSRHERRISQIQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 TRESLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTTFDKEFLLELLVSRHERRISQIQQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 LNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 IRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTRVRADVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTRVRADVT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 INLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 INLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 LDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYETFNIIMRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYETFNIIMRRK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 PKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 IEHLKASFPGHNVKVTVEDPALQIPPFRITFPVRSGKGKKRKDADVEDEDTEEAKTLIVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IEHLKASFPGHNVKVTVEDPALQIPPFRITFPVRSGKGKKRKDADVEDEDTEEAKTLIVE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 PHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNI 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 YHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 YHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 VLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYISKVKNKGSTLPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYISKVKNKGSTLPD 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 VTEVSTFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VTEVSTFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 LDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQN 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 PQDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PQDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRAR 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 ASLCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ASLCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQN 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 LGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTV 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 DRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAF 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 SQLTARPLHLHIIPTEPFPTTRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHHYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 SQLTARPLHLHIIPTEPFPTTRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHHYH 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 QTLLQLPPAMVEEGEEVQNQETELETEEEAMTVQADIIPSPTDTSCRQETPAFQTDTTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 QTLLQLPPAMVEEGEEVQNQETELETEEEAMTVQADIIPSPTDTSCRQETPAFQTDTTPS 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 pF1KA0 ETGATSTPEAIPALSETTPTVVGAVSAPAEANTPQDATSAPEETK ::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ETGATSTPEAIPALSETTPTVVGAVSAPAEANTPQDATSAPEETK 1450 1460 1470 1480 >>CCDS12386.1 UPF1 gene_id:5976|Hs108|chr19 (1118 aa) initn: 269 init1: 133 opt: 324 Z-score: 334.8 bits: 74.2 E(32554): 2.5e-12 Smith-Waterman score: 354; 24.2% identity (52.4% similar) in 492 aa overlap (1013-1481:590-1048) 990 1000 1010 1020 1030 1040 pF1KA0 KGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRS-KYLLVKEAKIIAMTCTH :.: .: :. . :. .: .: ::. CCDS12 ALHNQIRNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVG 560 570 580 590 600 610 1050 1060 1070 1080 1090 1100 pF1KA0 AALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLP :. : :.:. :. .::..:..: : : ..:..: :. :..::: :: CCDS12 AGDPR--LAKMQFR--SILIDESTQATEPECMVPVVLGA--------KQLILVGDHCQLG 620 630 640 650 660 1110 1120 1130 1140 1150 1160 pF1KA0 PVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNL-YNWRYKNLGNLPHV ::. : ... :::: :.: .:. . :..: : . .: . : :. :.: . CCDS12 PVVMCKKAAK-AGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYE--GSLQN- 670 680 690 700 710 720 1170 1180 1190 1200 1210 pF1KA0 QLLPEFSTANAGLLYDFQLINVED--F----QGVGESEPNPYFYQNLGEAEYVVALFMYM . . .. : .::: . . : :: : . : : :: : . . CCDS12 -GVTAADRVKKG--FDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKL 730 740 750 760 770 780 1220 1230 1240 1250 1260 1270 pF1KA0 CLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLS : :.:.:.: :.::. . . .. . . . . ....:: :::...:.:.:: CCDS12 LKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILS 790 800 810 820 830 840 1280 1290 1300 1310 1320 1330 pF1KA0 LVRT---RAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLH ::. ...: : : ::: ::..::: :. : . . ... : ...: . . CCDS12 CVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSK----QPLWNHLLNYYKEQK 850 860 870 880 890 1340 1350 1360 1370 1380 1390 pF1KA0 IIPTEPFPTTRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHHYHQTLLQLPPAMV .. :. . :.. . :. ...... : :. :: : .: .. CCDS12 VLVEGPLNNLRESLMQFSKPRKLVNTINPGARFM---------TTAMYDAREAIIPGSVY 900 910 920 930 940 1400 1410 1420 1430 1440 pF1KA0 EEGEEVQNQETELETEEEAMTVQADI-------IPSPTDTSCRQETPAFQTDTTPSETGA ... . . . ..:... ..: :: : . : . . ... CCDS12 DRSSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAG 950 960 970 980 990 1000 1450 1460 1470 1480 pF1KA0 TSTPEAIPALSETTPTVVGAVSAPAEANTP-----QDATSAPEETK .::.. . . . : . .:...: : ::..: : CCDS12 RGTPKGKTGRGGRQKNRFG-LPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQ 1010 1020 1030 1040 1050 1060 CCDS12 MSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY 1070 1080 1090 1100 1110 >>CCDS74315.1 UPF1 gene_id:5976|Hs108|chr19 (1129 aa) initn: 269 init1: 133 opt: 324 Z-score: 334.8 bits: 74.2 E(32554): 2.5e-12 Smith-Waterman score: 354; 24.2% identity (52.4% similar) in 492 aa overlap (1013-1481:601-1059) 990 1000 1010 1020 1030 1040 pF1KA0 KGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRS-KYLLVKEAKIIAMTCTH :.: .: :. . :. .: .: ::. CCDS74 ALHNQIRNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVG 580 590 600 610 620 630 1050 1060 1070 1080 1090 1100 pF1KA0 AALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLP :. : :.:. :. .::..:..: : : ..:..: :. :..::: :: CCDS74 AGDPR--LAKMQFR--SILIDESTQATEPECMVPVVLGA--------KQLILVGDHCQLG 640 650 660 670 1110 1120 1130 1140 1150 1160 pF1KA0 PVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNL-YNWRYKNLGNLPHV ::. : ... :::: :.: .:. . :..: : . .: . : :. :.: . CCDS74 PVVMCKKAAK-AGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYE--GSLQN- 680 690 700 710 720 730 1170 1180 1190 1200 1210 pF1KA0 QLLPEFSTANAGLLYDFQLINVED--F----QGVGESEPNPYFYQNLGEAEYVVALFMYM . . .. : .::: . . : :: : . : : :: : . . CCDS74 -GVTAADRVKKG--FDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKL 740 750 760 770 780 790 1220 1230 1240 1250 1260 1270 pF1KA0 CLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLS : :.:.:.: :.::. . . .. . . . . ....:: :::...:.:.:: CCDS74 LKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILS 800 810 820 830 840 850 1280 1290 1300 1310 1320 1330 pF1KA0 LVRT---RAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLH ::. ...: : : ::: ::..::: :. : . . ... : ...: . . CCDS74 CVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSK----QPLWNHLLNYYKEQK 860 870 880 890 900 1340 1350 1360 1370 1380 1390 pF1KA0 IIPTEPFPTTRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHHYHQTLLQLPPAMV .. :. . :.. . :. ...... : :. :: : .: .. CCDS74 VLVEGPLNNLRESLMQFSKPRKLVNTINPGARFM---------TTAMYDAREAIIPGSVY 910 920 930 940 950 1400 1410 1420 1430 1440 pF1KA0 EEGEEVQNQETELETEEEAMTVQADI-------IPSPTDTSCRQETPAFQTDTTPSETGA ... . . . ..:... ..: :: : . : . . ... CCDS74 DRSSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAG 960 970 980 990 1000 1010 1450 1460 1470 1480 pF1KA0 TSTPEAIPALSETTPTVVGAVSAPAEANTP-----QDATSAPEETK .::.. . . . : . .:...: : ::..: : CCDS74 RGTPKGKTGRGGRQKNRFG-LPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQ 1020 1030 1040 1050 1060 1070 CCDS74 MSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY 1080 1090 1100 1110 1120 1485 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 19:16:02 2016 done: Wed Nov 2 19:16:03 2016 Total Scan time: 2.860 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]